ライフサイエンスコーパス: polyadenylation factor

1 polyadenylation factors of CPF (cleavage and polyadenylation factor).

2 racts with FY, a highly conserved eukaryotic polyadenylation factor.

3 K1) identified PTI1, a potential 3' cleavage/polyadenylation factor.

4 and can be co-immunoprecipitated with other polyadenylation factors.

5 ed with gene 3' ends to recruit cleavage and polyadenylation factors.

6 hree distinct hubs involving the Arabidopsis polyadenylation factors.

7 sequence signals in pre-mRNA and a group of polyadenylation factors.

8 S4 forms a complex in vivo with FY and other polyadenylation factors.

9 ently requires a poly(A) signal and cleavage/polyadenylation factors.

10 cleavage complex (HCC) consisting of several polyadenylation factors.

11 the function of SSUP-72 and several nuclear polyadenylation factors.

12 this pattern with that of known splicing and polyadenylation factors.

13 -containing RNA binding protein, kinetoplast polyadenylation factor 3 (KPAF3), and demonstrate its ro

14 slinking patterns of multiple elongation and polyadenylation factors across transcribed genes.

15 Ser-2 carboxyl-terminal phosphorylation, and polyadenylation factor additions to RNA polymerase II.

16 in immunoprecipitation experiments show that polyadenylation factors and Rat1 localize to snoRNA gene

17 ivities of either generic or tissue-specific polyadenylation factors and/or splicing factors.

18 sing of EBV pol RNA by cellular cleavage and polyadenylation factors appears to be compensated for an

19 The same polyadenylation factors are associated with the endogeno

20 Polyadenylation factors are co-transcriptionally recruit

21 Our identification of two key polyadenylation factors as SUMO targets and of the role

22 , our results implicate CstF64, an essential polyadenylation factor, as a master regulator of 3'-UTR

23 e U7 snRNP, and suggest that in animal cells polyadenylation factors assemble into two alternative co

24 These findings suggest that polyadenylation factors can be recruited to an RNA 3'-pr

25 sable for Yra1 recruitment, but the cleavage/polyadenylation factor, CF1A, is required.

26 Polyadenylation factor CLP1 is essential for mRNA 3'-end

27 eraction of Srb5/Med18 with the cleavage and polyadenylation factor complex, however, could be detect

28 multiple components of the CPF (cleavage and polyadenylation factor) complex involved in messenger RN

29 The primary structure of the human CstF-64 polyadenylation factor contains 12 nearly identical repe

30 on the roles played by general cleavage and polyadenylation factors (CPA factors).

31 cture, but which do not bind the CPE-binding polyadenylation factor CPEB, failed to induce unmasking.

32 o very different complexes: the cleavage and polyadenylation factor CPF and the Set1 methylase, which

33 revisiae Pta1 is a component of the cleavage/polyadenylation factor (CPF) 3'-end processing complex a

34 hat Ssu72, a component of the yeast cleavage/polyadenylation factor (CPF) complex, is a CTD phosphata

35 factor Ssu72 is a component of the cleavage/polyadenylation factor (CPF) of Saccharomyces cerevisiae

36 e show that Clp1 interacts with the Cleavage-Polyadenylation Factor (CPF) through its N-terminal and

37 tase Glc7 associates with the yeast cleavage/polyadenylation factor (CPF), but the role of Glc7 in 3'

38 Yth1, a subunit of yeast Cleavage Polyadenylation Factor (CPF), contains five CCCH zinc fi

39 the 1-megadalton multiprotein cleavage and polyadenylation factor (CPF).

40 olytic cleavage is catalyzed by the cleavage/polyadenylation factor CPSF-73.

41 th morpholino technology or silencing of the polyadenylation factor CPSF1 caused a splice switch that

42 ng a truncated form of the mRNA cleavage and polyadenylation factor CPSF6, the completion of HIV-1 ve

43 Furthermore, the polyadenylation factor CPSF73 is not effectively recruit

44 mRNA cap methyltransferase and the Hrp1/CFIB polyadenylation factor cross-link to both promoter and c

45 In a complementary pattern, polyadenylation factors crosslink strongly at the 3' end

46 equences or the Rna14 protein causes loss of polyadenylation factor crosslinking and read-through of

47 The mRNA polyadenylation factor CstF interacts with the BRCA1-ass

48 quences are recognized by the heterotrimeric polyadenylation factor CstF, although how, and indeed if

49 We next show that the polyadenylation factor CstF, plays a direct role in the

50 ELL2 and the polyadenylation factor CstF-64 tracked together with RNA

51 n to identify factors that interact with the polyadenylation factor CstF-64, we uncovered an interact

52 including an association of PAF1-C with the polyadenylation factor CstF.

53 , a protein known to form a complex with the polyadenylation factors CstF and CPSF.

54 accumulation of one subunit of an essential polyadenylation factor (CstF-64) is specifically repress

55 Here a polyadenylation factor, CstF-50 (cleavage stimulation fa

56 factor, PC4 (or Sub1 in yeast), and an mRNA polyadenylation factor, CstF-64 (Rna15 in yeast), and pr

57 -PCR profiling identified elevated levels of polyadenylation factor CSTF3 in tumors with APA.

58 The cleavage/polyadenylation factor I (CF I) is one of four factors r

59 ur factors [cleavage factor I (CF I), CF II, polyadenylation factor I (PF I), and poly(A) polymerase

60 n four independent pedigrees in cleavage and polyadenylation factor I subunit 1 (CLP1).

61 The interaction of the Fip1 subunit of polyadenylation factor I with the Saccharomyces cerevisi

62 for specific polyadenylation when mixed with polyadenylation factor I, purified poly(A) polymerase, a

63 p1, CF II, and the Fip1 and Yth1 subunits of polyadenylation factor I.

64 s of cleavage factor IA (CFIA), an essential polyadenylation factor in Saccahromyces cerevisiae.

65 pe1 is involved in contact with the cleavage/polyadenylation factor in which Mpe1 resides.

66 nt (PEE), promoting the recruitment of other polyadenylation factors in yeast.

67 tone cleavage complex (HCC), and a subset of polyadenylation factors including the endonuclease CPSF7

68 Given evidence that certain polyadenylation factors, including Rna15p, are necessary

69 ever, also increases the affinity of general polyadenylation factors independently for the C2 poly(A)

70 lex that exploits Pab1p to link cleavage and polyadenylation factors of CFIA and CFIB (cleavage facto

71 and CFIB (cleavage factors IA and IB) to the polyadenylation factors of CPF (cleavage and polyadenyla

72 physically interacting with the cleavage and polyadenylation factor or cleavage factor 1 (CF1) comple

73 Depletion of cleavage and polyadenylation factors or of histone pre-mRNA processin

74 Surprisingly, polyadenylation factors promote RNP coassembly in vivo,

75 4 (PCFS4), an Arabidopsis homologue of yeast polyadenylation factor Protein 1 of Cleavage Factor 1 (P

76 Interestingly, levels of the polyadenylation factor Pta1 are also reduced in kin28 mu

77 educed in kin28 mutants, while several other polyadenylation factors remain stable.

78 ot inhibited by mutations in 3'-cleavage and polyadenylation factors, Rna14, Rna15 and Pap1, which bl

79 naffected, but cross-linking of the cleavage-polyadenylation factors Rna15 and Pta1 toward the 3' end

80 ired for the recruitment of the cleavage and polyadenylation factor Rna15p.

81 ns even under conditions in which functional polyadenylation factors should be in excess.

82 p binding protein, SR proteins, cleavage and polyadenylation factors, small nucleolar RNAs, nucleolar

83 CITY FACTOR30 (CPSF30) gene, which encodes a polyadenylation factor subunit homolog.

84 ks between PAP and several other Arabidopsis polyadenylation factor subunit homologs.

85 The N-terminal domain of another Arabidopsis polyadenylation factor subunit, AtFip1(V), dramatically

86 utants are suppressed by loss of function in Polyadenylation factor subunit-2 (PFS-2), a conserved WD

87 eins that are similar to mammalian and yeast polyadenylation factor subunits.

88 of this intronic PAS depends on the nuclear polyadenylation factor SYDN-1, which inhibits the RNA po

89 ghtly interacts with a unique combination of polyadenylation factors: symplekin, CstF64, and all CPSF

90 an effect on the efficiency of binding of a polyadenylation factor to an alternative polyadenylation

91 er, in ctk1Delta strains, the recruitment of polyadenylation factors to 3' regions of genes is disrup

92 unstructured domain which allows the general polyadenylation factors to efficiently assemble on the R

93 tion functions as a mechanism for recruiting polyadenylation factors to HSP genes to enhance the effi

94 ese results suggest that ubH2B helps recruit polyadenylation factors to STAT1-activated genes.

95 ecause FY has been shown to have homology to polyadenylation factors, we examined polyadenylation sit

96 quence homology search using human and yeast polyadenylation factors, we identified 28 proteins that

97 ases (CCNT2 and HEXIM1); mRNA processing and polyadenylation factors were also highlighted (HNRNPL/F,

98 n; beta(2) microglobulin; and a cleavage and polyadenylation factor) were identified as zinc-modulate

99 yer regulatory mechanisms controlling fungal polyadenylation factors, which have profound implication