ライフサイエンスコーパス: polyamide

1 h trimesoyl chloride, one of the monomers of polyamide.

2 eight, size, and color with the exception of polyamide.

3 cting a priori the nuclear uptake of a given polyamide.

4 the previously reported fluorescein-labeled polyamide.

5 incorporation of bromine and iodine into the polyamide.

6 culties synthesizing these tandem hairpin PI polyamides.

7 ys and compared to the corresponding hairpin polyamides.

8 g liver toxicity was only observed for three polyamides.

9 nker affects on the cellular permeability of polyamides.

10 d (alpha-amino-gamma-turn)-linked eight-ring polyamides.

11 inting data of DNA binding pyrrole-imidazole polyamides.

12 fective nuclear localization of HRE-targeted polyamides.

13 binds the HRE, is inhibited by HRE-targeted polyamides.

14 recognition motifs that can be inhibited by polyamides.

15 hway may also be involved in the response to polyamides.

16 In this study we introduce the Py-Im polyamide 1 that binds preferentially to the sequences 5

17 abeled radioactive pyrrole-imidazole (Py-Im) polyamide 1, targeted to the 5'-WGWWCW-3' DNA sequence,

18 An 8-ring hairpin polyamide 1, which targets the DNA sequence 5'-WGWWCW-3'

19 We find that cyclic Py-Im polyamides 1-3 bind DNA with exceptionally high affiniti

20 Cyclic 8-ring Py-Im polyamides 1-3 target the DNA sequence 5'-WGWWCW-3', whi

21 s that cause animal toxicity, we synthesized polyamides 1-4 with variations at the alpha- and beta-po

22 A focused library of cyclic polyamides 1-7 targeted to the androgen response element

23 A hairpin pyrrole-imidazole polyamide (1) targeted to the androgen receptor consensu

24 Three hairpin pyrrole-imidazole polyamides 2-4 that target their respective sequences 5'

25 or the largest proportion (38%), followed by polyamide (22%) and polypropylene (16%).

26 Polyamide 3, with an alpha-acetamide, caused no signific

27 -clay nanocomposites: polypropylene (PP) and polyamide 6 (PA6) with O-MMT.

28 th positively charged polymeric beads, e.g., polyamide 6/6 (Nylon) and polyoxymethylene (Delrin), and

29 ease of the nanofiller and transformation of polyamide-6 (PA6), a thermoplastic polymer widely used i

30 sited via atomic layer deposition (ALD) onto polyamide-6 nanofibers enable the formation of conformal

31 Bio-based unsaturated nylon-6,6 (unsaturated polyamide-6,6) was finally obtained by polymerization of

32 y developed novel porous nano-hydroxyapatite/polyamide 66 (nHP66)-based nanoscaffold materials contai

33 rpin with a second turn unit yields a cyclic polyamide, a lesser-studied architecture mainly attribut

34 .G mismatches in DNA by imidazole containing polyamides, a full thermodynamic profile for formation o

35 To directly identify the binding sites of polyamides across the genome, we designed, synthesized,

36 The fully aromatic polyamide active layer of a commercial nanofiltration me

37 averaged amide link scission in the aromatic polyamide active layer of a reverse osmosis membrane upo

38 uptake into the bulk region of the aromatic polyamide active layer of a reverse osmosis membrane upo

39 he partition coefficient of solutes into the polyamide active layer of reverse osmosis (RO) membranes

40 s, and measurements of charge density in the polyamide active layers of reverse osmosis (RO) and nano

41 rmine solute partition coefficients into the polyamide active layers of RO membranes.

42 o measure solute partition coefficients into polyamide active layers.

43 istic understanding of Cl uptake by aromatic polyamide active layers.

44 Small animal PET imaging of radiolabeled polyamides administered to mice revealed distinct differ

45 serum concentration was similar for all four polyamides after injection, dose-limiting liver toxicity

46 on between maleimides and resin-linked diene-polyamides allows the latter to be used in the preparati

47 quence specificity and binding affinity, six polyamide analogues containing the core triheterocyclic

48 The use of an oxime linkage between the polyamide and an aromatic functionality on the C-terminu

49 the carbon nanotubes are embedded within the polyamide and form ester bonds with trimesoyl chloride,

50 ation by fractionation on Amberlite(R) XAD16 polyamide and semi-preparative reverse-phase HPLC column

51 tructed from a DNA-binding pyrrole-imidazole polyamide and the peptide FYPWMK facilitates binding of

52 DNA dimerizer constructed from a DNA-binding polyamide and the peptide FYPWMKG facilitates the bindin

53 The high affinity of phenols toward polyamide and their high uptake may change membrane char

54 anscripts are affected by treatment with the polyamide and with bicalutamide.

55 In this study, the isolation with polyamide and XAD resin allowed detection of the presenc

56 s will influence the further design of Py-Im polyamides and facilitate their study in animal models.

57 ts point to a new design principle to deploy polyamides and perhaps other synthetic molecules to effe

58 ing oligonucleotides, peptide nucleic acids, polyamides, and other approaches, recognition of mixed-s

59 e nucleic acids (PNAs), minor groove binding polyamides, and--more recently--engineered proteins such

60 upramolecular polymers based on a multiblock polyamide architecture.

61 Hairpin pyrrole-imidazole (Py-Im) polyamides are a class of cell-permeable DNA-binding sma

62 Pyrrole-imidazole (Py-Im) hairpin polyamides are a class of programmable, sequence-specifi

63 DNA-binding polyamides are a class of programmable, sequence-specifi

64 Pyrrole-imidazole (Py-Im) hairpin polyamides are a class of small molecule DNA minor groov

65 Pyrrole-imidazole polyamides are a class of small molecules that can be pr

66 Pyrrole-imidazole polyamides are a class of small molecules that can be pr

67 Pyrrole-imidazole (Py-Im) polyamides are a group of chemicals that are able to bin

68 Pyrrole-imidazole polyamides are DNA minor-groove binding molecules that a

69 Pyrrole-imidazole polyamides are DNA-binding molecules that are programmab

70 no biological activity, two non-fluorescent polyamides are reported with activity rivaling that of t

71 h the DNA-binding properties of unconjugated polyamides are similar, the alpha-DABA conjugates displa

72 Groove specificity: pyrrole-imidazole polyamides are well-known for their specific interaction

73 Overall, our results identify Py-Im polyamide as a promising therapeutic strategy in enzalut

74 torily for the measured free energies of DNA-polyamide association in solution and the observed sites

75 A polyamide backbone is used for tuning the proteolytic st

76 minimum first step toward the translation of polyamide-based gene regulation from cell culture to sma

77 enome-wide view from live cells reveals that polyamide-based synthetic genome readers bind cognate si

78 Beta-alanine-linked pyrrole-imidazole polyamides bind GAA.TTC tracts with high affinity and di

79 Pyrrole-imidazole (PI) polyamides bind to the minor groove of DNA in a sequence

80 Pyrrole-imidazole (Py-Im) polyamides bind to the minor groove of DNA with programm

81 structural requirements for zinc finger and polyamide binding and may eventually lead to the develop

82 the impact of different chromatin states on polyamide binding in live cells remains an unresolved qu

83 the major groove to those induced by cyclic polyamide binding in the minor groove.

84 iation in solution and the observed sites of polyamide binding on nucleosomal DNA.

85 Comparison of polyamide biological activity in two cell lines revealed

86 Fluorescent polyamide-Bodipy conjugates localize in the nucleus of a

87 jor groove of the ERE, can be inhibited by a polyamide bound in the opposing minor groove of the ERE.

88 crystal structure of an 8-ring cyclic Py/Im polyamide bound to the central 6 bp of the sequence d(5'

89 ta-amino turn-linked eight-ring cyclic Py-Im polyamide bound to the central six base pairs of the seq

90 The analysis of polyamide-bound nucleosomal structures reveals other dis

91 The kinetics of polyamide bromination were first order with respect to t

92 overed after exposure to control, mismatched polyamides but was recovered from 7 of 8 of these patien

93 oligonucleotides, peptide nucleic acids, and polyamides, but substantial efforts are currently devote

94 In vivo imaging of pyrrole-imidazole polyamides by PET is a minimum first step toward the tra

95 nzaldehyde and a hydroxylamine moiety at the polyamide C terminus.

96 constructed by attaching the peptide to the polyamide C-terminus expand the range of protein-DNA dim

97 An FITC-labeled analogue of this polyamide can be detected in tumor-derived cells by conf

98 Polyamides can access cognate sites within repressive he

99 Pyrrole (Py) and imidazole (Im) polyamides can be designed to target specific DNA sequen

100 Pyrrole/imidazole-based polyamides can be rationally designed to target specific

101 Thus, polyamides can inhibit hERR2 by two mechanisms, by direc

102 Previous studies suggest that Py-Im polyamides can prevent transcription factor binding, as

103 Polyamides capable of nuclear localization unaided by fl

104 ute to the creation and application of these polyamide-carbon nanotube thin films is also reported.

105 A final clean up via SPE on polyamide cartridges was also employed.

106 o group on imidazole- and pyrrole-containing polyamides causes stacked polyamides to bind in the mino

107 Hairpin polyamide-chlorambucil conjugates containing an alpha-di

108 the latter exhibiting 50% higher adhesion to polyamide coated crystals (mimicking an RO membrane surf

109 ermodynamic profile for formation of the T.G-polyamide complex has been determined.

110 The 2-A crystal structure of the nucleosome-polyamide complex shows that the bivalent "clamp" effect

111 resent study, we synthesized tandem tetramer polyamides composed of four hairpin moieties, targeting

112 Polyamides, composed of N-methylpyrrole and N-methylimid

113 ze telomeres specifically, tandem hairpin PI polyamides conjugated with a fluorescent dye have been s

114 ractive alternative for constructing hairpin polyamide conjugates.

115 Polyamides containing an N-terminal formamido (f) group

116 binding sites in the reverse orientation for polyamides containing beta/Im pairs.

117 Cyclic Py-Im polyamides containing two GABA turn units exhibit enhanc

118 The occupancy patterns suggest that polyamides could be harnessed to target loci within regi

119 Programmable DNA-binding polyamides coupled to short peptides have led to the cre

120 The polyamide, cyclo-gamma-ImPyPy-gamma-PyPyPy-, binds to ta

121 Long-term treatment with Py-Im polyamide demonstrated a global decrease in RNA levels c

122 This polyamide demonstrates antitumor activity in a prostate

123 These self-terminated polyamide dendrimers are enzymatically and hydrolyticall

124 e, efficient synthesis of 1 --> 3 C-branched polyamide dendrons is described.

125 genome, we designed, synthesized, and tested polyamide derivatives that enabled covalent crosslinking

126 previously that a pyrrole-imidazole (Py-Im) polyamide designed to bind the consensus androgen respon

127 Thus, polyamides designed to target Watson-Crick base pairs sh

128 reached a maximum of approximately 25%, (iv) polyamide disintegration occurs when high free chlorine

129 the biological activity of pyrrole-imidazole polyamide DNA-binding molecules, we characterized the ag

130 igh-throughput analysis of pyrrole-imidazole polyamide DNA-binding specificity in a 10(12)-member DNA

131 l pairing rules are remarkably predictive of polyamide DNA-binding specificity.

132 ed covalent crosslinking and localization of polyamide-DNA interaction sites in live human cells.

133 ough mice treated with an alpha-DABA hairpin polyamide do not differ significantly from control mice,

134 However, polyamides do not show similar binding to duplex RNA, an

135 A series of monodisperse polyamide "drag-tags" was created using both chemical an

136 The polyamide-dye conjugates bound specific DNA sequences wi

137 implications of these data on the design of polyamide-dye conjugates for use in biological systems.

138 a benchmark for the nuclear localization of polyamide-dye conjugates.

139 Influence of cell line grafted on systemic polyamide elimination was established.

140 We used a technique with double polyamide experimental bags (1-mum mesh) to study the in

141 The polyamide f-ImPyIm has a higher affinity for its cognate

142 g diffusivities of several alcohols within a polyamide film of commercial RO membrane using attenuate

143 Recently, a polyamide-fluorescein conjugate targeted to the hypoxia

144 We have synthesized over 100 polyamide-fluorophore conjugates and assayed their nucle

145 To further optimize Py-Im polyamides for enhanced potency in cell culture, a focus

146 amides more easily, we have developed new PI polyamide fragments and have used them as units in Fmoc

147 of one PBD unit attached to tri-heterocyclic polyamide fragments was designed and synthesized.

148 n of dsDNA sequences using pyrrole-imidazole polyamide-GNP (PA-GNP) conjugates.

149 This study reveals that the combination of polyamide groups, open metal sites, appropriate pore geo

150 A facile modular approach toward cyclic polyamides has been developed via microwave-assisted sol

151 scopy to study uptake of fluorophore-labeled polyamides has demonstrated the difficulty of predicting

152 d, but the study of telomeres using these PI polyamides has not been reported because of difficulties

153 odeoxynucleotide decoys or pyrrole-imidazole polyamides) has demonstrated antitumor responses with mi

154 In cell-free systems, polyamides have been shown to regulate gene expression b

155 Fluorescein-labeled cyclic polyamides have been synthesized and imaged via confocal

156 Three hosts were studied: (1) two polyamide hosts, one with isophthaloyl spacers and the o

157 , e.g., polytetrafluoroethylene (Teflon) and polyamide-imide (Torlon), discharge when the like-charge

158 These polyamide-immobilized substrates selectively detected a

159 ing by hERR2 is sensitive to the presence of polyamides in both the upstream minor groove CTE site an

160 equent investigations of the availability of polyamides in mouse plasma to human cells.

161 to form composite products with unprotected polyamides in parallel.

162 sed library of non-fluorescent, HRE-targeted polyamides in which the C-terminus 'tail' has been syste

163 ynthetic alkylating agent (pyrrole-imidazole polyamide indole-seco-CBI conjugate; KR12) that selectiv

164 This suggests that polyamides induce replication stress that ATR can counte

165 In biochemical assays, polyamides inhibit DNA helicases, providing a plausible

166 In enzalutamide-resistant LREX' cells, Py-Im polyamide interfered with both AR- and GR-driven gene ex

167 ve binding hairpin pyrrole-imidazole (Py-Im) polyamide interferes with RNA polymerase II (RNAP2) acti

168 The cyclic polyamide is an allosteric modulator that perturbs the D

169 the mechanism of pol II inhibition by Py-Im polyamides is unclear.

170 ased monomers and polymers, and particularly polyamides, it should be noticed that very few natural a

171 have led to the formulation of a two-letter polyamide "language" in which the -ImPy- central pairing

172 membranes consist of a functional selective polyamide layer formed by highly reproducible interfacia

173 oscale nonuniformities inherently present in polyamide layer may reduce selectivity, e.g., for boron

174 The top polyamide layer of composite reverse osmosis (RO) membra

175 the mechanism of phenol transport across the polyamide layer of RO membranes is studied using model p

176 conformational adjustment or displacement of polyamide ligands) on observed high resolution structure

177 Smoked meat sausages were packed into o-polyamide/low density polyethylene laminated film and co

178 Polyamide material had a moderate reflectivity with subt

179 Polyamides may increase transcription by altering the DN

180 m that mimics the surface chemistry of an RO polyamide membrane was synthesized stepwise on gold-coat

181 As reverse osmosis (RO) and nanofiltration polyamide membranes become increasingly used for water p

182 ive to the long-existing thin-film composite polyamide membranes for water separation applications.

183 ar dynamic simulations, however, reveal that polyamide membranes have a distinctly different structur

184 d by reverse osmosis (RO) and nanofiltration polyamide membranes that are widely used for water purif

185 ine and chlorine-treated thin-film composite polyamide membranes with either MgCl2 or CaCl2 draw solu

186 anes compared to control thin-film composite polyamide membranes, in both reverse and forward osmosis

187 compared to the control thin-film composite polyamide membranes.

188 ative carboxyl groups of thin-film composite polyamide membranes.

189 ctions between uncharged organic solutes and polyamide membranes.

190 igh-yielding routes to commercially valuable polyamide monomers using a single catalyst, telescopic w

191 To synthesize tandem hairpin PI polyamides more easily, we have developed new PI polyami

192 s necessary for efficacy studies in animals, polyamides must be readily synthesized in solution.

193 The polyamide N-formamido imidazole-pyrrole-imidazole (f-ImP

194 rfacial polymerization to form free-standing polyamide nanofilms less than 10 nanometers in thickness

195 works (CAFs) by devitrification of amorphous polyamide network polymers using high-temperature and hi

196 ving a variable effect on the upper limit of polyamide nuclear accumulation.

197 Earlier, we have shown that an anti-TAR polyamide nucleotide analog (PNA(TAR)) conjugated to a m

198 utoxide) reacts with surface amide groups of polyamide nylon 6/6 to give (eta(2)-amidate)zirconium co

199 f 65 vol% isotropic NdFeB powder and 35 vol% polyamide (Nylon-12).

200 Our findings indicate that hairpin polyamide of sequence PyImbetaIm-gamma-PyImbetaIm (1), p

201 roperties of three pyrrole-imidazole (Py-Im) polyamides of similar size and Py-Im content but differe

202 e expression analysis of the effects of this polyamide on a set of glucocorticoid-induced and -repres

203 y stage therapeutic investigations involving polyamides or histone deacetylase inhibitors are being p

204 Analysis of polyamide (PA) 6, 46, 66, and 12 pellets and PA 6, 66, p

205 mers (G1-NH2) was covalently attached to the polyamide (PA) active layer of a commercially available

206 ormance of a RO membrane with fully aromatic polyamide (PA) active layer.

207 ed the interactions of an eight-ring hairpin polyamide (PA) and two beta derivatives as well as a six

208 standing the effects of chlorine exposure on polyamide (PA) based membranes is essential in membrane

209 process between an Al foil and a finite size polyamide (PA) film.

210 ouling performance comparable with that of a polyamide (PA) membrane.

211 The degradation of polyamide (PA) nanofiltration and reverse osmosis membra

212 53(Al), NH2-MIL-53(Al) and MIL-101(Cr)] in a polyamide (PA) thin film layer were synthesized via in s

213 walled carbon nanotubes (MWCNT) and aromatic polyamide (PA), was successfully prepared by interfacial

214 Polyamides (PAs) are distamycin-type ligands of DNA that

215 ere the most abundant compounds, followed by polyamides, plastic-based paints, polyvinyl chloride, po

216 Polyamide-polyamine hybrid macrobicycle L is explored wi

217 increases in MC, aw and DB, when compared to polyamide/polyethylene.

218 terials: aluminum laminated polyethylene and polyamide/polyethylene.

219 , they are key monomers for the synthesis of polyamides, polyureas, polyepoxydes, which are all of gr

220 , and degradability of long-chain polyester, polyamides, polyurethanes, polyureas, polyacetals, and p

221 otency in cell culture, a focused library of polyamides possessing various modifications at the C-ter

222 d down by the biotin-labeled tandem tetramer polyamide probe confirmed its effective binding to telom

223 synthetic method of fluorescent tandem dimer polyamide probes composed of two hairpin moieties with a

224 Fluorescently labeled tandem tetramer polyamide probes could visualize human telomeres in chem

225 new method, we synthesized four fluorescent polyamide probes for the human telomeric repeat TTAGGG,

226 xed cells with lower background signals than polyamide probes reported previously, suggesting that th

227 and fluorescence spectra of the fluorescent polyamide probes, and telomere staining in mouse MC12 an

228 A linear beta-linked polyamide programmed to target a (GAA)3 repeat yielded a

229 An eight-ring hairpin polyamide programmed to target the 5 bp sequence 5'-TACG

230 owed by an acidic treatment that removes the polyamide protecting groups with no harm to the cycloadd

231 This new class of polyamides provides a method to specifically detect DNA

232 ma-turn increase the DNA-binding affinity of polyamides relative to the ( R)-alpha-amino-gamma-turn.

233 egulation of endogenous genes by DNA-binding polyamides requires effective nuclear localization.

234 Gene regulation by polyamides requires efficient cellular uptake and nuclea

235 osaccharide purification uses a normal-phase polyamide resin (DPA-6S) in custom-made pipette tips.

236 robial modification of a thin-film composite polyamide reverse osmosis (RO) membrane.

237 n the surface of a thin-film composite (TFC) polyamide RO membrane.

238 nd the language of current design motifs for polyamide sequence recognition to include the use of "wo

239 ained from a complete set of triheterocyclic polyamides show a dramatic difference in the affinity of

240 ped TFC PRO membranes consist of a selective polyamide skin formed on the lumen side of well-construc

241 The observed effects were polyamide-specific and dose-dependent.

242 urn unit affords the classical hairpin Py-Im polyamide structure.

243 e instruments included forceps, metallic and polyamide subretinal needles, and soft silicone-tipped i

244 but had no effect on the EPS adhesion to the polyamide surface.

245 e applied our methodology for solution-phase polyamide synthesis to cyclic polyamides with an improve

246 The former dense skin is a polyamide synthesized via interfacial polymerization, wh

247 The polyamides synthesized using the new method successfully

248 nce-specific agents, and it is the first non-polyamide, synthetic compound to specifically recognize

249 ty of the semisynthetic covalent DNA-binding polyamide tallimustine, which contains a benzoic acid ni

250 stigation of a DNA-binding pyrrole-imidazole polyamide targeted to bind the DNA sequence 5'-WGGWWW-3'

251 oximately 20-fold increase in the potency of polyamides targeted to the androgen response element (AR

252 Pyrrole-imidazole polyamides targeted to the androgen response element wer

253 A specific pyrrole-imidazole polyamide targeting GAA.TTC triplet-repeat DNA partially

254 turn potentiates the biological effects of a polyamide targeting the sequence 5'-WGWWCW-3' (W =A/T) b

255 a small library of hairpin pyrrole-imidazole polyamides targeting the sequence 5'-CGCG-3' and assesse

256 turn modifications enhance the uptake of all polyamides tested, while having a variable effect on the

257 ion, we designed a DNA minor groove-targeted polyamide that inhibits NES with low micromolar efficacy

258 A DNA-binding polyamide that targets the consensus androgen response e

259 We show that a DNA-binding polyamide that targets the consensus GRE sequence binds

260 king on the development of pyrrole-imidazole polyamides that bind to the minor groove of DNA in a seq

261 dies based on the structures of DNA bound to polyamides that have been designed to recognize the mino

262 ctivity in N-methylpyrrole/N-methylimidazole polyamides that helps explain how these molecules locate

263 After exposure to any of 4 different polyamides that specifically block HDAC-1 recruitment by

264 utilizes pairing rules for pyrrole-imidazole polyamides that target specific sites in the minor groov

265 ing the intracellular concentration of Py-Im polyamides that will prove valuable for future applicati

266 s and specificities of the tandem hairpin PI polyamides, the UV-vis absorption and fluorescence spect

267 eriments with cellulose triacetate (CTA) and polyamide thin-film composite (TFC) FO membranes demonst

268 be reduced to a dipeptide WM attached to the polyamide through an epsilon-aminohexanoic acid linker w

269 ate the role of the linker that connects the polyamide to the peptide.

270 a foundation for design of DNA binding Py-Im polyamides to be tested in vivo.

271 pyrrole-containing polyamides causes stacked polyamides to bind in the minor groove of DNA in the sta

272 e N-terminus is important for the binding of polyamides to DNA in a stacked and staggered motif.

273 g of two bioactive and structurally distinct polyamides to genomes directly within live H1 human embr

274 containing an isopropyl substituted thiazole polyamide, to DNA.

275 Polyamide treatment activates p53 signaling in LNCaP pro

276 Polyamide treatment also induced accumulation of monoubi

277 Polyamide treatment induced accumulation of S-phase cell

278 Polyamide treatment results in a time- and dose-dependen

279 probes have been proposed as alternatives to polyamides, triplex-forming oligonucleotides, and peptid

280 the biodistribution of a 5-ring beta-linked polyamide versus an 8-ring hairpin, which exhibited bett

281 The polyamide was active against two enzalutamide-resistant

282 Down-regulation of PSA by this polyamide was comparable to that produced by the synthet

283 The solubility of both hairpin and cyclic polyamides was increased upon addition of carbohydrate s

284 , we found that the cellular permeability of polyamides was size-dependent.

285 lutes and the membrane phase (fully aromatic polyamide) was computed from molecular dynamics (MD) sim

286 Using the fluorescent polyamides, we demonstrated that the telomere length at

287 he presence of site-specifically bound Py-Im polyamides, we find that the pol II elongation complex b

288 on profiles in mice of two pyrrole-imidazole polyamides were determined by PET.

289 Nearly all studied polyamides were found to form measurable particles 50-50

290 Cyclooctyne-derivatized pyrrole-imidazole polyamides were immobilized on azide-modified glass subs

291 NA binding affinities of a library of cyclic polyamides were measured by DNA thermal denaturation ass

292 The (18)F-radiolabeled polyamides were prepared by oxime ligation between 4-[(1

293 We have used synthetic pyrrole-imidazole polyamides, which bind specific sequences in the minor g

294 In the same study, a polyamide with an acetamide at the beta-position of the

295 analysis by RNA-seq compares the DNA-binding polyamide with the well-characterized NF-kappaB inhibito

296 solution-phase polyamide synthesis to cyclic polyamides with an improved high-yield cyclization step.

297 of a new class of pyrrole-imidazole hairpin polyamides with beta-amino-gamma-turn units for recognit

298 These insights allow the redesign of hairpin polyamides with different turn units capable of distingu

299 ies that govern the molecular recognition of polyamides with DNA, we are poised to systematically edi

300 A hairpin polyamide-YPWM tetrapeptide conjugate facilitates the bi