ライフサイエンスコーパス: polyamine

1 esponse and demonstrate proviral effects for polyamines.

2 diates phloem transport of both thiamine and polyamines.

3 nto the HS biosynthesis related to miRNA and polyamines.

4 ere stimulated at the translational level by polyamines.

5 Sorghum is a significant source of polyamines.

6 -dependent block by endogenous intracellular polyamines.

7 m (SMOX, SSAT) and depleted cellular natural polyamines.

8 suppression is inhibited in the presence of polyamines.

9 tto and tempeh showed the highest content of polyamines (75-124 and 11-24 mg/kg of spermidine and spe

10 Polyamines act as bivalent regulators of cellular functi

11 have reported that the earliest response to polyamine addition is the increased expression of the ge

12 The most important effect of polyamine addition is the very rapid increase in the lev

13 rpoS(+)/gadE(+) cells with genes induced by polyamine addition to polyamine-free DeltarpoS/gadE(+) a

14 f microarrays comparing the genes induced by polyamine addition to polyamine-free rpoS(+)/gadE(+) cel

15 The three polyamines all showed higher accumulation in tolerant co

16 Depletion of cellular polyamines also increased CELF1 and enhanced CELF1 assoc

17 ditols) and small organic cations (including polyamines) also lacked consistent effects.

18 , formamide/acetamide, purines, pyrimidines, polyamines, amino acids and proteins increased significa

19 methylglyoxal-bis-guanylhydrazone (MGBG), a polyamine analog and potent S-adenosylmethionine decarbo

20 named DSS-BEN, which was synthesized from a polyamine analog N(1),N(11)-bisethylnorspermine (BENSpm)

21 s, known to be dosed with varying amounts of polyamine and amine corrosion inhibitor components.

22 No positive association between dietary polyamines and CRC or CRC-specific mortality risk in wom

23 standing of the modes of interaction between polyamines and DNA.

24 ntive efficacies is by down-regulating tumor polyamines and enhancing NK cell activities.

25 UHb plants showed increases in total polyamines and in particular polyamines such as spermidi

26 lyzes the initial step in the degradation of polyamines and is a critical enzyme for determining the

27 t for protein synthesis and the formation of polyamines and is involved in the synthesis of many meta

28 on in glycolysis, pentose phosphate pathway, polyamines and nucleotides, but an increase in TCA and u

29 is required for the uptake of extracellular polyamines and plays an important role in stabilizing th

30 d conditions in B. burgdorferi Among several polyamines and polyamine precursors, supplementation of

31 investigated the association between dietary polyamines and risk of CRC incidence and mortality.

32 Both polyamines and rpoS are necessary for the expression of

33 accumulation of the amino acid precursors of polyamines and with the expression of specific polyamine

34 nc deficiency) that included altered energy, polyamine, and purine and pyrimidine metabolism.

35 rostaglandins, cyclic nucleotides, odorants, polyamines, and vitamins.

36 of spermine, total biogenic amines and total polyamines; and iii) the highest spermidine levels and t

37 terumalide, oocydin A and the broad spectrum polyamine antibiotic, zeamine.

38 Similar to thiamine, polyamines are an essential set of charged molecules req

39 Notably, CNBP, ODC, and polyamines are elevated in Hedgehog-dependent medullobla

40 Polyamines are essential for cell proliferation, and the

41 Polyamines are involved in key developmental processes a

42 Although polyamines are mainly known for their essential roles in

43 Polyamines are organic polycations essential for cell gr

44 Polyamines are primordial polycations found in most cell

45 Our results demonstrate that polyamines are required early in the adipogenic process.

46 Polyamines are required for both normal and colorectal c

47 Biogenic polyamines are small organic polycations involving in a

48 Polyamines are tightly regulated polycations that are es

49 Polyamines are ubiquitous cations that are involved in r

50 Polyamines are ubiquitous small cationic molecules neces

51 Putrescine, spermidine, and spermine (i.e., polyamines) are small cationic amines synthesized by cel

52 A displays a preference for linear aliphatic polyamines as the amidino acceptor substrate, especially

53 t fails to grow in minimal medium containing polyamines as the sole nitrogen source.

54 iaturizable, and direct-readout detection of polyamines, as well as the understanding of the modes of

55 erapeutic targets for treating SRS and other polyamine-associated neurological disorders.

56 ecause frameshifting was also prevalent in a polyamine auxotroph double mutant, a polyamine-independe

57 ntation of the medium did not circumvent the polyamine auxotrophy of the Deltaarg line.

58 nes to an Escherichia coli mutant that lacks polyamines because of deletions in the genes in the poly

59 Expression of a polyamine-binding defective mutant of KCNJ15 significant

60 SpeG has an allosteric polyamine-binding site and acetylating polyamines regula

61 f ornithine decarboxylase, thereby enhancing polyamine biosynthesis and cell proliferation in neural

62 g by altering arginine catabolism, impairing polyamine biosynthesis and reducing aerobic glycolysis.

63 amine pathway for replication and highlights polyamine biosynthesis as a promising drug target.

64 uggests a potential interplay between NO and polyamine biosynthesis during drought response.

65 tion mutations in spermine synthase (SMS), a polyamine biosynthesis enzyme, cause Snyder-Robinson syn

66 lyamines and with the expression of specific polyamine biosynthesis genes.

67 We show here that Hedgehog promotes polyamine biosynthesis in GCPs by engaging a non-canonic

68 Altogether, we have uncovered a role for polyamine biosynthesis in pancreatic organogenesis and i

69 identify that the pancreatic requirement for polyamine biosynthesis is largely mediated through a req

70 a NO-ethylene influenced regulatory node in polyamine biosynthesis linked to drought tolerance/susce

71 two prozymes described to date reside in the polyamine biosynthesis pathway of the human parasite Try

72 We identified that inhibition of polyamine biosynthesis reduces exocrine pancreas and bet

73 dentified that it may be possible to exploit polyamine biosynthesis to manipulate pancreatic cell dif

74 A, PotB, PotC, and PotD), while homologs for polyamine biosynthesis were conspicuously absent.

75 ecarboxylase (ODC), the committed enzyme for polyamine biosynthesis, are reciprocally controlled by t

76 e decarboxylase, the rate-limiting enzyme of polyamine biosynthesis, is promoted by the protein antiz

77 everal metabolite profiles, such as those of polyamine biosynthesis, which are different from those o

78 a by-product in ethylene, nicotianamine, and polyamine biosynthesis.

79 boxylase gene, which sequesters arginine for polyamine biosynthesis.

80 by CNBP stabilization, ODC translation, and polyamine biosynthesis.

81 ese findings highlight the importance of the polyamine biosynthetic pathway to viral replication, as

82 and spermidine synthase, two enzymes of the polyamine biosynthetic pathway, are critical for promast

83 nes because of deletions in the genes in the polyamine biosynthetic pathway.

84 h a PVC membrane containing 12mmol/kg of the polyamine bisnaphthalimidopropyl-4,4'-diaminodiphenylmet

85 xiliary proteins, Neto1 and Neto2, attenuate polyamine block by enhancing blocker permeation.

86 Relief of polyamine block in GluK2/GluK5 heteromers results from a

87 fect to heteromerization, and thus relief of polyamine block is due to a different mechanism.

88 findings have broad implications for work on polyamine block of other cation-selective ion channels.

89 e structural data define the first view of a polyamine bound in an allosteric site of an N-acetyltran

90 The polyamine catabolic enzyme spermine oxidase (SMOX) is in

91 d the expression of rate-limiting enzymes in polyamine catabolism (SMOX, SSAT) and depleted cellular

92 SAT1 is a rate-limiting enzyme in polyamine catabolism critically involved in the conversi

93 Polyamine chemistry is widely used for example in large

94 contains a large macrocycle and an appended polyamine component and was shown to be both antimetasta

95 gates were prepared, and the sequence of the polyamine component was varied to optimize the antimigra

96 o be especially responsive in the endogenous polyamine concentration range, and this effect may be mo

97 antizyme is a negative regulator of cellular polyamine concentrations from yeast to mammals.

98 and is a critical enzyme for determining the polyamine concentrations in bacteria.

99 itiation of frameshifting was independent of polyamine concentrations.

100 A series of macrocycle-polyamine conjugates were prepared, and the sequence of

101 and/or combinations significantly decreased polyamine content and increased intra-tumoral NK cells e

102 A signaling system may communicate exogenous polyamine content to the cell to control biofilm formati

103 was to monitor the post-partum variation of polyamine content, in ovine and caprine milk, from indig

104 arameters, regarding low biogenic amines and polyamines content, for "Futoski" cabbage was: salt conc

105 GC analysis showed the highest polyamines contents compared with those obtained by TLC.

106 histone deacetylase 10 (HDAC10) is a robust polyamine deacetylase, using recombinant enzymes from Ho

107 The polyamine deficit in hippocampal neurons is likely cause

108 stent Na(+) currents is due to a relief from polyamine-dependent inhibition.

109 on of dendritic INaP is due to a relief from polyamine-dependent inhibition.

110 m permeability of CP-AMPARs while increasing polyamine-dependent rectification by diminishing outward

111 y of recombinant CP-AMPARs, while increasing polyamine-dependent rectification.

112 Conditional knockdown of CHOP in polyamine-depleted preadipocytes restored PPARgamma and

113 Polyamine depletion inhibited the second division of the

114 Here, we examined the effect of polyamine depletion on the differentiation of 3T3-L1 pre

115 Additionally, polyamine depletion resulted in elevation of mRNA and pr

116 The strip was employed for polyamine determination in some of the locally grown fru

117 se data indicate that aberrant activation of polyamine-driven oxidative stress is a marker of gastric

118 We conclude that de novo synthesis of polyamines during adipogenesis is required for down-regu

119 et of rapamycin complex 1 (mTORC1) regulates polyamine dynamics, a metabolic route that is essential

120 vanotaxis, whereas increase of intracellular polyamines enhances galvanotaxis in a Kir4.2-dependent m

121 es and we show the deletions extended to the polyamine enzyme methylthioadenosine (MTA) phosphorylase

122 ently demonstrated up-regulation of the main polyamine enzymes analyzed (ODC, polyamine oxidase, and

123 with genes induced by polyamine addition to polyamine-free DeltarpoS/gadE(+) and rpoS(+)/DeltagadE c

124 g the genes induced by polyamine addition to polyamine-free rpoS(+)/gadE(+) cells with genes induced

125 was developed for the determination of three polyamines from turkey breast meat samples.

126 We have implicated polyamines, generated by the rate-limiting enzyme ornith

127 s are post-translationally modified by short polyamine groups, which are known to enhance the silica

128 Depletion of cytoplasmic polyamines, highly positively charged small molecules th

129 insights into the Az-mediated regulation of polyamine homeostasis and proteasomal degradation.

130 ural basis of the Az1-mediated regulation of polyamine homeostasis has remained elusive.

131 e pivotal role of PUT3 mediated thiamine and polyamine homeostasis in plants, and its importance for

132 To maintain polyamine homeostasis, the catalytic activity and protei

133 Polyamide-polyamine hybrid macrobicycle L is explored with respect

134 in Drosophila recapitulates the pathological polyamine imbalance of SRS and causes survival defects a

135 Spermidine was the prevailing polyamine in caprine samples, reaching levels up to 4.41

136 Here we show that substituting polyamines in place of elemental counterions significant

137 , we examine the interplay between eIF5A and polyamines in promoting translation elongation.

138 echanism in which KCNJ15/Kir4.2 couples with polyamines in sensing weak electric fields.

139 We therefore hypothesized that other polyamines in the gastrointestinal tract may control V.

140 enic counterpart consisted of an increase in polyamines including N-acetyl-cadaverine (2.9-fold), N-a

141 Our current hypothesis is that polyamines increase the level of RpoS protein and that t

142 Polyamine-independent induction of antizyme expression w

143 nt in a polyamine auxotroph double mutant, a polyamine-independent regulation of antizyme frameshifti

144 s response and tolerance mechanism involving polyamine influx which modulates mRNA stability of heat-

145 Total dietary polyamine intake (mean +/- SD: 289.2 +/- 127.4 mumol/d)

146 gnificantly modified the association between polyamine intake and CRC.

147 </=25 or fiber consumption above the median, polyamine intake was associated with significantly lower

148 Polyamines involve in gene regulation by interacting wit

149 xiliary subunits, Neto1 and Neto2, attenuate polyamine ion-channel block by facilitating blocker perm

150 Channel block and permeation by cytoplasmic polyamines is a common feature of many cation-selective

151 The precise biochemical function of polyamines is thus one of the remaining mysteries of mol

152 rnithine into putrescine in the synthesis of polyamines, is reduced in Mga mutant cells, and the surv

153 arginase-AdoMetDC/ODC pathway to acquire the polyamines it needs to develop.

154 Here, we found that polyamine levels are correlated with the expression leve

155 In contrast, AzIN positively regulates polyamine levels by competing with ODC for Az1 binding.

156 of stable chromosomal genes governs cellular polyamine levels from yeasts to humans.

157 We show that reducing polyamine levels has a negative effect on diverse RNA vi

158 e key toward understanding the regulation of polyamine levels in bacteria during pathogenesis.

159 sary to maintain intracellular ornithine and polyamine levels in T. brucei, thereby decreasing sensit

160 When polyamine levels were varied, the stimulatory effect was

161 both ornithine decarboxylase expression and polyamine levels, accompanied by cell cycle blockade pre

162 wly than expression in response to increased polyamine levels, pointing to a more general reaction to

163 have a central role in maintaining cellular polyamine levels.

164 lase-1 and a resulting reduction in cellular polyamine levels.

165 ntiviral effects of two molecules that alter polyamine levels: difluoromethylornithine (DFMO; also ca

166 mines (putrescine, spermidine, spermine) and polyamine-like potent OCT1 blockers (1,10-diaminodecane,

167 istent with emerging evidence that exogenous polyamines may be beneficial in colon health and warrant

168 veal a previously unknown mechanism by which polyamines may encourage regeneration after CNS injury.

169 h and provide insight into the regulation of polyamine metabolism and ferroptosis-mediated tumor supp

170 Simultaneous regulation of polyamine metabolism and miR-34a expression by DSS-BEN/m

171 relationship between glucose deprivation and polyamine metabolism impairment, leading to cell death,

172 ble of simultaneously targeting dysregulated polyamine metabolism in cancer, thereby providing an ele

173 ing miR-34a mimic and targeting dysregulated polyamine metabolism in cancer.

174 ng the pathological consequences of abnormal polyamine metabolism in the nervous system and may provi

175 ated the effects of glycolysis impairment in polyamine metabolism in these cell lines.

176 ated to exposure to neonicotinoids, like the polyamine metabolism involved in CNS injuries.

177 d by reversible acetylation and dysregulated polyamine metabolism is associated with neoplastic disea

178 Intracellular polyamine metabolism is regulated by reversible acetylat

179 ll Host & Microbe, Mounce et al. (2016) link polyamine metabolism to the interferon response and demo

180 rboxylase (ODC), the rate-limiting enzyme in polyamine metabolism, has been well studied in epithelia

181 ed to NO signaling and it is also related to polyamine metabolism, we explored this connection.

182 Since NO biosynthesis has been related to polyamine metabolism, we investigated whether the observ

183 in vivo as a product of oxidative stress and polyamine metabolism.

184 The oncogene n-myc is known to potentiate polyamine metabolism.

185 s revealed the link between AR signaling and polyamine metabolism.

186 , fatty acid acylcarnitines, tryptophan, and polyamine metabolites and decreased levels of steroids,

187 analysis revealed that the bacteria utilize polyamine metabolites produced from colon adenomas/carci

188 Specifically, the polyamines norspermidine and spermidine enhance and repr

189 lites, including amino acids, nucleic acids, polyamines, nucleosides, and carbohydrate conjugates.

190 The levels of free polyamines obtained by TLC were higher in organic vegeta

191 arious vegetable types, and the influence of polyamines on metal uptake were calculated.

192 ses compete for l-arginine to produce either polyamines or nitric oxide, respectively.

193 ter (YAT) family, a branch of the amino acid polyamine organocation (APC) transporter superfamily.

194 Recombinant cotton polyamine oxidase (GhPAO) was found to catalyse the conv

195 A polyamine oxidase (PAO) gene was identified and cloned b

196 By contrast, knockdown of polyamine oxidase (ZmPAO) significantly increased SCMV a

197 asure the growth differences, we developed a polyamine oxidase fvpo1 mutant in this fungus that fails

198 In the present study, polyamine oxidase specific for spermine and spermidine a

199 of the main polyamine enzymes analyzed (ODC, polyamine oxidase, and spermine synthase) and reduction

200 Polyamines (PAs) are a group of nitrogen-rich dissolved

201 ies suggest inhibition of colorectal mucosal polyamines (PAs) may be a promising approach to prevent

202 The polyamines (PAs) spermidine, spermine, putrescine and ca

203 ression of the main metabolic enzymes of the polyamine pathway and spermine abundance in 120 well-cha

204 strates that diverse RNA viruses rely on the polyamine pathway for replication and highlights polyami

205 e of arginase (ARG), the first enzyme of the polyamine pathway in Leishmania, has not been analyzed i

206 role in prostate tumorigenesis and that the polyamine pathway is altered as early as HGPIN.

207 These data suggest that Arg1 and the polyamine pathway may offer novel therapeutic targets fo

208 ved drought-related NO changes could involve polyamine pathway.

209 itive, and therefore the structural basis of polyamine permeation and unblock is through a different

210 Consequently, polyamine permeation and unblock occur at more negative

211 lock mechanism has been studied extensively, polyamine permeation has been considered less significan

212 our data identify an unappreciated impact of polyamine permeation in shaping the signalling propertie

213 Polyamines play important roles in a range of cellular p

214 tent cell survival through regulation of the polyamine pool in pluripotent cells of the embryo, wheth

215 B. burgdorferi Among several polyamines and polyamine precursors, supplementation of spermine or spe

216 Az1 suppresses polyamine production by inhibiting the assembly of the f

217 first time a pivotal role for Arg-dependent polyamine production during Plasmodium's hepatic develop

218 appeared to be the rate-limiting enzyme for polyamine production.

219 ectively compete with ODC for Az1 to restore polyamine production.

220 Copper amine oxidases oxidize the polyamine putrescine (Put), producing an aldehyde, ammon

221 ich was accompanied by reduced levels of the polyamines putrescine, spermidine, and spermine in mutan

222 Thus, interactions of natural polyamines (putrescine, spermidine, spermine) and polyam

223 d anionic polypeptides) and polybases (e.g., polyamines, pyridine and imidazole containing polymers,

224 wn linkage between glycolysis impairment and polyamine reduction is unveiled.

225 teric polyamine-binding site and acetylating polyamines regulate their intracellular concentrations.

226 more fully represent the elegant biology of polyamine regulation.

227 es ranged from 5.8 to 41.4 mg/100 g, and the polyamines represented 60-100% of the total.

228 rvation is essential for the biosynthesis of polyamines required for flowering and seed development.

229 lized by the arginase pathway to produce the polyamines required for Plasmodium growth.

230 We show that eIF5A can obviate the polyamine requirement for general translation elongation

231 strategy for the optimization of multivalent polyamine scaffolds as DNA/RNA ligands.

232 he dendritic glycopolymers compared to their polyamine scaffolds.

233 ications of dendritic glycopolymers based on polyamine scaffolds.

234 icles (CS/CF/nZnO) hybrid support to yield a polyamine sensing strip.

235 iprocal mutation in OCT1 (F161L) shifted the polyamine-sensitivity phenotype toward that of OCT3.

236 e frameshift site has weaker stimulatory and polyamine sensitizing effects on frameshifting.

237 our carbon spacers revealed that the natural polyamine sequence (norspermidine, a 3,3-triamine) was s

238 A survey of different polyamine sequences containing two, three, or four carbo

239 the 15-membered carbocycle and the appended polyamine showed improved antimigration properties.

240 nts with external application of these three polyamines showed that only the triamine spermine could

241 l viruses has been described to rely on host polyamines, small and abundant positively charged molecu

242 Polyamines, small positively charged molecules within th

243 how that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and ex

244 The polyamine spermidine is absolutely required for growth a

245 Ubiquitous polyamine spermidine is not required for normal plankton

246 g autophagic flux by treating cells with the polyamine spermidine suppresses prion formation in mutan

247 The up-regulation of polyamines (spermidine and putrescine) and potassium may

248 nic amines (tryptamine and tyramine) and two polyamines (spermidine and spermine) were detected in co

249 s were down-regulated, and the levels of the polyamines, spermidine and putrescine, were found to be

250 Diamine putrescine (Put) and polyamines; spermidine (Spd) and spermine (Spm) are esse

251 Interactions between the polyamine spermine and nucleic acids drive important cel

252 hydrogen peroxide from the catabolism of the polyamine spermine.

253 of MPS I revealed a marked elevation of the polyamine, spermine, in affected animals, and gene thera

254 tion of three of the most important biogenic polyamines; spermine (SPM), spermidine (SPD) and putresc

255 iological processes that constrain or expand polyamine structural and functional diversity.

256 At first glance, the diversity of polyamine structures in different organisms appears chao

257 acids including proline and citrulline, and polyamines such as putrescine.

258 Cationic polyamines such as spermidine and spermine are critical

259 of an acetyl group from acetyl coenzyme A to polyamines such as spermidine and spermine.

260 reases in total polyamines and in particular polyamines such as spermidine.

261 ut was incapable of growth in the absence of polyamine supplementation, but the auxotrophic phenotype

262 d therapies targeting glucose metabolism and polyamine synthesis could be effective in the treatment

263 mine transport leads to up regulation of the polyamine synthesis genes speE and cad in vitro.

264 Increased polyamine synthesis is known to play an important role i

265 tinamide N-methyltransferase, which promotes polyamine synthesis, enables nicotinamide salvage to reg

266 was found to be essential for ornithine and polyamine synthesis, ornithine decarboxylase appeared to

267 xylase 1 (ODC1), the rate-limiting enzyme of polyamine synthesis, was observed and verified by immuno

268 additional branch of metabolism in the cell-polyamine synthesis-that is important for prostate cance

269 in upregulation of arginase I and increased polyamine synthesis.

270 on and enzymes involved in prostaglandin and polyamine synthesis.

271 arboxylated S-adenosylmethionine (dcSAM) and polyamine synthesis.

272 ite through the modulation of Arg uptake and polyamine synthesis.

273 The regulation of the polyamines system can become dysfunctional during diseas

274 Putrescine, a polyamine that is not a sole carbon or nitrogen source f

275 microarray analysis on the effect of adding polyamines to an Escherichia coli mutant that lacks poly

276 These effects arose from the ability of polyamines to condense DNA and cross-link DNA-coated nan

277 Strong binding of polyamines to DNA makes the DNA a suitable recognition e

278 e body of eIF5A functionally substitutes for polyamines to promote general protein synthesis and that

279 f the blocking mechanism of the prototypical polyamine toxin NMDAR ion channel blocker argiotoxin-636

280 e, a paucity of genetic pathways involved in polyamine transport and B vitamin biosynthesis is associ

281 he borrelial genome revealed the presence of polyamine transport components (PotA, PotB, PotC, and Po

282 Additionally, we found that deficiency of polyamine transport leads to up regulation of the polyam

283 ic deletion strain of S. pneumoniae TIGR4 in polyamine transport operon (DeltapotABCD) with the wild

284 Polyamine transport system is an attractive therapeutic

285 , we identified an important function of the polyamine transporter LHR1 (LOWER EXPRESSION OF HEAT RES

286 ng identified that the LHR1 gene encodes the polyamine transporter PUT3 (POLYAMINE UPTAKE TRANSPORTER

287 nism consistent with active transport by the polyamine transporter.

288 ms of N and P, including urea and amino acid/polyamine transporters and numerous C-N hydrolases under

289 Our combined results indicate that polyamines trigger conformational changes and induce the

290 gene encodes the polyamine transporter PUT3 (POLYAMINE UPTAKE TRANSPORTER 3) localized in the plasma

291 Instead, a protective effect of dietary polyamines was suggested in women with some CRC risk-low

292 To study the physiological roles of polyamines, we carried out a global microarray analysis

293 Polyamines were demonstrated necessary for adipogenesis;

294 The antioxidant polyamines were found in both non-fermented and fermente

295 Polyamines were not significantly associated with CRC-sp

296 High concentrations of polyamines, which are aliphatic amines, are reported in

297 Cellular polyamines, which are associated with protein aggregatio

298 b values were obtained in the interaction of polyamines with 80% AT (mixed) DNA sequence.

299 We also studied the interaction of polyamines with three different DNA sequences with base

300 We further used polyamine wrapped DNA nanostructures as structural templ