ライフサイエンスコーパス: polycation

1 ing 12 times more potent than the unmodified polycation.

2 aPPE, and poly(allylamine hydrochloride) PAH polycation.

3 DNA molecules bind electrostatically to this polycation.

4 NA in the presence of spermine, a biological polycation.

5 eglycol and a tetraethylenepentamine-grafted polycation.

6 dent on the identity and charge state of the polycation.

7 al lipids, gemini surfactants, or lipophilic polycations.

8 poly(2-ethyl-2-oxazoline), yielding the pure polycations.

9 ious agents including glycosaminoglycans and polycations.

10 ed by a variety of condensing agents such as polycations.

11 previously studied minor groove binders, and polycations.

12 and some other inorganic cations and organic polycations.

13 ere abrogated by preincubation of cells with polycations.

14 alency in titration experiments with various polycations.

15 protein toxin architecture that is devoid of polycations.

16 dramatically improved by treating cells with polycations.

17 hallenging owing to the high cytotoxicity of polycations.

18 a gold surface via an intermediate layer of polycations.

19 After deprotection, three water-soluble polycations (9a, 9b, or 9c) were obtained with similar d

20 We propose that in the absence of polycations, access of target proteins to their binding

21 shift depends on the amount of biotinylated polycation added to the etalon, which can subsequently b

22 tails configuration, accompanied by greater polycation adsorption.

23 Planar potentiometric polycation and polyanion PSEs are prepared by incorporat

24 -lysine (PLL) and succinylated PLL (SPLL) as polycation and polyanion, respectively, we demonstrated

25 bited by divalent inorganic cations, soluble polycations and amphipathic organic cations.

26 Competing influences of polycations and monovalent cations suggest a significant

27 ndensation to be driven by electrostatics of polycations and not hydration, and the concentration of

28 evidence that gene complexes, consisting of polycations and plasmid DNA enter cells via binding to m

29 ver, the enhancing and inhibitory effects of polycations and polyanions on HIV-1 infection are largel

30 Moreover, combining VSV with polycations and ruxolitinib (which inhibits antiviral si

31 articles formed with cyclodextrin-containing polycations and siRNA.

32 N-terminal domains of MyBPC may act as small polycations and therefore bind actin via nonspecific ele

33 Here, by using polycation- and polyanion-directed intrafibrillar minera

34 not to small inorganic cations because only polycations are able to form cooperative ion pairs with

35 midoamines (PAA) and cyclodextrin (CD)-based polycations are also in a significant interest because o

36 Complexes formed from DNA and polycations are of interest because of their potential u

37 of DNA sequence-mediated isomer preference, polycations are the major contributor to biasing strand

38 Organic polycations are used as zeolite crystal shape modifiers

39 electron microcopies data indicate that the polycations are wrapped around NTs forming a uniform coa

40 the resulting gelled spheres are coated with polycations as a cross-linker; and (iii) these complexes

41 o a conformational change in the presence of polycations as demonstrated by its increased trypsin cle

42 developments on these three major degradable polycations as promising carriers for deoxyribonucleic a

43 ms of ds-DNA and polydiallyldimethylammonium polycations assembled layer-by-layer.

44 or can be employed for FIA detection of both polycations at levels >/=10 mug/mL and polyanions at lev

45 void renal clearance, many cationic polymer (polycation)-based siRNA nanoparticles that are used for

46 we compared the phosphorylcholine (PC)- and polycation-based binding activities of human CRP.

47 Although PC inhibits both PC- and polycation-based binding, none of the amines that inhibi

48 egies to be evaluated using a single type of polycation-based vector.

49 oquine (CQ) enhances transgene expression in polycation-based, nonviral gene delivery systems, a numb

50 particles were coated with a polyanion and a polycation bearing thymine chromophores.

51 indicate that the negative charges to which polycations bind are multiple and mobile.

52 The tobramycin polycation binds to loops in tRNA (Asp) and induces RNA

53 VIPER is composed of a polycation block for condensation of nucleic acids, and

54 sed on peptide-modified low molecular weight polycations can possess versatile properties including e

55 Experiment has shown that polycations can turn electrostatic self-repulsion of DNA

56 olumes containing siRNAs in complexes with a polycation carrier.

57 NA duplex d(CGCGAATTCGCG) in the presence of polycation chains are carried out to shed light on the s

58 the polyamines decreased with a decrease of polycation charge: spermine(4+) > spermidine(3+) >>> cad

59 The polycation chitosan (pKa 6.4) has been used to efficient

60 tion with confocal microscopy shows that the polycation chitosan coadsorbs to interfacial layers of b

61 Hybrid polycation-clay composites, based on methylated poly vin

62 eparation of approximately 50 A, the DNA and polycation come together and form a stable complex withi

63 anding of the structure and formation of DNA-polycation complexes at atomic scale.

64 etic vectors involves the endocytosis of DNA-polycation complexes, escape from endosomes, and diffusi

65 s were labeled by incubation with ferumoxide:polycation complexes.

66 etween nanosphere size, surface charge, PLGA-polycation composition, and protein loading is also inve

67 s, we developed a non-viral lipid-entrapped, polycation-condensed delivery system (LPD) for central n

68 ated i.v. administration of lipid-entrapped, polycation-condensed RB complementary DNA.

69 Synthetic vectors based on reducible polycations consisting of histidine and polylysine resid

70 which one end of a long-chained hydrophobic polycation containing antimicrobial monomers is attached

71 tra(ethylene glycol) chains to PLL abrogated polycation cytotoxicity in a charge density and PEG depe

72 his relatively simple microtiter plate-based polycation detection system.

73 Mechanistic insight into how polycations disrupt and cross cell membranes is needed f

74 nanoparticle formulations, cationic liposome-polycation-DNA (LPD) and anionic liposome-polycation-DNA

75 me-polycation-DNA (LPD) and anionic liposome-polycation-DNA (LPD-II), for systemic co-delivery of dox

76 thetic nucleic acid delivery vectors such as polycation/DNA or polycation/siRNA complexes (polyplexes

77 PC-based binding required calcium, whereas a polycation (e.g. poly-l-lysine) was bound in the presenc

78 ber, transduction time, and concentration of polycation (e.g., Polybrene).

79 Surprisingly, polycations enhance titers 20- to 30-fold by stabilizing

80 refore, other techniques based on the use of polycations, enzymes, nanomaterials, and photoactive age

81 spermidine, and spermine) are major organic polycations essential for a wide spectrum of cellular pr

82 Polyamines are organic polycations essential for a wide variety of cellular fun

83 Polyamines are organic polycations essential for cell growth and differentiatio

84 involves electrostatic interactions with the polycation forming a poorly fitting "plug" in the mouths

85 Polyamines are primordial polycations found in most cells and perform different fu

86 ar-type ion pair complex between the analyte polycation from aqueous sample phase and the deprotonate

87 in endocytic vesicles, (ii) displacement of polycations from the nucleic acids in polyplexes, and (i

88 Introduction of pNTs in a polycation-gene complex (polyplex) enhanced the extent o

89 The polycations have been designed to contain repeated oligo

90 ing an injectable polyvalent coacervate of a polycation, heparin, and fibroblast growth factor-2 (FGF

91 siRNA into a core-membrane structured lipid-polycation-hyaluronic acid (LPH) nanoparticle for system

92 atechol-functionalized weak polyanion with a polycation in dimethyl sulphoxide (DMSO), the solution w

93 block copolymer of polyethylene glycol and a polycation in solvents of different polarity.

94 impairs activation by metal ions and organic polycations in the presence of NPS 568 but not the syner

95 Combining both photoreactive and inert polycations in the same film yielded additional control

96 activity in vivo based on its requirement of polycations in vitro.

97 in is induced to form bundles by a number of polycations including divalent metal ions, Co(NH3)63+, a

98 Thus certain polycations, including polyhistidine and wall glycoprote

99 views of the structures that are formed when polycations interact with lipid membranes that will be i

100 ine, spermidine, and spermine, are essential polycations, intimately involved in the regulation of ce

101 amine to eliminate addition of the indicator polycation into the sample.

102 A, immune-stimulatory RNA, and biodegradable polycations into the immune-cell-rich epidermis, using m

103 These polycations introduced little change in DNA superhelicit

104 nly interact with DNA phosphate groups, with polycation intrusion into the major and minor grooves de

105 Biogenic polyamines are small organic polycations involving in a variety of biological process

106 A threshold concentration of polycation is required to form lateral aggregates of act

107 ions of the 14-3-3 isoforms in regulation by polycations is not clear.

108 Surprisingly, optical response toward polycations is shown to result from the extraction of th

109 In the presence of DEAE-dextran, the polycation known to enhance HIV-1 infectivity in cell cu

110 oped polyanionic SPAN layer, grown on a 2-nm polycation layer, was conductive between about 0.1 and -

111 id of a poly(allylamine hydrochloride) (PAH) polycation layer.

112 y, we developed tetraethylenepentamine-based polycation liposomes (TEPA-PCL) as a vector for the deli

113 med complex, the charged amine groups of the polycation mainly interact with DNA phosphate groups, wi

114 ption of certain amine side chain-containing polycations may become continuous, i.e., asymptotically

115 polyamine disulfides as preferred agents for polycation-mediated controlled condensation and function

116 vidence supports a role for proteoglycans in polycation-mediated gene delivery.

117 is needed for understanding and controlling polycation-membrane interactions, yet such information i

118 branes that will be important for predicting polycation-membrane interactions.

119 they substantiate the use of polycation/PEG-polycation mixtures for facile product evaluation in ord

120 Pyrene removal by polycation-montmorillonite (MMT) composites and granulat

121 tocols for the synthesis of the microbicidal polycation N,N-dodecyl,methyl-polyethylenimine and coati

122 Here we report the engineering of PLGA-polycation nanoparticles with a core-shell structure tha

123 e nanosphere complexes contain multiple PLGA-polycation nanoparticles, surrounded by large amounts of

124 The polycation neomycin (250-500 microM) reduced the PIP(2)-

125 n of D4938 and D4945 was confirmed using the polycation neomycin.

126 role for head group charge was supported by polycations (neomycin, spermine, and polylysine) reversi

127 of the zinc finger structures, NC acts as a polycation, neutralizing the highly negative phosphodies

128 e attractive force between dsDNA mediated by polycations of valence >/= 3.

129 ts toward heparin (polyanion) and protamine (polycation) of at least 1 order of magnitude (to 0.01 un

130 The delivery of nucleic acids with polycations offers tremendous potential for developing h

131 by sequentially chemisorbing polyanions and polycations on miniature (5 x 10(-4) cm2) enzyme electro

132 deposit alternating layers of polyanions and polycations on the surface surrounding the core of conde

133 Electrostatic binding of polycations or basic polypeptides to the DNA phosphate b

134 Yet the counterions for these polycations or polyanions are often ignored, even though

135 targeting, and they substantiate the use of polycation/PEG-polycation mixtures for facile product ev

136 294002 stimulated TRPC6 activity, as did the polycation PIP(2) scavenger poly-L-lysine.

137 lfonate), PSS, to layer alternately with the polycation poly(allyamine hydrochloride), PAH, is shown

138 nanoparticles (DNPs) functionalized with the polycation poly(allylamine HCl) in a manner that depends

139 The osmium bipyridil redox relay sites on polycation poly(allylamine) backbone efficiently work as

140 mproved by a coating of alternated shells of polycation poly(diallyldimethylammonium chloride) and of

141 he cross-linked polyion complex of SOD1 with polycation poly(ethylene glycol) (PEG)-polylysine (singl

142 ofmeister series of counterions for a common polycation, poly(diallyldimethylammonium), enthalpy chan

143 romising DNA vector candidates, and a second polycation, poly-L-lysine, are compared.

144 d virus, as for virus used alone or with the polycation Polybrene, showed first-order dependence on v

145 spectrographic graphite electrodes with the polycation polyethyleneimine (PEI) prior to adsorption o

146 we developed a novel formulation between the polycation polyethyleneimine and DNA that mediates high-

147 n using a sample probe surface modified by a polycation (polyethylenimine or poly(acrylic acid) compl

148 However, another polycation, polyhistidine, strongly promoted RG-II dimer

149 In contrast, polycations (polylysine and polyethylenimine) and low-mo

150 While ion-selective electrodes for the polycation protamine have been reported, for instance, a

151 The polycations protect pDNA against nuclease degradation, w

152 Calcium/polycation receptor proteins (CaRs) enable cells in the

153 hing of the formal charge of a photoreactive polycation resulted in repulsive interlayer electrostati

154 nium linkers (represented by g) provides the polycation ribonucleic guanidine (RNG).

155 coating (painting) of glass slides with this polycation's butanol solution are described.

156 ppropriate current pulse is applied across a polycation-selective polymer membrane to induce a strong

157 A polycation-sensitive membrane electrode based on the ion

158 decrease in the potentiometric response of a polycation-sensitive membrane electrode toward protamine

159 e potentiometric response characteristics of polycation-sensitive membrane electrodes toward two clas

160 It is further shown that the rotating polycation sensor can be used as an end-point detector t

161 d delivery vectors such as polycation/DNA or polycation/siRNA complexes (polyplexes) will be facilita

162 etal in both the presence and absence of the polycation spermine.

163 lent metals (Mg(2+), Gd(3+)) and the organic polycations spermine and poly-l-Arginine.

164 The effects of Mg2+ and the polycations spermine and spermidine are partially additi

165 ot seem to involve intracellular Mg2+ or the polycations spermine and spermidine.

166 ese oligopeptides as well as another type of polycation, spermine, shifted the equilibrium toward H-D

167 Polycations such as polylysine, polyarginine, histone H1

168 s exhibit sensitive colorimetric response to polycations such as protamine but not to small inorganic

169 Small polycations such as spermine and a cationic decapeptide

170 to the skin and hair; this process produces polycation-surfactant anion coacervates that entrain the

171 Similarly, organic polycations synergistically activate T903-Rhoc with di-

172 o this targeting agent, polyethyleneimine (a polycation that binds DNA and enhances transfection) was

173 Polyamines are small organic polycations that are absolutely required for cell growth

174 Polyamines are tightly regulated polycations that are essential for life.

175 ly(ethylenimine) (PEI) is one of a number of polycations that has been used successfully to transfer

176 he allosteric modulators NPS 568 and organic polycations that may play important roles in the regulat

177 rst incorporated into a polyion complex with polycation, then coated by anionic block copolymer, PEG-

178 livery system uses a cyclodextrin-containing polycation to bind and protect siRNA and transferrin as

179 The ability of the polycation to effectively neutralize the charge of the D

180 art of a gate that opens with the binding of polycations to loop 8.

181 that uses a linear, cyclodextrin-containing polycation, transferrin (Tf) protein targeting ligand, a

182 ide polyionic clusters that include aluminum polycations, transition-metal polyoxometalates, and the

183 nical shortcomings, we developed a synthetic polycation, Universal Heparin Reversal Agent (UHRA), whi

184 Indeed, the polycation used to counteract heparin-associated bleedin

185 neimine (PEI) represents a family of organic polycations used as nucleic acid transfection reagents i

186 ltiple passages, a degradable version of the polycation was observed to make E. coli cells more susce

187 tly functionalized with a representative BCN polycation were also able to repetitively kill bacteria

188 Bicyclo[3.3.1]nonane (BCN) polycations were synthesized by the reaction of the biva

189 er a thousand combinations of polyanions and polycations were tested to search for new polymer candid

190 e surface occurs only on the addition of the polycation, whereas PSS merely compensates the PDADMAC.

191 Polycations, which enhance the infectivity of several ot

192 amino groups of 2-kDa PEI yields a nontoxic polycation whose transfection efficiency in the presence