ライフサイエンスコーパス: polycationic

1 We synthesized first- and second-generation polycationic adamantane-based dendrons via a combined pr

2 y potentiate the actions of Ca(2+) and other polycationic agonists on the T903-Rhoc receptor.

3 o potentially modulate CaR activation by its polycationic agonists.

4 ic strength could modulate CaR activation by polycationic agonists.

5 required stereoelectronic arrangement of the polycationic amines and their basicity requirements to f

6 We subsequently used a polycationic amino acid compound, poly(L-lysine), to con

7 eotides via a new delivery system based on a polycationic amphipathic polymer, PS980.

8 s polypseudorotaxanes with cellulose and its polycationic analogue chitosan.

9 ) because cleavage of the linker between the polycationic and polyanionic domains, typically by a pro

10 The polycationic arginine peptide was engineered into the A1

11 otonated at neutrality because of the nearby polycationic backbone.

12 Herein, a novel series of multivalent polycationic beta-cyclodextrin "click clusters" with dis

13 The best small ligands for the polycationic binding site were Lys-Lys and Lys4.

14 ibits PC binding, suggesting that the PC and polycationic binding sites do not overlap.

15 Polyamines (PAs) are ubiquitous, polycationic biogenic amines that are implicated in many

16 A direct ionotropic gelation of the polycationic biopolymer chitosan (CHIT) with the polyani

17 These polycationic blockers traverse a long (>70 A) pore, disp

18 EVI enhances viral infection by serving as a polycationic bridge that neutralizes the negative charge

19 (ACPPs), in which the fluorescently labeled, polycationic cell-penetrating peptide (CPP) is coupled v

20 nic acid-containing cleavable linker between polycationic cell-penetrating peptide and polyanionic fr

21 The polycationic character of pcPNA pairs, carrying the dupl

22 tained with a photoimmunoconjugate bearing a polycationic charge, mice were treated 3 h after i.v. in

23 vercome by pre-treatment of samples with the polycationic chitosan that was able to agglomerate all n

24 veal that, upon contact with the hydrophobic polycationic coating, influenza viruses (including patho

25 ed using lipofection, electroporation, and a polycationic compound.

26 competitive blockers (GYKI 53655, SYM 2206), polycationic compounds (spermine, Naspm, philanthotoxin)

27 study, we examined a novel class of nontoxic polycationic compounds initially designed as universal h

28 ve membrane electrodes toward two classes of polycationic dendrimers are examined.

29 Some polycationic dendritic systems, such as the commercially

30 emonstrate how a newly synthesized series of polycationic dendron-MWNT constructs with a precisely ta

31 the design and synthesis of a novel type of polycationic dendrons that are able to penetrate into ce

32 Among non-viral systems, the polycationic derivatives are the most popular gene carri

33 Our experiments suggest that the polycationic domain of PDE6 gamma containing these two p

34 PDE alpha subunit that binds to the central polycationic domain of Pgamma.

35 The effect of polycationic DOSPA:DOPE was dependent upon the viral env

36 iation between the polyanionic DNA helix and polycationic dye stacks.

37 n intact platelets, PIP2 acts as a target of polycationic effectors, including Ca(2+), to promote PS

38 First a polycationic electron-conducting redox polymer is cross-

39 Polycationic enzyme mimics provide not only a hydrophobi

40 e-rich protamine substrate, yielding smaller polycationic fragments that are not sensed by the electr

41 Other degradable polycationic gene carriers such as polyamidoamines (PAA)

42 ass of 25 kDa (PEI25, one of the most potent polycationic gene delivery vectors) with alanine nearly

43 s perhaps most prevalent in current nonviral polycationic gene-delivery systems in which the polycati

44 ient than the 25-kDa PEI, one of the premier polycationic gene-delivery vectors.

45 ooptodes either selective for calcium or the polycationic heparin antidote protamine.

46 These results suggest that the polycationic HYDRAmers are potentially interesting as ne

47 ign of and manipulation with the DNA-binding polycationic ligands in general and PNA-based drugs in p

48 is RNA site an accommodating target for such polycationic ligands.

49 These vehicles include polyamines, polycationic lipids, and neutral polymers, capable of co

50 In conclusion, polycationic liposome-mediated EC-SOD gene delivery prot

51 Our previous study demonstrated that polycationic liposomes are highly stable in the bloodstr

52 rapeutic efficacy of EC-SOD gene delivery by polycationic liposomes was determined against the toxici

53 EC-SOD has a polycationic matrix-binding domain that binds to polyani

54 Polyamines are biogenic polycationic molecules involved in key cellular function

55 scine, spermidine, and cadaverine are small, polycationic molecules that are required for optimal gro

56 Polyamines are polycationic molecules with a hydrocarbon backbone and m

57 CaR agonists are polycationic molecules, and charged residues in the extr

58 CaR agonists are polycationic molecules, and our previous studies suggest

59 The confluence of properties imparted by the polycationic MOP architecture and plug-and-play CB[n] co

60 by electrostatic interactions, and that the polycationic nature of calponin is primarily responsible

61 n of the excellent dispersing properties and polycationic nature of polyhistidine, the stability of t

62 ycationic gene-delivery systems in which the polycationic nature of the delivery system can lead to c

63 tatic attraction between polyanionic RNA and polycationic NCp7 eliminated this immobilization.

64 n are detected using protamine and synthetic polycationic oligopeptides that possess specific cleavag

65 As there is no difference when a polycationic or a polyanionic electrolyte is used to dir

66 ilica spheres through the incorporation of a polycationic peptide (derived from the C. fusiformis sil

67 In this study, we used a membrane-permeant polycationic peptide (RhB-QRLFQVKGRR), derived from the

68 colistin (polymyxin E) and polymyxin B, two polycationic peptide antimicrobial agents, against multi

69 .e., polyanionic pentasaccharide Arixtra and polycationic peptide protamine, to yield the membrane pe

70 The free energies of binding for polycationic peptide-oligonucleotides were enhanced comp

71 tic polycationic peptides as well as natural polycationic peptides (e.g., protamine) that lack specif

72 med electrostatic interactions between these polycationic peptides and the polyanionic N terminus of

73 Other synthetic polycationic peptides as well as natural polycationic pe

74 Following the identification of polycationic peptides from the diatom Cylindrotheca fusi

75 ymer membrane to induce a strong flux of the polycationic peptides from the sample phase into the org

76 ay be compromised by the general capacity of polycationic peptides to activate mast cell secretion.

77 activities (trypsin and plasmin) that cleave polycationic peptides/proteins such as protamine into sm

78 therapy (PDT) targeted bacteria, by use of a polycationic photosensitizer conjugate, which is designe

79 To understand the role of polycationic PLL in the cellular uptake of bCD-PLL conju

80 We found that a polycationic polyelectrolyte can penetrate through the A

81 this submission we report that biotinylated polycationic polymer can penetrate through the Au overla

82 enhanced dramatically in the presence of the polycationic polymer Polybrene or when centrifugal force

83 the most active precursor to SEVI, and other polycationic polymers to investigate the physical mechan

84 particles were prepared from a biodegradable polycationic prodrug, named DSS-BEN, which was synthesiz

85 Furthermore, the polycationic properties of PolyMet permits capture of si

86 Polycationic PxB binds to anionic vesicles.

87 verrucaria, a polyanion at pH >4.1, and the polycationic redox copolymer of polyacrylamide and poly

88 g electrodes on which an electron-conducting polycationic redox polymer and avidin were coelectrodepo

89 on increases with the surface density of the polycationic redox polymer, its practicality depends on

90 , in which one photoprobe was located in the polycationic region and the other in the C terminus.

91 asymmetry of interaction between the Pgamma polycationic region and the Palphabeta subunits was obse

92 terminal 1-45 segment containing the central polycationic region binds to G alpha t's alpha 3 helix a

93 results suggest that a direct binding of the polycationic region of Pgamma to the GAFa domains of PDE

94 excitable peptide probe corresponding to the polycationic region of Pgamma, Pgamma-21-45, was specifi

95 The polycationic region of Pgamma, Pgamma-24-45, was mainly

96 and site-directed mutagenesis of the Pgamma polycationic region to identify residues required for th

97 he interaction with Palphabeta are a central polycationic region, Pgamma-24-45, and a C-terminal regi

98 er role of Pgamma has been attributed to its polycationic region.

99 e sequence, PHGGGWGQ, that is flanked by two polycationic residue clusters.

100 A series of "viologen" based dendrimers with polycationic scaffold carrying 10, 18, 26, 42, and 90 ch

101 pling may provide a promising alternative to polycationic sequences as a means for rendering peptides

102 y sensing macromolecular protamine and other polycationic species are described.

103 reviously reported polyP inhibitors based on polycationic substances, such as polyethylenimine, polya

104 method is based on utilizing a protamine (a polycationic substrate for trypsin-like proteinases)-sen

105 force (EMF) responses toward these and other polycationic substrates at microgram/milliliter levels u

106 The use of patterned, polycationic surfaces also shows great promise for selec

107 step in translocation and suggests that the polycationic tag binds to a different site.

108 The polycationic tracts may bind to anionic sites at the cel

109 Fusion of these polycationic tracts to the amino terminus of the enzymic

110 udy is to present protocols using SPIO and a polycationic transfection agent for magnetic labeling of

111 arged nucleic acids are often complexed with polycationic transfection agents before delivery.

112 derophoric, aminoglycosidic, amphoteric, and polycationic vectors are discussed.

113 Nevertheless, polycationic vectors are often associated with potential

114 Many synthetic polycationic vectors for non-viral gene delivery show hi

115 pointing in this series, aminoglycosidic and polycationic vectors were able for the first time to ach

116 and 9e were the most effective and promising polycationic vehicles to be further optimized for future