ライフサイエンスコーパス: polycistronic

1 tails, and the fact that the messages can be polycistronic.

2 The late mRNAs of simian virus 40 (SV40) are polycistronic.

3 Bacterial and viral mRNAs are often polycistronic.

4 d that the ahpCF genes were transcribed as a polycistronic 2.4-kb mRNA and that ahpC also was present

5 se and restriction subunits are encoded on a polycistronic 6.9 kb operon.

6 A) against ctfB (the second CoAT gene on the polycistronic aad-ctfA-ctfB message) was used in order t

7 of inwardly rectifying potassium channels in polycistronic adenoviral vectors.

8 n of protein-coding genes in trypanosomes is polycistronic and gene expression is primarily regulated

9 present evidence for the production of both polycistronic and monocistronic transcripts from A. cart

10 We have additionally characterised polycistronic and monocistronic transcripts from two pla

11 The polycistronic and non-canonical gene tarsal-less encodes

12 The polycistronic approach enables efficient construction an

13 parasites where genes are co-transcribed in polycistronic arrays but not necessarily co-regulated.

14 Bloodstream VSG genes are transcribed from polycistronic bloodstream expression sites with promoter

15 Our strategy employed a polycistronic cassette containing a non-fused GFP protei

16 red for the translation of internal genes in polycistronic chloroplast mRNAs.

17 gulated miRNA transcripts, including a large polycistronic cluster of brain-specific miRNAs, are DNA-

18 We recently demonstrated that a polycistronic cluster of miRNAs, miR-17-92, is oncogenic

19 ein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription

20 genes are organized into large (>100-300 kb) polycistronic clusters of adjacent genes on the same DNA

21 anscribed at an equivalent rate within large polycistronic clusters.

22 cripts carrying subsets of miRNAs encoded by polycistronic clusters.

23 to HCV genes delivered intramuscularly as a polycistronic construct capsid/E1/E2/NS2/NS3 (pRC/C-NS3)

24 eprogramming factors are carried on a single polycistronic construct, the mice can be easily maintain

25 Polycistronic copies of multiple p28 genes were not dete

26 Bacterial chromosomes are organized into polycistronic cotranscribed operons, but the evolutionar

27 characterized the site of termination of the polycistronic distal gene transcript beyond the D-loop r

28 , we propose a model in which both mono- and polycistronic ESs are controlled by a similar mechanism

29 d 7 (transferrin receptors), suggesting that polycistronic ESs are partially active in this clone.

30 ases upstream of the vsg, in contrast to the polycistronic ESs in which the promoters are located 45-

31 difications similar to that reported for the polycistronic ESs.

32 at occur between the promoter and the vsg in polycistronic ESs.

33 Here, we show that it is possible to drive polycistronic expression from a single pol III promoter

34 -cleaving" peptides, which support efficient polycistronic expression from a single promoter.

35 sociated proteins (NAPs), possibly through a polycistronic expression of a clustered group of genes.

36 n (VSG) genes found adjacent to telomeres in polycistronic expression sites (ESs).

37 malian genes for which there is evidence for polycistronic expression via translation through an inte

38 te that lbpB and lbpA are cotranscribed on a polycistronic Fe-repressible mRNA.

39 , subsequent transcription into the opposing polycistronic gene cluster does not lead to downregulati

40 rimarily organized into two large convergent polycistronic gene clusters (i.e. transcribed from the t

41 s in transcription termination at the end of polycistronic gene clusters and the generation of antise

42 reduction of base J at specific sites within polycistronic gene clusters in L. major leads to read th

43 n termination and expression of genes within polycistronic gene clusters in trypanosomatids.

44 ever, the loss of J at specific sites within polycistronic gene clusters led to altered transcription

45 'divergent junction' region between the two polycistronic gene clusters may be a candidate for an or

46 genomes of kinetoplastids are organized into polycistronic gene clusters that are flanked by the modi

47 s of Trypanosoma cruzi are arranged in large polycistronic gene clusters transcribed by polymerase II

48 in-coding genes organized into two divergent polycistronic gene clusters with the mRNAs transcribed t

49 ating transcriptional uncoupling of genes in polycistronic gene clusters.

50 oteome of about 6200 genes in large syntenic polycistronic gene clusters.

51 and gene expression at specific sites within polycistronic gene clusters.

52 tegy to produce numerous gRNAs from a single polycistronic gene.

53 Identification of additional polycistronic genes may provide new insights into diseas

54 Polycistronic genes were annotated in the same manner wi

55 gradual recognition that a growing number of polycistronic genes, originally discovered in viruses, a

56 ng complexes associate preferentially with a polycistronic gRNA over non-processed RNAs.

57 I are gRNA processing complexes that cleave polycistronic gRNA transcripts into monocistrons.

58 followed by reprogramming with loxP-flanked polycistronic (human Oct4, Klf4, Sox2, and c-Myc) STEMCC

59 HI had a 20-fold higher transcription of the polycistronic hydrogenase mRNA encoding SHI, and the spe

60 Although primary transcripts are polycistronic in the mitochondria of Trypanosoma brucei,

61 the generation of human iPSCs using a single polycistronic lentiviral vector (pLM-fSV2A) coexpressing

62 actors FOXA3, GATA4, HNF1A, and HNF4A from a polycistronic lentiviral vector converts mouse myofibrob

63 NF1A), MODY5 (HNF1B), and MODY8 (CEL) with a polycistronic lentiviral vector expressing a Cre-excisab

64 system for the rapid engineering of complex polycistronic lentiviruses, allowing combinatorial gene

65 The Drosophila let-7-Complex (let-7-C) is a polycistronic locus encoding three ancient microRNAs: le

66 opposing functions encoded by genes within a polycistronic locus of the human cytomegalovirus (HCMV)

67 n signal and studied first in the context of polycistronic luciferase reporter constructs.

68 e mce1 genes can be transcribed as a 13-gene polycistronic message encompassing Rv0166 to Rv0178.

69 iptase PCR analysis, we have found that this polycistronic message extends downstream of prgH to incl

70 plementary to the mgtC portion of the mgtCBR polycistronic message from Salmonella enterica.

71 of Pig, pigA-O, are transcribed as a single polycistronic message in an N-AHL-dependent manner.

72 xpressing human IL-2 and neor markers from a polycistronic message was constructed and transduced int

73 Furthermore, invA was cotranscribed in a polycistronic message with rrp, a gene encoding the resp

74 gene of R. rickettsii is cotranscribed in a polycistronic message with the putative nuoF (encoding N

75 in the coding region of the first gene of a polycistronic message, manXYZ.

76 nscribed as a large ( approximately 16.7-kb) polycistronic message.

77 s that the operon is transcribed as a single polycistronic message.

78 which suggests that fap1 is transcribed as a polycistronic message.

79 Although a few examples exist, the use of polycistronic messages in mammalian cells is not widely

80 rnative splicing, alternative translation of polycistronic messages is a mechanism to generate protei

81 nd significantly higher folding potential in polycistronic messages than in monocistronic messages in

82 Many viral mRNAs encode polycistronic messages where programmed -1 ribosomal fra

83 To identify other polycistronic messages, we carried out genome-wide ribos

84 ion, including alternative monocistronic and polycistronic messages.

85 tion from the second open reading frame of a polycistronic messenger RNA, which would not be translat

86 a means of regulating protein synthesis on a polycistronic messenger RNA.

87 ning at least 19 genes distributed over four polycistronic messenger RNAs, appears to be regulated by

88 miR-17 approximately 92 is a polycistronic microRNA (miR) cluster (consisting of miR-

89 Polycistronic microRNA (miRNA) clusters are a common fea

90 The polycistronic miR-183/96/182 cluster is preferentially a

91 erized by high expression of miRNAs from the polycistronic miR17-92 cluster and its paralogs, miR-106

92 genome-wide view of how the components of a polycistronic miRNA cluster affect gene expression in vi

93 fferential expression characteristic of many polycistronic miRNA clusters.

94 The structural complexity of mir-17-92 as a polycistronic miRNA oncogene, along with the complex mod

95 pt produces one protein, mir-17-92 encodes a polycistronic miRNA transcript that yields six individua

96 3'-Extended forms of this mRNA, including a polycistronic mRNA ADI1-YMR010W mRNA, also accumulate in

97 We also identified a polycistronic mRNA for RID-alpha and RID-beta.

98 Polycistronic mRNA fragments revealed a 5'-untranslated

99 This polycistronic mRNA is induced by paraquat in a wild-type

100 es 44 and 62, which are directly adjacent on polycistronic mRNA molecules, are-to some degree-transla

101 sly, we have shown that MSP2 is encoded on a polycistronic mRNA transcript in erythrocyte stages of A

102 . pyogenes, mutS and mutL are organized on a polycistronic mRNA under control of a common promoter.

103 lated as a downstream gene from the ORF35-37 polycistronic mRNA via a unique mechanism involving shor

104 In this experiment a long polycistronic mRNA was sampled repeatedly.

105 different heterologous operons revealed that polycistronic mRNA was the predominant transcript produc

106 of the Gr64 gene family are transcribed as a polycistronic mRNA, providing a mechanism for the coexpr

107 he ompB promoter and transcribed as a single polycistronic mRNA, the expression of envZ is known to b

108 Despite being part of the same polycistronic mRNA, the relative levels of transcription

109 t the remaining hut genes are expressed as a polycistronic mRNA.

110 hort intergenic region, and transcribed as a polycistronic mRNA.

111 anscription of both pvuIIC and pvuIIR into a polycistronic mRNA.

112 otein of A. marginale, MSP2, is encoded on a polycistronic mRNA.

113 crete open reading frames (ORFs) in a single polycistronic mRNA.

114 tical protein) and RT0216 (TolC) as a single polycistronic mRNA.

115 onfirmed that M2-1 enhances the synthesis of polycistronic mRNAs and that the magnitude of this effec

116 of translational control in prokaryotes, but polycistronic mRNAs are not usable (and usually not prod

117 ene expression of single genes or even large polycistronic mRNAs as a function of environmental chang

118 ctural outcome, not unlike operons and their polycistronic mRNAs do in prokaryotic organisms.

119 to a substantial increase in the quantity of polycistronic mRNAs generated by the polymerase failing

120 iral mRNA and suggests a widespread role for polycistronic mRNAs in the innate immune system.

121 internal translational initiation on latent polycistronic mRNAs is the principal source of v-FLIP in

122 ulosomal cbpA gene cluster is transcribed as polycistronic mRNAs of 8 and 12 kb.

123 Genes are transcribed as polycistronic mRNAs that are dissected by the concerted

124 long with SmN from a bicistronic transcript; polycistronic mRNAs therefore are encoded in mammalian g

125 mutation also affects the atpA gene cluster; polycistronic mRNAs with psbI or cemA 3'-ends accumulate

126 codon readthrough, 125 new candidate ORFs of polycistronic mRNAs, and several candidate translational

127 f adjacent genes co-transcribed on bacterial polycistronic mRNAs, translation of the first coding reg

128 The synthesis of polycistronic mRNAs, which presumably involves antitermi

129 to express more than one protein from bi- or polycistronic mRNAs.

130 their structural and enzymatic proteins from polycistronic mRNAs.

131 t this approach can also be used to regulate polycistronic mRNAs; such regulation has rarely been ach

132 titatively monitored via direct injection of polycistronic MuLE lentiviruses into mouse tissues.

133 s have garnered increased interest for their polycistronic nature, small size and high "cleavage" eff

134 adigm whereby the unique gene structure of a polycistronic oncomir confers an intricate balance betwe

135 mir-17-92, a potent polycistronic oncomir, encodes six mature miRNAs with co

136 termined that fhuD and fhuG are members of a polycistronic operon comprised of four genes, fhuCDBG, t

137 secreted Esp molecules are part of a fourth polycistronic operon designated LEE4.

138 ding 203 aa and was transcribed as part of a polycistronic operon, consisting of orfY-fumC-orfX-sodA.

139 A putative polycistronic operon, yfeABCD, is Fur regulated and resp

140 ducreyi flp gene cluster was likely to be a polycistronic operon.

141 atelet binding locus consists of an apparent polycistronic operon.

142 some, they can be monocistronic or part of a polycistronic operon.

143 ified pathway for the maturation of tRNAs in polycistronic operons (valV valW and leuQ leuP leuV) whe

144 c island was found to be organized into five polycistronic operons along with eight individual genes

145 Genes were divided into putatively polycistronic operons and those predicted to be monocist

146 secretion system are transcribed from three polycistronic operons designated LEE1, LEE2 and LEE3.

147 etected overrepresented uPSS and iPSS in the polycistronic operons encoding ribosomal proteins, and t

148 about 864 monocistronic transcripts and 533 polycistronic operons from the protein-encoding genes in

149 Efficient transcription of long polycistronic operons in bacteria frequently relies on a

150 rtance in post-transcriptional regulation of polycistronic operons in Escherichia coli, little is kno

151 Thus, the four polycistronic operons of the LEE that encode type III se

152 ator), which activates expression of several polycistronic operons within the 35.6-kb LEE pathogenici

153 The LEE is comprised of multiple polycistronic operons, most of which are controlled by t

154 lytic activity starts the processing of both polycistronic operons, such as glyW cysT leuZ, argX hisR

155 is unusual because it resembles prokaryotic polycistronic operons, whereas tomPRO2 encodes a full-le

156 5' UTR and a long 3' UTR similar to those of polycistronic ORF60 and ORF62.

157 as a decrease in polysome association of the polycistronic petA mRNA in the DeltapetB and DeltapetD m

158 the entire HCV protein coding genome in two polycistronic plasmids encoding HCV capsid-E1-E2-NS2-NS3

159 tobacco plants transformed with a prototype polycistronic plastid vector, pPRV110L, designed to expr

160 onreplicating canarypox booster encoding HCV polycistronic pRC/C-NS3 genes appears to diversify and e

161 r results indicate that mice that received a polycistronic pRC/C-NS3 with canarypox booster had enhan

162 ated multigene transcription units, in which polycistronic pre-messenger RNA (pre-mRNA coding for mul

163 promoter upstream of another gene creates a polycistronic pre-mRNA that receives SL2, whereas transc

164 pecificity information is encoded within the polycistronic pre-mRNA, and that trans-splicing specific

165 ocessing of a heat shock-induced gpd-2-gpd-3 polycistronic pre-mRNA.

166 lates E6 and E7 expression of the early E6E7 polycistronic pre-mRNA.

167 In Caenorhabditis elegans, polycistronic pre-mRNAs are processed by cleavage and po

168 tion and trans-splicing in the processing of polycistronic pre-mRNAs from C. elegans operons.

169 Polycistronic pre-mRNAs from Caenorhabditis elegans are

170 ract that are required for trans splicing of polycistronic pre-mRNAs in trypanosomatids.

171 rhabditis elegans operons are transcribed as polycistronic pre-mRNAs in which downstream gene product

172 ated in downstream positioned genes in these polycistronic pre-mRNAs is critical for their expression

173 8 encodes two major (one early and one late) polycistronic pre-mRNAs that are regulated by alternativ

174 gulated by alternative RNA splicing of viral polycistronic pre-mRNAs to produce a repertoire of viral

175 of genes that are co-transcribed to produce polycistronic pre-mRNAs, is a trait found in a wide rang

176 chosen C. elegans operons are transcribed as polycistronic pre-mRNAs.

177 C/D and box H/ACA) and are transcribed as a polycistronic pre-snoRNA transcript from an upstream pro

178 deficiency resulted in reduced abundance of polycistronic precursor transcripts and mature counterpa

179 ex that cleaves the 5' ends of mt-tRNAs from polycistronic precursor transcripts.

180 t-transcriptionally processed from a stable, polycistronic precursor.

181 d for the processing of the petD mRNA from a polycistronic precursor.

182 itis elegans genes exist in operons in which polycistronic precursors are processed by cleavage at th

183 sm in dinoflagellate chloroplasts where long polycistronic precursors are processed to form mature tr

184 tes trans-splicing of spliced leader (SL) to polycistronic precursors conveys a hypermethylated cap 4

185 (small nucleolar RNAs) that are excised from polycistronic precursors or from mRNA introns is also a

186 pping transcripts derived by processing from polycistronic precursors.

187 endogenous miRNA-17-92 cluster to generate a polycistronic primary miRNA that is processed into five

188 together with 11 mRNAs and 2 rRNAs from long polycistronic primary transcripts with almost no spacers

189 of these potential enoplean operons confers polycistronic processing activity when expressed as part

190 Initiation sites in polycistronic prokaryotic mRNAs are usually selected via

191 The virus displayed increased levels of polycistronic readthrough mRNAs resulting from failure o

192 Interestingly, the synthesis of polycistronic readthrough mRNAs was elevated 1.6- to 3.8

193 length mRNAs as well as for the synthesis of polycistronic readthrough mRNAs, which are characteristi

194 ulted in decreased production of the related polycistronic readthrough mRNAs, which normally arise du

195 o acid polypeptide encoded at the start of a polycistronic region.

196 e strain with a single copy of an inducible, polycistronic reprogramming cassette, allowing for the i

197 f hematopoietic stem cells transduced with a polycistronic retrovirus expressing both human ferrochel

198 Polycistronic rgg-gtfG as well as rgg- and gtfG-specific

199 We also define a class of short, polycistronic ribosome-associated coding RNAs (sprcRNAs)

200 ter-driven transcription, with the resultant polycistronic RNA being processed (5' and 3') and excise

201 tionation assays, which allowed detection of polycistronic RNA in lower fractions of the sucrose grad

202 to be sites of translation from the CaMV 35S polycistronic RNA intermediate, the precise role of thes

203 he coat initiation site, present on the same polycistronic RNA molecule, is repressed by Qbeta replic

204 ice variants, as well as between overlapping polycistronic RNA molecules.

205 r (SL) upstream of protein-coding regions in polycistronic RNA precursors through trans splicing.

206 criptional and involves the orchestration of polycistronic RNA processing, 3'-terminal maturation, RN

207 Consistent with the mechanism of polycistronic RNA resolution in other nematodes, the mRN

208 is transcribed from both strands, producing polycistronic RNA species that are immediately processed

209 expressed through alternative splicing of a polycistronic RNA to yield four major splice isoforms (E

210 ly transcribed from both strands, generating polycistronic RNA units that are processed and matured.

211 uster are transcribed in an unusual way as a polycistronic RNA.

212 tion between genes prevents the formation of polycistronic RNAs and anti-sense RNAs, which are genera

213 liced leader RNAs, and we are able to detect polycistronic RNAs derived from these operons.

214 As a result, the polycistronic rpsL-bmpD mRNA level increased from 3 to 1

215 I catalyzes several processing events of the polycistronic rRNA precursor.

216 The processing of the initial polycistronic rRNA transcript is also a conserved proces

217 To produce mature ribosomal RNAs (rRNAs), polycistronic rRNA transcripts are cleaved in an ordered

218 protein was shown to bind monocistronic and polycistronic RS virus mRNAs during infection.

219 Among these, we identified a polycistronic, sensory organ-specific paralogous miRNA c

220 dification sites, initial gene organization (polycistronic, single gene and intronic) and the number

221 The polycistronic structure of mRNAs is an important aspect

222 iguity with other dap genes, suggestive of a polycistronic structure.

223 NAs generated from a cluster of tRNA-related polycistronic structures located at the left end of the

224 The UL138 transcripts are polycistronic, such that each transcript expresses pUL13

225 ook advantage of the inherent feature of the polycistronic system and generated all possible combinat

226 Finally, we developed a polycistronic system to simultaneously express multiple

227 he coordination of multiple events including polycistronic transcript cleavage, polyadenylation, RNA

228 gene, mille-pattes, that encodes an unusual polycistronic transcript predicted to produce four conse

229 aseZ activity display impaired mitochondrial polycistronic transcript processing, increased reactive

230 Our results demonstrate how a variable polycistronic transcript provides an evolutionary altern

231 ing of these different snoRNAs from the same polycistronic transcript suggests that the processing ma

232 ly downstream of the fatA gene, is part of a polycistronic transcript that also includes the iron tra

233 s of a synthetic miRNA can be expressed in a polycistronic transcript to increase the inhibition of a

234 or the expression of an approximately 200-kb polycistronic transcript within the imprinted Dlk1-Dio3

235 pri-miR-100, the first miRNA in this let-7-C polycistronic transcript, leads to enhanced miRNA proces

236 Mir-17-92 encodes 6 miRNAs inside a single polycistronic transcript, the proper expression of which

237 n the expression of multiple products from a polycistronic transcript, under the control of a single

238 ich HER2 and Cre are expressed from a single polycistronic transcript, we showed that palpable tumor

239 on morphogenesis are expressed from the same polycistronic transcript.

240 cifically cleaving stem-loop segments of its polycistronic transcript.

241 enes should allow its processing from the mt polycistronic transcript.

242 ms for control of gene expression, including polycistronic transcription and trans-splicing.

243 Trypanosomatids utilise polycistronic transcription for production of the vast m

244 ssion sites" (ESs), each of which contains a polycistronic transcription unit that includes ES-associ

245 of base J at regions flanking polymerase II polycistronic transcription units (Pol II PTUs) througho

246 , the fractionation behavior of ribosomes in polycistronic transcription units encoding both membrane

247 The long polycistronic transcription units of trypanosomes do not

248 BESs are polycistronic transcription units, containing a variety

249 ol II) in Trypanosoma brucei are arranged in polycistronic transcription units.

250 ssion because their genome is organized into polycistronic transcription units.

251 found no evidence to support the proposal of polycistronic transcription, including a marked underrep

252 features of kinetoplastid biology, including polycistronic transcription, trans-splicing, and a glyco

253 an organism with widespread and constitutive polycistronic transcription.

254 As a polycistronic transcriptional unit of one or more adjace

255 reading frames MPN140 to MPN142 constitute a polycistronic transcriptional unit.

256 hat the ery gene cluster contains four major polycistronic transcriptional units, the largest one ext

257 f all seven valine tRNAs from three distinct polycistronic transcripts (valV valW, valU valX valY lys

258 on impaired mitochondrial RNA processing and polycistronic transcripts accumulated.

259 , which cause quantitative variation between polycistronic transcripts and accumulation of transcript

260 ed polynucleotide tails in the rpsJ and rpsM polycistronic transcripts and the lpp monocistronic tran

261 he processing intermediates of mitochondrial polycistronic transcripts and their products including t

262 organized in operons that are coexpressed as polycistronic transcripts and then often are processed f

263 Polycistronic transcripts are common in prokaryotes but

264 In animals, protein-coding polycistronic transcripts are rare.

265 'UTRs has identified several bicistronic and polycistronic transcripts as the novel targets of viral

266 ed transcripts in A. carterae, and show that polycistronic transcripts can be terminally polyuridylyl

267 Two overlapping polycistronic transcripts extending from eryBIV to eryBV

268 Polycistronic transcripts from such operons are trans-sp

269 ere identified by their inability to silence polycistronic transcripts in enhanced RNAi (Eri) mutant

270 siae are consistent with the near absence of polycistronic transcripts in eukaryotes.

271 rotein, correlating with the absence of SH/G polycistronic transcripts in RS virus-infected cells.

272 of the 5' proximal genes of bicistronic and polycistronic transcripts offer additional regulatory ta

273 The UL138 polycistronic transcripts serve to coordinate the expres

274 leuU and metT leuW glnU glnW metU glnV glnX polycistronic transcripts takes place through a differen

275 ssential initial cleavages by RNase E within polycistronic transcripts to generate pre-tRNAs that sub

276 NAs that are likely to be encoded as part of polycistronic transcripts.

277 s and encodes many genes with bicistronic or polycistronic transcripts.

278 s locus involves both classical and atypical polycistronic transcripts.

279 transcription terminators for both mono- and polycistronic transcripts.

280 snoRNAs processed from pre-mRNA introns and polycistronic transcripts.

281 were identified; four of these would produce polycistronic transcripts.

282 onally related proteins encoded by bacterial polycistronic transcripts.

283 by which RNase P processes the valU and lysT polycistronic transcripts.

284 r role in the processing of all three valine polycistronic transcripts.

285 3'UTRs has revealed abundant bicistronic and polycistronic transcripts.

286 report that the 3'ETS of the glyW-cysT-leuZ polycistronic tRNA precursor is highly and specifically

287 r the processing and maturation of mono- and polycistronic tRNA precursors in Escherichia coli involv

288 fully edited, cDNAs derived from unprocessed polycistronic tRNA precursors often lack some of the edi

289 unnecessary for the initial cleavage of some polycistronic tRNA precursors.

290 However, recently we identified two polycistronic tRNA transcripts whose endonucleolytic pro

291 NAs that target different genomic sites, the polycistronic tRNA-gRNA gene (PTG) strategy enables mult

292 Murid herpesvirus 4 (MuHV-4) contains eight polycistronic tRNA-microRNA encoded RNA (TMER) genes tha

293 J) is present within sequences flanking the polycistronic units (PTUs) in T. cruzi.

294 RNA genes or as gene clusters transcribed as polycistronic units.

295 ased on this analysis, we developed a single polycistronic vector encoding the five pentamer genes se

296 Using a polycistronic vector we misexpress Pdx1, Ngn3, and MafA

297 n keratinocytes, demonstrating that a single polycistronic virus can reprogram human somatic cells.

298 Inclusion of Mycn and Meis1 and use of polycistronic viruses increase reprogramming efficacy.

299 he procyclic stage, in contrast to the known polycistronic vsg ESs which undergo abortive transcripti

300 Chromosomal norD expression is polycistronic with the upstream oligopeptide permease ge