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3 -doublecortin antibodies, such as the rabbit polyclonal Abcam 18732, are widely used as neurogenesis
8 gle-cell basis the affinity and frequency of polyclonal Ag-specific T cells directly ex vivo, we demo
9 but also mismatches in HLA-DRB3 may induce a polyclonal allo-immune response associated with conversi
13 g, because similar kinetics were observed in polyclonal and antigen-specific transgenic contexts.
14 nces showed that these responding cells were polyclonal and encompassed a broad range of structural T
15 ing new insights: (i) Barrett's esophagus is polyclonal and highly mutated even in the absence of dys
17 notypes, subtypes, and variants to serum and polyclonal and monoclonal antibodies isolated from patie
19 igate the role of IL-10 during conditions of polyclonal and neoplastic plasmacytosis for the regulati
20 ells were analyzed with flow cytometry after polyclonal and pathogen-specific stimulation (with varic
23 theless, T-cell receptor rearrangements were polyclonal and showed a diverse repertoire, demonstratin
24 involved in regulating negative selection of polyclonal and T cell receptor (TCR) transgenic thymocyt
25 ing Bhlhe40 reporter mice and analyzing both polyclonal and TCR transgenic Th cells, we found that Bh
27 e evolved antigenic sites effectively evades polyclonal anti-AAV1 neutralizing sera from immunized mi
30 fetus and newborn is highly effective using polyclonal anti-D, a recombinant alternative is long ove
31 resulting surfaces were used to investigate polyclonal anti-diclofenac antibodies recognition and re
32 sive immunization of DENV-infected mice with polyclonal anti-DJ NS1 Abs reduced viral Ag expression a
34 is by monocytes, inhibit binding of maternal polyclonal anti-HPA-1a Abs, and weakly inhibit aggregati
37 1beta during an immune response could elicit polyclonal anti-IL-1beta antibody responses that modulat
42 murine model in which immunoprophylaxis with polyclonal anti-KEL sera prevents alloimmunization in wi
43 ond electrode is surface-functionalized with polyclonal anti-M1 antibodies, which then serve to ident
44 quently incubated with a fluorophore-labeled polyclonal anti-peroxidase antibody (anti-HRP-Alexa Fluo
45 ant SasX or passive immunization with rabbit polyclonal anti-SasX IgG significantly decreased the siz
48 12), monoclonal antibodies (aIRR = 1.83), or polyclonal antibodies (aIRR = 2.03); in recipients who w
50 on commercial ELISA kits which are based on polyclonal antibodies (pAbs) not previously tested for c
51 ls after the addition of either RSV-specific polyclonal antibodies (PAbs) or RSV glycoprotein-specifi
52 mining the reactivity of plasmablast-derived polyclonal antibodies (PPAbs) to influenza proteins.
56 s method utilizes oligonucleotide-conjugated polyclonal antibodies and quantifies antibody-antigen bi
59 RNA immunoprecipitation assays) using m(6)A polyclonal antibodies coupled with mRNA isolation, quant
60 viral protein 40 antigen was used to derive polyclonal antibodies for RDT and enzyme-linked immunoso
61 orthogonal alkyne handle into monoclonal or polyclonal antibodies from different species in an Fc-sp
64 using the conventional Ricin monoclonal and polyclonal antibodies have also been demonstrated for co
65 amplified via liposomes; (ii) the use of two polyclonal antibodies in the sandwich assay format incre
67 standard membrane-feeding assays, anti-FREP1 polyclonal antibodies significantly blocked transmission
68 ination in the amount and the avidity of the polyclonal antibodies specific for the HA1 subunit of th
69 the R5, G12 and Skerritt monoclonal and two polyclonal antibodies to well-defined gluten protein typ
71 ned monoclonal (outer surface protein A) and polyclonal antibodies were performed on all tissue secti
72 iously, we have demonstrated that B virus gD polyclonal antibodies were unable to neutralize B virus
73 immunoassays (with the use of monoclonal or polyclonal antibodies), parathyroid hormone, and albumin
75 and immunohistochemistry detection by HSV-1 polyclonal antibodies, showed a lack of viral proteins i
83 EqCXCL16 or by pretreatment with guinea pig polyclonal antibody against EqCXCL16 protein (Gp anti-Eq
85 s were screened by measuring binding to IgG (polyclonal antibody against peanut allergen) and IgE (se
86 emical staining of paraffin sections using a polyclonal antibody against the protein LIN28A, and (3)
87 using sandwich assay by utilising the rabbit polyclonal antibody as the capture antibody and conjugat
88 absence of NK cells, because treatment with polyclonal antibody asialogangloside GM-1 did not augmen
90 following transplantation and increased with polyclonal antibody induction therapy (IRR=1.65, 95% CI
94 ylactic or therapeutic administration of the polyclonal antibody preparations (TcPAbs) can protect mi
96 as well as resistance to neutralization by a polyclonal antibody raised against the wild-type virus.
97 SSTI with USA300, despite eliciting a strong polyclonal antibody response against antigens whose expr
99 we found that S. aureus SSTI elicited broad polyclonal antibody responses in both BALB/c and C57BL/6
103 the results of anatomical studies using our polyclonal antibody specifically against human melanopsi
106 iple inflammatory conditions, and anti-HMGB1 polyclonal antibody treatment improves survival in a mod
107 sor chip was used to immobilise alpha-casein-polyclonal antibody using EDC/NHS coupling procedure.
108 a positive correlation with the anti-cod PAV polyclonal antibody, but no correlation with the anti-ca
109 search on novel approaches to produce potent polyclonal antibody-based therapies have been deficient.
111 ulated that a bolus of enhanced IL-21-primed polyclonal antigen-specific CTL combined with CTLA4 bloc
114 purified preparations of the resultant human polyclonal antisera against low- and high-dose VEEV chal
115 iruses with RBS deletions are able to escape polyclonal antiserum binding and are able to infect and
117 e to developmental landmarks and revealing a polyclonal architecture of the human cerebral cortex.
119 ng blood samples (r = 0.53 and P = 0.008 for polyclonal assay; r = 0.54 and P = 0.004 for monoclonal
120 erval on chromosome 4 display high titers of polyclonal autoantibodies with generalized B cell hypera
121 e sought to investigate the possibility of a polyclonal autoimmune event in the airways of asthmatic
123 d by iNKT cells, because similarly activated polyclonal autologous T cells did not have this effect.
126 otein A (SpA), a surface protein that drives polyclonal B cell expansion and induces cell death in th
127 ly abused prescription opioid oxycodone, the polyclonal B cell population specific for an oxycodone-b
128 i-PAR2 antibodies, the monoclonal SAM-11 and polyclonal B5, inhibited AHR, airway eosinophilia, the i
130 ileukemia activity of adoptively transferred polyclonal cancer antigen-reactive T cells deficient in
132 specificity plays in the partitioning of the polyclonal CD4 T cell repertoire between Tfh and NonTfh
135 owever, in vivo effects of A2aR signaling on polyclonal CD4 T cells during a primary response to fore
136 sis for this anatomic preference by tracking polyclonal CD4(+) T cells specific for an MHC class II-b
138 ntial allogeneic immune synapse formation in polyclonal CD4(+) T cells using high-throughput imaging
140 naturally occurring subpopulation of anergic polyclonal CD4(+) T cells, enriched for self antigen-spe
141 spectrum of helminth-induced effects on the polyclonal CD8 T response, indicating the lack of requir
145 enhanced IFN-gamma production compared with polyclonal cells, protected immune-deficient mice agains
147 that patient-derived xenografts were highly polyclonal, consisting of tens to hundreds of LPC clones
148 nding antibodies perform optimally when in a polyclonal context and that the targeted elicitation of
150 erties of broadly neutralizing antibodies in polyclonal contexts will be essential for guiding design
151 e biological activity of these antibodies in polyclonal contexts, comparing both IgG and IgA isotypes
154 that, when TnBVank1 was stably expressed in polyclonal Drosophila S2 cells, apoptosis is induced.
156 fluoresceinated IgG constant H chain-binding polyclonal F(ab')2 (IgHPolyFab) is used as the fluoresce
158 mechanisms to transiently stimulate a broad, polyclonal germinal center reaction, an inherently mutag
159 strain, resistant to neutralization by both polyclonal-HCV-infected plasma and multiple broadly neut
162 ining patients, 4 presented a clonal and 7 a polyclonal hematopoiesis, suggesting that certain triple
163 erm line JAK2 mutations were associated with polyclonal hereditary thrombocytosis and triple-negative
165 because of the difficulties of working with polyclonal human antibodies usually available only in sm
166 gen-specific highly neutralizing therapeutic polyclonal human antibody (TcPAb) preparations in 6 mont
167 in the alpha1KI mouse model, which produces polyclonal human IgA1 prone to mesangial deposition.
170 nce of the three binders, allergic patients' polyclonal IgE reacted with Phl p 1, indicating high-den
173 , we measured increasing affinity of macaque polyclonal IgG responses over the course of the immuniza
178 om wild-type mice, as well as by engineering polyclonal Ighgamma1/gamma1 and Ighepsilon/epsilon mice,
181 resistance to in vitro neutralization by MV polyclonal immune sera without altering its thermostabil
187 ependent effector functions are regulated by polyclonal influenza virus-binding antibody mixtures in
188 munogenic and cross-reactive with MOG at the polyclonal level, it fails to expand a threshold level o
190 nd low-avidity cells sorted from a severe HA polyclonal line revealed that 94% of the high-avidity ce
192 itis, inflammatory arthropathy, intermittent polyclonal lymphoproliferation, and significant chronic
193 oliferation, and effector differentiation of polyclonal memory CD8(+) T cells after infection with wi
194 uing observations raise the question: How do polyclonal metastases emerge from the primary tumor?
195 Limitations of these analyses include a polyclonal method of ApoE measurement, rather than isofo
199 CD34(+) cell products are capable of stable, polyclonal multilineage reconstitution with follow-up of
200 retreated bone marrow-derived DC (BMDC) with polyclonal murine or human IgM prior to LPS activation a
205 Clonal tracking techniques confirmed the polyclonal nature of CNS-infiltrating cells, with multip
207 l now, but the reliability, pan-specificity, polyclonal nature, and stability of the available pan-sp
208 bstitution in E that significantly increased polyclonal neutralization but nonetheless were successfu
210 t lysis of articular chondrocytes by PBMC or polyclonal NK cells was potentiated by stimulation with
212 ated and significantly more suppressive than polyclonal or DeltaCAR Tregs in the presence of HLA-A2,
213 grade or high-grade metastasizing neoplasms, polyclonal or monoclonal lymphoproliferative disorders,
215 gainst BRCA deficiencies in cancer cells and polyclonal patient-derived xenograft models, including t
216 myeloid BM cells (59% vs 22%; P = .03) and a polyclonal pattern of inactivation of the X-chromosome o
217 GUS also suggest the possible existence of a polyclonal phase preceding the development of MGUS.
218 ferring resistance to neutralization by both polyclonal plasma and broadly neutralizing monoclonal an
219 ed reprogramming and the pooled selection of polyclonal pluripotent cells results in high-quality, st
220 s, granulocytes, B cells, and T cells from a polyclonal pool of hematopoietic stem and progenitor cel
221 ere was rapid engraftment and expansion of a polyclonal pool of transgene-positive functional T cells
222 expression of Nur77GFP and OX40 identifies a polyclonal population of high-affinity tumor-associated
223 T cells increased following infection in the polyclonal populations, suggesting an increase in pathog
224 en screening for pathogenic effectors within polyclonal populations, Tregs should be removed from the
225 thought to be present within the cells of a polyclonal premalignant lesion and the features that und
229 AAVs, specifically, to obtain a picture of "polyclonal" reactivity as is the situation in humans.
231 ed with the ability to phenotype a patient's polyclonal repertoire in the same analysis further shows
232 in-resident memory T cells that arise from a polyclonal repertoire of cells induced by infection with
233 ncy of anti-insulin B lymphocytes within the polyclonal repertoire of VH125Tg/NOD mice, suggesting en
236 ss-reactivity with MOG-specific T cells, the polyclonal response to NFM15-35 did not expand threshold
240 lticolor lineage tracing to demonstrate that polyclonal seeding by cell clusters is a frequent mechan
241 ght definitive evidence for the existence of polyclonal seeding in human malignancy and to establish
243 DS-PAGE and immunoassay analysis with rabbit polyclonal sera and human IgE indicated only minor diffe
244 as standardized reagents to monitor complex polyclonal sera for neutralization activity and to chara
247 uated the anti-HIV Ab effector activities in polyclonal serum samples from HIV-infected donors, VAX00
250 d a rapid, sensitive, and robust method, the polyclonal serum-based proximity ligation assay (polyPLA
254 -gamma unresponsive even after TCR-dependent polyclonal stimulation (anti-CD3 plus anti-CD28) but pro
255 8) but produced IFN-gamma by TCR-independent polyclonal stimulation (phorbol 12-myristate 13-acetate
256 d activation by CD4(+) and CD8(+) T cells on polyclonal stimulation, and displayed lower major histoc
257 tive responses to alloantigen, as well as to polyclonal stimulation, than did their CD244(-) counterp
259 an naive CD4 T-cell expansion in response to polyclonal stimuli by inducing their apoptosis and promo
260 lated in vitro with CT, mmCT, or dmLT plus a polyclonal stimulus (staphylococcal enterotoxin B) or sp
261 ome (TSS), bacterial superantigens trigger a polyclonal T -cell response leading to a potentially cat
262 splenocytes or human PBMCs was elevated upon polyclonal T cell activation, and this was reduced by mi
263 phospholipids within human skin in vivo, and polyclonal T cell responses are dependent on CD1a protei
264 -containing multimers of naturally occurring polyclonal T cell responses, which represents a strong a
265 but fails to induce demyelinating disease by polyclonal T cells despite having the same TCR contact r
266 CD8(+) T cells and in fibrosarcoma-reactive polyclonal T cells enhanced the persistence of PD-1 gene
268 The reduced diabetes transfer efficiency by polyclonal T cells in NSG recipients was associated with
269 ane-induced arthritis (PIA) in the rat where polyclonal T cells induce chronic arthritis after being
271 minority of Reed-Sternberg cells and by most polyclonal T cells rosetting around Reed-Sternberg cells
272 pecific antibody (bsAb) that redirects human polyclonal T cells to AC133(+) GBM stem cells (GBM-SC),
274 to express synthetic receptors that redirect polyclonal T cells to surface antigens for subsequent tu
275 ucible inactivation of Dicer1 in early stage polyclonal T-ALL cells was sufficient to abrogate T-ALL
276 ells, thereby inducing target cell-dependent polyclonal T-cell activation and proliferation, and lead
279 ncrease in IL-17A (P = .03) production after polyclonal T-cell stimulation, and an enhanced IL-10 res
280 lesional and nonlesional AD showed a highly polyclonal TCR pattern, without evidence of oligoclonal
281 elf-reactive response has not only a diverse polyclonal TCR repertoire, but also comprises a broad ra
283 resulting Ran-SPION-rIgPxcIgY carries chick polyclonal to microtubule-associated protein 2 (MAP2) as
285 ed normal suppressive function in peripheral polyclonal Treg cells from patients with celiac disease,
287 sisting of in situ injection of preactivated polyclonal Treg cells that would exert bystander suppres
290 However, the affinity of naturally occurring polyclonal Tregs for any self-antigen, let alone MOG, ha
291 We used CAR technology to redirect human polyclonal Tregs toward donor-MHC class I molecules, whi
292 d a model where the TCR repertoire of normal polyclonal Tregs was limited by serial transfers into IL
293 Emerging data indicate that, compared with polyclonal Tregs, disease-relevant antigen-specific Treg
297 man primates and humans points to a role for polyclonal vaccine-induced antibody responses in protect
299 s (91 of 360), of whom 28.6% (26 of 91) were polyclonal, with mutations associated with acquired resi
300 s (63 of 161), of whom 49.1% (27 of 55) were polyclonal, with rates of mutation detection unaffected
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