ライフサイエンスコーパス: polyene

1 ission in aggregates of astaxanthin, a small polyene.

2 atalyst resulted in the formation of soluble polyenes.

3 and tandem oxidation reactions of conjugated polyenes.

4 rnation resulting from Peierls distortion in polyenes.

5 re compared to these data for cyclacenes and polyenes.

6 r systems such as donor-acceptor-substituted polyenes.

7 electrophilic addition to aromatic rings and polyenes.

8 e pigments belong to xanthomonadin-like aryl polyenes.

9 cess attractive for the synthesis of complex polyenes.

10 cluster dihydrides can thus be considered as polyene analogues, or "polyboroenes".

11 Butadiene is the simplest polyene and has long served as a model system for many c

12 Diphenylamine (DPA), a known inhibitor of polyene and isoprene biosynthesis, is shown to inhibit f

13 ic nitrogen heterocycles were prepared using polyene and polyenyne metathesis cascades.

14 e structures featured layers with all carbon polyene and polyphenylene arrays.

15 ization reactions incorporated the sensitive polyene and provided the protected roxaticin seco-acid,

16 f Ru(II)-based electron donor-acceptor (D-A) polyene and some closely related chromophores.

17 nd are remarkably similar to those of simple polyenes and carotenoids.

18 d in previous studies of intermediate length polyenes and carotenoids.

19 ure on the radiative properties of all-trans polyenes and carotenoids.

20 Azoles, polyenes and echinocandins constitute the mainstay of an

21 icacy of other classes of drugs, such as the polyenes and echinocandins, was not affected by the pres

22 s to both of their conjugated relatives, the polyenes and polyynes.

23 ave smaller band gaps than the corresponding polyenes and triplet ground states for nine or more benz

24 reodivergent synthesis of unbranched 1,5,9,n-polyenes (and -polyynes) was investigated.

25 uce toxicity (e.g. new lipid formulations of polyenes), and new derivatives of drugs have been develo

26 ille cross-coupling reaction to assemble the polyene, and an intramolecular Horner-Wadsworth-Emmons o

27 ly for the analogues of this state in longer polyenes, and consequently studies of longer polyenes ar

28 In a second step, the effects of the polyene antibiotic MS-8209, the polyanion dextran sulfat

29 ng domain of Ncr1p conferred temperature and polyene antibiotic sensitivity without changes in sterol

30 Nystatin isolated from Streptomyces is a polyene antibiotic that is frequently used in the treatm

31 led with the fluorescent cholesterol-binding polyene antibiotic, filipin, although there are differen

32 These mutant cells are also resistant to the polyene antibiotic, nystatin.

33 In previous studies, the polyene antibiotics amphotericin B (AmB) and MS-8209 pro

34 The polyene antibiotics are the only group of antifungal ant

35 In contrast to other polyene antibiotics that form pores in the membrane, the

36 new method for studying the interactions of polyene antibiotics with sterol-containing membranes, an

37 teins is a general mode of action of all the polyene antibiotics, of which some have been shown addit

38 t cells when administering nystatin or other polyene antibiotics.

39 ction of a cholesterol-binding compound, the polyene antifungal antibiotic amphotericin B methyl este

40 2 and IZH3 gene dosage affects resistance to polyene antifungal drugs.

41 polyenes, and consequently studies of longer polyenes are very limited.

42 Five bivalent homodimeric polyenes based on stipiamide linked with polyethylene gl

43 A combinatorial library of polyenes, based on (-)-stipiamide, has been constructed

44 explored collection of structurally diverse, polyene-based metabolites.

45 nazole (n = 39), caspofungin (n = 16), and a polyene-based product (n = 12).

46 nt relationship to a third subfamily of aryl polyene BGCs, and together the three subfamilies represe

47 tive to its Huckel isomer is confined to the polyene bridge and is not due to a delocalized pi circui

48 on of uncorrected ISE(II) values of just the polyene bridge portion of 1 and its Huckel counterpart s

49 eous in vitro production of three octaketide polyenes by biosynthetic enzymes for the 10-membered ene

50 ericyclic reactions meet again to expand the polyene-carbonyl manifold.

51 egio- and stereocontrolled catalytic radical polyene cascade cyclization from preoleanatetraene oxide

52 ared to their neutral forms as, for example, polyene cations and dyes such as indigo and the cyanines

53 static and vulnerable to resistance, whereas polyenes cause serious host toxicity.

54 roups) and into the adjoining segment of the polyene chain (at C8).

55 inding pocket are straightening of retinal's polyene chain and separation of its beta-ionone ring fro

56 he three different planes that represent the polyene chain and the beta-ionone ring of retinal.

57 -cis-retinal shows torsional twisting of the polyene chain and the beta-ionone ring.

58 steric interactions between Ala-117 and the polyene chain at the C13 position, torsion of the polyen

59 thermal reactions in which relaxation of the polyene chain back to all-trans is coupled to various ch

60 ate NMR, we were able to analyze the retinal polyene chain between positions C10 and C15 as well as t

61 yl Batho, even though the C8-hydrogen of the polyene chain cannot interact with a ring C5-methyl grou

62 s double bonds and s-cis single bonds in the polyene chain determine the topology space of the carote

63 ne chain at the C13 position, torsion of the polyene chain due to steric constraints in the binding p

64 hyl retinal, where the 9-methyl group on the polyene chain has been deleted.

65 e orientation of the beta-ionone ring to the polyene chain has both modest barrier heights and a tors

66 The polyene chain is rigidly locked into a single, twisted c

67 a twisted 6-s-cis conformation, whereas the polyene chain is twisted 12-s-trans.

68 orientation of the beta-ionone ring and the polyene chain of the chromophore 11-Z-retinylidene of rh

69 The other dihedral angles along the polyene chain of the chromophore, although having lower

70 The planarity of the polyene chain of the retinal chromophore in bacteriorhod

71 data indicate that the methyl groups on the polyene chain point toward the cytoplasmic side of the m

72 cient steric bulk at the terminal end of the polyene chain to mimic the trimethylcyclohexenyl ring of

73 pward movement of the C(5)-C(13) part of the polyene chain toward the cytoplasmic surface or with inc

74 ature of the analogues and the length of the polyene chain with all-trans-C17 aldehyde and all-trans-

75 olves a shift of electron density within the polyene chain, and it does not involve participation of

76 ined rotation about each bond in the retinal polyene chain, for both the protonated and deprotonated

77 beta-ionone ring can rotate relative to the polyene chain, thereby populating both positively and ne

78 ence of an electron-withdrawing group on the polyene chain, which would inhibit carbocation formation

79 pagating away from the Schiff base along the polyene chain.

80 -s-cis conformation between the ring and the polyene chain.

81 181, points toward the center of the retinal polyene chain.

82 ii) changes in tilt and slant of the retinal polyene chain.

83 f the beta-ionone ring or carbon C(9) of the polyene chain.

84 yl, ethyl, propyl) at the C9 position of the polyene chain.

85 rotation about the long-axis of the retinal polyene chain.

86 s containing keto units positioned along the polyene chain.

87 sing number of cis and/or s-cis bonds in the polyene chain.

88 order reversal in the central portion of the polyene chain.

89 proximity and favorable geometry for the two polyene chains, but from the heptahelical crystallograph

90 garding the effects of extension of bridging polyene chains.

91 85 as a photochemical reaction pathway for a polyene chromophore imbedded in a protein binding cavity

92 nt reaction pathway for a diene, or a longer polyene confined in a rigid (relative to isomerization r

93 By analogy to conjugated polyenes, conjugative stabilization of polyynes with the

94 Bronsted acid (chiral LBA) mediated cationic polyene cyclization and a titanocene-mediated radical cy

95 erated in 12 steps underwent a nonbiomimetic polyene cyclization mediated by ferric chloride to gener

96 nd 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP), polyene cyclizations using allylic alcohols as initiator

97 rpene synthesis, particularly in the area of polyene cyclizations, much remains to be learned if the

98 many reagent combinations that can initiate polyene cyclizations, simple electrophilic halogen sourc

99 Combination lipid polyene-echinocandin therapy is the most promising of su

100 Metatricycloene is a tricyclic polyene encoded by a reductive, iterative polyketide-lik

101 itions agrees with theoretical treatments of polyene excited-state energies and is consistent with th

102 Fragmentation of polyene FAME yields major diagnostic ions resulting from

103 cell surface Y2 sites could be activated by polyene filipin III through complexing of membrane chole

104 eck reaction for selective complex diene and polyene formation.

105 Several methods for the generation of the polyene fragment were explored, and the side-chain was u

106 se of antifungal drugs, primarily azoles and polyenes, has increased in parallel.

107 periments imply that the S1 states of longer polyenes have local energy minima, corresponding to a ra

108 resistance to the azoles, echinocandins, and polyenes have occurred in several Candida species, most

109 Polyene hydrocarbons and epoxides are used as pheromone

110 ty can be used to furnish complex dienes and polyenes in good yields and excellent selectivities (gen

111 n = 2, in marked contrast to other known D-A polyenes in which beta(0) increases steadily with n.

112 0.89, 0.81.0.89; p<0.0001) with ratio of PI (polyene index) to PRs - suggesting the plausible signifi

113 Charge is moved from the allenic side of the polyene into the furanic ring region and is accompanied

114 highly substituted and stereodefined skipped polyenes is described from the reductive cross-coupling

115 The finding that fluorescence from linear polyenes is so strongly dependent on molecular symmetry

116 oximately a 1/N dependence) to a common long polyene limit at approximately 16,000 cm(-1).

117 the Proteobacteria; their products are aryl polyenes, lipids with an aryl head group conjugated to a

118 These compounds are members of polyene macrocycles, pyrroloindole alkaloids, angucyclin

119 of a new class of bis-salicylate-containing polyene macrodiolides, which have potent antibiotic acti

120 ritical for the structure elucidation of the polyene macrolactam salinilactam A, but its structural a

121 A total synthesis of the oxo-polyene macrolide (+)-roxaticin is achieved in 20 steps

122 Polyene macrolide antibiotics are naturally occurring an

123 n (NYT), an antifungal drug of the family of polyene macrolide antibiotics, elevated YFP expression b

124 y will be applicable to other members of the polyene macrolide natural products.

125 ents the most concise preparation of any oxo-polyene macrolide reported to date, is achieved in the a

126 discovered selvamicin, an unusual antifungal polyene macrolide, in bacterial isolates from two neighb

127 t the opposite end of selvamicin's shortened polyene macrolide.

128 Two new polyene macrolides, marinisporolides A and B (1, 2), wer

129 to prepare polyol chains associated with the polyene macrolides.

130 Although polyenes, marinisporolides A (1) and B (2) showed weak t

131 The combination of a triazole and polyene may be antagonistic in the treatment of invasive

132 tres at the central positions of the skipped polyene motif.

133 A series of cyclobutanes substituted 1,2- by polyenes of increasing radical-stabilizing power has bee

134 This paper reports the synthesis of polyene oligomers ("oligoenes") that contain up to 15 do

135 dy nonlinear photoexcitation dynamics in the polyene oligomers by using a quantum-chemical method sui

136 cal bond between the protein and the retinal polyene only slightly affected the main electron transpo

137 owever, quite different from those of either polyenes or polyynes.

138 Selective polyene oxidation provides an archetypical example of th

139 The use of cyclic polyene perimeter-model approaches, such as Gouterman's

140 mands a re-evaluation of current theories of polyene photophysics and highlights the robustness of ca

141 the first example of Type II PKS-synthesized polyene pigments and show that the metabolites serve as

142 rot feathers contain red, orange, and yellow polyene pigments called psittacofulvins.

143 Remarkably, this aryl polyene PKS complex only contains the KS (ORF17), but no

144 Finally, we incubated the polyene-PKS with the NRPS module in the presence of orni

145 Other options include combination lipid polyene plus deferasirox or posaconazole therapy.

146 r can provide access to other members of the polyene-polyol macrolides, including stereoisomers of RK

147 photochemical transformations from a common polyene precursor are described.

148 s constructed from four principal modules: a polyene precursor for carbons 3-9, and three alkyne-term

149 ules (tricyclic to pentacyclic) from achiral polyene precursors by enantioselective proton-initiated

150 ity chemical 1,3-butadiene to afford skipped polyene products is reported.

151 Alongside these two polyene products, we have additionally detected a hydroc

152 n, and acid-sensitive moieties, particularly polyenes prone to cyclization.

153 The results indicate that both ends of the polyene reversal agent are involved in Pgp interaction a

154 tivation pathway: excited-state trans-to-cis polyene rotation.

155 ring the energy change for hydrogen loss for polyene series 2 (n double bonds) with polyene series 3

156 s for polyene series 2 (n double bonds) with polyene series 3 (n double bonds), which are combined in

157 For three different polyene series, the intense, visible d-->pi* metal-to-li

158 (2)H NMR structure shows a reduction of the polyene strain, while torsional twisting of the beta-ion

159 esymmetrization of readily available achiral polyene substrates, 5,6-, 5,7-, and 5,8-bicyclic amides

160 useful site selectivities can be obtained in polyene substrates.

161 ve cation-olefin cyclization/fluorination of polyene substrates.

162 contribution of a cyclopropyl ring linked to polyene systems.

163 pids with an aryl head group conjugated to a polyene tail.

164 triphosphate (ATP), and we detected the same polyene tetramate as that in Streptomyces transformed wi

165 howed the production of HSAF analogues and a polyene tetramate intermediate.

166 mical methods for the preparation of skipped polyenes that contain varied stereochemistries and subst

167 Skipped polyenes (that is, 1,4-dienes and higher homologues) are

168 lective access to a diverse array of skipped polyenes through a process that establishes one C-C bond

169 This method converts linear polyenes to functionalized polycyclic systems bearing up

170 Polyene-type polyketides are known to be biosynthesized

171 the stabilization of conjugated ground-state polyenes vs polyynes.

172 de adenine dinucleotide phosphate (NADPH), a polyene was detected in the tryptic acyl carrier protein

173 Construction of the polyene was realized using two successive Heck couplings

174 cture, and excited-state properties of model polyenes, we propose a molecular mechanism that accounts

175 erved for cis/trans isomerization in acyclic polyenes, which occurs via singlet diradical transition

176 gy is applicable to the synthesis of 1,5,9,n-polyenes with any possible double bond configuration acc

177 upted fatty acid methyl esters (NMI-FAME) of polyenes with three and more double bonds.

178 tional groups resulted in soluble telechelic polyenes with up to 20 double bonds.