ライフサイエンスコーパス: polyether

1 esis of lasalocid A, an ionophore antibiotic polyether.

2 complete removal of external K by 18-Crown-6 polyether.

3 ecognition sites being part of a macrocyclic polyether.

4 branched, hyperbranched, and dendrimer like polyethers.

5 lted in conversion to the hexafunctionalized polyether 15.

6 ment, we have tested tyloxapol, an alkylaryl polyether alcohol polymer detergent previously used as a

7 Ligand 9 is the most active polyether analogue in rodents and is also very effective

8 arboxylic acid [(S)-4'-(HO)-DADFT-PE, 11], a polyether analogue, along with its ethyl and isopropyl e

9 Both polyether analogues in subcutaneous (sc) versus oral (po

10 This compelled a closer look at additional polyether analogues, the subject of this work.

11 The parent polyether and its isopropyl and ethyl esters were all sh

12 d for molecular weight (MW) determination of polyether and polyester polyurethane (PUR) soft blocks.

13 of surfactants consisting of perfluorinated polyether and polyethylene glycol (PFPE-PEG).

14 ngs in the case of both the free macrocyclic polyether and the [2]catenane have led to a deeper funda

15 sing approximately 50 potentially hemilabile polyethers and amino ethers.

16 until his retirement to synthesis of cyclic polyethers and evaluation of their metal ion complexatio

17 the macroporogen and a variety of aliphatic polyethers and triblock copolymeric surfactants as porog

18 to O-containing aromatic compounds, complex polyether- and ester-containing alkyl molecules of prebi

19 mistry present in the C13-C21 portion of the polyether antibiotic semduramycin (1).

20 rase (RNAP) by sorangicin (Sor), a macrolide polyether antibiotic.

21 ases responsible for the biosynthesis of the polyether antibiotics nanchangmycin (1) and salinomycin

22 find that it acts by a mechanism similar to polyether antibiotics, which are structurally highly div

23 Based on similarities to polyether anticancer agents we have further examined TDA

24 Ionophore antibiotics (IPAs) are polyether antimicrobials widely used in the livestock in

25 Three DADFT polyethers are evaluated: (S)-4,5-dihydro-2-[2-hydroxy-4

26 reochemically defined flexible cyclic ethers/polyethers as high affinity P2-ligands.

27 ioxynaphthalene (DNP)-containing macrocyclic polyethers as pi-electron donor rings have been synthesi

28 ncorporating 34- and 36-membered macrocyclic polyethers as recognition modules in the construction of

29 sin, principles underlying the initiation of polyether assemblies are proposed.

30 ne droplets in Fomblin Y 06/6 perfluorinated polyether at capillary numbers up to 0.81 and with a dro

31 a polymeric hydrocarbon and a perfluorinated polyether) at a common junction leads to molecular frust

32 urfactant composed of perfluoropolyether and polyether blocks.

33 Treatment of polyether bridged bis(diphenylacetylenes) with a source

34 which are separated from each other along a polyether chain carrying 2,6-diisopropylphenyl stoppers

35 These findings suggest that polyether chain length has a profound effect on ICE, tis

36 two chelating IL systems (one with a pendent polyether chain with three ether oxygens, MPEG3PyrTFSI,

37 oxypyridine unit attached to either end of a polyether chain, mixed with a transition metal ion (e.g.

38 yridyl complexes of Co decorated with 350-Da polyether chains (Co(350)(2+)) form molten phases of nuc

39 Chelating ionic liquids (ILs), in which polyether chains are pendent from the organic pyrrolidin

40 Quantitative analysis revealed that the polyether chains can displace both TFSI(-) and BH4(-) fr

41 ing aggregated bilirubin cores within mobile polyether chains.

42 and free states of borohydride, TFSI(-), and polyether COC groups.

43 rrence of a trifurcated hydrogen bond at the polyether compartment of the macrobicycle, account for t

44 The majority of reported polyether complexes contain lead(ii) and thallium(i) but

45 in regard to the chemical properties of the polyether complexes is highlighted.

46 ations by macrocyclic and diazamacrobicyclic polyethers, composed of ordered arrays of hard oxygen (a

47 Veterinary ionophore antibiotics (IPAs) are polyether compounds used extensively in the livestock in

48 Ionophore antibiotics (IPAs) are polyether compounds used in broiler feed to promote grow

49 rganoplatinum square and a {2+2} macrocyclic polyether containing two 1,5-dioxynaphthalene (DNP) and

50 An electron-rich macrocyclic polyether containing two TTF units of different constitu

51 opper(I) catalysts having multiple sites for polyether coordination, intramolecular oxonium ylide for

52 bed that contain duplex DNA as the anion and polyether-decorated transition metal complexes based on

53 cules were linked to the core of a family of polyether dendrimers, which caused the hexamer to be for

54 Some of the SAMs prepared with new acyclic polyether derivatives are able to detect potassium catio

55 Acyclic polyether derivatives can also self-assemble on gold to

56 The eight spirotricyclic polyethers differ in the size of the rings containing th

57 oly(2-butenediol), an unsaturated telechelic polyether diol with molecular weights between 400 and 46

58 The resulting polyether displays predictable end groups, molar mass, a

59 We show that like polyether drugs, TDA collapses the proton motive force b

60 mechanism for epoxide selection by ionophore polyether epoxide hydrolases.

61 nomycin biosynthetic pathway resembles other polyether epoxide hydrolases/cyclases of the MonB family

62 )-poly(butylene terephthalate) (PEOT/PBT), a polyether-ester multiblock copolymer to direct different

63 The polyether fatty acid, okadaic acid has been shown previo

64 zyme intermediates, whereas tandem cyclic PK polyether formation of furans and pyrans can be initiate

65 y nucleophilic attack, and in the subsequent polyether formation process, it promotes the reaction of

66 l phenoxides with halobenzenes as models for polyether formation.

67 introduction of either a hydroxyl group or a polyether fragment onto the aromatic ring resulted in or

68 ed coordination and interlocking of diolefin polyether fragments around the cyclic polymer backbone u

69 de, providing a short and versatile route to polyether fragments.

70 ature trans-anti-trans 7,7,6-fused tricyclic polyether framework was constructed in a single bromoniu

71 synthesis of oxepanes and oxepane-containing polyethers from di- and trisubstituted epoxides.

72 Macrocyclic polyether fullerenes are a new class of ionophores, whic

73 lubricated with Fomblin RT15 perfluorinated polyether grease in order to ensure compatibility with t

74 The polyethers had uniformly higher ICEs than their correspo

75 The redox behavior of the macrocyclic polyether has been investigated by electrochemical techn

76 Anthraquinone-containing cyclic polyether hosts form 1:1 complexes with hydronium ion, p

77 in (DMDFT, 1) hydroxamates and a bis-salicyl polyether hydroxamate are evaluated for their iron-clear

78 tone via polysulfide, addition silicone, and polyether impression materials.

79 indicating the importance of the macrocyclic polyether in PQT2+ docking.

80 table [2]catenane, composed of a macrocyclic polyether incorporating 1,5-dioxynaphthalene (DNP) and t

81 he determination of six antibiotics from the polyether ionophore class (lasalocid, maduramicin, monen

82 e biosynthetic gene cluster (97 kbp) for the polyether ionophore monensin from Streptomyces cinnamone

83 agmentation reactions in the carboxylic acid polyether ionophore nigericin.

84 We discovered that the polyether ionophore salinomycin potently inhibited the f

85 These data identify salinomycin and other polyether ionophores as novel potential antiscarring the

86 ion reactions in macrotetrolides, a class of polyether ionophores produced by Streptomyces species, w

87 an potentially identify different classes of polyether ionophores rapidly and selectively.

88 and those adopted in European Community for polyether ionophores.

89 The [2]catenane in which the macrocyclic polyether is mechanically interlocked with the cyclobis(

90 helatase antibody 7G12 was found to bind the polyether jeffamine in addition to its cognate hapten N-

91 Evidence that the natural substrate for the polyether KR(0) domains is, as predicted, a (2R)-2-methy

92 ble seven-membered rings embodied in a large polyether ladder-like scaffold structure, and (iii) dete

93 ligation of K(+) with different macrocyclic polyether ligands (L).

94 ns are complexed by either cyclic or acyclic polyether ligands and which have well-characterized sing

95 th the syntheses of various cyclic ether and polyether ligands have been described.

96 g components, and macrocyclic isophthalamide polyether ligands have been prepared using a general ani

97 ble aspects of the chemistry of complexes of polyether ligands including crown ethers, cryptands, gly

98 ers, cryptands, glycols, glymes, and related polyether ligands with heavier group 13 and 14 elements

99 ric and electronic effects for the different polyether ligands.

100 initrobenzene in the presence of macrocyclic polyether ligands: L(C) (cryptand) and L(E) (crown-ether

101 mbered macrocyclic nucleoside analogues with polyether linkages, including C2-symmetric molecules, ha

102 These were transformed into polyether-linked basket dioxocyclams 4a,b and bis-dioxoc

103 as a flexible linker to produce macrocyclic polyether-linked malonates 5, 6, 8, and 9 under solid-li

104 A polyether macrocycle monomer with two parallel diacetyle

105 All rotaxanes involve the well known polyether macrocycle, benzo[24]crown-8.

106 etates for the construction in high yield of polyether macrocycles having ring sizes greater than 25

107 capable of forming one-to-one complexes with polyether macrocycles that consist of two pi-electron-ri

108 n marked the beginning of research on cyclic polyether macrocyclic compounds.

109 ly, multiple additions to C60 of macrocyclic polyether malonate 5 gave C60 bis-adduct 10 selectively,

110 Structural characterization of the "ladder" polyether marine natural products raised a puzzle that p

111 y metabolite to be discovered as of yet, the polyether marine neurotoxin maitotoxin constitutes a maj

112 gurational assignment of this largest of the polyether marine toxin include (i) introduction of p-(me

113 o the highly viscous, semisolid hybrid redox polyether melt, [Co(phenanthroline)(3)](MePEG-SO(3))(2),

114 bout the Co complexes in the semisolid redox polyether melts.

115 ynthesis of two pentacyclic analogues of the polyether monensin A is described.

116 des offer the potential to construct complex polyether natural products expeditiously and in a manner

117 Biosynthesis of some polyether natural products involves a kinetically disfav

118 plications in the biosynthesis of the ladder polyether natural products, such as the brevetoxins and

119 he context of the synthesis of marine ladder polyether natural products.

120 (PbTx-1 to PbTx-10) are potent lipid-soluble polyether neurotoxins produced by the marine dinoflagell

121 (PbTx-1 to PbTx-10) are potent lipid soluble polyether neurotoxins produced by the marine dinoflagell

122 istable [2]catenanes composed of macrocyclic polyethers of different sizes incorporating both electro

123 depolymerize an environmentally recalcitrant polyether, poly(ethylene oxide) (PEO), that cannot penet

124 polymers, including aliphatic polyesters and polyethers, poly(alpha-peptoid)s, poly(meth)acrylates, p

125 onally protected two-generation, trifurcated polyether-polyamide dendron.

126 me, a new class of multifunctional dendritic polyether polyketals containing different ketal linkages

127 controlled mainly by the amount of aliphatic polyether porogen.

128 Polyether precursors to the polyradicals are prepared vi

129 Polyarylmethyl polyether precursors to the spin clusters, with linear a

130 Ethanolamine is applied for polyether PUR degradation.

131 ctivities of five caged crown ethers and two polyether reference compounds in methanol solution.

132 +) rings encircling dumbbells or macrocyclic polyethers, respectively, that contain a BIPY(2+) unit w

133 of diiminoisoindoline with amine-terminated polyethers results in the formation of phthalocrown macr

134 le in that it consists of two separate fused polyether ring assemblies linked by a methylene group.

135 c N-(X)sulfonyl carbamoyl lariat ethers with polyether ring sizes of 12-crown-4, 14-crown-4, 15-crown

136 roup of natural neurotoxins characterized by polyether ring systems that are found in the blooms of r

137 yne/azide handles and fluorine) flanking the polyether scaffold.

138 Our recent work with cyclic and acyclic polyether self-assembled monolayers (SAMs) on gold is pr

139 unterion relaxation is in turn controlled by polyether "solvent" fluctuations, this is a new form of

140 analyses of brevetoxins have shown that the polyether structure invariably has a very high affinity

141 brevis metabolites, though the "interrupted" polyether structure of brevisin is novel and provides fu

142 s leading to a variety of substituted ladder polyether structures.

143 PQT2+ inside a framework (MOF-177) devoid of polyether struts showed negligible uptake of PQT2+, indi

144 Polyphenylquinoxaline/polyether-sulfone (PPQ/PES) copolymers are synthesized s

145 ses, the epimerase-active KR(0) domains from polyether synthases lack one or both residues of the con

146 sight into the biogenesis of such fused-ring polyether systems.

147 PEG-SO(3))(2), where MePEG-SO(3) is a MW 350 polyether-tailed sulfonate anion, remarkably accelerates

148 lic acid [(S)-4'-(HO)-DADFT, 1] revealed the polyether to be more tolerable, achieving higher concent

149 as paralytic shellfish poisoning toxins and polyether toxins are also discussed, and genetic aspects

150 ns for a hypothetical biosynthesis of marine polyether toxins are discussed.

151 ed in the biosynthesis of ladder-type marine polyether toxins.

152 long an isotactic hydroxyl-group-derivatized polyether track by the formation/breakage of ester linka

153 e to the physical diffusion (D(PHYS)) of the polyether-transition metal complex.

154 The one-step synthesis of amino-polyether tri-tert-butyl ester monomer 2, by condensatio

155 For this application, a polyether-type Ni-catalyst 37c, readily soluble in the r

156 owing toolbox for epoxide polymerization, a "polyether universe" may be envisaged that in its structu

157 antitative analysis of a matrix, hydrophilic polyether urethane (HPEU) intravaginal ring (IVR) for su

158 Although 3 was superior to its isomers, this polyether was overshadowed by 15 to an extent in excess

159 th selected proton-based systems: 18-crown-6 polyether with protonated peptides and base-pairing ener