ライフサイエンスコーパス: polyfunctional

1 lls than WT mice, and these T cells are more polyfunctional.

2 d CD4(+)T cell responses that were broad and polyfunctional.

3 ition to long-lived memory cells but are not polyfunctional.

4 nd they point to the potential importance of polyfunctional Ab responses.

5 Overall, these data show that the polyfunctional abilities of HIV-specific CD8(+) T cells

6 Our results showed that the polyfunctional abilities of HIV-specific CD8(+) T cells

7 We postulate that together with polyfunctional adapter proteins such as AnkG119, Golgi s

8 ion, quantification, and characterization of polyfunctional Ag-specific T cells.

9 hey are traditionally prepared by condensing polyfunctional aldehydes and amines at elevated temperat

10 erent electrophiles are possible and lead to polyfunctional amide derivatives of the biuret type whic

11 Reductive amination of repromicin with polyfunctional amines has led to new macrolide antibacte

12 important intermediates for the synthesis of polyfunctional amino derivatives and natural products an

13 Polyfunctional analysis revealed a pattern of TNFalpha a

14 alone or with IL2, those induced by DCs are polyfunctional and coexpress IL17 and IFNgamma (Th17-1 c

15 These T cells are polyfunctional and cytotoxic and can inhibit mycobacteri

16 higher frequencies of mycobacterial-specific polyfunctional and cytotoxic T cells and higher concentr

17 in the T-cell-intact SHIV-immunized animals, polyfunctional and degranulating SIV-specific CD8(+) T c

18 m, the NS3-specific TCR-redirected CTLs were polyfunctional and inhibited HCV RNA replication through

19 L1 pathway dramatically reduces apoptosis of polyfunctional and interferon gamma(+)/granzyme B(-) mem

20 These T cells were polyfunctional and lysed peptide-pulsed target cells in

21 CD8(+) T cells from infected mice were polyfunctional and mediated cytotoxicity.

22 nt of new methods and strategies to assemble polyfunctional and polycyclic molecular architectures.

23 TriVax vaccination generated robust, polyfunctional, and protective CD8(+) T cell responses i

24 me systems that catalyze the biosynthesis of polyfunctional aromatic natural products such as actinor

25 s that catalyze the biosynthesis of numerous polyfunctional aromatic natural products.

26 The primer unit of such polyfunctional aromatic polyketides is an attractive sit

27 pe II polyketide synthases (PKSs) synthesize polyfunctional aromatic polyketides through iterative co

28 ften the synthetic precursors of traditional polyfunctional aryl amine monomers and are more stable,

29 infected mice, CD4 T cells are not cytokine polyfunctional, but there is a division of labor in the

30 The preparation of sterically hindered and polyfunctional C(alpha,alpha)-disubstituted alpha-amino

31 In contrast, CMV-specific CD8(+) T cell polyfunctional capacities were similar across all memory

32 tracellular TNF-alpha, which impact on their polyfunctional capacities.

33 Thus, the polyfunctional capacity and increased survival potential

34 f Chlamydia-specific CD4 TCR-Tg T cells with polyfunctional capacity offers a powerful approach for a

35 ne boronate ester-linked COFs from protected polyfunctional catechols and bis(boronic acids).

36 After in vitro stimulation with T27K, polyfunctional CD4 and CD8 lymphocytes of PBMC from immu

37 High-magnitude, polyfunctional CD4 and CD8(+) T cells were detected duri

38 Polyfunctional CD4 lymphocytes, defined as producing int

39 The frequency of Pf-specific polyfunctional CD4 memory T cells was associated with pr

40 The presence of mycobacterial-specific polyfunctional CD4 T cells measured by flow cytometry 10

41 response appeared to be most associated with polyfunctional CD4 T cells raised against the SseI pepti

42 s immunodominant among lipid Ags tested, and polyfunctional CD4 T cells specific for this lipid simul

43 The proportion of polyfunctional CD4 T cells was significantly higher in i

44 d for antigen presentation, the frequency of polyfunctional CD4 T lymphocytes did not significantly i

45 ne response revealed strong antigen-specific polyfunctional CD4(+) and CD8(+) T cell responses.

46 Vaccine-induced polyfunctional CD4(+) and CD8(+) T cells targeted 58 (60

47 as maintained and cure became prevalent when polyfunctional CD4(+) effector cells were prevented from

48 motherapy with cyclophosphamide gave rise to polyfunctional CD4(+) effector cells, which in turn inte

49 Among patients, a high quality, polyfunctional CD4(+) T cell response was associated wit

50 ecific T-cell response that was dominated by polyfunctional CD4(+) T cells and that targeted multiple

51 T-cell responses, including splenic and lung polyfunctional CD4(+) T cells expressing the three cytok

52 +)) with a significantly higher frequency of polyfunctional CD4(+) T cells producing IFN-gamma, TNF-a

53 nduced robust and durable response of mostly polyfunctional CD4(+) T cells, coexpressing IFN-gamma, t

54 esponses, and protection was associated with polyfunctional CD4(+) T-cell responses 2 wk after primin

55 sue of Blood, Mahnke and colleagues identify polyfunctional CD4(+) T-cell responses directed against

56 ontrast, BAL and blood mycobacteria-specific polyfunctional CD4(+) T-cell responses were impaired in

57 Rapid expansion of tuberculosis-specific polyfunctional CD4(+) T-cell responses, likely linked to

58 binant IL-7 markedly amplified and sustained polyfunctional CD4+ effector cells, resulting in improve

59 a expression, giving rise to IL-7-responsive polyfunctional CD4+ effector cells.

60 The frequency of polyfunctional CD4+ T cells in rectal mucosa positively

61 n large responses, as did the proportions of polyfunctional CD8 (IFN-gamma(+) IL-2(+/-) TNF-alpha(+))

62 multiparameter flow cytometry revealed that polyfunctional CD8 cells were less prevalent in children

63 eath, leading to activation and expansion of polyfunctional CD8 CTLs and tumor regression.

64 asis of how alphaPD-L1 therapy reinvigorates polyfunctional CD8 response during chronic infections.

65 tors and suggest the functional relevance of polyfunctional CD8(+) and CD4(+) T-lymphocyte responses.

66 individuals, the most frequent, robust, and polyfunctional CD8(+) T cell responses, as assessed by a

67 There was an increased proportion of polyfunctional CD8(+) T cells after antigen stimulation

68 ced assessment of the importance of inducing polyfunctional CD8(+) T cells by vaccination.

69 rol of viral load, and only antigen-specific polyfunctional CD8(+) T cells correlated with protection

70 CD8(+) interferon (IFN) gamma(+) T cells and polyfunctional CD8(+) T cells producing IFN-gamma, tumor

71 The generation of polyfunctional CD8(+) T cells, in response to vaccinatio

72 Polyfunctional CD8(+) T cells, producing IFN-gamma, TNF-

73 icited cellular responses were predominantly polyfunctional CD8(+) T cells.

74 gene expression and elicited high-frequency, polyfunctional CD8(+) T lymphocytes that trafficked broa

75 esearch revealed that VACV is able to induce polyfunctional CD8(+) T-cell responses after immunizatio

76 moDC, LC, and idDC, can prime multispecific, polyfunctional CD8(+) T-cell responses to HIV-1 and othe

77 Polyfunctional CD8(+) T-cell responses, defined as singl

78 To determine whether the presence of polyfunctional CD8+ T cell responses distinguishes prote

79 cells, directly influences the generation of polyfunctional CD8+ T cells and that the number of CD4+

80 e that was greatest in the lungs and yielded polyfunctional CD8+ T cells, including a subset that exp

81 In both CD8 + and CD4 + cells, polyfunctional cells with high cytotoxic potential accou

82 suggesting increased antigen sensitivity in polyfunctional cells.

83 immunology space that survey vaccine-induced polyfunctional cellular activity by flow cytometry, tran

84 ce adsorption is jointly associated with the polyfunctional character of the nanoparticles, analogous

85 dditionally, activated DN1 T cells exhibited polyfunctional characteristics, accumulated in lung gran

86 NA-loaded DCs would enhance the frequency of polyfunctional CMV pp65-specific CD8(+) T cells after AT

87 These increases in polyfunctional CMV-specific CD8(+) T cells correlated (R

88 Polyfunctional CMV-specific immunity was assessed by sti

89 In summary, our findings show that polyfunctional CMV-specific T cells were not superseded

90 ies of IFNgamma(+), TNFalpha(+), and CCL3(+) polyfunctional, CMV-specific CD8(+) T cells.

91 zyme-linked immunosorbent spot (ELISpot) and polyfunctional cytokine assays.

92 e but were still capable of antigen-specific polyfunctional cytokine expression and cytotoxicity in r

93 t Lys27 and, consequently, stimulated T cell polyfunctional cytokine expression and promoted their su

94 CD14(hi) monocytes exhibited the most polyfunctional cytokine expression patterns, with more t

95 Twp CD8(+) T cells showed impaired polyfunctional cytokine production, whereas cytotoxicity

96 + effector frequencies, immunodominance, and polyfunctional cytokine responses predominating in the l

97 Gag-specific CD4(+) and CD8(+) T lymphocyte polyfunctional cytokine responses were more robust in mi

98 derate IL-17 and affect differentiation into polyfunctional cytokine-producing cells.

99 e vaccine mixture improves the generation of polyfunctional cytolytic CD8(+) T cell responses as char

100 toward the ex vivo quantification of T cell polyfunctional diversity via the simultaneous measuremen

101 dimeric mitomycins were designed to react as polyfunctional DNA alkylators, generating novel types of

102 y are the DNA end binding protein Ku and the polyfunctional DNA ligase LigD.

103 and sulfoxide functionalities in protonated polyfunctional drug metabolites.

104 ative set of 17 organozinc pivalates with 18 polyfunctional druglike electrophiles (informers) in Neg

105 -type response, and it tended to become less polyfunctional during the course of this transition.

106 ody to OX40 strongly enhanced development of polyfunctional effector CD8 T cells that were induced af

107 individuals, the most frequent, robust, and polyfunctional effector CD8(+) T cell responses, as asse

108 mory phenotype as well as characteristics of polyfunctional effector cells such us IFN-gamma and TNF-

109 tigen-specific Teff:Treg ratios and inducing polyfunctional effector cells.

110 of vaccine recipients) and were mediated by polyfunctional effector memory CD4(+) T cells, with the

111 lly derived help, this population acquired a polyfunctional effector phenotype and antitumor immunity

112 Tumor-infiltrating Th17 cells exhibit a polyfunctional effector T-cell phenotype, are positively

113 bjects maintained high levels of humoral and polyfunctional effector/memory CD4(+) T cells responses,

114 lass I-restricted transgenic TCR function as polyfunctional effectors that can exhibit a helper as we

115 ation shows that recombinant viruses induced polyfunctional Env-specific CD4 or Gag-specific CD8 T ce

116 the first protein boost, a greater number of polyfunctional Env-specific CD4 T cells (those with > or

117 DNA ligase D (LigD) is a large polyfunctional enzyme involved in nonhomologous end-join

118 In all of these polyfunctional enzymes, a product formed from the cataly

119 CD8(+) TEM cell epitopes induced robust and polyfunctional epitope-specific CD8(+) TEM cells that we

120 7 cells cultured in IL1beta were also highly polyfunctional, expressing high levels of effector molec

121 gnize peptide-loaded targets and demonstrate polyfunctional features such as IL-2, IFN-gamma, and TNF

122 ward, providing ready access to libraries of polyfunctional fluorophores with long Stokes shifts base

123 fied functional subsets including quiescent, polyfunctional fully activated, partially activated popu

124 nificantly associated with a high-magnitude, polyfunctional Gag-specific CD8(+) T-cell response but n

125 covery arena, in which low molecular weight, polyfunctional heterocyclic derivatives are playing an i

126 C-H functionalization method gives access to polyfunctional heterocyclic zinc and magnesium reagents,

127 erized by the robust increase of preexisting polyfunctional, highly differentiated effector CD4(+) T-

128 ties appears to contribute to maintenance of polyfunctional HIV-1-specific CD8+ T cells from HIV-1 co

129 of programmed death-1, and the emergence of polyfunctional HIV-specific CD8 T cells.

130 SHIV(KU2)) induced long-lasting, potent, and polyfunctional HIV-specific CD8(+) T-cell responses.

131 five immunized macaques developed broad and polyfunctional HIV-specific T-cell IR that persisted for

132 es from ASYMP individuals induced robust and polyfunctional HSV-specific CD8(+) T cells associated wi

133 es from ASYMP individuals induced robust and polyfunctional HSV-specific CD8(+) TEM cells associated

134 Frequent polyfunctional HSV-specific IFN-gamma(+)CD107(a/b+)CD44(

135 CD4 and CD8), T-helper type 1 polarized, and polyfunctional (ie, they produced interferon gamma, tumo

136 es in the frequency of tuberculosis-specific polyfunctional IFN-gamma(+)/IL-2(+)/TNF-alpha(+) CD4(+)

137 roportions of interleukin-2(+) (IL-2(+)) and polyfunctional IFN-gamma(+)/TNF-alpha(+)/IL-2(+) T-lymph

138 A significant increase in polyfunctional IFN-gamma/tumor necrosis factor alpha (TN

139 CMV reactivation had a reduced proportion of polyfunctional (IFN-gamma+/tumor necrosis factor alpha-p

140 e the capacity of DCs to induce expansion of polyfunctional IL17-producing T cells in humans, and sug

141 We report here polyfunctional immune activation associated with increas

142 omprise an immune correlate-thus implicating polyfunctional immune control of HIV-1 transmission.

143 T lymphocyte response was significantly more polyfunctional in SM compared with RM, and granzyme B-po

144 of IL-17 expression, ex-Th17 cells were more polyfunctional in terms of cytokine production than eith

145 3) These memory cells were polyfunctional in terms of degranulation and production

146 n metathesis is increasingly incorporated in polyfunctional industrial processes.

147 o estimate the magnitude of sorption for any polyfunctional ionogenic compound of interest.

148 Polyfunctional ionogenic compounds are unique in that th

149 brid that combines Ca(2+) ions and the rigid polyfunctional ligand 5-(dihydroxyphosphoryl)isophthalic

150 Instead, fragmentation produces polyfunctional low molecular weight carboxylic acids aft

151 differentiation, with decreased formation of polyfunctional lymphoid memory cells.

152 nd its broad application in the synthesis of polyfunctional materials demonstrated.

153 ate that PD-1 is preferentially expressed on polyfunctional memory CD8(+) T cells, which renders them

154 the patient ultimately developed long-term, polyfunctional memory T-cell responses to Lassa virus.

155 CD4(+) and CD8(+) T cells with HCV-specific polyfunctional memory were expanded in all 5 individuals

156 c cells that were found in the LNs resembled polyfunctional memory-type cells.

157 infected animals induced high frequencies of polyfunctional MML-specific CD4+ T cells.

158 The GAT domain is a polyfunctional module that interacts with various partne

159 Polyfunctional molecules and a range of previously elusi

160 erforming selective modifications of complex polyfunctional molecules through the use of tailoring en

161 at differentiate unique functional groups in polyfunctional molecules.

162 in films, surface-mediated polymerization of polyfunctional monomers, and solid-state topochemical po

163 A blood polyfunctional, Mtb DosR latency antigen specific, regul

164 both HLA-DRB1*13 and HLA-DQB1*06 had highly polyfunctional mucosal CD4+ T cells compared to individu

165 The frequency of polyfunctional mucosal CD4+ T cells was also higher in c

166 Previous studies have suggested that polyfunctional mucosal CD8(+) T-cell responses may be a

167 Polyfunctional MVA-specific CD8(+) T cells were detected

168 Inflated cells were polyfunctional, not senescent, and displayed high ex viv

169 ly, immunization with the coNS5A gene primed polyfunctional NS5A-specific CD8(+) T cell responses.

170 classical phenotypic memory markers and are polyfunctional, only Flu-TM protects against a lethal vi

171 There was no difference in the polyfunctional or memory profile of Ag-specific CD4(+) T

172 ations is in the synthesis of water-soluble, polyfunctional organic molecules such as carbohydrates.

173 HLA-DR, and PD-1 expression), phenotype, and polyfunctional pathogen-specific cellular immune respons

174 ractive intermediates for the preparation of polyfunctional phenazines and extended polyheteroacenes.

175 that latency-associated T cells exhibited a polyfunctional phenotype and could secrete a range of ef

176 ty to produce interleukin-2, indicative of a polyfunctional phenotype as found in controlled chronic

177 ro numerical expansion of a clonally diverse polyfunctional population of Ag-specific CD8(+) T cells

178 iles react by ring opening to afford a novel polyfunctional product.

179 ct elicited larger numbers of T cells with a polyfunctional profile and a good Env-GagPolNef balance,

180 This polyfunctional profile was associated with a terminally

181 ecific T cells, we analyzed the kinetics and polyfunctional profiles of Gag-specific CD4(+) and CD8(+

182 lls exhibited pathogenic features, including polyfunctional proinflammatory cytokine production, an a

183 DNA ligase D (LigD) is a large polyfunctional protein that participates in a recently d

184 azides has been developed in order to access polyfunctional pseudopeptides.

185 high yielding protocol for the synthesis of polyfunctional pyrazoles has been developed through one-

186 the chlorides are useful precursors to other polyfunctional pyrazoles.

187 method very versatile for the preparation of polyfunctional pyridines.

188 with an in situ bromination gives access to polyfunctional pyrrole scaffolds.

189 equency virus-specific T-cell responses with polyfunctional repertoires.

190 that describe the quality of an individual's polyfunctional response and can be correlated directly w

191 f SPRY2 expression enhanced the HIV-specific polyfunctional response independently of the PD-1 pathwa

192 ty during anti-CTLA-4 treatment, revealing a polyfunctional response pattern of IFN-gamma, MIP-1beta

193 Candida albicans displayed microbe-specific polyfunctional response profiles, antigen sensitivity, a

194 e identified and validated a specific T-cell polyfunctional response to CMV antigen stimulation that

195 h in turn translated to a stronger, and more polyfunctional, response of engineered T cells to their

196 re, we demonstrate higher magnitude and more polyfunctional responses for HLA alleles associated with

197 ting its 3'UTR-specific interaction with the polyfunctional RNA-binding factor nucleolin.

198 lls and a decrease in functional avidity and polyfunctional sensitivity were evident in emerging epit

199 In addition, polyfunctional SIV-specific CD8+ T cells were consistent

200 on after live attenuated SHIV infection have polyfunctional SIV-specific CD8+ T cells with an increas

201 ation, converting aromatic hydrocarbons into polyfunctional species widely found in tropospheric aero

202 int measurements have obscured whether these polyfunctional states arise from the simultaneous or suc

203 ve CD8 + and CD4 + T cells contained similar polyfunctional subsets, and the level of polyfunctionali

204 Cu-catalyzed protocols; in cases involving a polyfunctional substrate, unique profiles in chemoselect

205 The applicability of the new catalysts to polyfunctional substrates was demonstrated by two C-C bo

206 ached to the pyridazinone ring, a variety of polyfunctional systems can be readily accessed by sequen

207 While a cytotoxicity response from a polyfunctional T cell activation caused hepatotoxicity a

208 We additionally show that DC reveal polyfunctional T cell responses after many years of trea

209 endogenous retrovirus-K Gag and Env, induced polyfunctional T cell responses to all Ags, and Ab respo

210 d T cells consist of a smaller proportion of polyfunctional T cells and require more peptide ligands

211 Recently, investigators have shown that polyfunctional T cells correlate best with long-term pro

212 had an 11-fold increase in frequency of CD8+ polyfunctional T cells expressing multiple cytokines, as

213 ighlight the measurement of vaccine-induced, polyfunctional T cells may not reflect the extent or deg

214 We sought to determine whether polyfunctional T cells secreting multiple cytokines simu

215 as associated with increased accumulation of polyfunctional T cells that secreted multiple effector c

216 Polyfunctional T cells were predominantly of the effecto

217 of VACV as a vaccine platform able to induce polyfunctional T cells.

218 evel BK viremia expressed low frequencies of polyfunctional T cells.

219 to type I interferon, gave rise to activated polyfunctional T helper cells with high interleukin-7 re

220 These data demonstrate the presence of polyfunctional T lymphocytes in the peripheral blood of

221 ic flow cytometry, the in vitro frequency of polyfunctional T lymphocytes in the peripheral blood of

222 However, the proportion of T(H)1 and polyfunctional T(H) cells (producing multiple cytokines

223 f TIL containing about 25% mutation-specific polyfunctional T(H)1 cells, the patient achieved a decre

224 The epitopes inducing polyfunctional T-cell activities were highly conserved a

225 pilot trial in patients with GBM implicates polyfunctional T-cell responses as a biomarker for effec

226 Our data implicate polyfunctional T-cell responses as a potential biomarker

227 re, whereas control patients had rejuvenated polyfunctional T-cell responses by 3 months after ART, I

228 DNA vaccine alone to induce long-lasting and polyfunctional T-cell responses in the nonhuman primate

229 ort, we identified a specific combination of polyfunctional T-cell subsets to pp65 that predicted pro

230 nflammation-induced conversion of Tregs to a polyfunctional T-helper phenotype similar to proinflamma

231 Our hypothesis was that "polyfunctional" T cells producing multiple antiviral fac

232 Representative polyfunctional tetrahydropyrido[3,4-b]pyrazine scaffolds

233 Polyfunctional Tg Th1 effectors demonstrated enhanced IF

234 igrate to the infected tissue, and acquire a polyfunctional Th1 phenotype in infected mice.

235 cterized by the production of IFN-gamma, and polyfunctional Th1 responses are associated with enhance

236 and consequently prevented the generation of polyfunctional Th1/17 effector cells.

237 evoked as well, which suggests the onset of polyfunctional Th17 cells.

238 (-) patients, but also in the frequencies of polyfunctional Th2-like (CD4(+)IL-4(+)IL-5(+) and CD4(+)

239 tribution; and (iv) BAL CD4 T cells are more polyfunctional than CD4 T cells in blood, and their func

240 e CD4 T-cell response to HSV-2 was much more polyfunctional than was the response to CMV.

241 s induced by both MVA and Dryvax were highly polyfunctional; they degranulated and produced interfero

242 re shown to contain very high amounts of two polyfunctional thiol precursors (3-S-glutathionylhexan-1

243 1, the capacity of CD8 T cells to attain the polyfunctional trait of IL-2 production is consistently

244 27(-) (but not gammadelta27(+)) cells become polyfunctional upon IL-1beta plus IL-23 stimulation, cos

245 cination regimens, higher frequency and more polyfunctional vaccine-elicited virus-specific CD8(+) T-

246 iated immune suppression to massively expand polyfunctional Vgamma2Vdelta2 T cells, and whether such

247 Blockade of IL-10 in vitro rescued polyfunctional virus-specific CD8 T cell responses.

248 markedly enhanced the number of high-quality polyfunctional virus-specific CD8 T cells with a nonexha

249 educed apoptosis, increased the abundance of polyfunctional virus-specific CD8 T cells, and improved

250 These responses were highly polyfunctional, with 64.5% of responses having 3 to 5 fu

251 the adenoviral-primed T cells markedly more polyfunctional, with the number of gamma interferon (INF

252 Polyfunctional zinc and magnesium organometallic reagent