ライフサイエンスコーパス: polygenic

1 rlying these defense outputs are also highly polygenic.

2 n in sensitivity to lead exposure are highly polygenic.

3 uggesting that the trans component is highly polygenic.

4 ween Europeans and Africans is influenced by polygenic adaptation and that differences in LTL between

5 d with other complex traits, suggesting that polygenic adaptation has played a pervasive role in shap

6 For polygenic adaptation, we find that recent selection for

7 Estimation of polygenic AF risk is feasible and together with clinical

8 .1% and was substantially influenced by both polygenic and clinical risk factor burden.

9 free of AF at 55 years of age, those in low-polygenic and clinical risk tertiles had a lifetime risk

10 d the lifetime risk of AF within tertiles of polygenic and clinical risk.

11 disorder (ASD) risk is influenced by common polygenic and de novo variation.

12 ASD is polygenic and genetically complex, so we hypothesized th

13 first results suggest that ASB may be highly polygenic and has potential heterogeneous genetic effect

14 Our findings show that schizophrenia is polygenic and highlight the utility of this resource for

15 orthogonal modeling (NOIA), we estimated the polygenic and interactive nature of these loci against m

16 pulation to assess the ability of predicting polygenic and oligogenic traits controlled by different

17 velopment, which are amplified by the highly polygenic and pleiotropic nature of these genetic contri

18 is consistent with treatment efficacy being polygenic and suggests that single-target therapeutics m

19 ess-related disorders are highly complex and polygenic and, despite substantial progress in other are

20 genetic overlap between human monogenic and polygenic anthropometric traits and find signal enrichme

21 also describe recent studies that utilize a polygenic approach to examine GxEs.

22 projects and the use of novel methods (e.g., polygenic approaches, machine learning) that enhance the

23 using a statistical framework that draws on polygenic architecture and ancillary information on gene

24 n studies to test whether chronic pain has a polygenic architecture and examine whether genomic risk

25 rt.Genetic prediction of complex traits with polygenic architecture has wide application from animal

26 Due to the polygenic architecture of complex diseases, the identifi

27 linical psychiatry is limited by the complex polygenic architecture of psychiatric disorders.

28 Within the cohorts studied here, polygenic architecture plays an important role in modify

29 , novel statistical methodology designed for polygenic architecture revealed more potential risk vari

30 Because most complex traits have a polygenic architecture, accurate genetic prediction ofte

31 in is genetically correlated with MDD, has a polygenic architecture, and is associated with polygenic

32 chiatric diseases with a complex overlapping polygenic architecture.

33 of ALS being a complex genetic trait with a polygenic architecture.

34 ream of the first protein-coding gene in the polygenic array.

35 ion of various immune system genes to common polygenic autoimmune disorders, as well as the pathophys

36 een environmental exposure and a susceptible polygenic background and comprising multiple independent

37 t nucleotide (QTN) detection, the absence of polygenic background control in single-marker associatio

38 mes were used to calculate kinship matrix as polygenic background control.

39 rical Bayes to perform multilocus GWAS under polygenic background control.

40 ygenic background was more accurate than the polygenic background model alone for moderately complex

41 significantly associated SNPs along with the polygenic background was more accurate than the polygeni

42 herein refer to this method as the pLARmEB (polygenic-background-control-based least angle regressio

43 species in the face of gene flow, despite a polygenic basis for adaptation to divergent environments

44 This study provides the first evidence for a polygenic basis for GERD and supports for a polygenic ov

45 Recently, overlap between the polygenic basis for specific personality traits and spec

46 mplex genetic architecture of AIS in which a polygenic burden of rare variants across extracellular m

47 of these brain regions is also heritable and polygenic but whether their genetic architecture overlap

48 The timing of puberty is a highly polygenic childhood trait that is epidemiologically asso

49 nship matrix calculation, and the second for polygenic component analyses and genome scanning for mai

50 Finally, we demonstrate that there is no polygenic component of nsCL/P detectable that is shared

51 ant peak on chromosome 2 associated with the polygenic component of the shell thickness trait (based

52 n studies provide evidence for a substantial polygenic component to schizophrenia, although the neuro

53 ith clinical heterogeneity and a substantial polygenic component.

54 Schizophrenia is a highly heritable, polygenic condition characterized by a relatively divers

55 Using these 53 loci, we show a polygenic contribution to familial partial lipodystrophy

56 ses are beginning to elucidate the additive, polygenic contributions of risk variants on specific cel

57 upin quantitative trait loci (QTLs) revealed polygenic control of vernalization responsiveness and an

58 Finally, we found robust polygenic correlations between cognitive performance and

59 tely and lack the genetic pattern present in polygenic CVID cases.

60 RBA, and CD27 as genetically dissimilar from polygenic CVID.

61 Type 2 diabetes (T2D) is a complex and polygenic disease yet in need of a complete picture of i

62 e for single-gene disorders, whereas complex polygenic diseases are typically due to multiple genetic

63 promising for repositioning drugs for use in polygenic diseases such as PD, and is capable of address

64 y associated with targeting a single gene in polygenic diseases.

65 Type 2 diabetes is a complex polygenic disorder that affects about 1 in 12 adults.

66 diseases and indicate that sporadic FTD is a polygenic disorder where multiple pleiotropic loci with

67 t's disease, which is typically considered a polygenic disorder with onset in early adulthood.

68 the phenotypic underpinnings of these highly polygenic disorders and for understanding the contributi

69 ome modifications downstream of monogenic or polygenic disorders have the potential to uncover novel

70 sorders have also been shown to be linked to polygenic disorders.

71 This reliance is tempered if adaptation is polygenic-does not depend on one allele completely repla

72 rts, meta-analysis showed that a 1 SD higher polygenic education score was associated with approximat

73 ed within the genetic effects of markers and polygenic effects caused by a pedigree.

74 We thus show that polygenic effects of AD risk variants on brain structure

75 ASD- and schizophrenia-related polygenic effects were unrelated to each other and chang

76 cognitive functions have found evidence for polygenic effects yet, to date, there are few replicated

77 epsy and for common variants associated with polygenic epilepsy.

78 d small to moderate effects with significant polygenic epistasis.

79 tatic genetic effects (PEPIS), for analyzing polygenic epistatic effects.

80 (r = 0.680; P = .0003), supporting a common polygenic etiology.

81 We examined the polygenic features of MDD and two common clinical subtyp

82 The relationship between monogenic and polygenic forms of epilepsy is poorly understood and the

83 e disease is younger than that of the common polygenic forms, and this feature combined with the mani

84 a modestly heritable trait that has a highly polygenic genetic architecture.

85 Furthermore, a polygenic genetic model that explains adaptation to cont

86 ease Genetics Consortium (ADGC), providing a polygenic hazard score (PHS) for each participant.

87 mptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted tim

88 additive plus dominance effects, to predict polygenic (height) and oligogenic (fusiform rust resista

89 We establish a polygenic heritability for all biomarkers, confirm assoc

90 The estimated polygenic heritability for susceptibility to bTB was 0.2

91 of moderate-to-large effect associated with polygenic human phenotypes, and that these variants impl

92 ith FH and 12 common alleles associated with polygenic hypercholesterolemia was performed in 103 pati

93 FH variants had a score highly suggestive of polygenic hypercholesterolemia.

94 reproductive isolation appears to be highly polygenic, indicating that multiple incompatibility loci

95 nologies inform the complex genetic basis of polygenic inflammatory bowel disease (IBD) as well as Me

96 tis and systemic lupus erythematosus, show a polygenic inheritance pattern.

97 that geneticists argue both for and against polygenic inheritance.

98 ypes are characterized by partially distinct polygenic liabilities and may represent more homogeneous

99 disorder is partially attributable to shared polygenic liability.

100 uggests that cis-regulation can evolve under polygenic lineage-specific selection in prokaryotes.

101 phenotype correlated with Tourette syndrome polygenic load and was present in otherwise Tourette-una

102 Heritability and polygenic load associated with Tourette syndrome, OCD, a

103 n that whitened the covariance matrix of the polygenic matrix K and environmental noise.

104 was used to whiten the covariance matrix of polygenic matrix K and environmental noise.

105 e of additional high-risk genes or perhaps a polygenic mechanism involving multiple genetic modifiers

106 Here, we develop such a polygenic method, which we refer to as the latent Dirich

107 s modeling all genetic variants together via polygenic methods.

108 his observation suggests that HLH may have a polygenic mode of inheritance, the latter is very diffic

109 We build a polygenic model for complex traits that distinguishes ca

110 dest to strong effects, thereby supporting a polygenic model of cancer development.

111 se findings provide additional support for a polygenic model of MM and insight into the biological ba

112 Our findings support a polygenic model of risk and provide insight into the bio

113 Our results form the basis of a polygenic model of the occurrence of secondary HLH.

114 ncy, we present RolyPoly, a regression-based polygenic model that can prioritize trait-relevant cell

115 Finally, polygenic modification score and heritability analyses s

116 ng segments was sequenced between our unique polygenic mouse Fat and Lean strains that were generated

117 y localized selective sweeps that point to a polygenic, multitrait basis for serpentine adaptation.

118 In nutritional and polygenic murine models of obesity, DPD prevented and cu

119 hese results provide strong evidence for the polygenic nature of earlobe attachment and offer insight

120 Accumulating evidence supports the polygenic nature of most complex diseases, suggesting th

121 geting compound could be used to address the polygenic nature of multifactorial diseases.

122 ent genomic studies have revealed the highly polygenic nature of psychiatric disorders, including sch

123 le loci across the genome contributes to the polygenic nature of schizophrenia.

124 The polygenic nature of these traits is consistent with prev

125 Against the background of its polygenic nature there is a necessity to identify how sc

126 stantial heritability (0.54) and a confirmed polygenic nature, initial genetic studies were mostly un

127 le sclerosis (MS) as an example of a complex polygenic neurological disease, we sought to determine w

128 The aim of this study was to examine the polygenic overlap between ASD/ADHD and cognitive ability

129 The observed polygenic overlap between CAD and cardiometabolic risk f

130 polygenic basis for GERD and supports for a polygenic overlap between GERD and BE, and GERD and EA.

131 Our results suggest that there is a polygenic overlap between schizophrenia and NSS score, a

132 This study demonstrates polygenic overlaps between common genetic polymorphisms

133 iation studies summary statistics and shared polygenic pleiotropy-informed conditional and conjunctio

134 in-coding genes are transcribed as part of a polygenic precursor mRNA (pre-mRNA) that is initiated wi

135 or protective factors has been neglected by polygenic prediction models.

136 h additional autoimmunity usually reflects a polygenic predisposition, but rare cases result from mon

137 autoimmune endocrinopathies can result from polygenic predisposition, or more rarely, may present as

138 Polygenic profile analysis indicated considerable shared

139 Linkage disequilibrium score regression and polygenic profile score analyses were used to test for s

140 wide association study consortia, we created polygenic profile scores for 24 vascular-metabolic, neur

141 fied between tiredness phenotypic scores and polygenic profile scores for BMI, HDL cholesterol, low-d

142 est scores in the UK Biobank sample and many polygenic profile scores, including coronary artery dise

143 e used linkage disequilibrium regression and polygenic profile scoring to test for shared genetic aet

144 Recently, we developed polygenic rat models that gain differentially for runnin

145 ed these to discover molecular correlates of polygenic risk (e.g., genetic risk for inflammatory bowe

146 comorbid AD and MD and to determine whether polygenic risk alleles are shared with neuropsychiatric

147 se onset, we investigated whether effects of polygenic risk are detectable by neuroimaging in young a

148 Lastly, we show that elements of polygenic risk are independent and differ in their relat

149 th a diagnosis of schizophrenia and elevated polygenic risk burden for the disease across multiple br

150 variants, pharmacogenomic associations, and polygenic risk estimates for cardiometabolic traits.

151 d the specificity of the Alzheimer's disease polygenic risk finding.

152 We found that AD+P is associated with polygenic risk for a set of novel loci and inversely ass

153 Polygenic risk for ADHD and ASD was calculated from geno

154 We did not find consistent evidence that polygenic risk for ADHD was associated with cognitive fu

155 Polygenic risk for AF was derived using a score of appro

156 We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of ASD

157 We report that polygenic risk for ASD is positively correlated with gen

158 families with a child with ASD, we show that polygenic risk for ASD, schizophrenia, and greater educa

159 Individuals with elevated polygenic risk for MDD may also be at risk for AD.

160 ubcortical volumes or WM microstructure, and polygenic risk for MDD, SCZ or BP.

161 ition, they provide an unbiased link between polygenic risk for schizophrenia and a lower risk of psy

162 of novel loci and inversely associated with polygenic risk for schizophrenia.

163 h strongly acting de novo variants, in which polygenic risk is relevant.

164 andom forest regression (PRFR), to construct polygenic risk models using hundreds of SNPs, thereby ca

165 and older age at first child whereas higher polygenic risk of ADHD is associated with having more ch

166 Polygenic risk of autism and ADHD is associated with num

167 Higher polygenic risk of autism is associated with fewer childr

168 ddress this issue by examining the impact of polygenic risk of MDD, SCZ, and BP on subcortical brain

169 lygenic architecture, and is associated with polygenic risk of MDD.

170 evidence for a selective advantage of a high polygenic risk of schizophrenia or bipolar disorder.

171 ican-American individuals-and can be used in polygenic risk prediction and genetic correlation studie

172 Polygenic risk profile scores (RPSs) for psychosis were

173 Polygenic risk profiles for pain, generated using indepe

174 Further, we found that a standardized CRP polygenic risk score (CRPPRS) at p-value thresholds of 1

175 ociation analyses were conducted between MDD polygenic risk score (PRS) and AD case-control status in

176 A polygenic risk score (PRS) composed of single nucleotide

177 d with risk for BE or EAC, and constructed a polygenic risk score (PRS) for cases and controls by sum

178 A higher polygenic risk score (PRS) for DZ twinning, calculated b

179 measure of total susceptibility burden, the polygenic risk score (PRS) for each individual was defin

180 MD), and a 77-single nucleotide polymorphism polygenic risk score (PRS) were associated with breast c

181 Polygenic risk score analyses showed prognostication of

182 Polygenic risk score analysis did not support a higher b

183 Previous estimates of the utility of polygenic risk score analysis for the prediction of Alzh

184 OPS), as well as the association between the polygenic risk score and coronary artery calcification (

185 The estrogen receptor-positive polygenic risk score built from 89 known susceptibility

186 eotide polymorphisms from which we conducted polygenic risk score comparisons for COS probands and th

187 A polygenic risk score comprising 93 single-nucleotide pol

188 For each participant, we calculated a polygenic risk score derived from up to 57 common DNA se

189 assortative mating and the relatively small polygenic risk score effect sizes.

190 any substance use disorder diagnosis and the polygenic risk score for schizophrenia (mega-analysis ps

191 Increased polygenic risk score for schizophrenia was associated wi

192 To test the association of a polygenic risk score for waist-to-hip ratio (WHR) adjust

193 A polygenic risk score for WHR adjusted for BMI, a measure

194 Conclusion A polygenic risk score may be used to refine risk from the

195 We demonstrate the utility of using a polygenic risk score to identify molecular variation ass

196 Each 1-SD increase in the polygenic risk score was associated with 1.32-fold (95%

197 ease in WHR adjusted for BMI mediated by the polygenic risk score was associated with 27-mg/dL higher

198 Polygenic risk score was associated with all subtypes ex

199 10-5), while the estrogen receptor-negative polygenic risk score was much higher in blacks than in w

200 Polygenic risk score were generated from a published Psy

201 those at high genetic risk (top quintile of polygenic risk score) versus all others (WOSCOPS), as we

202 benign breast disease, mammographic density, polygenic risk score, family history of breast cancer, a

203 e identified multiple disease-associated and polygenic risk score-associated differentially methylate

204 Polygenic risk scores (PGS) enable rapid estimation of g

205 We included genetic polygenic risk scores (PRS) for schizophrenia, bipolar d

206 n models and molecular genetic methods, i.e. polygenic risk scores (PRS).

207 orts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing

208 We hypothesized that higher polygenic risk scores (PRSs) for AD would be associated

209 Polygenic risk scores (PRSs) for schizophrenia generated

210 herefore investigated the possible effect of polygenic risk scores (PRSs) for schizophrenia on the as

211 Polygenic risk scores (PRSs) have successfully summarize

212 netic risk variant load for ADHD (indexed by polygenic risk scores [PRS]), but not for other psychiat

213 The schizophrenia polygenic risk scores also predicted social and behaviou

214 We used polygenic risk scores derived from a patient discovery s

215 Polygenic risk scores derived from a Tourette syndrome g

216 Tests were performed to determine whether polygenic risk scores derived from potentially related t

217 Polygenic risk scores derived from the primary UK Bioban

218 (7.05-21.6; P=1 x 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the vari

219 ed published summary statistics to calculate polygenic risk scores for eight well-studied phenotypes.

220 brain regions and highlights the utility of polygenic risk scores for identifying molecular pathways

221 We used polygenic risk scores for major depressive disorder (MDD

222 To do this, polygenic risk scores for schizophrenia derived from a l

223 Whole-genome polygenic risk scores for the development of Alzheimer's

224 Analyses of polygenic risk scores identified pleiotropy with neurops

225 At age 7-9 years, schizophrenia polygenic risk scores showed associations with lower per

226 Analyses of polygenic risk scores showed that individuals with a hig

227 The calculation of polygenic risk scores was based on genome-wide associati

228 Polygenic risk scores were constructed based on common g

229 OCD polygenic risk scores were significantly associated with

230 We show a significant interaction of the polygenic risk scores with personal life events (0.12% o

231 Other imaging technologies, polygenic risk, and nonadherence were not considered.

232 A genome-wide polygenic score (GPS), derived from a 2013 genome-wide a

233 gle polygenic score, but here we use a multi-polygenic score (MPS) approach to increase predictive po

234 Polygenic score analyses indicate that up to 5% of the v

235 he clinical relevance is uncertain, although polygenic score analyses may provide clues to behavioral

236 tion, we utilized individual SNP lookups and polygenic score analyses to identify genetic overlap wit

237 Using polygenic score analyses, we show that earlier-onset MDD

238 Polygenic score analysis was used to examine whether dif

239 fined as the association between an additive polygenic score and its associated phenotype-across birt

240 ther AD and MDD overlap genetically, using a polygenic score approach.

241 Having a higher well-being polygenic score buffered against increased depressive sy

242 e-environment (GxE) interactions, as well as polygenic score calculations in consortia studies that i

243 A genome-wide polygenic score constructed from the GWA results account

244 thesized genetic buffer was measured using a polygenic score derived from a published genome-wide ass

245 rents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compare

246 enetic pleiotropy; in the best-fit model the polygenic score for intelligence explained 0.99% (p = 0.

247 tability; and 3) examine the relationship of polygenic score for schizophrenia with baseline startle

248 A polygenic score from the case-control genetic associatio

249 Using a polygenic score of DNA sequence polymorphisms, we quanti

250 This is typically achieved using a single polygenic score, but here we use a multi-polygenic score

251 We show that an educational attainment polygenic score, POLYEDU, constructed from results of a

252 sment models as well as the state-of-the-art polygenic score.

253 Genome-wide polygenic scores (GPS), which aggregate the effects of t

254 Moreover, genome-wide polygenic scores based on a previously published genome-

255 HRS adults with higher well-being polygenic scores experienced fewer depressive symptoms d

256 e GWAS summary data were also used to create polygenic scores for the two traits, with within- and cr

257 We calculated polygenic scores from genome-wide association studies (G

258 select from and estimate contributions of 81 polygenic scores in a UK representative sample of 6710 u

259 I leverage these findings to construct polygenic scores that use individuals' genotypes to pred

260 whether married older adults who had higher polygenic scores were less vulnerable to depressive symp

261 hose at low genetic risk (bottom quintile of polygenic scores) (hazard ratio, 1.91; 95% confidence in

262 ipants at high genetic risk (top quintile of polygenic scores) than among those at low genetic risk (

263 A primary goal of polygenic scores, which aggregate the effects of thousan

264 Genomics Consortium 2 was used to calculate polygenic scores.

265 had also lost their spouse and who had lower polygenic scores.

266 Thus, we suggest that polygenic selection is surprisingly effective in alterin

267 ion across taxa identifies strong and highly polygenic selection signals affecting viral processes.

268 This pattern of polygenic selection suggested species-specific adaptatio

269 genome for evidence of selective sweeps and polygenic selection.

270 moving beyond single-gene effects to assess polygenic sensitivity scores.

271 e-by-environment interactions that support a polygenic sex determination system in domesticated (labo

272 mponent of each blood trait explained by the polygenic signal across different genome regulatory doma

273 vascular disease risk factors using a shared polygenic signal-informed statistical framework.

274 MDD subtypes had differential polygenic signatures: typical was strongly associated wi

275 lyses indicated that these traits are mainly polygenic, such that individual genomic regions have sma

276 tic pulse wave velocity and suggest distinct polygenic susceptibility for arterial stiffness and salt

277 together, our findings are in line with the polygenic theory of psychiatric disorders.

278 CNV carriers, but does offer support for the polygenic threshold model of schizophrenia.

279 In contrast, under a polygenic threshold model, high-penetrance rare allele c

280 er, baseline skin pigmentation is a complex, polygenic trait in the KhoeSan.

281 mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to

282 Height is a highly heritable, classic polygenic trait with approximately 700 common associated

283 icate that human height is not only a highly polygenic trait, but also has high allelic heterogeneity

284 ution is thought to be less likely in highly polygenic traits and distantly related species, this has

285 Validated prediction of polygenic traits improves our understanding of ancient p

286 alone for moderately complex but not highly polygenic traits measured in the maize nested associatio

287 rmation can favor genetic analysis of highly polygenic traits, but not genome-wide prediction accurac

288 However, the evolutionary paths along which polygenic traits, such as size, evolve are poorly unders

289 Psychiatric disorders are heritable, polygenic traits, which often share risk alleles and for

290 We present a novel way to select for highly polygenic traits.

291 es over marker-assisted selection for highly polygenic traits.

292 Using a novel approach called the polygenic transmission disequilibrium test and data from

293 for lineage-specific selection revealed the polygenic up-regulation of dozens of biofilm suppressor

294 Education-associated polygenic variation also captured covariation between en

295 variation between offspring trait-associated polygenic variation and parental behavior and characteri

296 We find that polygenic variation contributes additively to risk in AS

297 tigated covariation between trait-associated polygenic variation identified by genome-wide associatio

298 oma have putatively pathogenic monogenic and polygenic variation in known and novel cancer genes, wit

299 , we interrogated the contribution of common polygenic variation to the genetic susceptibility for sc

300 ciation analysis suggests that BMI is highly polygenic, with 75% of the SNP heritability attributable