ライフサイエンスコーパス: polygenic disorder

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1 study the biology of common and devastating polygenic disorders.

2 ppreciated role of rare sequence variants in polygenic disorders.

3 ss in yielding genes associated with complex polygenic disorders.

4 ification of susceptibility genes in complex polygenic disorders.

5 sorders have also been shown to be linked to polygenic disorders.

6 unctionally cluster variant genes underlying polygenic disorders.

7 ecessary to find the genes underlying highly polygenic disorders.

8 the phenotypic underpinnings of these highly polygenic disorders and for understanding the contributi

9 iments and might be useful for other complex polygenic disorders as well.

10 s hypothesized to represent genetic risk for polygenic disorders at more biologically tractable level

11 d populations also reduces the complexity of polygenic disorders by reducing the number of loci proba

12 gene that contributes to the development of polygenic disorders characterized by thalamocortical dys

13 cts observed in both monogenetic and complex polygenic disorders have been elucidated and functionall

14 ome modifications downstream of monogenic or polygenic disorders have the potential to uncover novel

15 Thus, HSCR has become a model of a complex polygenic disorder in which the interplay of different g

16 Mood disorders are polygenic disorders in which the alteration of several s

17 isorders presenting at any age, with complex polygenic disorders, most commonly the common variable i

18 radigm for unraveling the much more complex, polygenic disorders responsible for such psychiatric dis

19 Hypertension is now believed to be a polygenic disorder resulting from the interaction of mul

20 s resources that will transform the study of polygenic disorders such as stroke.

21 however, some have claimed that it occurs in polygenic disorders, such as Crohn disease, in which its

22 enetic ill health lies in the more prevalent polygenic disorders, such as diabetes, hypertension and

23 yzing quantitative variations seen in common polygenic disorders, such as kidney diseases, diabetes m

24 Type 2 diabetes is a complex polygenic disorder that affects about 1 in 12 adults.

25 Gallstones represent a polygenic disorder that affects more than 30,000,000 Ame

26 Bipolar disorder (BD) is a polygenic disorder that shares substantial genetic risk

27 CD and UC are closely related, but distinct, polygenic disorders that share some, but not all, suscep

28 diseases and indicate that sporadic FTD is a polygenic disorder where multiple pleiotropic loci with

29 are threefold: (1) schizophrenia is a highly polygenic disorder with a complex array of contributing

30 single-gene defect and tetralogy of Fallot a polygenic disorder with a small number of interacting ge

31 urrent family studies indicate that AIS is a polygenic disorder with multiple patterns of inheritance

32 t's disease, which is typically considered a polygenic disorder with onset in early adulthood.

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