ライフサイエンスコーパス: polygenic risk

1 al designs comparing cases with high and low polygenic risk.

2 several individual risk alleles and for the polygenic risk.

3 1.96, P = .02) compared with women with low polygenic risk.

4 We report that a higher polygenic risk allele load for MDD was significantly ass

5 comorbid AD and MD and to determine whether polygenic risk alleles are shared with neuropsychiatric

6 eas single-gene diseases are rare disorders, polygenic risk alleles arise in common adult-onset disea

7 hese 33 loci and a significant enrichment of polygenic risk alleles from genome-wide association stud

8 nent renal single-gene kidney disorders, and polygenic risk alleles of common disorders.

9 gions and implies the presence of additional polygenic risk alleles.

10 icits, genome-wide association study-derived polygenic risk, and life impairment indicators were asse

11 Other imaging technologies, polygenic risk, and nonadherence were not considered.

12 comorbid disorders, neurocognitive deficits, polygenic risk, and residual adult life impairment.

13 se onset, we investigated whether effects of polygenic risk are detectable by neuroimaging in young a

14 Lastly, we show that elements of polygenic risk are independent and differ in their relat

15 th a diagnosis of schizophrenia and elevated polygenic risk burden for the disease across multiple br

16 associated with the high and low ends of the polygenic risk distribution were compared.

17 Non-BRCA1/2 women in the top quartile of the polygenic risk distribution were more likely to have had

18 ed these to discover molecular correlates of polygenic risk (e.g., genetic risk for inflammatory bowe

19 variants, pharmacogenomic associations, and polygenic risk estimates for cardiometabolic traits.

20 ders that arise from the interaction between polygenic risk factors and environmental factors.

21 ction, but the mechanisms of the more common polygenic risk factors are still poorly understood and u

22 e disorders share genes that together act as polygenic risk factors for autoimmunity.

23 d the specificity of the Alzheimer's disease polygenic risk finding.

24 We found that AD+P is associated with polygenic risk for a set of novel loci and inversely ass

25 Polygenic risk for ADHD and ASD was calculated from geno

26 Polygenic risk for ADHD showed a positive association wi

27 Polygenic risk for ADHD was also negatively associated w

28 We did not find consistent evidence that polygenic risk for ADHD was associated with cognitive fu

29 Polygenic risk for ADHD, derived from the meta-analysis,

30 Polygenic risk for AF was derived using a score of appro

31 We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of ASD

32 We report that polygenic risk for ASD is positively correlated with gen

33 families with a child with ASD, we show that polygenic risk for ASD, schizophrenia, and greater educa

34 in childhood or adulthood, nor did they show polygenic risk for childhood ADHD.

35 in healthy young adults were associated with polygenic risk for MDD (n = 438) using risk scores deriv

36 Individuals with elevated polygenic risk for MDD may also be at risk for AD.

37 ubcortical volumes or WM microstructure, and polygenic risk for MDD, SCZ or BP.

38 ition, they provide an unbiased link between polygenic risk for schizophrenia and a lower risk of psy

39 Greater polygenic risk for schizophrenia was associated with mor

40 In LBC1936, polygenic risk for schizophrenia was negatively associat

41 of novel loci and inversely associated with polygenic risk for schizophrenia.

42 h strongly acting de novo variants, in which polygenic risk is relevant.

43 Polygenic risk (measured by the PRS) was greater in wome

44 Our findings suggest a polygenic risk model of autism and reveal that some neur

45 ording to the number of SNPs included in the polygenic risk model.

46 andom forest regression (PRFR), to construct polygenic risk models using hundreds of SNPs, thereby ca

47 and older age at first child whereas higher polygenic risk of ADHD is associated with having more ch

48 Polygenic risk of autism and ADHD is associated with num

49 Higher polygenic risk of autism is associated with fewer childr

50 ddress this issue by examining the impact of polygenic risk of MDD, SCZ, and BP on subcortical brain

51 lygenic architecture, and is associated with polygenic risk of MDD.

52 Increased polygenic risk of schizophrenia is associated with lower

53 evidence for a selective advantage of a high polygenic risk of schizophrenia or bipolar disorder.

54 ican-American individuals-and can be used in polygenic risk prediction and genetic correlation studie

55 We also compared additive and multiplicative polygenic risk prediction models using per-allele odds r

56 Determining the effects of an overall polygenic risk profile score on neuroimaging abnormaliti

57 Polygenic risk profile scores (RPSs) for psychosis were

58 Schizophrenia polygenic risk profile scores were calculated using info

59 Polygenic risk profiles for pain, generated using indepe

60 ion modelling indicate that the effects of a polygenic risk score (90 obesity-related loci) on measur

61 Further, we found that a standardized CRP polygenic risk score (CRPPRS) at p-value thresholds of 1

62 Schizophrenia was associated with the polygenic risk score (OR, 8.01; 95% CI, 4.53-14.16 for h

63 ociation analyses were conducted between MDD polygenic risk score (PRS) and AD case-control status in

64 A polygenic risk score (PRS) composed of single nucleotide

65 We created a polygenic risk score (PRS) comprising 28 common obesity-

66 d with risk for BE or EAC, and constructed a polygenic risk score (PRS) for cases and controls by sum

67 A higher polygenic risk score (PRS) for DZ twinning, calculated b

68 measure of total susceptibility burden, the polygenic risk score (PRS) for each individual was defin

69 A polygenic risk score (PRS) is a sum of trait-associated

70 MD), and a 77-single nucleotide polymorphism polygenic risk score (PRS) were associated with breast c

71 A polygenic risk score (PRS), calculated as the sum of the

72 ibility loci, individually and combined as a polygenic risk score (PRS).

73 Polygenic risk score analyses showed prognostication of

74 Polygenic risk score analysis did not support a higher b

75 Previous estimates of the utility of polygenic risk score analysis for the prediction of Alzh

76 OPS), as well as the association between the polygenic risk score and coronary artery calcification (

77 There was an interaction between the polygenic risk score and family history (P = .03).

78 show a significant correlation between a BP polygenic risk score and the clinical dimension of mania

79 tential relationship between an individual's polygenic risk score and their disease age at onset.

80 mong women in the top and bottom fifths of a polygenic risk score based on 7 SNPs was 8.8% (8.3%-9.4%

81 The estrogen receptor-positive polygenic risk score built from 89 known susceptibility

82 eotide polymorphisms from which we conducted polygenic risk score comparisons for COS probands and th

83 A polygenic risk score comprising 93 single-nucleotide pol

84 For each participant, we calculated a polygenic risk score derived from up to 57 common DNA se

85 assortative mating and the relatively small polygenic risk score effect sizes.

86 any substance use disorder diagnosis and the polygenic risk score for schizophrenia (mega-analysis ps

87 (2) imaging studies of the brain; and (3) a polygenic risk score for schizophrenia across 108 geneti

88 Increased polygenic risk score for schizophrenia was associated wi

89 To test the association of a polygenic risk score for waist-to-hip ratio (WHR) adjust

90 A polygenic risk score for WHR adjusted for BMI, a measure

91 Conclusion A polygenic risk score may be used to refine risk from the

92 We create a polygenic risk score that is significantly different bet

93 We demonstrate the utility of using a polygenic risk score to identify molecular variation ass

94 Each 1-SD increase in the polygenic risk score was associated with 1.32-fold (95%

95 ease in WHR adjusted for BMI mediated by the polygenic risk score was associated with 27-mg/dL higher

96 Polygenic risk score was associated with all subtypes ex

97 10-5), while the estrogen receptor-negative polygenic risk score was much higher in blacks than in w

98 The polygenic risk score was substantially more predictive o

99 Polygenic risk score were generated from a published Psy

100 those at high genetic risk (top quintile of polygenic risk score) versus all others (WOSCOPS), as we

101 2 values were 3.4% (95% CI, 2.1-4.6) for the polygenic risk score, 3.1% (95% CI, 1.9-4.3) for parenta

102 benign breast disease, mammographic density, polygenic risk score, family history of breast cancer, a

103 Schizophrenia was associated with the polygenic risk score, family psychiatric history, and so

104 e identified multiple disease-associated and polygenic risk score-associated differentially methylate

105 zophrenia/psychoses was mediated through the polygenic risk score.

106 l thickness in male participants with a high polygenic risk score.

107 d arthritis and developed a new method using polygenic risk-score analyses to infer the total liabili

108 Polygenic risk scores (PGS) enable rapid estimation of g

109 We included genetic polygenic risk scores (PRS) for schizophrenia, bipolar d

110 n models and molecular genetic methods, i.e. polygenic risk scores (PRS).

111 orts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing

112 We hypothesized that higher polygenic risk scores (PRSs) for AD would be associated

113 Polygenic risk scores (PRSs) for schizophrenia generated

114 herefore investigated the possible effect of polygenic risk scores (PRSs) for schizophrenia on the as

115 Polygenic risk scores (PRSs) have successfully summarize

116 netic risk variant load for ADHD (indexed by polygenic risk scores [PRS]), but not for other psychiat

117 The schizophrenia polygenic risk scores also predicted social and behaviou

118 Elastic Nets estimated from cohort data, and polygenic risk scores constructed using published summar

119 We used polygenic risk scores derived from a patient discovery s

120 Polygenic risk scores derived from a Tourette syndrome g

121 Tests were performed to determine whether polygenic risk scores derived from potentially related t

122 Polygenic risk scores derived from the primary UK Bioban

123 (7.05-21.6; P=1 x 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the vari

124 ed published summary statistics to calculate polygenic risk scores for eight well-studied phenotypes.

125 brain regions and highlights the utility of polygenic risk scores for identifying molecular pathways

126 We used polygenic risk scores for major depressive disorder (MDD

127 We tested whether polygenic risk scores for schizophrenia and bipolar diso

128 To do this, polygenic risk scores for schizophrenia derived from a l

129 Higher polygenic risk scores for schizophrenia were consistentl

130 To create polygenic risk scores for schizophrenia, we obtained dat

131 In parallel, polygenic risk scores for SCZ were associated with lower

132 Whole-genome polygenic risk scores for the development of Alzheimer's

133 Polygenic risk scores have shown great promise in predic

134 Analyses of polygenic risk scores identified pleiotropy with neurops

135 IoGRAMplusC4D study of CAD/MI, we calculated polygenic risk scores in 2599 participants of the Dutch

136 At age 7-9 years, schizophrenia polygenic risk scores showed associations with lower per

137 Analyses of polygenic risk scores showed that individuals with a hig

138 The calculation of polygenic risk scores was based on genome-wide associati

139 Polygenic risk scores were calculated in the Avon Longit

140 Polygenic risk scores were calculated separately for BD

141 Polygenic risk scores were constructed based on common g

142 OCD polygenic risk scores were significantly associated with

143 We show a significant interaction of the polygenic risk scores with personal life events (0.12% o

144 Polygenic risk scores, parental socioeconomic status, an

145 ntrol individuals) were applied to calculate polygenic risk scores.