ライフサイエンスコーパス: polygenic risk score

1 l thickness in male participants with a high polygenic risk score.

2 zophrenia/psychoses was mediated through the polygenic risk score.

3 ntrol individuals) were applied to calculate polygenic risk scores.

4 2 values were 3.4% (95% CI, 2.1-4.6) for the polygenic risk score, 3.1% (95% CI, 1.9-4.3) for parenta

5 ion modelling indicate that the effects of a polygenic risk score (90 obesity-related loci) on measur

6 The schizophrenia polygenic risk scores also predicted social and behaviou

7 Polygenic risk score analyses showed prognostication of

8 d arthritis and developed a new method using polygenic risk-score analyses to infer the total liabili

9 Polygenic risk score analysis did not support a higher b

10 Previous estimates of the utility of polygenic risk score analysis for the prediction of Alzh

11 OPS), as well as the association between the polygenic risk score and coronary artery calcification (

12 There was an interaction between the polygenic risk score and family history (P = .03).

13 show a significant correlation between a BP polygenic risk score and the clinical dimension of mania

14 tential relationship between an individual's polygenic risk score and their disease age at onset.

15 e identified multiple disease-associated and polygenic risk score-associated differentially methylate

16 mong women in the top and bottom fifths of a polygenic risk score based on 7 SNPs was 8.8% (8.3%-9.4%

17 The estrogen receptor-positive polygenic risk score built from 89 known susceptibility

18 eotide polymorphisms from which we conducted polygenic risk score comparisons for COS probands and th

19 A polygenic risk score comprising 93 single-nucleotide pol

20 Elastic Nets estimated from cohort data, and polygenic risk scores constructed using published summar

21 Further, we found that a standardized CRP polygenic risk score (CRPPRS) at p-value thresholds of 1

22 For each participant, we calculated a polygenic risk score derived from up to 57 common DNA se

23 We used polygenic risk scores derived from a patient discovery s

24 Polygenic risk scores derived from a Tourette syndrome g

25 Tests were performed to determine whether polygenic risk scores derived from potentially related t

26 Polygenic risk scores derived from the primary UK Bioban

27 assortative mating and the relatively small polygenic risk score effect sizes.

28 (7.05-21.6; P=1 x 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the vari

29 benign breast disease, mammographic density, polygenic risk score, family history of breast cancer, a

30 Schizophrenia was associated with the polygenic risk score, family psychiatric history, and so

31 any substance use disorder diagnosis and the polygenic risk score for schizophrenia (mega-analysis ps

32 (2) imaging studies of the brain; and (3) a polygenic risk score for schizophrenia across 108 geneti

33 Increased polygenic risk score for schizophrenia was associated wi

34 To test the association of a polygenic risk score for waist-to-hip ratio (WHR) adjust

35 A polygenic risk score for WHR adjusted for BMI, a measure

36 ed published summary statistics to calculate polygenic risk scores for eight well-studied phenotypes.

37 brain regions and highlights the utility of polygenic risk scores for identifying molecular pathways

38 We used polygenic risk scores for major depressive disorder (MDD

39 We tested whether polygenic risk scores for schizophrenia and bipolar diso

40 To do this, polygenic risk scores for schizophrenia derived from a l

41 Higher polygenic risk scores for schizophrenia were consistentl

42 To create polygenic risk scores for schizophrenia, we obtained dat

43 In parallel, polygenic risk scores for SCZ were associated with lower

44 Whole-genome polygenic risk scores for the development of Alzheimer's

45 Polygenic risk scores have shown great promise in predic

46 Analyses of polygenic risk scores identified pleiotropy with neurops

47 IoGRAMplusC4D study of CAD/MI, we calculated polygenic risk scores in 2599 participants of the Dutch

48 Conclusion A polygenic risk score may be used to refine risk from the

49 Schizophrenia was associated with the polygenic risk score (OR, 8.01; 95% CI, 4.53-14.16 for h

50 Polygenic risk scores, parental socioeconomic status, an

51 Polygenic risk scores (PGS) enable rapid estimation of g

52 ociation analyses were conducted between MDD polygenic risk score (PRS) and AD case-control status in

53 A polygenic risk score (PRS) composed of single nucleotide

54 We created a polygenic risk score (PRS) comprising 28 common obesity-

55 d with risk for BE or EAC, and constructed a polygenic risk score (PRS) for cases and controls by sum

56 A higher polygenic risk score (PRS) for DZ twinning, calculated b

57 measure of total susceptibility burden, the polygenic risk score (PRS) for each individual was defin

58 A polygenic risk score (PRS) is a sum of trait-associated

59 MD), and a 77-single nucleotide polymorphism polygenic risk score (PRS) were associated with breast c

60 A polygenic risk score (PRS), calculated as the sum of the

61 ibility loci, individually and combined as a polygenic risk score (PRS).

62 We included genetic polygenic risk scores (PRS) for schizophrenia, bipolar d

63 n models and molecular genetic methods, i.e. polygenic risk scores (PRS).

64 netic risk variant load for ADHD (indexed by polygenic risk scores [PRS]), but not for other psychiat

65 orts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing

66 We hypothesized that higher polygenic risk scores (PRSs) for AD would be associated

67 Polygenic risk scores (PRSs) for schizophrenia generated

68 herefore investigated the possible effect of polygenic risk scores (PRSs) for schizophrenia on the as

69 Polygenic risk scores (PRSs) have successfully summarize

70 At age 7-9 years, schizophrenia polygenic risk scores showed associations with lower per

71 Analyses of polygenic risk scores showed that individuals with a hig

72 We create a polygenic risk score that is significantly different bet

73 We demonstrate the utility of using a polygenic risk score to identify molecular variation ass

74 those at high genetic risk (top quintile of polygenic risk score) versus all others (WOSCOPS), as we

75 Each 1-SD increase in the polygenic risk score was associated with 1.32-fold (95%

76 ease in WHR adjusted for BMI mediated by the polygenic risk score was associated with 27-mg/dL higher

77 Polygenic risk score was associated with all subtypes ex

78 10-5), while the estrogen receptor-negative polygenic risk score was much higher in blacks than in w

79 The polygenic risk score was substantially more predictive o

80 The calculation of polygenic risk scores was based on genome-wide associati

81 Polygenic risk score were generated from a published Psy

82 Polygenic risk scores were calculated in the Avon Longit

83 Polygenic risk scores were calculated separately for BD

84 Polygenic risk scores were constructed based on common g

85 OCD polygenic risk scores were significantly associated with

86 We show a significant interaction of the polygenic risk scores with personal life events (0.12% o