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1 stimulation with TLR ligands (Pam3CSK4, LPS, polyinosinic-polycytidylic acid).
2 ize the synthetic MDA5 agonist/(ds)RNA mimic polyinosinic-polycytidylic acid.
3 al genes induced by a synthetic viral mimic, polyinosinic-polycytidylic acid.
4 icity induced by TNF, lipopolysaccharide and polyinosinic-polycytidylic acid.
5 n of apoptosis by both transfected PRNAs and polyinosinic-polycytidylic acid.
6 administration of low doses of a TLR ligand, polyinosinic-polycytidylic acid.
7 i such as lipopolysaccharide, IFN-gamma, and polyinosinic-polycytidylic acid.
8 on with OVA together with anti-CD40 mAbs and polyinosinic-polycytidylic acid.
9  to CD8(+) T cells following activation with polyinosinic-polycytidylic acid.
10 n hematopoietic cells upon inducing Cre with polyinosinic-polycytidylic acid.
11 FN-alphabeta-inducing viral infections or by polyinosinic:polycytidylic acid.
12  rat virus following brief pretreatment with polyinosinic:polycytidylic acid.
13  DCs after activation with the TLR3 agonist, polyinosinic:polycytidylic acid.
14  intraperitoneally at gestational day 9 with polyinosinic:polycytidylic acid.
15 EW.1W and Wistar Furth) strains induced with polyinosinic:polycytidylic acid.
16 6 production in response to the viral mimic, polyinosinic:polycytidylic acid.
17 o injections with LPS (a bacterial mimic) or polyinosinic-polycytidylic acid (a viral mimic), M-TRAF3
18 eport in this study that TLR3 stimulation by polyinosinic-polycytidylic acid, a double-stranded RNA a
19  murine DCs in response to the dsRNA agonist polyinosinic-polycytidylic acid, a subset of which were
20        In this study, we describe a model of polyinosinic: polycytidylic acid-accelerated lupus nephr
21                                              Polyinosinic-polycytidylic acid activated IFN regulatory
22 tranded PRNAs 50 nucleotides long as well as polyinosinic-polycytidylic acid activated the RNA-depend
23 dies markedly diminished the cytotoxicity of polyinosinic-polycytidylic acid-activated natural killer
24 llular immunity as well as an enhancement of polyinosinic-polycytidylic acid activation of TLR3.
25 ls have a deficiency in activation following polyinosinic:polycytidylic acid administration in vivo.
26 he synthetic analogue of viral nucleic acid, polyinosinic-polycytidylic acid, also induced IL-6-depen
27  response to inflammatory stimuli, including polyinosinic polycytidylic acid and LPS.
28 ng APC pretreated ex vivo with TLR agonists, polyinosinic-polycytidylic acid and CpG, to prime naive
29                    We found that TLR3-ligand polyinosinic-polycytidylic acid and human rhinovirus inf
30                   The synthetic dsRNA analog polyinosinic-polycytidylic acid and infection with live
31 ase to athymic WAG-rnu/rnu rats treated with polyinosinic: polycytidylic acid and a monoclonal antibo
32 ls readily develop IDDM after treatment with polyinosinic:polycytidylic acid and a cytotoxic anti-RT6
33  of autoimmune diabetes after treatment with polyinosinic:polycytidylic acid and an antibody that dep
34 DDM can readily be induced by treatment with polyinosinic:polycytidylic acid and depletion of RT6+ T-
35 (lsl-)(DTA) bone marrow with the viral mimic polyinosinic:polycytidylic acid and found a significant
36 sponse to the immunostimulatory nucleic acid polyinosinic:polycytidylic acid and UV light irradiation
37 D8(+) T cell epitope M282-90, a TLR agonist (polyinosinic-polycytidylic acid), and a costimulatory an
38 s, including Sendai virus, the dsRNA mimetic polyinosinic-polycytidylic acid, and LPS all activated d
39               In vivo administration of CpG, polyinosinic-polycytidylic acid, and Pam(3)CSK(4) in com
40 an ISCOMATRIX vaccine with the TLR3 agonist, polyinosinic-polycytidylic acid, and TLR9 agonist, CpG,
41  analog of viral double-stranded RNA (dsRNA) polyinosinic-polycytidylic acid, and type-II interferon-
42 uced in numbers upon in vivo activation with polyinosinic:polycytidylic acid, and have poor survival
43 ld be modulated by crude LPS, peptidoglycan, polyinosinic:polycytidylic acid, and rIFN-gamma in cell
44 major producers of IFN-lambda in response to polyinosinic-polycytidylic acid but are similar to CD1c(
45        XCR1(+) DC were strongly activated by polyinosinic-polycytidylic acid but not LPS, and convers
46 jection of the synthetic double-stranded RNA polyinosinic-polycytidylic acid causes a PPI deficit in
47                         Prenatal exposure to polyinosinic:polycytidylic acid causes an imbalanced exp
48                          Downregulation upon polyinosinic-polycytidylic acid challenge and expression
49 l effect of IFN-alpha/beta induced by either polyinosinic-polycytidylic acid complex or by lymphocyti
50 ated pathogen-exposed mice intranasally with polyinosinic-polycytidylic acid condensed with poly-l-ly
51                         We demonstrated that polyinosinic:polycytidylic acid consistently up-regulate
52 ull cells treated with lipopolysaccharide or polyinosinic-polycytidylic acid coordinate with constitu
53 rejection, and the interferon-inducing agent polyinosinic:polycytidylic acid did not induce allograft
54 bromide/monomycoloyl glycerol liposomes with polyinosinic:polycytidylic acid electrostatically adsorb
55 ecipient exposure to the viral-like adjuvant polyinosinic:polycytidylic acid enhanced anti-FVIII anti
56 beta)-, prion peptide-, double-stranded RNA (polyinosinic-polycytidylic acid)-, HIV-1 Tat-, 1-methyl-
57 ion is observed in macrophages after LPS and polyinosinic:polycytidylic acid in vitro.
58 -activating lipopeptide-2, or a TLR3 ligand, polyinosinic-polycytidylic acid, increased Cox-2 mRNA an
59 macrophage activation by TLR ligands LPS and polyinosinic-polycytidylic acid induced a time-dependent
60  fibrosis, natural killer cell activation by polyinosinic-polycytidylic acid induced cell death to ac
61                                     Notably, polyinosinic:polycytidylic acid induced nuclear localiza
62              In contrast, a synthetic dsRNA, polyinosinic polycytidylic-acid, induced CD11c(+) DC, bu
63 in LP hosts were markedly less responsive to polyinosinic-polycytidylic acid-induced acute proliferat
64                                              Polyinosinic-polycytidylic acid-induced antiviral genes
65 ttern recognition receptors was required for polyinosinic-polycytidylic acid-induced IFN-alpha/beta p
66                        Compound II inhibited polyinosinic-polycytidylic acid-induced immune activatio
67          Importantly, we discovered that the polyinosinic-polycytidylic acid-induced increase in prod
68 essing RIPK1 D138N are resistant to TNF- and polyinosinic-polycytidylic acid-induced necroptosis in v
69                                  A defect in polyinosinic-polycytidylic acid-induced TLR3 responses c
70 induced or synthetic dsRNA-based viral mimic polyinosinic:polycytidylic acid-induced expression of pr
71 , unlike those transfused in the presence of polyinosinic:polycytidylic acid-induced inflammation.
72 w-derived macrophages; however, priming with polyinosinic-polycytidylic acid induces it and confers n
73         Instead, challenge of TM with LPS or polyinosinic-polycytidylic acid induces MAPK, AP-1, and
74  of stimulating anti-CD40 Ab and TLR3 ligand polyinosinic-polycytidylic acid induces protective respo
75         Here we show that TLR3 activation by polyinosinic:polycytidylic acid induces up-regulation of
76 ytomegalovirus infection or after repetitive polyinosinic-polycytidylic acid injection.
77 eritoneal injection of lipopolysaccharide or polyinosinic:polycytidylic acid into mice, mimicking bac
78 lity of RIG-I to respond to stimulation with polyinosinic:polycytidylic acid is abolished when its in
79                         TLR3 activation with polyinosinic-polycytidylic acid led to comparable or eve
80                      Treatment with CVB3 and polyinosinic:polycytidylic acid led to higher IFNbeta ex
81 g HEK293 cells to stimulation with Pam3CSK4, polyinosinic-polycytidylic acid, LPS, and ODN2006, respe
82 s gene greatly sensitizes cells to cytosolic polyinosinic/polycytidylic acid-mediated induction of ty
83 31 breast cancer cells, we demonstrated that polyinosinic:polycytidylic acid-mediated activation of T
84 r LPS to shorten allograft survival, whereas polyinosinic:polycytidylic acid mediates its effects thr
85            The observed protective effect of polyinosinic-polycytidylic acid on liver fibrosis was di
86                               Treatment with polyinosinic-polycytidylic acid or a combination of mono
87                     Moreover, treatment with polyinosinic-polycytidylic acid or interferon gamma enha
88 ted a cell-associated Ag upon stimulation by polyinosinic-polycytidylic acid or R848, likewise to wha
89 nal antibody and then exposed them to either polyinosinic:polycytidylic acid or a diabetogenic virus
90  accelerated following the administration of polyinosinic:polycytidylic acid or allogeneic cells (gra
91 DC) maturation induced by LPS, as opposed to polyinosinic:polycytidylic acid or cytosine-phosphate-gu
92 or ATI-free diet and in mice given low-level polyinosinic:polycytidylic acid or dextran sodium sulfat
93 inistered systemically with the TLR3 agonist polyinosinic:polycytidylic acid or were given subcutaneo
94 domain-containing adapter inducing IFN-beta (polyinosinic-polycytidylic acid) or MyD88 (imiquimod), d
95 27(p28) after engagement of either the TLR3 (polyinosinic-polycytidylic acid) or TLR4 (LPS) receptor.
96 during virus infection, cellular exposure to polyinosinic-polycytidylic acid, or TBK1 overexpression.
97 ed with macrophage-activating lipopeptide-2, polyinosinic-polycytidylic acid, or UVB (15 mJ/cm(2)), b
98                            In the absence of polyinosinic:polycytidylic acid, or in the presence of a
99                   We show that IFN-alpha and polyinosinic:polycytidylic acid (p-I:C) synergize with t
100  in conjunction with the Th1-biased adjuvant polyinosinic:polycytidylic acid (pI:C).
101           MIA was induced in C57BL/6 mice by polyinosinic-polycytidylic acid (PIC) injected during em
102 oaded with Torula Yeast RNA (TYRNA)(640 nm), polyinosinic: polycytidylic acid (pIC)(680 nm), or splic
103       To test whether retinoic acid (RA) and polyinosinic:polycytidylic acid (PIC), an inducer of int
104                  Among the compounds tested, polyinosinic:polycytidylic acid (PIC, a Toll-like recept
105 blast-like synoviocytes were stimulated with polyinosinic-polycytidylic acid (poly [I-C]) after trans
106                                              Polyinosinic-polycytidylic acid (Poly I:C) or IFN-gamma
107                                              Polyinosinic-polycytidylic acid (poly I:C) or IFN-gamma
108 y in murine astrocyte primary cultures using polyinosinic-polycytidylic acid (poly I:C), a synthetic
109                                              Polyinosinic-polycytidylic acid (poly I:C), a TLR3 ligan
110 t and human islets with dsRNA in the form of polyinosinic-polycytidylic acid (poly IC) and IFN-gamma
111 y, we assessed the effect of the TLR3 ligand polyinosinic-polycytidylic acid (poly IC) on CD8 T cell
112                 The synthetic dsRNA molecule polyinosinic-polycytidylic acid (poly IC) stimulates bet
113 randed RNA (dsRNA) (in the form of synthetic polyinosinic-polycytidylic acid (poly IC)) on islet expr
114 ly induced by the Toll-like receptor ligands polyinosinic-polycytidylic acid (poly(I:C)) and flagelli
115 an absence of response to TLR3 activation by polyinosinic-polycytidylic acid (poly(I:C)) and related
116 tured microglia responded to synthetic dsRNA polyinosinic-polycytidylic acid (poly(I:C)) by increasin
117 ecific abrogation of macrophage responses to polyinosinic-polycytidylic acid (poly(I:C)) resulting fr
118  of systemic IFN-beta expression elicited by polyinosinic-polycytidylic acid (poly(I:C)) treatment or
119  lung fibroblasts, the synthetic TLR3 ligand polyinosinic-polycytidylic acid (poly(I:C)), a dsRNA ana
120         TLR3 is activated by viral dsRNA and polyinosinic-polycytidylic acid (poly(I:C)), a synthetic
121                                              Polyinosinic-polycytidylic acid (poly(I:C)), an analog o
122 -regulates the induction by a viral mimetic, polyinosinic-polycytidylic acid (poly(I:C)), of the endo
123 ry molecules such as LPS, lipoteichoic acid, polyinosinic-polycytidylic acid (poly(I:C)), TNF-alpha,
124 P2), expressed in the presence or absence of polyinosinic-polycytidylic acid (poly(I:C)), which elici
125                     Anti-CD40 also increased polyinosinic-polycytidylic acid (poly(I:C))-inducible IF
126 64.7 macrophage cells stimulated with LPS or polyinosinic-polycytidylic acid (poly(I:C)).
127 opolysaccharide (LPS, bacterial antigen) and polyinosinic-polycytidylic acid (poly(I:C), viral antige
128 Escherichia coli (TLR4), lipoprotein (TLR2), polyinosinic-polycytidylic acid (poly-IC) (TLR9), and th
129 ctive cytokine responses upon challenge with polyinosinic-polycytidylic acid (poly-IC).
130                                           As polyinosinic-polycytidylic acid (poly[I:C]), which mimic
131 Of the TLRs ligands tested, the TLR3 ligand, polyinosinic/polycytidylic acid (Poly(I:C)), most highly
132                                              Polyinosinic:polycytidylic acid (poly I:C), a synthetic
133 ts and develop diabetes after treatment with polyinosinic:polycytidylic acid (poly I:C), a synthetic
134  that lipopolysaccharide, a TLR4 ligand; and polyinosinic:polycytidylic acid (poly I:C), a TLR3 ligan
135 r ability to prime T cells: the TLR3 ligand, polyinosinic:polycytidylic acid (poly I:C), and immunost
136 aradigm, we treated timed-pregnant mice with polyinosinic:polycytidylic acid (Poly I:C), which simula
137 llenged with virus or with the viral mimetic polyinosinic:polycytidylic acid (poly I:C).
138  inflammatory cytokine induction elicited by polyinosinic:polycytidylic acid (poly I:C; a synthetic d
139  toll-like receptor (TLR) agonists, we found polyinosinic:polycytidylic acid (poly IC) to be the most
140                                       dsRNA [polyinosinic:polycytidylic acid (poly IC)]-stimulated in
141 c acid) (PLGA) nanoparticles adjuvanted with polyinosinic:polycytidylic acid (poly(I:C) as an adjuvan
142 Double-stranded RNA and the synthetic analog polyinosinic:polycytidylic acid (poly(I:C)) bind and act
143 esponse to stimulation by the dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) was dependen
144 necrosis factor (TNF), lipopolysaccharide or polyinosinic:polycytidylic acid (poly(I:C))-induced necr
145 on of NK cells by influenza-infected DCs and polyinosinic:polycytidylic acid (poly(I:C))-treated DCs
146 y reported that viral-like inflammation with polyinosinic polycytidylic acid [poly (I:C)] significant
147                                              Polyinosinic-polycytidylic acid [Poly (I:C)], a dsRNA re
148 edge, we demonstrate for the first time that polyinosinic-polycytidylic acid [poly (I:C)], a syntheti
149           Alpha/beta interferon induction by polyinosinic-polycytidylic acid [poly(I-C)] treatment ef
150 mice treated with the IFN-alpha/beta inducer polyinosinic-polycytidylic acid [poly(I-C)].
151  or peptidoglycan (PGN; a TLR 2 agonist) and polyinosinic-polycytidylic acid [poly(I:C); a TLR3 agoni
152 diator production induced by the viral mimic polyinosinic-polycytidylic acid [poly(I:C)] in primary h
153                                              Polyinosinic-polycytidylic acid [poly(I:C)] is a known i
154 of the study was to evaluate the activity of polyinosinic-polycytidylic acid [poly(I:C)] on IL-17A pr
155                               Application of polyinosinic-polycytidylic acid [poly(I:C)] or LPS induc
156 antigen (GAA) epitopes and administration of polyinosinic-polycytidylic acid [poly(I:C)] stabilized b
157 n regulatory factor 3 in response to LPS and polyinosinic-polycytidylic acid [poly(I:C)] stimulus, co
158 lovirus (MCMV) infection and the TLR3 ligand polyinosinic-polycytidylic acid [poly(I:C)] were used to
159 hat preconditioning with the synthetic dsRNA polyinosinic-polycytidylic acid [poly(I:C)], a mimetic o
160  CD8+ cells and was mimicked by injection of polyinosinic-polycytidylic acid [poly(I:C)], an inducer
161 port that a potent inducer of IFN-alphabeta, polyinosinic-polycytidylic acid [poly(I:C)], led to the
162 se combinations were resiquimod (R-848) plus polyinosinic-polycytidylic acid [Poly(I:C)], R-848 plus
163 by treatment of cells or fish with the dsRNA polyinosinic-polycytidylic acid [poly(I:C)], which induc
164 phorothioate oligonucleotide [Poly(dT)], and polyinosinic-polycytidylic acid [Poly(I:C)].
165 ied in Montanide ISA51 with or without TLR3 (polyinosinic-polycytidylic acid [poly-IC]), TLR4 (monoph
166  in humans to synthetic double-stranded RNA (polyinosinic:polycytidylic acid [poly IC] stabilized wit
167 ured vascular smooth muscle cells (VSMCs) to polyinosinic:polycytidylic acid [poly(I:C)] and was nece
168 uvant to boost CD8 T-cell function; however, polyinosinic:polycytidylic acid [poly(I:C)] can also sup
169 served in mice born to mothers injected with polyinosinic:polycytidylic acid [poly(I:C)] during pregn
170 ing the Toll-like receptor 3 (TLR-3) agonist polyinosinic:polycytidylic acid [poly(I:C)] in the SN of
171      Tlr4(-/-) mice primed with TLR3 agonist polyinosinic:polycytidylic acid [poly(I:C)] to induce pr
172 n of TLR4 and TLR3 signaling through LPS and polyinosinic:polycytidylic acid [poly(I:C)] treatments r
173 n vivo administration of the synthetic dsRNA polyinosinic:polycytidylic acid [poly(I:C)], but not lip
174             In combination, synthetic dsRNA (polyinosinic-polycytidylic acid, poly(I-C)) and interfer
175 he effects of double-stranded RNA (synthetic polyinosinic-polycytidylic acid; poly(I-C)) on macrophag
176                        Activation of TLR3 by polyinosinic-polycytidylic acid (polyI:C) leads to induc
177 by the synthetic double-stranded RNA ligand, polyinosinic-polycytidylic acid (polyI:C), leads to decr
178 une programming of fetal loss in response to polyinosinic:polycytidylic acid (polyI:C), a viral mimic
179 mmune activation (MIA) during pregnancy with polyinosinic:polycytidylic acid (polyI:C).
180 nt study, we employed the viral RNA mimetic (polyinosinic-polycytidylic acid [polyI:C]) to emulate vi
181                                              Polyinosinic-polycytidylic acid (PolyIC), a "mimic" of d
182  virus infection and treatment of cells with polyinosinic-polycytidylic acid (polyIC; a dsRNA mimetic
183 uction, whereas CpG oligodeoxynucleotide and polyinosinic:polycytidylic acid primarily stimulated Th1
184 nd did not decrease in spleen in response to polyinosinic-polycytidylic acid-promoted hepatitis.
185 XCL4-moDCs exclusively upon stimulation with polyinosinic-polycytidylic acid, R848, and CL075 ligands
186                               Challenge with polyinosinic-polycytidylic acid results in a rapid and s
187 g via TLR7) and MyD88-independent receptors (polyinosinic:polycytidylic acid signaling via TLR3 or ds
188 duce immune responses via active delivery of polyinosinic-polycytidylic acid sodium salt (poly I:C) t
189 M-CSF, rmIFN-gamma, rmIFN-alpha, rmIL-4, and polyinosinic-polycytidylic acid stabilized by lysine and
190 1 and given every 3 weeks with intramuscular polyinosinic-polycytidylic acid stabilized by lysine and
191 e viral mimic synthetic double-stranded RNA (polyinosinic:polycytidylic acid stabilized with poly-l-l
192  viral mimic, synthetic double-stranded RNA (polyinosinic:polycytidylic acid stabilized with poly-L-l
193         These data indicate that CpG DNA and polyinosinic-polycytidylic acid stimulate different type
194     In rainbow trout RTG-2 and RTS-11 cells, polyinosinic-polycytidylic acid stimulation resulted in
195                                 In contrast, polyinosinic:polycytidylic acid strongly represses CpG's
196 omodulators (monomycolyl glycerol analog and polyinosinic-polycytidylic acid) that efficiently induce
197 the effects of the inhaled viral TLR ligands polyinosinic-polycytidylic acid (TLR3) and resiquimod (T
198  including LPS (TLR4), peptidoglycan (TLR2), polyinosinic-polycytidylic acid (TLR3), CpG DNA (TLR9),
199 nistration of the TLR agonists LPS (TLR4) or polyinosinic:polycytidylic acid (TLR3) to mice treated w
200 LR7/8 activation, but selectively spared the polyinosinic-polycytidylic acid/TLR3 pathway.
201 s were coinjected with TLR2 (Pam3Cys), TLR3 (polyinosinic:polycytidylic acid), TLR4 (LPS), or TLR9 (C
202 t to necroptosis after stimulation with LPS, polyinosinic-polycytidylic acid, TNF-alpha, or IFN-beta
203 nation, even in the presence of anti-CD40 or polyinosinic:polycytidylic acid to induce DC maturation.
204 l growth factors and innate immune activator polyinosinic:polycytidylic acid to induce endothelial ce
205                   However, KCs isolated from polyinosinic:polycytidylic acid-treated mice expressed s
206                                              Polyinosinic-polycytidylic acid treatment also ameliorat
207                                              Polyinosinic-polycytidylic acid treatment of RAG(-/-) mi
208 cted in primary head kidney leukocytes after polyinosinic-polycytidylic acid treatment, whereas a mod
209 lysaccharide, cytosine-phosphate-guanine, or polyinosinic:polycytidylic acid) using flow cytometry an
210             The Toll-like receptor 3 ligand, polyinosinic-polycytidylic acid, was used to activate in
211 RNA viruses (polyuridine) and dsRNA viruses (polyinosinic-polycytidylic acid) were significantly weak
212 r subsequent transfusions in the presence of polyinosinic:polycytidylic acid, whereas anti-hGPA level
213  head kidney leukocytes when stimulated with polyinosinic:polycytidylic acid, whereas group II IFN wa
214 Treatment of infected mice with a complex of polyinosinic-polycytidylic acid with poly-L-lysine and c

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