ライフサイエンスコーパス: polyketide

1 Unexpectedly, it also required the DIF-1 polyketide.

2 in future combinatorial biosynthesis of new polyketides.

3 for engineered biosynthesis of new bioactive polyketides.

4 ntify additional biologically active complex polyketides.

5 evolutionary significance of clostrubin-type polyketides.

6 e for regiospecific cyclization of bacterial polyketides.

7 ains to produce targeted variants of natural polyketides.

8 he asymmetric synthesis of a wide variety of polyketides.

9 ly of natural products for human health, the polyketides.

10 new members of a rapamycin-related family of polyketides.

11 eltolide, are a key functional group in many polyketides.

12 The structures of the new polyketides 2-5 were elucidated by analysis of spectrosc

13 ementation assays, we demonstrate that these polyketides act as chemical triggers of sporulation and

14 provide new methods for synthesis of acyclic polyketide analogs with complex stereochemical arrays.

15 al assignments of the previously undescribed polyketide analogues.

16 ctural information relevant to understanding polyketide and fatty acid biosynthesis.

17 been identified as the source of almost all polyketide and modified peptides families reported from

18 ies may be broadly applicable to fatty acid, polyketide and non-ribosomal biosynthesis.

19 he role of editing thioesterases involved in polyketide and non-ribosomal peptide synthase synthases.

20 nus Salinispora for pathways associated with polyketide and nonribosomal peptide biosynthesis, the pr

21 ced, revealing potential as a rich source of polyketides and nonribosomal peptides.

22 Almost all bioactive polyketides and peptides known from this animal were att

23 mentally from previously described boronated polyketides and represent the first boronated aromatic p

24 ngement in the biosynthesis of the bacterial polyketide antibiotic enterocin.

25 incorporated into the stambomycin family of polyketide antibiotics are assembled by direct carboxyla

26 ise to the majority of characterized type II polyketide antibiotics.

27 Nonribosomal peptides and polyketides are a diverse group of natural products with

28 Polyketides are a large family of bioactive natural prod

29 Polyketides are an important class of bioactive small mo

30 While numerous polyketides are known to be derived from aerobic organis

31 These findings afford a view of a polyketide "atom-replaced" mimetic in a NR-PKS active si

32 itrogen atom, which is incorporated into the polyketide backbone, remained unknown.

33 ycin SV, which contained modification in the polyketide backbone.

34 Following the biosynthesis of polyketide backbones by polyketide synthases (PKSs), pos

35 inspiring the development of methodology for polyketide bio-orthogonal tagging via incorporation of 6

36 ed cyclization patterns that are crucial for polyketide bioactivity.

37 thy-3-ketoacyl-ACP products during bacterial polyketide biosynthesis mediated by trans-AT polyketide

38 s targeting either ketosynthase domains from polyketide biosynthesis or adenylation domains from nonr

39 alytic domains play an important role during polyketide biosynthesis through the dehydration of the n

40 in protein folding to thioester exchange in polyketide biosynthesis, indicate how dynamic covalent b

41 ion reminiscent of malonyl-CoA reactivity in polyketide biosynthesis.

42 genetic link between transport by ABCG26 and polyketide biosynthesis.

43 erved domains central to both fatty acid and polyketide biosynthesis.

44 are found in many natural systems, including polyketide biosynthesis.

45 teps that convert the nascent hybrid peptide-polyketide biosynthetic intermediate into LNM.

46 nd genes encoding the proposed sporopollenin polyketide biosynthetic metabolon (ACYL COENZYME A SYNTH

47 As more polyketide biosynthetic pathways are characterized, this

48 Polyketide biosynthetic pathways have been engineered to

49 elective access to stereotriads as important polyketide building blocks is reported on the basis of t

50 proposed deprotonation at C4 of the nascent polyketide by the catalytic His1345 and the role of a pr

51 hat the covalent linkage between the growing polyketide chain and the enzyme is lost in these cases,

52 yl and methylmalonyl-CoA building blocks for polyketide chain assembly.

53 ng for reductive processing of the ACP-bound polyketide chain elongation intermediate.

54 are required to accomplish twenty cycles of polyketide chain elongation.

55 to as a module, which catalyzes one round of polyketide chain extension and modification.

56 ifferentially and precisely positioned after polyketide chain substrate loading on the active site of

57 by variable aryl ketone moieties and linear polyketide chains (bearing alkyne/azide handles and fluo

58 s learned about how natural selection drives polyketide chemical innovation can be applied to the rat

59 ise only observed in the recently discovered polyketide clostrubin from a present-day Clostridium bac

60 producer mutant, produces high levels of the polyketide compounds aspinolides (Asp) B and C.

61 The antibacterial polyketide compounds described in the present study may

62 revealed that hydrophobic descriptor of the polyketide compounds significantly contribute towards it

63 papillosa was used to isolate antibacterial polyketide compounds.

64 omal peptide synthetase (NRPS) to synthesize polyketides conjugated to amino acids.

65 Desertomycin A is an aminopolyol polyketide containing a macrolactone ring.

66 The required DIF-1 polyketide could also be endogenous, as shown by the ina

67 aining two homologous domains related to the polyketide cyclase family comprising 37 annotated Arabid

68 The polyketide cyclase-related motifs support association of

69 product template (PT) domain that catalyzes polyketide cyclization, we developed the first mechanism

70 ore unveiled new routes and biocatalysts for polyketide cyclization.

71 ins, providing an unrivaled model system for polyketide dehydration.

72 Elucidation of amino-polyketide derivatives from a species of marine bacteria

73 led to isolation of three unprecedented aryl polyketide derivatives, characterized as (E)-12-(17-ethy

74 of the probes generated a range of unnatural polyketide derivatives, including novel putative lasaloc

75 this study, we identified a series of amino-polyketide derivatives, vitroprocines A-J, from the mari

76 noids exhibits a substitution pattern of the polyketide-derived aromatic core that seemingly contradi

77 The gem-dimethyl groups in polyketide-derived natural products add steric bulk and,

78 Solanapyrones are polyketide-derived secondary metabolites produced by div

79 n monolayers in vitro, can be induced by the polyketide DIF-1 or by the cyclical dinucleotide c-di-GM

80 Nogalamycin, an aromatic polyketide displaying high cytotoxicity, has a unique st

81 Lasonolide A is a novel polyketide displaying potent anticancer activity across

82 was prepared and utilized to explore in vivo polyketide diversification.

83 logenated and then elaborated by peptidic or polyketide extensions.

84 rinol and mupirocin are assembled on similar polyketide/fatty acid backbones and exhibit potent antib

85 s and represent the first boronated aromatic polyketides found so far.

86 The potential of hitherto undescribed polyketides from P. malabarica as natural antioxidative

87 ucts, particularly nonribosomal peptides and polyketides, from sequence data.

88 nts of a B. cinerea mutant that overproduces polyketides gave sufficient quantities of 1, now named c

89 " this family can be correlated to a type II polyketide gene cluster in the producing organism.

90 The ancestral type II polyketide gene cluster likely comprised a core set of f

91 nome sequencing revealed the putative type I polyketide gene cluster responsible for selvamicin's bio

92 his method to infer the evolution of type II polyketide gene clusters, tracing the path of evolution

93 udies of site-selective alteration including polyketides, glycopeptides, terpenoids, macrolides, alka

94 m aerobic organisms, only a single family of polyketides has been identified from anaerobic organisms

95 ahuoic acid Ci(Bii) (3), a novel cis-decalin polyketide, has been achieved.

96 Fungal polyketides have significant biological activities, yet

97 The responsible non-ribosomal peptide-polyketide hybrid pathway encodes 'colibactin', which be

98 emonstrating the existence and importance of polyketides in anaerobes, and showcases a strategy of ma

99 ition potential (IC50 0.76-0.92mg/mL) of the polyketides in consonant with significantly greater anti

100 herein a total synthesis of the widely used polyketide insecticide spinosyn A by exploiting the prow

101 dol addition of an acyl donor to a beta-keto-polyketide intermediate acceptor.

102 We show that nor-toralactone is the key polyketide intermediate and the substrate for the unusua

103 the reaction chamber to deliver the upstream polyketide intermediate for subsequent extension and mod

104 xide hydrolase, Lsd19, converts the bisepoxy polyketide intermediate into the tetrahydrofuranyl-tetra

105 Alkyl branching at the beta position of a polyketide intermediate is an important variation on can

106 yl-carrier protein (ACP) carries the growing polyketide intermediate through iterative rounds of elon

107 hesis through the dehydration of the nascent polyketide intermediate to provide olefins.

108 on of the beta-hydroxy groups of the nascent polyketide intermediates, DH10 acts in a long-range mann

109 olute configuration of cryptomoscatone E3, a polyketide isolated from the Brazilian tree Cryptocarya

110 e A is a fascinating tetrachlorinated marine polyketide isolated from the sponge of Phorbas sp.

111 of nonribosomal peptide adenylation (AD) and polyketide ketosynthase (KS) domain fragments amplified

112 Mandelalides A-D (1-4) are macrocyclic polyketides known to have an unusual bioactivity profile

113 tion sequence, thus affording highly complex polyketide-like fragments.

114 ic polyene encoded by a reductive, iterative polyketide-like gene cluster.

115 tein secretion system ESX-1, biosynthesis of polyketide lipids, and utilization of sterols.

116 in part due to WhiB3-dependent production of polyketide lipids.

117 Aromatic polyketides make up a large class of natural products wi

118 Four cyclopentenone-containing ansamycin polyketides (mccrearamycins A-D), and six new geldanamyc

119 ses to infectious diseases and terpenoid and polyketide metabolism were enriched in subjects with hal

120 monooxygenase for oxidative cleavage of the polyketide moiety.

121 mentally involved during dimerization of the polyketide monomers.

122 The total synthesis of cytotoxic polyketides myceliothermophins E (1), C (2), and D (3) t

123 rylenequinones are a class of photoactivated polyketide mycotoxins produced by fungal plant pathogens

124 , we identify a structurally novel tricyclic polyketide, named vanitaracin A, which specifically inhi

125 Here we uncover a family of polyketides native to the anaerobic bacterium Clostridiu

126 The polyketide natural product (+)-SCH 351448, a macrodiolid

127 diate is an important variation on canonical polyketide natural product biosynthesis.

128 The polyketide natural product borrelidin displays antibacte

129 The polyketide natural product cryptocaryol A is prepared in

130 The first synthesis of gracilioether F, a polyketide natural product with an unusual tricyclic cor

131 The nonaromatic polyketide natural product zincophorin methyl ester has

132 ight be exploited to incorporate sulfur into polyketide natural products by PKS engineering.

133 Polyketide natural products constitute a broad class of

134 The kinamycin family of aromatic polyketide natural products contains an atypical angucyc

135 relevant biological activities, nonaromatic polyketide natural products have for decades attracted a

136 ruction of the core architecture of aromatic polyketide natural products in fungi.

137 ermectin and rapamycin are clinically useful polyketide natural products produced on modular polyketi

138 Phenalenones are polyketide natural products that display diverse structu

139 The total syntheses of several iconic type I polyketide natural products were undertaken using these

140 h to the validation of linker strategies for polyketide natural products with few or no obvious handl

141 now allows access to a much wider family of polyketide natural products with stereochemistry being d

142 opyran rings are a common feature of complex polyketide natural products, but much remains to be lear

143 ns essential for the formation of olefins in polyketide natural products.

144 roduce structurally and functionally diverse polyketides, nonribosomal peptides and their hybrids.

145 The colibactins are hybrid polyketide-nonribosomal peptide natural products produce

146 e belonging to the chemical family of hybrid polyketide/nonribosomal peptide compounds.

147 tyostelium only in the presence of the DIF-1 polyketide or its metabolites.

148 cally labeled precursors clearly supported a polyketide origin for the formal monoterpenoid gibepyron

149 E)-pent-2-enyl)-2H-chromene-6-carboxylate of polyketide origin, with activity against human opportuni

150 ctional theory calculations and reveal their polyketide origin.

151 arbocycle fused to an anthraquinone, both of polyketide origin.

152 droxy-6-methylacetophenone is derived from a polyketide pathway, we report a differentially expressed

153 required for the synthesis of colibactin, a polyketide-peptide genotoxin that causes genomic instabi

154 ese modules that enable correct formation of polyketide-peptide hybrid products.

155 erative biosynthetic mechanism for bacterial polyketide-peptide natural products.

156 adicts the established reactivity pattern of polyketide phenol nucleophiles and terpene diphosphate e

157 An efficient total synthesis of the unusual polyketide portentol is reported.

158 ntaketide analogue of the presumed monomeric polyketide precursor of elaiophylin, specifically its N-

159 tricyclic ring system cyclized from a linear polyketide precursor via an unresolved mechanism.

160 acyls, glycerolipids, phosphoglycerolipids, polyketides, prenols, saccharolipids, sphingolipids, and

161 influence of protein-protein interactions on polyketide product outcome.

162 the cAT domain is capable of esterifying the polyketide product with polyalcohol nucleophiles.

163 g of assembly lines that construct primarily polyketide products, structural aspects of the assembly-

164 ow can be unambiguously linked to the modern polyketide, providing evidence that the fossil pigments

165 film cells to identify alternate respiratory polyketide quinones (PkQs) from both Mycobacterium smegm

166 r to programmed cell death in the absence of polyketides, raising the possibility that they are incor

167 rediction has been improved by incorporating polyketide reduction states.

168 Polyketides represent an important class of bioactive na

169 d enables convergent construction of type II polyketide ring systems of the angucycline class.

170 lactone core with its northern and southern polyketide side chains.

171 nt asymmetric access to anti,syn and syn,syn polyketide stereotriads from the same alpha-chiral start

172 ration mechanism that could be exploited for polyketide structural diversity by combinatorial biosynt

173 Our findings reveal that (i) type II polyketide structure is predictable from its gene roster

174 cal characterization of DH10 in vitro, using polyketide substrate mimics with varying chain lengths.

175 for transferring the elongated and processed polyketide substrate to the next module in the PKS pathw

176 es enable convergent construction of type II polyketide substructures.

177 new, convergent means of assembling Type II polyketide substructures.

178 sing microalga as a substrate, including the polyketide sugar unit, lipopolysaccharide, peptidoglycan

179 ble construction of the actin-binding marine polyketide swinholide A in only 15 steps (longest linear

180 d substitution (R644W) in an uncharacterized polyketide synthase (MuPKS).

181 A nonreducing polyketide synthase (NR-PKS) PhnA was shown to synthesiz

182 by a hybrid nonribosomal peptide synthetase-polyketide synthase (NRPS-PKS) system of the trans-acyl

183 lic fatty acid synthase of type 1 (FAS1) and polyketide synthase (PKS) and the down-regulation of the

184 omain FosDH1 from module 1 of the fostriecin polyketide synthase (PKS) catalyzed the stereospecific i

185 r nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) enzyme complexes by a conserve

186 of bioactive natural products synthesized by polyketide synthase (PKS) enzyme complexes predominantly

187 Polyketide synthase (PKS) enzymes continue to hold great

188 ducts are produced by multifunctional type I polyketide synthase (PKS) enzymes that operate as biosyn

189 athway, we report a differentially expressed polyketide synthase (PKS) gene candidate.

190 Here, we identified and deleted a polyketide synthase (PKS) gene PfmaE and showed that it

191 nt antibiotic produced via a trans-AT Type I polyketide synthase (PKS) in Pseudomonas fluorescens, co

192 Detailed analysis of the modular Type I polyketide synthase (PKS) involved in the biosynthesis o

193 The programming of the fungal polyketide synthase (PKS) is quite complex, with a simpl

194 The polyketide synthase (PKS) mega-enzyme assembly line uses

195 The potential for recombining intact polyketide synthase (PKS) modules has been extensively e

196 his moiety, the gem-dimethyl group producing polyketide synthase (PKS) modules of yersiniabactin and

197 mains of cryptic function are often found in polyketide synthase (PKS) modules that produce epimerize

198 , encodes a trans-acyltransferase (trans-AT) polyketide synthase (PKS) multienzyme that was hypothesi

199 HR) and a non-reducing (NR) iterative type I polyketide synthase (PKS) pair.

200 Metabolic engineering of polyketide synthase (PKS) pathways represents a promisin

201 The virulent gene island polyketide synthase (pks) produces the secondary metabol

202 mains (DHs) of the iso-migrastatin (iso-MGS) polyketide synthase (PKS) were investigated by systemati

203 a chersina previously identified an enediyne polyketide synthase (PKS), but no anthraquinone PKS, sug

204 in, which exhibits a putative combination of polyketide synthase (PKS), non-ribosomal peptide synthet

205 viously identified as a cluster containing a polyketide synthase (PKS)-encoding (FUB1) and four addit

206 ticancer activity that are biosynthesized by polyketide synthase (PKS)-nonribosomal peptide synthetas

207 tase (NRPS)-acyltransferase (AT)-less type I polyketide synthase (PKS).

208 m non-ribosomal peptide synthetase (NRPS) or polyketide synthase (PKS).

209 investigation of the model type I iterative polyketide synthase 6-methylsalicylic acid synthase (6-M

210 etic metabolon (ACYL COENZYME A SYNTHETASE5, POLYKETIDE SYNTHASE A [PKSA], PKSB, and TETRAKETIDE alph

211 nt tool for comparative analysis of trans-AT polyketide synthase assembly line architectures.

212 macrodiolide produced on a bacterial modular polyketide synthase assembly line.

213 e hybrid nonribosomal peptide synthetase and polyketide synthase biosynthetic gene cluster is encoded

214 Furthermore, in vitro investigations of the polyketide synthase central to cercosporin biosynthesis

215 ction of atrochrysone carboxylic acid by the polyketide synthase ClaG and the beta-lactamase ClaF.

216 a shunt product in all related non-reducing polyketide synthase clusters containing homologues of Tp

217 en fluorescent protein (GFP, 27 kDa) and the polyketide synthase DEBS1 (394 kDa).

218 Although polyketide synthase encoding genes have been successfull

219 inition: A long-standing paradigm in modular polyketide synthase enzymology, namely the definition of

220 antroquinonol biosynthesis in mycelium, and polyketide synthase for antrocamphin biosynthesis in fru

221 recently a large trans-acyltransferase (AT) polyketide synthase gene cluster responsible for the bio

222 ow describe a method for rapidly recombining polyketide synthase gene clusters to replace, add or rem

223 We also found expansions in reducing polyketide synthase genes specific to the brown-rot fung

224 milarities in key genes such as 16S rRNA and polyketide synthase genes.

225 lly, we introduced the S148C mutation into a polyketide synthase module (PikAIII-TE) to impart increa

226 yketide natural products produced on modular polyketide synthase multienzymes by an assembly-line pro

227 We have used a polyketide synthase mutant that accumulates an elevated

228 7, should thus be informative to the modular polyketide synthase novice and expert alike.

229 le that targets the thioesterase activity of polyketide synthase Pks13, an essential enzyme that form

230 gene deletion verified that the F. fujikuroi polyketide synthase PKS13, designated Gpy1, is responsib

231 thase (DEBS) is a prototypical assembly line polyketide synthase produced by the actinomycete Sacchar

232 ormed by an iterative highly reducing fungal polyketide synthase supported by a hydrolase, together w

233 e show that chlorizidine A is assembled by a polyketide synthase that uniquely incorporates a fatty a

234 We also characterized a truncated polyketide synthase with a ketoreductase function that c

235 ltransferase domain of module 6 of rifamycin polyketide synthase with that of module 2 of rapamycin p

236 gested to be the product of a modular type I polyketide synthase working in trans with two monofuncti

237 The interplay of a dedicated type III polyketide synthase, a prenyl diphosphate synthase, and

238 Chalcone synthase (CHS), a type III plant polyketide synthase, is critical for flavonoid biosynthe

239 ort the characterization of a novel Type III polyketide synthase, quinolone synthase (QNS), from A. m

240 nated when both the tpc and enc non-reducing polyketide synthase-encoding genes, tpcC and encA, respe

241 We report expression of a microalgal polyketide synthase-like PUFA synthase system, comprisin

242 c gene cluster contains only a single-module polyketide synthase-nonribosomal peptide synthetase (PKS

243 ase activity missing from two modules of the polyketide synthase.

244 BonMT2 from module 2 of the bongkrekic acid polyketide synthase.

245 synthase with that of module 2 of rapamycin polyketide synthase.

246 Highly reducing polyketide synthases (HR-PKSs) from fungi synthesize com

247 ies, yet the biosynthesis by highly reducing polyketide synthases (HRPKSs) remains enigmatic.

248 In fungal non-reducing polyketide synthases (NR-PKS) the acyl-carrier protein (

249 Iterative, nonreducing polyketide synthases (NR-PKSs) are multidomain enzymes r

250 emplate (PT) domains from fungal nonreducing polyketide synthases (NR-PKSs) are responsible for contr

251 Modular polyketide synthases (PKSs) and nonribosomal peptide syn

252 Acyltransferase (AT)-less type I polyketide synthases (PKSs) break the type I PKS paradig

253 Modular polyketide synthases (PKSs) direct the biosynthesis of c

254 Biochemical characterization of polyketide synthases (PKSs) has relied on synthetic subs

255 Engineering modular polyketide synthases (PKSs) has the potential to be an e

256 PKS11 is one of three type III polyketide synthases (PKSs) identified in Mycobacterium

257 The mechanistic details of many polyketide synthases (PKSs) remain elusive due to the in

258 Polyketide synthases (PKSs) represent a powerful catalyt

259 However, manipulation of modular type I polyketide synthases (PKSs) to make unnatural metabolite

260 iosynthetic machinery, represented by type I polyketide synthases (PKSs), has an architecture in whic

261 the biosynthesis of polyketide backbones by polyketide synthases (PKSs), post-PKS modifications resu

262 Type I modular polyketide synthases (PKSs), which are responsible for t

263 and di-domain ARO/CYCs in bacterial type II polyketide synthases and lays the groundwork for enginee

264 te pathway that is extended by the action of polyketide synthases and non-ribosomal peptide synthetas

265 2) An important subset of polyketide synthases and nonribosomal peptide synthetase

266 lism is shown by gene expression analyses of polyketide synthases and the determination of the second

267 Type I modular polyketide synthases assemble diverse bioactive natural

268 Many modular polyketide synthases harbor one or more redox-inactive d

269 ar compounds (marginolactones) are formed by polyketide synthases primed not with gamma-aminobutanoyl

270 The polyketide synthases responsible for the biosynthesis of

271 polyketide biosynthesis mediated by trans-AT polyketide synthases that lack integrated acyl transfera

272 tory quinones, PkQs are produced by type III polyketide synthases using fatty acyl-CoA precursors.

273 module and intermodule substrate transfer in polyketide synthases, and establishes a new model for mo

274 teins of several families including type-III polyketide synthases, hydrolases, and cytochrome P450s r

275 quence-specific synthesis by the ribosome to polyketide synthases, where tethered molecules are passe

276 y, terpenoid pathways, cytochrome P450s, and polyketide synthases, which may contribute to the produc

277 -amino acids and other elements derived from polyketide synthases.

278 e mechanism of natural evolution for modular polyketide synthases.

279 d, much like an in vitro version of Nature's polyketide synthases.

280 cillaene, difficidin, and mupirocin trans-AT polyketide synthases.

281 Putative biosynthetic route by means of polyketide synthatase biocatalyzed pathways unambiguousl

282 domains of type II thioesterases involved in polyketide synthesis.

283 dies integrated with the outcome obtained by polyketide synthetase (pks) coding genes established tha

284 Circulating M. bovis proteins, specifically polyketide synthetase 5, detected M. bovis-infected catt

285 allow formation of a highly unusual aromatic polyketide-terpene hybrid intermediate which features an

286 ein are syntheses of the naturally occurring polyketides (-)-tetrapetalones A and C and their respect

287 Hippolachnin A (1) is an antifungal polyketide that bristles with ethyl groups mounted onto

288 fferentiation-inducing factor-1 (DIF-1) is a polyketide that induces Dictyostelium amoebae to differe

289 Mensacarcin is a highly oxygenated polyketide that was first isolated from soil-dwelling St

290 enzymes used in this study produce aromatic polyketides that are representative of the four main che

291 The tedanolides are biologically active polyketides that exhibit a macrolactone constructed from

292 The lasonolides are novel polyketides that have displayed remarkable biological ac

293 , as well as on the amenability of unnatural polyketides to further structural modifications, the che

294 We propose a model where ABCG26-exported polyketides traffic from tapetal cells to form the sporo

295 he biosynthesis of nonribosomal peptides and polyketides, we found that urban park soil microbiomes a

296 The structures of the polyketides were assigned by extensive spectroscopic exp

297 owever, no other bioactive compounds such as polyketides were detected at any time, strongly suggesti

298 Homodimericin A is a hexacyclic polyketide with a carbon backbone containing eight conti

299 Forazoline A, a novel antifungal polyketide with in vivo efficacy against Candida albican

300 streamlining the synthesis of other complex polyketides with more elaborate post-PKS modifications.