ライフサイエンスコーパス: polyketide synthase

1 se and an oxygenase, in addition to the core polyketide synthase.

2 ormed by biphenyl synthase (BIS), a type III polyketide synthase.

3 the organization displayed by this singular polyketide synthase.

4 he programming selectivities of the tenellin polyketide synthase.

5 it formation to the ACPs integrated into the polyketide synthase.

6 line skeleton is biosynthesized by a type II polyketide synthase.

7 higher than that of any other known type III polyketide synthase.

8 ase activity missing from two modules of the polyketide synthase.

9 synthase with that of module 2 of rapamycin polyketide synthase.

10 BonMT2 from module 2 of the bongkrekic acid polyketide synthase.

11 e mechanism of natural evolution for modular polyketide synthases.

12 quinolone and acridone alkaloid by type III polyketide synthases.

13 e clade of the functionally diverse type III polyketide synthases.

14 onyl-CoA, a common substrate of multimodular polyketide synthases.

15 tituted components from a variety of modular polyketide synthases.

16 d, much like an in vitro version of Nature's polyketide synthases.

17 chalcone synthase families of fatty acid and polyketide synthases.

18 yketides biosynthesized by bacterial type II polyketide synthases.

19 cillaene, difficidin, and mupirocin trans-AT polyketide synthases.

20 -amino acids and other elements derived from polyketide synthases.

21 jacent rppA gene, which encodes the type III polyketide synthase, 1,3,6,8-tetrahydroxynaphthalene syn

22 cific lipid branching patterns introduced by polyketide synthase 12 (pks12).

23 toacyl-acyl-carrier protein (ACP) synthases, polyketide synthases, 3-hydroxy-3-methylglutaryl-CoA syn

24 investigation of the model type I iterative polyketide synthase 6-methylsalicylic acid synthase (6-M

25 of ACP domains of the erythromycin precursor polyketide synthase, 6-deoxyerythronolide B synthase (DE

26 ACYL-COA SYNTHETASE, POLYKETIDE SYNTHASE A (PKSA) and PKSB, TETRAKETIDE alpha

27 etic metabolon (ACYL COENZYME A SYNTHETASE5, POLYKETIDE SYNTHASE A [PKSA], PKSB, and TETRAKETIDE alph

28 structural analyses of the TE/CLC domain in polyketide synthase A, the multidomain PKS central to th

29 d by the combined action of a modular Type-I polyketide synthase, a conserved set of enzymes involved

30 It encodes a chimeric multimodular polyketide synthase, a nonribosomal peptide synthetase,

31 The interplay of a dedicated type III polyketide synthase, a prenyl diphosphate synthase, and

32 re is no model available for a fungal type I polyketide synthase ACP.

33 bitor occurs in root hair cells, involving a polyketide synthase activity that utilizes an atypical 1

34 nd CTB3 genes that encode, respectively, the polyketide synthase and a dual methyltransferase/monooxy

35 cluster, followed by characterization of the polyketide synthase and acyltransferase involved in bios

36 iochemical and structural similarity between polyketide synthase and fatty acid synthase enzymology.

37 Microbially derived modular polyketide synthase and nonribosomal peptide synthetase

38 ne backbone is biosynthesized by the minimal polyketide synthases and an amidotransferase homologue O

39 on and release from six of these nonreducing polyketide synthases and have identified the products.

40 and di-domain ARO/CYCs in bacterial type II polyketide synthases and lays the groundwork for enginee

41 te pathway that is extended by the action of polyketide synthases and non-ribosomal peptide synthetas

42 In mycobacteria, polyketide synthases and nonribosomal peptide synthetase

43 ers are converted by thioesterase domains of polyketide synthases and nonribosomal peptide synthetase

44 2) An important subset of polyketide synthases and nonribosomal peptide synthetase

45 Structural conservation with type I polyketide synthases and related fatty-acid synthases al

46 lism is shown by gene expression analyses of polyketide synthases and the determination of the second

47 module and intermodule substrate transfer in polyketide synthases, and establishes a new model for mo

48 Nonribosomal peptide synthetases (NRPSs) and polyketide synthases are large, multidomain enzymes that

49 Highly reducing iterative polyketide synthases are large, multifunctional enzymes

50 Acyltransferase (AT) domains of multimodular polyketide synthases are the primary gatekeepers for ste

51 Type I modular polyketide synthases assemble diverse bioactive natural

52 nt tool for comparative analysis of trans-AT polyketide synthase assembly line architectures.

53 initiating and terminating an unusual type I polyketide synthase assembly line, and discover that mac

54 macrodiolide produced on a bacterial modular polyketide synthase assembly line.

55 e hybrid nonribosomal peptide synthetase and polyketide synthase biosynthetic gene cluster is encoded

56 ibe a pathway to chloroethylmalonyl-CoA as a polyketide synthase building block in the biosynthesis o

57 n the dark: the fermentation products of the polyketide synthase CalE8 (without its cognate thioester

58 Polyketide synthases cannot be functional unless their a

59 Furthermore, in vitro investigations of the polyketide synthase central to cercosporin biosynthesis

60 ction of atrochrysone carboxylic acid by the polyketide synthase ClaG and the beta-lactamase ClaF.

61 a shunt product in all related non-reducing polyketide synthase clusters containing homologues of Tp

62 s); each encodes acyltransferase-less type I polyketide synthases commensurate with iso-migrastatin b

63 oding hybrid nonribosomal peptide synthetase/polyketide synthases consistent with thalassospiramide a

64 ation and heterologous expression of type II polyketide synthase-containing eDNA clones is reported h

65 en fluorescent protein (GFP, 27 kDa) and the polyketide synthase DEBS1 (394 kDa).

66 MAL cluster, we identified malleilactone, a polyketide synthase-derived cytotoxic siderophore encode

67 of the biosynthesis of an important group of polyketide synthase-derived mycobacterial lipids, and su

68 a highly biologically active lipid species-a polyketide synthase-derived phenolic glycolipid (PGL) pr

69 associated with the production by HN878 of a polyketide synthase-derived phenolic glycolipid (PGL), a

70 Polyketide synthases elongate a polyketide backbone by c

71 Although polyketide synthase encoding genes have been successfull

72 conducted rational domain swaps between the polyketide synthases encoding the biosynthesis of the cl

73 nated when both the tpc and enc non-reducing polyketide synthase-encoding genes, tpcC and encA, respe

74 lly at three specific sites within the giant polyketide synthase-encoding genes.

75 ly required for the release of products from polyketide synthase enzymes, but no such enzyme has been

76 inition: A long-standing paradigm in modular polyketide synthase enzymology, namely the definition of

77 chloroethylmalonyl-CoA, a novel halogenated polyketide synthase extender unit of the proteasome inhi

78 important step toward harnessing these rare polyketide synthase extender units for combinatorial bio

79 A new series of coenzyme A-tethered polyketide synthase extender units were discovered in re

80 antroquinonol biosynthesis in mycelium, and polyketide synthase for antrocamphin biosynthesis in fru

81 PhlD, a type III polyketide synthase from Pseudomonas fluorescens, cataly

82 y catalytic domains is critical for NRPS and polyketide synthase function.

83 The Strongylocentrotus purpuratus polyketide synthase gene (SpPks) encodes an enzyme requi

84 recently a large trans-acyltransferase (AT) polyketide synthase gene cluster responsible for the bio

85 g the DNA flanking the insertions revealed a polyketide synthase gene cluster that would encode three

86 ow describe a method for rapidly recombining polyketide synthase gene clusters to replace, add or rem

87 One is a cluster of four genes including a polyketide synthase gene, ausA.

88 attenuated mutants is interrupted in pks1, a polyketide synthase gene.

89 tants showed significant upregulation of the polyketide synthase genes ppsA-ppsE and drrA, which cons

90 We also found expansions in reducing polyketide synthase genes specific to the brown-rot fung

91 milarities in key genes such as 16S rRNA and polyketide synthase genes.

92 Many modular polyketide synthases harbor one or more redox-inactive d

93 LovF is a highly reducing polyketide synthase (HR-PKS) from the filamentous fungus

94 Highly reducing polyketide synthases (HR-PKSs) from fungi synthesize com

95 ies, yet the biosynthesis by highly reducing polyketide synthases (HRPKSs) remains enigmatic.

96 teins of several families including type-III polyketide synthases, hydrolases, and cytochrome P450s r

97 e, can be incorporated by the actions of the polyketide synthase III (KSIII) AsuC3/C4 as well as the

98 In this study we show that a bimodular polyketide synthase in conjunction with a fatty acyl-AMP

99 We found that a predicted type III polyketide synthase in the genome of the brown alga Ecto

100 of a hybrid nonribosomal peptide synthetase/polyketide synthase in the myxobacterium Sorangium cellu

101 e for the mandatory homodimeric structure of polyketide synthases, in contrast to the monomeric nonri

102 r protein-thioesterase linker from a modular polyketide synthase, increased mobility of the thioester

103 Pks13 is a type I polyketide synthase involved in the final biosynthesis s

104 The iterative type I polyketide synthases (IPKSs) are central to the biosynth

105 oxin B1, is one of the multidomain iterative polyketide synthases (IPKSs), a large, poorly understood

106 l polyketide intermediate from the iterative polyketide synthases (iPKSs), most frequently by a thioe

107 Two fungal iterative polyketide synthases (IPKSs), Rdc5, the highly reducing

108 s involves a pair of collaborating iterative polyketide synthases (iPKSs): a highly reducing iPKS wit

109 Combinatorial biosynthesis of type I polyketide synthases is a promising approach for the gen

110 The role of interdomain linkers in modular polyketide synthases is poorly understood.

111 Chalcone synthase (CHS), a type III plant polyketide synthase, is critical for flavonoid biosynthe

112 nge assay directly establishes that specific polyketide synthase ketoreductase domains also have an i

113 eptide synthetase, which resembles iterative polyketide synthases known in fungi.

114 We report expression of a microalgal polyketide synthase-like PUFA synthase system, comprisin

115 The final step in polyketide synthase-mediated biosynthesis of macrocyclic

116 hat encode three acyltransferase-less type I polyketide synthases (MgsEFG), one discrete acyltransfer

117 lly, we introduced the S148C mutation into a polyketide synthase module (PikAIII-TE) to impart increa

118 Every polyketide synthase module has an acyl carrier protein (

119 Thus, this polyketide synthase module showed considerable tolerance

120 e course of the enigmatic iterative use of a polyketide synthase module was deduced from targeted dom

121 e AT and the KS domains of this prototypical polyketide synthase module.

122 The disorazole polyketide synthase modules lack an acyltransferase doma

123 ing both nonribosomal peptide synthetase and polyketide synthase modules.

124 yketide natural products produced on modular polyketide synthase multienzymes by an assembly-line pro

125 d substitution (R644W) in an uncharacterized polyketide synthase (MuPKS).

126 We have used a polyketide synthase mutant that accumulates an elevated

127 Pathway engineering of the chartreusin polyketide synthase, mutational synthesis, and molecular

128 ketide/amino acid structure encodes a hybrid polyketide synthase nonribosomal peptide synthetase (PKS

129 d substrate specificities during assembly by polyketide synthases, nonribosomal peptide synthetases,

130 ay-specific enzyme CpaS, a hybrid two module polyketide synthase-nonribosomal peptide synthetase (PKS

131 CpaS is a hybrid, two module polyketide synthase-nonribosomal peptide synthetase (PKS

132 c gene cluster contains only a single-module polyketide synthase-nonribosomal peptide synthetase (PKS

133 erial strains and contains an unusual hybrid polyketide synthase-nonribosomal peptide synthetase, whi

134 7, should thus be informative to the modular polyketide synthase novice and expert alike.

135 aced, en masse, the promoters of nonreducing polyketide synthase (NR-PKS) genes, key genes in NP bios

136 A nonreducing polyketide synthase (NR-PKS) PhnA was shown to synthesiz

137 of fungal nonreducing, multidomain iterative polyketide synthases (NR-PKS group of IPKSs) results fro

138 In fungal non-reducing polyketide synthases (NR-PKS) the acyl-carrier protein (

139 Iterative, nonreducing polyketide synthases (NR-PKSs) are multidomain enzymes r

140 Nonreducing iterative polyketide synthases (NR-PKSs) are responsible for assem

141 emplate (PT) domains from fungal nonreducing polyketide synthases (NR-PKSs) are responsible for contr

142 The fungal iterative nonreducing polyketide synthases (NRPKSs) synthesize aromatic polyke

143 by a hybrid nonribosomal peptide synthetase-polyketide synthase (NRPS-PKS) system of the trans-acyl

144 n termination mechanism is described for the polyketide synthase of curacin A, an anticancer lead com

145 n is described for the loading module of the polyketide synthase of curacin A, an anticancer lead der

146 idated this system by expressing nonreducing polyketide synthases of Aspergillus terreus and addition

147 hat employs the final two monomodular type I polyketide synthases of the pikromycin pathway in vitro

148 re the extent of phosphopantetheinylation of polyketide synthase (PKS) acyl carrier protein (ACP) dom

149 tes and virulence factors biosynthesized via polyketide synthase (PKS) and nonribosomal peptide synth

150 en reading frames (ORFs), encoding a type II polyketide synthase (PKS) and tailoring enzymes as well

151 lic fatty acid synthase of type 1 (FAS1) and polyketide synthase (PKS) and the down-regulation of the

152 eaturing an acyltransferase (AT)-less type I polyketide synthase (PKS) and three tailoring enzymes Mg

153 olide B synthase (DEBS) and pikromycin (Pik) polyketide synthase (PKS) are unique multifunctional enz

154 nd sequenced, and shown to possess a type II polyketide synthase (PKS) at its core.

155 ential to both fatty acid synthase (FAS) and polyketide synthase (PKS) biosynthetic pathways, yet rel

156 omain FosDH1 from module 1 of the fostriecin polyketide synthase (PKS) catalyzed the stereospecific i

157 onribosomal polypeptide synthetase (NRPS) or polyketide synthase (PKS) domains.

158 r nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) enzyme complexes by a conserve

159 of bioactive natural products synthesized by polyketide synthase (PKS) enzyme complexes predominantly

160 n postulated to be synthesized by a type III polyketide synthase (PKS) enzyme, but so far type III PK

161 Polyketide synthase (PKS) enzymes continue to hold great

162 ducts are produced by multifunctional type I polyketide synthase (PKS) enzymes that operate as biosyn

163 The actinorhodin (act) minimal polyketide synthase (PKS) from Streptomyces coelicolor c

164 athway, we report a differentially expressed polyketide synthase (PKS) gene candidate.

165 son mutagenesis, we identified a stand-alone polyketide synthase (PKS) gene cluster required for the

166 Here, we identified and deleted a polyketide synthase (PKS) gene PfmaE and showed that it

167 Type I polyketide synthase (PKS) genes consist of modules appro

168 Deletion of the polyketide synthase (pks) genotoxic island from E. coli

169 The PLM polyketide synthase (PKS) has the predicted dehydratase

170 nt antibiotic produced via a trans-AT Type I polyketide synthase (PKS) in Pseudomonas fluorescens, co

171 These techniques were applied to CalE8, the polyketide synthase (PKS) involved in calicheamicin bios

172 Detailed analysis of the modular Type I polyketide synthase (PKS) involved in the biosynthesis o

173 The type II polyketide synthase (PKS) is a complex consisting of 5-1

174 The programming of the fungal polyketide synthase (PKS) is quite complex, with a simpl

175 The polyketide synthase (PKS) mega-enzyme assembly line uses

176 tide ring oxidation, and at least one of the polyketide synthase (PKS) megagenes, tylGI.

177 ybrid nonribosomal peptide synthetase (NRPS)/polyketide synthase (PKS) megasynthase followed by the t

178 h nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) modules acting along with cata

179 The potential for recombining intact polyketide synthase (PKS) modules has been extensively e

180 his moiety, the gem-dimethyl group producing polyketide synthase (PKS) modules of yersiniabactin and

181 nits through the use of dedicated initiation polyketide synthase (PKS) modules offers opportunities t

182 mains of cryptic function are often found in polyketide synthase (PKS) modules that produce epimerize

183 , encodes a trans-acyltransferase (trans-AT) polyketide synthase (PKS) multienzyme that was hypothesi

184 by heterologous complementation of enediyne polyketide synthase (PKS) mutants from the C-1027 produc

185 HR) and a non-reducing (NR) iterative type I polyketide synthase (PKS) pair.

186 Metabolic engineering of polyketide synthase (PKS) pathways represents a promisin

187 The virulent gene island polyketide synthase (pks) produces the secondary metabol

188 en 77 and 80 kb and encode five multimodular polyketide synthase (PKS) proteins, a hydroxymethylgluta

189 erythronolide B synthase (DEBS) is a modular polyketide synthase (PKS) responsible for the biosynthes

190 f multidomain type I fatty acid synthase and polyketide synthase (PKS) systems.

191 To elucidate early post polyketide synthase (PKS) tailoring steps of the landomy

192 nd the characterization of a highly reducing polyketide synthase (PKS) that acts in both a sequential

193 olyketides are biosynthesized by the type II polyketide synthase (PKS) that consists of 5-10 stand-al

194 antibiotic erythromycin, is synthesized by a polyketide synthase (PKS) that has emerged as the protot

195 core has been predicted to be initiated by a polyketide synthase (PKS) that is distinct from all know

196 ycin/methymycin synthase (PICS) is a modular polyketide synthase (PKS) that is responsible for the bi

197 mains (DHs) of the iso-migrastatin (iso-MGS) polyketide synthase (PKS) were investigated by systemati

198 ) from Streptomyces coelicolor is a type III polyketide synthase (PKS) with broad substrate flexibili

199 acyl carrier protein (ACP) component of the polyketide synthase (PKS), and it has been shown that a

200 a chersina previously identified an enediyne polyketide synthase (PKS), but no anthraquinone PKS, sug

201 in, which exhibits a putative combination of polyketide synthase (PKS), non-ribosomal peptide synthet

202 viously identified as a cluster containing a polyketide synthase (PKS)-encoding (FUB1) and four addit

203 Curacin A is a polyketide synthase (PKS)-non-ribosomal peptide syntheta

204 nt anticancer natural products produced by a polyketide synthase (PKS)-nonribosomal peptide synthetas

205 ticancer activity that are biosynthesized by polyketide synthase (PKS)-nonribosomal peptide synthetas

206 hesis of lovastatin uses an iterative type I polyketide synthase (PKS).

207 chain, which is synthesized by an iterative polyketide synthase (PKS).

208 by using a dissected and reassembled fungal polyketide synthase (PKS).

209 d biosynthesis or protein engineering of the polyketide synthase (PKS).

210 on, is catalyzed by an enzyme complex called polyketide synthase (PKS).

211 m non-ribosomal peptide synthetase (NRPS) or polyketide synthase (PKS).

212 tase (NRPS)-acyltransferase (AT)-less type I polyketide synthase (PKS).

213 ural product macrocycles generated by hybrid polyketide synthase (PKS)/nonribosomal peptide synthetas

214 Our examination of the 27 polyketide synthases (PKS) in A. nidulans revealed that

215 Non-ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) produce numerous secondary me

216 compounds is proposed to involve two fungal polyketide synthases (PKS) that function collaboratively

217 Nonribosomal peptide synthetases (NRPS), polyketide synthases (PKS), and hybrid NRPS/PKS are of p

218 line-like multiprotein complexes of modular polyketide synthases (PKS).

219 le that targets the thioesterase activity of polyketide synthase Pks13, an essential enzyme that form

220 gene deletion verified that the F. fujikuroi polyketide synthase PKS13, designated Gpy1, is responsib

221 22) and a 6-domain reducing iterative type I polyketide synthase (Pks15/1) for production of p-hydrox

222 ing the norsolorinic acid anthrone-producing polyketide synthase, PksA, from the aflatoxin biosynthet

223 Previous work identified enediyne-specific polyketide synthases (PKSEs) that can be phylogeneticall

224 tion and functionalization encoded by type I polyketide synthase (PKSs), cascade reactions can take p

225 Insights into how bacterial polyketide synthases (PKSs) acquire new metabolic capabi

226 tural families is determined by the enediyne polyketide synthases (PKSs) alone.

227 id lactone (TAL) is a signature byproduct of polyketide synthases (PKSs) and a valuable synthetic pre

228 The final transformation catalyzed by both polyketide synthases (PKSs) and fatty acid synthases is

229 Modular polyketide synthases (PKSs) and nonribosomal peptide syn

230 Bacterial type I polyketide synthases (PKSs) are complex, multifunctional

231 Nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs) are large enzymes responsibl

232 Iterative polyketide synthases (PKSs) are large, multifunctional e

233 Acyltransferase (AT)-less type I polyketide synthases (PKSs) break the type I PKS paradig

234 The dehydratases (DHs) of modular polyketide synthases (PKSs) catalyze dehydrations that o

235 Polyketide synthases (PKSs) catalyze the production of n

236 Ketoreductase (KR) domains from modular polyketide synthases (PKSs) catalyze the reduction of 2-

237 Modular polyketide synthases (PKSs) direct the biosynthesis of c

238 nonribosomal peptide synthetases (NRPSs) or polyketide synthases (PKSs) found in the biosynthetic pa

239 Biochemical characterization of polyketide synthases (PKSs) has relied on synthetic subs

240 Engineering modular polyketide synthases (PKSs) has the potential to be an e

241 Multimodular polyketide synthases (PKSs) have an assembly line archit

242 PKS11 is one of three type III polyketide synthases (PKSs) identified in Mycobacterium

243 most of the fatty acid synthases (FASs) and polyketide synthases (PKSs) known to date are characteri

244 The mechanistic details of many polyketide synthases (PKSs) remain elusive due to the in

245 Polyketide synthases (PKSs) represent a powerful catalyt

246 Type III polyketide synthases (PKSs) show diverse cyclization spe

247 e alkylresorcinol synthases (ARSs), type III polyketide synthases (PKSs) that produce 5-alkylresorcin

248 However, manipulation of modular type I polyketide synthases (PKSs) to make unnatural metabolite

249 Polyketide synthases (PKSs) use chemistry similar to fat

250 polyketide intermediates are set by modular polyketide synthases (PKSs) when condensation is not imm

251 Type I polyketide synthases (PKSs), and related fatty acid synt

252 iosynthetic machinery, represented by type I polyketide synthases (PKSs), has an architecture in whic

253 rbon framework is assembled by two iterative polyketide synthases (PKSs), Hpm8 (highly reducing) and

254 Multimodular enzymes, including polyketide synthases (PKSs), nonribosomal peptide synthe

255 the biosynthesis of polyketide backbones by polyketide synthases (PKSs), post-PKS modifications resu

256 Type I modular polyketide synthases (PKSs), which are responsible for t

257 The plant type III polyketide synthases (PKSs), which produce diverse secon

258 H enzymes in fatty acid synthases (FASs) and polyketide synthases (PKSs).

259 and sequencing of genes encoding a number of polyketide synthases (PKSs).

260 nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs).

261 portant natural products produced by type II polyketide synthases (PKSs).

262 a spontaneous point mutation in the putative polyketide synthase PpsD that results in a G44C amino ac

263 of mellein by a partially reducing iterative polyketide synthase (PR-PKS) as a pentaketide product.

264 ar compounds (marginolactones) are formed by polyketide synthases primed not with gamma-aminobutanoyl

265 thase (DEBS) is a prototypical assembly line polyketide synthase produced by the actinomycete Sacchar

266 rmations responsible for converting the post-polyketide synthase product into the exciting anticancer

267 ort the characterization of a novel Type III polyketide synthase, quinolone synthase (QNS), from A. m

268 Two novel type III polyketide synthases, quinolone synthase (QNS) and acrid

269 of programming of iterative highly reducing polyketide synthases remains one of the key unsolved pro

270 The polyketide synthases responsible for the biosynthesis of

271 fatty acyl-CoA serves as a starter unit for polyketide synthases, resulting in the formation of 5-pe

272 the hybrid nonribosomal peptide synthetases/polyketide synthase rifamycin biosynthetic cluster of Am

273 ng 3-amino-5-hydroxybenzoic acid (AHBA), the polyketide synthase starter unit of both natural product

274 hioluteus catalyzes the formation of unusual polyketide synthase starter unit p-nitrobenzoic acid (pN

275 ing an extensive literature on assembly line polyketide synthases such as the 6-deoxyerythronolide B

276 ormed by an iterative highly reducing fungal polyketide synthase supported by a hydrolase, together w

277 unctional analysis of three soil DNA-derived polyketide synthase systems in Streptomyces albus reveal

278 The S. tropica genome features polyketide synthase systems of every known formally clas

279 , we have constructed pathways involving two polyketide synthase systems, and we show that fluoroacet

280 mediating substrate specificity of bacterial polyketide synthase TEs.

281 by DynE8, a highly reducing iterative type I polyketide synthase that assembles polyketide intermedia

282 Tylactone synthase (TYLS) is a modular polyketide synthase that catalyzes the formation of tyla

283 OTC is synthesized by a type II polyketide synthase that generates the poly-beta-ketone

284 e show that chlorizidine A is assembled by a polyketide synthase that uniquely incorporates a fatty a

285 polyketide biosynthesis mediated by trans-AT polyketide synthases that lack integrated acyl transfera

286 The unique ability of the pikromycin (Pik) polyketide synthase to generate 12- and 14-membered ring

287 influences the ability of the OTC "minimal" polyketide synthase to make a polyketide product of the

288 The minimal ssf polyketide synthase together with the amidotransferase S

289 ding frames that encode three modular type I polyketide synthases (TtmHIJ), one type II thioesterase

290 tory quinones, PkQs are produced by type III polyketide synthases using fatty acyl-CoA precursors.

291 licolor RppA (Sc-RppA), a bacterial type III polyketide synthase, utilizes malonyl-CoA as both starte

292 s of DynE8, fatty acid synthase, and modular polyketide synthases, we overexpressed a 44-kDa fragment

293 quence-specific synthesis by the ribosome to polyketide synthases, where tethered molecules are passe

294 opolone nucleus: tropA encodes a nonreducing polyketide synthase which releases 3-methylorcinaldehyde

295 y, terpenoid pathways, cytochrome P450s, and polyketide synthases, which may contribute to the produc

296 nthetases, and to the related fatty acid and polyketide synthases, will further our biophysical under

297 We also characterized a truncated polyketide synthase with a ketoreductase function that c

298 suggest that Pks15/1 is an iterative type I polyketide synthase with a relaxed control of catalytic

299 ltransferase domain of module 6 of rifamycin polyketide synthase with that of module 2 of rapamycin p

300 gested to be the product of a modular type I polyketide synthase working in trans with two monofuncti