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1 se and an oxygenase, in addition to the core polyketide synthase.
2 ormed by biphenyl synthase (BIS), a type III polyketide synthase.
3 the organization displayed by this singular polyketide synthase.
4 he programming selectivities of the tenellin polyketide synthase.
5 it formation to the ACPs integrated into the polyketide synthase.
6 line skeleton is biosynthesized by a type II polyketide synthase.
7 higher than that of any other known type III polyketide synthase.
8 ase activity missing from two modules of the polyketide synthase.
9 synthase with that of module 2 of rapamycin polyketide synthase.
10 BonMT2 from module 2 of the bongkrekic acid polyketide synthase.
11 e mechanism of natural evolution for modular polyketide synthases.
12 quinolone and acridone alkaloid by type III polyketide synthases.
13 e clade of the functionally diverse type III polyketide synthases.
14 onyl-CoA, a common substrate of multimodular polyketide synthases.
15 tituted components from a variety of modular polyketide synthases.
16 d, much like an in vitro version of Nature's polyketide synthases.
17 chalcone synthase families of fatty acid and polyketide synthases.
18 yketides biosynthesized by bacterial type II polyketide synthases.
19 cillaene, difficidin, and mupirocin trans-AT polyketide synthases.
20 -amino acids and other elements derived from polyketide synthases.
21 jacent rppA gene, which encodes the type III polyketide synthase, 1,3,6,8-tetrahydroxynaphthalene syn
23 toacyl-acyl-carrier protein (ACP) synthases, polyketide synthases, 3-hydroxy-3-methylglutaryl-CoA syn
24 investigation of the model type I iterative polyketide synthase 6-methylsalicylic acid synthase (6-M
25 of ACP domains of the erythromycin precursor polyketide synthase, 6-deoxyerythronolide B synthase (DE
27 etic metabolon (ACYL COENZYME A SYNTHETASE5, POLYKETIDE SYNTHASE A [PKSA], PKSB, and TETRAKETIDE alph
28 structural analyses of the TE/CLC domain in polyketide synthase A, the multidomain PKS central to th
29 d by the combined action of a modular Type-I polyketide synthase, a conserved set of enzymes involved
33 bitor occurs in root hair cells, involving a polyketide synthase activity that utilizes an atypical 1
34 nd CTB3 genes that encode, respectively, the polyketide synthase and a dual methyltransferase/monooxy
35 cluster, followed by characterization of the polyketide synthase and acyltransferase involved in bios
36 iochemical and structural similarity between polyketide synthase and fatty acid synthase enzymology.
38 ne backbone is biosynthesized by the minimal polyketide synthases and an amidotransferase homologue O
39 on and release from six of these nonreducing polyketide synthases and have identified the products.
40 and di-domain ARO/CYCs in bacterial type II polyketide synthases and lays the groundwork for enginee
41 te pathway that is extended by the action of polyketide synthases and non-ribosomal peptide synthetas
43 ers are converted by thioesterase domains of polyketide synthases and nonribosomal peptide synthetase
46 lism is shown by gene expression analyses of polyketide synthases and the determination of the second
47 module and intermodule substrate transfer in polyketide synthases, and establishes a new model for mo
48 Nonribosomal peptide synthetases (NRPSs) and polyketide synthases are large, multidomain enzymes that
50 Acyltransferase (AT) domains of multimodular polyketide synthases are the primary gatekeepers for ste
53 initiating and terminating an unusual type I polyketide synthase assembly line, and discover that mac
55 e hybrid nonribosomal peptide synthetase and polyketide synthase biosynthetic gene cluster is encoded
56 ibe a pathway to chloroethylmalonyl-CoA as a polyketide synthase building block in the biosynthesis o
57 n the dark: the fermentation products of the polyketide synthase CalE8 (without its cognate thioester
59 Furthermore, in vitro investigations of the polyketide synthase central to cercosporin biosynthesis
60 ction of atrochrysone carboxylic acid by the polyketide synthase ClaG and the beta-lactamase ClaF.
61 a shunt product in all related non-reducing polyketide synthase clusters containing homologues of Tp
62 s); each encodes acyltransferase-less type I polyketide synthases commensurate with iso-migrastatin b
63 oding hybrid nonribosomal peptide synthetase/polyketide synthases consistent with thalassospiramide a
64 ation and heterologous expression of type II polyketide synthase-containing eDNA clones is reported h
66 MAL cluster, we identified malleilactone, a polyketide synthase-derived cytotoxic siderophore encode
67 of the biosynthesis of an important group of polyketide synthase-derived mycobacterial lipids, and su
68 a highly biologically active lipid species-a polyketide synthase-derived phenolic glycolipid (PGL) pr
69 associated with the production by HN878 of a polyketide synthase-derived phenolic glycolipid (PGL), a
72 conducted rational domain swaps between the polyketide synthases encoding the biosynthesis of the cl
73 nated when both the tpc and enc non-reducing polyketide synthase-encoding genes, tpcC and encA, respe
75 ly required for the release of products from polyketide synthase enzymes, but no such enzyme has been
76 inition: A long-standing paradigm in modular polyketide synthase enzymology, namely the definition of
77 chloroethylmalonyl-CoA, a novel halogenated polyketide synthase extender unit of the proteasome inhi
78 important step toward harnessing these rare polyketide synthase extender units for combinatorial bio
80 antroquinonol biosynthesis in mycelium, and polyketide synthase for antrocamphin biosynthesis in fru
84 recently a large trans-acyltransferase (AT) polyketide synthase gene cluster responsible for the bio
85 g the DNA flanking the insertions revealed a polyketide synthase gene cluster that would encode three
86 ow describe a method for rapidly recombining polyketide synthase gene clusters to replace, add or rem
89 tants showed significant upregulation of the polyketide synthase genes ppsA-ppsE and drrA, which cons
96 teins of several families including type-III polyketide synthases, hydrolases, and cytochrome P450s r
97 e, can be incorporated by the actions of the polyketide synthase III (KSIII) AsuC3/C4 as well as the
100 of a hybrid nonribosomal peptide synthetase/polyketide synthase in the myxobacterium Sorangium cellu
101 e for the mandatory homodimeric structure of polyketide synthases, in contrast to the monomeric nonri
102 r protein-thioesterase linker from a modular polyketide synthase, increased mobility of the thioester
105 oxin B1, is one of the multidomain iterative polyketide synthases (IPKSs), a large, poorly understood
106 l polyketide intermediate from the iterative polyketide synthases (iPKSs), most frequently by a thioe
108 s involves a pair of collaborating iterative polyketide synthases (iPKSs): a highly reducing iPKS wit
111 Chalcone synthase (CHS), a type III plant polyketide synthase, is critical for flavonoid biosynthe
112 nge assay directly establishes that specific polyketide synthase ketoreductase domains also have an i
116 hat encode three acyltransferase-less type I polyketide synthases (MgsEFG), one discrete acyltransfer
117 lly, we introduced the S148C mutation into a polyketide synthase module (PikAIII-TE) to impart increa
120 e course of the enigmatic iterative use of a polyketide synthase module was deduced from targeted dom
124 yketide natural products produced on modular polyketide synthase multienzymes by an assembly-line pro
128 ketide/amino acid structure encodes a hybrid polyketide synthase nonribosomal peptide synthetase (PKS
129 d substrate specificities during assembly by polyketide synthases, nonribosomal peptide synthetases,
130 ay-specific enzyme CpaS, a hybrid two module polyketide synthase-nonribosomal peptide synthetase (PKS
132 c gene cluster contains only a single-module polyketide synthase-nonribosomal peptide synthetase (PKS
133 erial strains and contains an unusual hybrid polyketide synthase-nonribosomal peptide synthetase, whi
135 aced, en masse, the promoters of nonreducing polyketide synthase (NR-PKS) genes, key genes in NP bios
137 of fungal nonreducing, multidomain iterative polyketide synthases (NR-PKS group of IPKSs) results fro
141 emplate (PT) domains from fungal nonreducing polyketide synthases (NR-PKSs) are responsible for contr
143 by a hybrid nonribosomal peptide synthetase-polyketide synthase (NRPS-PKS) system of the trans-acyl
144 n termination mechanism is described for the polyketide synthase of curacin A, an anticancer lead com
145 n is described for the loading module of the polyketide synthase of curacin A, an anticancer lead der
146 idated this system by expressing nonreducing polyketide synthases of Aspergillus terreus and addition
147 hat employs the final two monomodular type I polyketide synthases of the pikromycin pathway in vitro
148 re the extent of phosphopantetheinylation of polyketide synthase (PKS) acyl carrier protein (ACP) dom
149 tes and virulence factors biosynthesized via polyketide synthase (PKS) and nonribosomal peptide synth
150 en reading frames (ORFs), encoding a type II polyketide synthase (PKS) and tailoring enzymes as well
151 lic fatty acid synthase of type 1 (FAS1) and polyketide synthase (PKS) and the down-regulation of the
152 eaturing an acyltransferase (AT)-less type I polyketide synthase (PKS) and three tailoring enzymes Mg
153 olide B synthase (DEBS) and pikromycin (Pik) polyketide synthase (PKS) are unique multifunctional enz
155 ential to both fatty acid synthase (FAS) and polyketide synthase (PKS) biosynthetic pathways, yet rel
156 omain FosDH1 from module 1 of the fostriecin polyketide synthase (PKS) catalyzed the stereospecific i
158 r nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) enzyme complexes by a conserve
159 of bioactive natural products synthesized by polyketide synthase (PKS) enzyme complexes predominantly
160 n postulated to be synthesized by a type III polyketide synthase (PKS) enzyme, but so far type III PK
162 ducts are produced by multifunctional type I polyketide synthase (PKS) enzymes that operate as biosyn
165 son mutagenesis, we identified a stand-alone polyketide synthase (PKS) gene cluster required for the
170 nt antibiotic produced via a trans-AT Type I polyketide synthase (PKS) in Pseudomonas fluorescens, co
171 These techniques were applied to CalE8, the polyketide synthase (PKS) involved in calicheamicin bios
172 Detailed analysis of the modular Type I polyketide synthase (PKS) involved in the biosynthesis o
177 ybrid nonribosomal peptide synthetase (NRPS)/polyketide synthase (PKS) megasynthase followed by the t
178 h nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) modules acting along with cata
180 his moiety, the gem-dimethyl group producing polyketide synthase (PKS) modules of yersiniabactin and
181 nits through the use of dedicated initiation polyketide synthase (PKS) modules offers opportunities t
182 mains of cryptic function are often found in polyketide synthase (PKS) modules that produce epimerize
183 , encodes a trans-acyltransferase (trans-AT) polyketide synthase (PKS) multienzyme that was hypothesi
184 by heterologous complementation of enediyne polyketide synthase (PKS) mutants from the C-1027 produc
188 en 77 and 80 kb and encode five multimodular polyketide synthase (PKS) proteins, a hydroxymethylgluta
189 erythronolide B synthase (DEBS) is a modular polyketide synthase (PKS) responsible for the biosynthes
192 nd the characterization of a highly reducing polyketide synthase (PKS) that acts in both a sequential
193 olyketides are biosynthesized by the type II polyketide synthase (PKS) that consists of 5-10 stand-al
194 antibiotic erythromycin, is synthesized by a polyketide synthase (PKS) that has emerged as the protot
195 core has been predicted to be initiated by a polyketide synthase (PKS) that is distinct from all know
196 ycin/methymycin synthase (PICS) is a modular polyketide synthase (PKS) that is responsible for the bi
197 mains (DHs) of the iso-migrastatin (iso-MGS) polyketide synthase (PKS) were investigated by systemati
198 ) from Streptomyces coelicolor is a type III polyketide synthase (PKS) with broad substrate flexibili
199 acyl carrier protein (ACP) component of the polyketide synthase (PKS), and it has been shown that a
200 a chersina previously identified an enediyne polyketide synthase (PKS), but no anthraquinone PKS, sug
201 in, which exhibits a putative combination of polyketide synthase (PKS), non-ribosomal peptide synthet
202 viously identified as a cluster containing a polyketide synthase (PKS)-encoding (FUB1) and four addit
204 nt anticancer natural products produced by a polyketide synthase (PKS)-nonribosomal peptide synthetas
205 ticancer activity that are biosynthesized by polyketide synthase (PKS)-nonribosomal peptide synthetas
213 ural product macrocycles generated by hybrid polyketide synthase (PKS)/nonribosomal peptide synthetas
215 Non-ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) produce numerous secondary me
216 compounds is proposed to involve two fungal polyketide synthases (PKS) that function collaboratively
217 Nonribosomal peptide synthetases (NRPS), polyketide synthases (PKS), and hybrid NRPS/PKS are of p
219 le that targets the thioesterase activity of polyketide synthase Pks13, an essential enzyme that form
220 gene deletion verified that the F. fujikuroi polyketide synthase PKS13, designated Gpy1, is responsib
221 22) and a 6-domain reducing iterative type I polyketide synthase (Pks15/1) for production of p-hydrox
222 ing the norsolorinic acid anthrone-producing polyketide synthase, PksA, from the aflatoxin biosynthet
223 Previous work identified enediyne-specific polyketide synthases (PKSEs) that can be phylogeneticall
224 tion and functionalization encoded by type I polyketide synthase (PKSs), cascade reactions can take p
227 id lactone (TAL) is a signature byproduct of polyketide synthases (PKSs) and a valuable synthetic pre
228 The final transformation catalyzed by both polyketide synthases (PKSs) and fatty acid synthases is
231 Nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs) are large enzymes responsibl
236 Ketoreductase (KR) domains from modular polyketide synthases (PKSs) catalyze the reduction of 2-
238 nonribosomal peptide synthetases (NRPSs) or polyketide synthases (PKSs) found in the biosynthetic pa
243 most of the fatty acid synthases (FASs) and polyketide synthases (PKSs) known to date are characteri
247 e alkylresorcinol synthases (ARSs), type III polyketide synthases (PKSs) that produce 5-alkylresorcin
248 However, manipulation of modular type I polyketide synthases (PKSs) to make unnatural metabolite
250 polyketide intermediates are set by modular polyketide synthases (PKSs) when condensation is not imm
252 iosynthetic machinery, represented by type I polyketide synthases (PKSs), has an architecture in whic
253 rbon framework is assembled by two iterative polyketide synthases (PKSs), Hpm8 (highly reducing) and
255 the biosynthesis of polyketide backbones by polyketide synthases (PKSs), post-PKS modifications resu
262 a spontaneous point mutation in the putative polyketide synthase PpsD that results in a G44C amino ac
263 of mellein by a partially reducing iterative polyketide synthase (PR-PKS) as a pentaketide product.
264 ar compounds (marginolactones) are formed by polyketide synthases primed not with gamma-aminobutanoyl
265 thase (DEBS) is a prototypical assembly line polyketide synthase produced by the actinomycete Sacchar
266 rmations responsible for converting the post-polyketide synthase product into the exciting anticancer
267 ort the characterization of a novel Type III polyketide synthase, quinolone synthase (QNS), from A. m
269 of programming of iterative highly reducing polyketide synthases remains one of the key unsolved pro
271 fatty acyl-CoA serves as a starter unit for polyketide synthases, resulting in the formation of 5-pe
272 the hybrid nonribosomal peptide synthetases/polyketide synthase rifamycin biosynthetic cluster of Am
273 ng 3-amino-5-hydroxybenzoic acid (AHBA), the polyketide synthase starter unit of both natural product
274 hioluteus catalyzes the formation of unusual polyketide synthase starter unit p-nitrobenzoic acid (pN
275 ing an extensive literature on assembly line polyketide synthases such as the 6-deoxyerythronolide B
276 ormed by an iterative highly reducing fungal polyketide synthase supported by a hydrolase, together w
277 unctional analysis of three soil DNA-derived polyketide synthase systems in Streptomyces albus reveal
279 , we have constructed pathways involving two polyketide synthase systems, and we show that fluoroacet
281 by DynE8, a highly reducing iterative type I polyketide synthase that assembles polyketide intermedia
284 e show that chlorizidine A is assembled by a polyketide synthase that uniquely incorporates a fatty a
285 polyketide biosynthesis mediated by trans-AT polyketide synthases that lack integrated acyl transfera
286 The unique ability of the pikromycin (Pik) polyketide synthase to generate 12- and 14-membered ring
287 influences the ability of the OTC "minimal" polyketide synthase to make a polyketide product of the
289 ding frames that encode three modular type I polyketide synthases (TtmHIJ), one type II thioesterase
290 tory quinones, PkQs are produced by type III polyketide synthases using fatty acyl-CoA precursors.
291 licolor RppA (Sc-RppA), a bacterial type III polyketide synthase, utilizes malonyl-CoA as both starte
292 s of DynE8, fatty acid synthase, and modular polyketide synthases, we overexpressed a 44-kDa fragment
293 quence-specific synthesis by the ribosome to polyketide synthases, where tethered molecules are passe
294 opolone nucleus: tropA encodes a nonreducing polyketide synthase which releases 3-methylorcinaldehyde
295 y, terpenoid pathways, cytochrome P450s, and polyketide synthases, which may contribute to the produc
296 nthetases, and to the related fatty acid and polyketide synthases, will further our biophysical under
298 suggest that Pks15/1 is an iterative type I polyketide synthase with a relaxed control of catalytic
299 ltransferase domain of module 6 of rifamycin polyketide synthase with that of module 2 of rapamycin p
300 gested to be the product of a modular type I polyketide synthase working in trans with two monofuncti
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