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1 se and an oxygenase, in addition to the core polyketide synthase.
2 ormed by biphenyl synthase (BIS), a type III polyketide synthase.
3  the organization displayed by this singular polyketide synthase.
4 he programming selectivities of the tenellin polyketide synthase.
5 it formation to the ACPs integrated into the polyketide synthase.
6 line skeleton is biosynthesized by a type II polyketide synthase.
7 higher than that of any other known type III polyketide synthase.
8 ase activity missing from two modules of the polyketide synthase.
9  synthase with that of module 2 of rapamycin polyketide synthase.
10  BonMT2 from module 2 of the bongkrekic acid polyketide synthase.
11 e mechanism of natural evolution for modular polyketide synthases.
12  quinolone and acridone alkaloid by type III polyketide synthases.
13 e clade of the functionally diverse type III polyketide synthases.
14 onyl-CoA, a common substrate of multimodular polyketide synthases.
15 tituted components from a variety of modular polyketide synthases.
16 d, much like an in vitro version of Nature's polyketide synthases.
17 chalcone synthase families of fatty acid and polyketide synthases.
18 yketides biosynthesized by bacterial type II polyketide synthases.
19 cillaene, difficidin, and mupirocin trans-AT polyketide synthases.
20 -amino acids and other elements derived from polyketide synthases.
21 jacent rppA gene, which encodes the type III polyketide synthase, 1,3,6,8-tetrahydroxynaphthalene syn
22 cific lipid branching patterns introduced by polyketide synthase 12 (pks12).
23 toacyl-acyl-carrier protein (ACP) synthases, polyketide synthases, 3-hydroxy-3-methylglutaryl-CoA syn
24  investigation of the model type I iterative polyketide synthase 6-methylsalicylic acid synthase (6-M
25 of ACP domains of the erythromycin precursor polyketide synthase, 6-deoxyerythronolide B synthase (DE
26                         ACYL-COA SYNTHETASE, POLYKETIDE SYNTHASE A (PKSA) and PKSB, TETRAKETIDE alpha
27 etic metabolon (ACYL COENZYME A SYNTHETASE5, POLYKETIDE SYNTHASE A [PKSA], PKSB, and TETRAKETIDE alph
28  structural analyses of the TE/CLC domain in polyketide synthase A, the multidomain PKS central to th
29 d by the combined action of a modular Type-I polyketide synthase, a conserved set of enzymes involved
30           It encodes a chimeric multimodular polyketide synthase, a nonribosomal peptide synthetase,
31        The interplay of a dedicated type III polyketide synthase, a prenyl diphosphate synthase, and
32 re is no model available for a fungal type I polyketide synthase ACP.
33 bitor occurs in root hair cells, involving a polyketide synthase activity that utilizes an atypical 1
34 nd CTB3 genes that encode, respectively, the polyketide synthase and a dual methyltransferase/monooxy
35 cluster, followed by characterization of the polyketide synthase and acyltransferase involved in bios
36 iochemical and structural similarity between polyketide synthase and fatty acid synthase enzymology.
37                  Microbially derived modular polyketide synthase and nonribosomal peptide synthetase
38 ne backbone is biosynthesized by the minimal polyketide synthases and an amidotransferase homologue O
39 on and release from six of these nonreducing polyketide synthases and have identified the products.
40  and di-domain ARO/CYCs in bacterial type II polyketide synthases and lays the groundwork for enginee
41 te pathway that is extended by the action of polyketide synthases and non-ribosomal peptide synthetas
42                             In mycobacteria, polyketide synthases and nonribosomal peptide synthetase
43 ers are converted by thioesterase domains of polyketide synthases and nonribosomal peptide synthetase
44                    2) An important subset of polyketide synthases and nonribosomal peptide synthetase
45          Structural conservation with type I polyketide synthases and related fatty-acid synthases al
46 lism is shown by gene expression analyses of polyketide synthases and the determination of the second
47 module and intermodule substrate transfer in polyketide synthases, and establishes a new model for mo
48 Nonribosomal peptide synthetases (NRPSs) and polyketide synthases are large, multidomain enzymes that
49                    Highly reducing iterative polyketide synthases are large, multifunctional enzymes
50 Acyltransferase (AT) domains of multimodular polyketide synthases are the primary gatekeepers for ste
51                               Type I modular polyketide synthases assemble diverse bioactive natural
52 nt tool for comparative analysis of trans-AT polyketide synthase assembly line architectures.
53 initiating and terminating an unusual type I polyketide synthase assembly line, and discover that mac
54 macrodiolide produced on a bacterial modular polyketide synthase assembly line.
55 e hybrid nonribosomal peptide synthetase and polyketide synthase biosynthetic gene cluster is encoded
56 ibe a pathway to chloroethylmalonyl-CoA as a polyketide synthase building block in the biosynthesis o
57 n the dark: the fermentation products of the polyketide synthase CalE8 (without its cognate thioester
58                                              Polyketide synthases cannot be functional unless their a
59  Furthermore, in vitro investigations of the polyketide synthase central to cercosporin biosynthesis
60 ction of atrochrysone carboxylic acid by the polyketide synthase ClaG and the beta-lactamase ClaF.
61  a shunt product in all related non-reducing polyketide synthase clusters containing homologues of Tp
62 s); each encodes acyltransferase-less type I polyketide synthases commensurate with iso-migrastatin b
63 oding hybrid nonribosomal peptide synthetase/polyketide synthases consistent with thalassospiramide a
64 ation and heterologous expression of type II polyketide synthase-containing eDNA clones is reported h
65 en fluorescent protein (GFP, 27 kDa) and the polyketide synthase DEBS1 (394 kDa).
66  MAL cluster, we identified malleilactone, a polyketide synthase-derived cytotoxic siderophore encode
67 of the biosynthesis of an important group of polyketide synthase-derived mycobacterial lipids, and su
68 a highly biologically active lipid species-a polyketide synthase-derived phenolic glycolipid (PGL) pr
69 associated with the production by HN878 of a polyketide synthase-derived phenolic glycolipid (PGL), a
70                                              Polyketide synthases elongate a polyketide backbone by c
71                                     Although polyketide synthase encoding genes have been successfull
72  conducted rational domain swaps between the polyketide synthases encoding the biosynthesis of the cl
73 nated when both the tpc and enc non-reducing polyketide synthase-encoding genes, tpcC and encA, respe
74 lly at three specific sites within the giant polyketide synthase-encoding genes.
75 ly required for the release of products from polyketide synthase enzymes, but no such enzyme has been
76 inition: A long-standing paradigm in modular polyketide synthase enzymology, namely the definition of
77  chloroethylmalonyl-CoA, a novel halogenated polyketide synthase extender unit of the proteasome inhi
78  important step toward harnessing these rare polyketide synthase extender units for combinatorial bio
79          A new series of coenzyme A-tethered polyketide synthase extender units were discovered in re
80  antroquinonol biosynthesis in mycelium, and polyketide synthase for antrocamphin biosynthesis in fru
81                             PhlD, a type III polyketide synthase from Pseudomonas fluorescens, cataly
82 y catalytic domains is critical for NRPS and polyketide synthase function.
83            The Strongylocentrotus purpuratus polyketide synthase gene (SpPks) encodes an enzyme requi
84  recently a large trans-acyltransferase (AT) polyketide synthase gene cluster responsible for the bio
85 g the DNA flanking the insertions revealed a polyketide synthase gene cluster that would encode three
86 ow describe a method for rapidly recombining polyketide synthase gene clusters to replace, add or rem
87   One is a cluster of four genes including a polyketide synthase gene, ausA.
88 attenuated mutants is interrupted in pks1, a polyketide synthase gene.
89 tants showed significant upregulation of the polyketide synthase genes ppsA-ppsE and drrA, which cons
90         We also found expansions in reducing polyketide synthase genes specific to the brown-rot fung
91 milarities in key genes such as 16S rRNA and polyketide synthase genes.
92                                 Many modular polyketide synthases harbor one or more redox-inactive d
93                    LovF is a highly reducing polyketide synthase (HR-PKS) from the filamentous fungus
94                              Highly reducing polyketide synthases (HR-PKSs) from fungi synthesize com
95 ies, yet the biosynthesis by highly reducing polyketide synthases (HRPKSs) remains enigmatic.
96 teins of several families including type-III polyketide synthases, hydrolases, and cytochrome P450s r
97 e, can be incorporated by the actions of the polyketide synthase III (KSIII) AsuC3/C4 as well as the
98       In this study we show that a bimodular polyketide synthase in conjunction with a fatty acyl-AMP
99           We found that a predicted type III polyketide synthase in the genome of the brown alga Ecto
100  of a hybrid nonribosomal peptide synthetase/polyketide synthase in the myxobacterium Sorangium cellu
101 e for the mandatory homodimeric structure of polyketide synthases, in contrast to the monomeric nonri
102 r protein-thioesterase linker from a modular polyketide synthase, increased mobility of the thioester
103                            Pks13 is a type I polyketide synthase involved in the final biosynthesis s
104                         The iterative type I polyketide synthases (IPKSs) are central to the biosynth
105 oxin B1, is one of the multidomain iterative polyketide synthases (IPKSs), a large, poorly understood
106 l polyketide intermediate from the iterative polyketide synthases (iPKSs), most frequently by a thioe
107                         Two fungal iterative polyketide synthases (IPKSs), Rdc5, the highly reducing
108 s involves a pair of collaborating iterative polyketide synthases (iPKSs): a highly reducing iPKS wit
109         Combinatorial biosynthesis of type I polyketide synthases is a promising approach for the gen
110   The role of interdomain linkers in modular polyketide synthases is poorly understood.
111    Chalcone synthase (CHS), a type III plant polyketide synthase, is critical for flavonoid biosynthe
112 nge assay directly establishes that specific polyketide synthase ketoreductase domains also have an i
113 eptide synthetase, which resembles iterative polyketide synthases known in fungi.
114         We report expression of a microalgal polyketide synthase-like PUFA synthase system, comprisin
115                            The final step in polyketide synthase-mediated biosynthesis of macrocyclic
116 hat encode three acyltransferase-less type I polyketide synthases (MgsEFG), one discrete acyltransfer
117 lly, we introduced the S148C mutation into a polyketide synthase module (PikAIII-TE) to impart increa
118                                        Every polyketide synthase module has an acyl carrier protein (
119                                   Thus, this polyketide synthase module showed considerable tolerance
120 e course of the enigmatic iterative use of a polyketide synthase module was deduced from targeted dom
121 e AT and the KS domains of this prototypical polyketide synthase module.
122                               The disorazole polyketide synthase modules lack an acyltransferase doma
123 ing both nonribosomal peptide synthetase and polyketide synthase modules.
124 yketide natural products produced on modular polyketide synthase multienzymes by an assembly-line pro
125 d substitution (R644W) in an uncharacterized polyketide synthase (MuPKS).
126                               We have used a polyketide synthase mutant that accumulates an elevated
127       Pathway engineering of the chartreusin polyketide synthase, mutational synthesis, and molecular
128 ketide/amino acid structure encodes a hybrid polyketide synthase nonribosomal peptide synthetase (PKS
129 d substrate specificities during assembly by polyketide synthases, nonribosomal peptide synthetases,
130 ay-specific enzyme CpaS, a hybrid two module polyketide synthase-nonribosomal peptide synthetase (PKS
131                 CpaS is a hybrid, two module polyketide synthase-nonribosomal peptide synthetase (PKS
132 c gene cluster contains only a single-module polyketide synthase-nonribosomal peptide synthetase (PKS
133 erial strains and contains an unusual hybrid polyketide synthase-nonribosomal peptide synthetase, whi
134 7, should thus be informative to the modular polyketide synthase novice and expert alike.
135 aced, en masse, the promoters of nonreducing polyketide synthase (NR-PKS) genes, key genes in NP bios
136                                A nonreducing polyketide synthase (NR-PKS) PhnA was shown to synthesiz
137 of fungal nonreducing, multidomain iterative polyketide synthases (NR-PKS group of IPKSs) results fro
138                       In fungal non-reducing polyketide synthases (NR-PKS) the acyl-carrier protein (
139                       Iterative, nonreducing polyketide synthases (NR-PKSs) are multidomain enzymes r
140                        Nonreducing iterative polyketide synthases (NR-PKSs) are responsible for assem
141 emplate (PT) domains from fungal nonreducing polyketide synthases (NR-PKSs) are responsible for contr
142             The fungal iterative nonreducing polyketide synthases (NRPKSs) synthesize aromatic polyke
143  by a hybrid nonribosomal peptide synthetase-polyketide synthase (NRPS-PKS) system of the trans-acyl
144 n termination mechanism is described for the polyketide synthase of curacin A, an anticancer lead com
145 n is described for the loading module of the polyketide synthase of curacin A, an anticancer lead der
146 idated this system by expressing nonreducing polyketide synthases of Aspergillus terreus and addition
147 hat employs the final two monomodular type I polyketide synthases of the pikromycin pathway in vitro
148 re the extent of phosphopantetheinylation of polyketide synthase (PKS) acyl carrier protein (ACP) dom
149 tes and virulence factors biosynthesized via polyketide synthase (PKS) and nonribosomal peptide synth
150 en reading frames (ORFs), encoding a type II polyketide synthase (PKS) and tailoring enzymes as well
151 lic fatty acid synthase of type 1 (FAS1) and polyketide synthase (PKS) and the down-regulation of the
152 eaturing an acyltransferase (AT)-less type I polyketide synthase (PKS) and three tailoring enzymes Mg
153 olide B synthase (DEBS) and pikromycin (Pik) polyketide synthase (PKS) are unique multifunctional enz
154 nd sequenced, and shown to possess a type II polyketide synthase (PKS) at its core.
155 ential to both fatty acid synthase (FAS) and polyketide synthase (PKS) biosynthetic pathways, yet rel
156 omain FosDH1 from module 1 of the fostriecin polyketide synthase (PKS) catalyzed the stereospecific i
157 onribosomal polypeptide synthetase (NRPS) or polyketide synthase (PKS) domains.
158 r nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) enzyme complexes by a conserve
159 of bioactive natural products synthesized by polyketide synthase (PKS) enzyme complexes predominantly
160 n postulated to be synthesized by a type III polyketide synthase (PKS) enzyme, but so far type III PK
161                                              Polyketide synthase (PKS) enzymes continue to hold great
162 ducts are produced by multifunctional type I polyketide synthase (PKS) enzymes that operate as biosyn
163               The actinorhodin (act) minimal polyketide synthase (PKS) from Streptomyces coelicolor c
164 athway, we report a differentially expressed polyketide synthase (PKS) gene candidate.
165 son mutagenesis, we identified a stand-alone polyketide synthase (PKS) gene cluster required for the
166            Here, we identified and deleted a polyketide synthase (PKS) gene PfmaE and showed that it
167                                       Type I polyketide synthase (PKS) genes consist of modules appro
168                              Deletion of the polyketide synthase (pks) genotoxic island from E. coli
169                                      The PLM polyketide synthase (PKS) has the predicted dehydratase
170 nt antibiotic produced via a trans-AT Type I polyketide synthase (PKS) in Pseudomonas fluorescens, co
171  These techniques were applied to CalE8, the polyketide synthase (PKS) involved in calicheamicin bios
172      Detailed analysis of the modular Type I polyketide synthase (PKS) involved in the biosynthesis o
173                                  The type II polyketide synthase (PKS) is a complex consisting of 5-1
174                The programming of the fungal polyketide synthase (PKS) is quite complex, with a simpl
175                                          The polyketide synthase (PKS) mega-enzyme assembly line uses
176 tide ring oxidation, and at least one of the polyketide synthase (PKS) megagenes, tylGI.
177 ybrid nonribosomal peptide synthetase (NRPS)/polyketide synthase (PKS) megasynthase followed by the t
178 h nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) modules acting along with cata
179         The potential for recombining intact polyketide synthase (PKS) modules has been extensively e
180 his moiety, the gem-dimethyl group producing polyketide synthase (PKS) modules of yersiniabactin and
181 nits through the use of dedicated initiation polyketide synthase (PKS) modules offers opportunities t
182 mains of cryptic function are often found in polyketide synthase (PKS) modules that produce epimerize
183 , encodes a trans-acyltransferase (trans-AT) polyketide synthase (PKS) multienzyme that was hypothesi
184  by heterologous complementation of enediyne polyketide synthase (PKS) mutants from the C-1027 produc
185 HR) and a non-reducing (NR) iterative type I polyketide synthase (PKS) pair.
186                     Metabolic engineering of polyketide synthase (PKS) pathways represents a promisin
187                     The virulent gene island polyketide synthase (pks) produces the secondary metabol
188 en 77 and 80 kb and encode five multimodular polyketide synthase (PKS) proteins, a hydroxymethylgluta
189 erythronolide B synthase (DEBS) is a modular polyketide synthase (PKS) responsible for the biosynthes
190 f multidomain type I fatty acid synthase and polyketide synthase (PKS) systems.
191                      To elucidate early post polyketide synthase (PKS) tailoring steps of the landomy
192 nd the characterization of a highly reducing polyketide synthase (PKS) that acts in both a sequential
193 olyketides are biosynthesized by the type II polyketide synthase (PKS) that consists of 5-10 stand-al
194 antibiotic erythromycin, is synthesized by a polyketide synthase (PKS) that has emerged as the protot
195 core has been predicted to be initiated by a polyketide synthase (PKS) that is distinct from all know
196 ycin/methymycin synthase (PICS) is a modular polyketide synthase (PKS) that is responsible for the bi
197 mains (DHs) of the iso-migrastatin (iso-MGS) polyketide synthase (PKS) were investigated by systemati
198 ) from Streptomyces coelicolor is a type III polyketide synthase (PKS) with broad substrate flexibili
199  acyl carrier protein (ACP) component of the polyketide synthase (PKS), and it has been shown that a
200 a chersina previously identified an enediyne polyketide synthase (PKS), but no anthraquinone PKS, sug
201 in, which exhibits a putative combination of polyketide synthase (PKS), non-ribosomal peptide synthet
202 viously identified as a cluster containing a polyketide synthase (PKS)-encoding (FUB1) and four addit
203                               Curacin A is a polyketide synthase (PKS)-non-ribosomal peptide syntheta
204 nt anticancer natural products produced by a polyketide synthase (PKS)-nonribosomal peptide synthetas
205 ticancer activity that are biosynthesized by polyketide synthase (PKS)-nonribosomal peptide synthetas
206 hesis of lovastatin uses an iterative type I polyketide synthase (PKS).
207  chain, which is synthesized by an iterative polyketide synthase (PKS).
208  by using a dissected and reassembled fungal polyketide synthase (PKS).
209 d biosynthesis or protein engineering of the polyketide synthase (PKS).
210 on, is catalyzed by an enzyme complex called polyketide synthase (PKS).
211 m non-ribosomal peptide synthetase (NRPS) or polyketide synthase (PKS).
212 tase (NRPS)-acyltransferase (AT)-less type I polyketide synthase (PKS).
213 ural product macrocycles generated by hybrid polyketide synthase (PKS)/nonribosomal peptide synthetas
214                    Our examination of the 27 polyketide synthases (PKS) in A. nidulans revealed that
215 Non-ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) produce numerous secondary me
216  compounds is proposed to involve two fungal polyketide synthases (PKS) that function collaboratively
217     Nonribosomal peptide synthetases (NRPS), polyketide synthases (PKS), and hybrid NRPS/PKS are of p
218  line-like multiprotein complexes of modular polyketide synthases (PKS).
219 le that targets the thioesterase activity of polyketide synthase Pks13, an essential enzyme that form
220 gene deletion verified that the F. fujikuroi polyketide synthase PKS13, designated Gpy1, is responsib
221 22) and a 6-domain reducing iterative type I polyketide synthase (Pks15/1) for production of p-hydrox
222 ing the norsolorinic acid anthrone-producing polyketide synthase, PksA, from the aflatoxin biosynthet
223   Previous work identified enediyne-specific polyketide synthases (PKSEs) that can be phylogeneticall
224 tion and functionalization encoded by type I polyketide synthase (PKSs), cascade reactions can take p
225                  Insights into how bacterial polyketide synthases (PKSs) acquire new metabolic capabi
226 tural families is determined by the enediyne polyketide synthases (PKSs) alone.
227 id lactone (TAL) is a signature byproduct of polyketide synthases (PKSs) and a valuable synthetic pre
228   The final transformation catalyzed by both polyketide synthases (PKSs) and fatty acid synthases is
229                                      Modular polyketide synthases (PKSs) and nonribosomal peptide syn
230                             Bacterial type I polyketide synthases (PKSs) are complex, multifunctional
231 Nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs) are large enzymes responsibl
232                                    Iterative polyketide synthases (PKSs) are large, multifunctional e
233             Acyltransferase (AT)-less type I polyketide synthases (PKSs) break the type I PKS paradig
234            The dehydratases (DHs) of modular polyketide synthases (PKSs) catalyze dehydrations that o
235                                              Polyketide synthases (PKSs) catalyze the production of n
236      Ketoreductase (KR) domains from modular polyketide synthases (PKSs) catalyze the reduction of 2-
237                                      Modular polyketide synthases (PKSs) direct the biosynthesis of c
238  nonribosomal peptide synthetases (NRPSs) or polyketide synthases (PKSs) found in the biosynthetic pa
239              Biochemical characterization of polyketide synthases (PKSs) has relied on synthetic subs
240                          Engineering modular polyketide synthases (PKSs) has the potential to be an e
241                                 Multimodular polyketide synthases (PKSs) have an assembly line archit
242               PKS11 is one of three type III polyketide synthases (PKSs) identified in Mycobacterium
243  most of the fatty acid synthases (FASs) and polyketide synthases (PKSs) known to date are characteri
244              The mechanistic details of many polyketide synthases (PKSs) remain elusive due to the in
245                                              Polyketide synthases (PKSs) represent a powerful catalyt
246                                     Type III polyketide synthases (PKSs) show diverse cyclization spe
247 e alkylresorcinol synthases (ARSs), type III polyketide synthases (PKSs) that produce 5-alkylresorcin
248      However, manipulation of modular type I polyketide synthases (PKSs) to make unnatural metabolite
249                                              Polyketide synthases (PKSs) use chemistry similar to fat
250  polyketide intermediates are set by modular polyketide synthases (PKSs) when condensation is not imm
251                                       Type I polyketide synthases (PKSs), and related fatty acid synt
252 iosynthetic machinery, represented by type I polyketide synthases (PKSs), has an architecture in whic
253 rbon framework is assembled by two iterative polyketide synthases (PKSs), Hpm8 (highly reducing) and
254              Multimodular enzymes, including polyketide synthases (PKSs), nonribosomal peptide synthe
255  the biosynthesis of polyketide backbones by polyketide synthases (PKSs), post-PKS modifications resu
256                               Type I modular polyketide synthases (PKSs), which are responsible for t
257                           The plant type III polyketide synthases (PKSs), which produce diverse secon
258 H enzymes in fatty acid synthases (FASs) and polyketide synthases (PKSs).
259 and sequencing of genes encoding a number of polyketide synthases (PKSs).
260 nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs).
261 portant natural products produced by type II polyketide synthases (PKSs).
262 a spontaneous point mutation in the putative polyketide synthase PpsD that results in a G44C amino ac
263 of mellein by a partially reducing iterative polyketide synthase (PR-PKS) as a pentaketide product.
264 ar compounds (marginolactones) are formed by polyketide synthases primed not with gamma-aminobutanoyl
265 thase (DEBS) is a prototypical assembly line polyketide synthase produced by the actinomycete Sacchar
266 rmations responsible for converting the post-polyketide synthase product into the exciting anticancer
267 ort the characterization of a novel Type III polyketide synthase, quinolone synthase (QNS), from A. m
268                           Two novel type III polyketide synthases, quinolone synthase (QNS) and acrid
269  of programming of iterative highly reducing polyketide synthases remains one of the key unsolved pro
270                                          The polyketide synthases responsible for the biosynthesis of
271  fatty acyl-CoA serves as a starter unit for polyketide synthases, resulting in the formation of 5-pe
272  the hybrid nonribosomal peptide synthetases/polyketide synthase rifamycin biosynthetic cluster of Am
273 ng 3-amino-5-hydroxybenzoic acid (AHBA), the polyketide synthase starter unit of both natural product
274 hioluteus catalyzes the formation of unusual polyketide synthase starter unit p-nitrobenzoic acid (pN
275 ing an extensive literature on assembly line polyketide synthases such as the 6-deoxyerythronolide B
276 ormed by an iterative highly reducing fungal polyketide synthase supported by a hydrolase, together w
277 unctional analysis of three soil DNA-derived polyketide synthase systems in Streptomyces albus reveal
278               The S. tropica genome features polyketide synthase systems of every known formally clas
279 , we have constructed pathways involving two polyketide synthase systems, and we show that fluoroacet
280 mediating substrate specificity of bacterial polyketide synthase TEs.
281 by DynE8, a highly reducing iterative type I polyketide synthase that assembles polyketide intermedia
282       Tylactone synthase (TYLS) is a modular polyketide synthase that catalyzes the formation of tyla
283              OTC is synthesized by a type II polyketide synthase that generates the poly-beta-ketone
284 e show that chlorizidine A is assembled by a polyketide synthase that uniquely incorporates a fatty a
285 polyketide biosynthesis mediated by trans-AT polyketide synthases that lack integrated acyl transfera
286   The unique ability of the pikromycin (Pik) polyketide synthase to generate 12- and 14-membered ring
287  influences the ability of the OTC "minimal" polyketide synthase to make a polyketide product of the
288                              The minimal ssf polyketide synthase together with the amidotransferase S
289 ding frames that encode three modular type I polyketide synthases (TtmHIJ), one type II thioesterase
290 tory quinones, PkQs are produced by type III polyketide synthases using fatty acyl-CoA precursors.
291 licolor RppA (Sc-RppA), a bacterial type III polyketide synthase, utilizes malonyl-CoA as both starte
292 s of DynE8, fatty acid synthase, and modular polyketide synthases, we overexpressed a 44-kDa fragment
293 quence-specific synthesis by the ribosome to polyketide synthases, where tethered molecules are passe
294 opolone nucleus: tropA encodes a nonreducing polyketide synthase which releases 3-methylorcinaldehyde
295 y, terpenoid pathways, cytochrome P450s, and polyketide synthases, which may contribute to the produc
296 nthetases, and to the related fatty acid and polyketide synthases, will further our biophysical under
297            We also characterized a truncated polyketide synthase with a ketoreductase function that c
298  suggest that Pks15/1 is an iterative type I polyketide synthase with a relaxed control of catalytic
299 ltransferase domain of module 6 of rifamycin polyketide synthase with that of module 2 of rapamycin p
300 gested to be the product of a modular type I polyketide synthase working in trans with two monofuncti

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