ライフサイエンスコーパス: polymodal

1 sentative of the TRP family, TRPM3 is highly polymodal.

2 erstand the structural basis underlying this polymodal activation and the regulation by intracellular

3 ed as calcium-permeable cation channels with polymodal activation properties.

4 ate multiple stimuli through their typically polymodal activation.

5 ngeal afferent neurones regulating cough are polymodal Adelta-fibres that arise from the nodose gangl

6 Fasting, to unload mechanically sensitive polymodal afferents in the proximal gastrointestinal tra

7 Future risk stratification using a polymodal approach could combine basal ganglia network c

8 shing for the first time in humans that this polymodal area is modified after early sensory deprivati

9 of deep compared with superficial, nuclei to polymodal areas in the temporal pole.

10 Projections to other sensory and polymodal areas, in contrast, terminate in a columnar ma

11 esponses to soluble repellents sensed by the polymodal ASH neurons.

12 aptation to soluble repellents sensed by the polymodal ASH nociceptors.

13 The C. elegans polymodal ASH sensory neurons detect mechanical, osmotic

14 The perirhinal cortex is a polymodal association area that contributes importantly

15 , but also with a wide range of unimodal and polymodal association areas.

16 jections from temporal auditory, visual, and polymodal association cortices.

17 cortical, paralimbic, and limbic structures, polymodal association, and ventromedial prefrontal corte

18 izing principles: the first being a rotating polymodal-association pinwheel structure around which ac

19 tmc-1 is expressed in the ASH polymodal avoidance neurons, where it is required for sa

20 d not affect the axotomy-induced decrease in polymodal C-fiber (CPM) heat threshold, but transiently

21 (TRPV1) cation channel is characteristic of polymodal C-fiber nociceptors and is sensitive to noxiou

22 whage-stimulated pathway primarily involving polymodal C-fibres.

23 Receptor Potential Vanilloid 1 (TRPV1) is a polymodal, Ca(2+)-permeable cation channel crucial to re

24 TRPV4 is a polymodal cation channel gain-of-function (GOF) allele w

25 TRPV1 receptors are polymodal cation channels that open in response to diver

26 nsient receptor potential (TRP) channels are polymodal cell sensors responding to diverse stimuli and

27 ensory neurons where it acts as an important polymodal cellular sensor for heat, acidic pH, capsaicin

28 or potential (TRP) ion channel family act as polymodal cellular sensors, which aid in regulating Ca(2

29 TRPV1 is a polymodal channel activated by noxious heat, capsaicin,

30 ids needed to restore protein expression and polymodal channel activity.

31 The carotid body (CB) is a polymodal chemosensor of arterial blood located next to

32 ce of a previously unidentified cholinergic, polymodal chemosensory cell in the mammalian urethra, th

33 RP activity localized to auditory cortex and polymodal cortex of the temporal lobe, concurrent with g

34 ently cloned and confirmed functionally as a polymodal detector of multiple pain stimuli: heat, acid,

35 neuron-specific ion channel that serves as a polymodal detector of pain-producing chemical and physic

36 loid 1) is a cation channel that serves as a polymodal detector of pain-producing stimuli such as cap

37 ptor potential ion channels (thermoTRPs) are polymodal detectors of various stimuli including tempera

38 the noise-dependent stabilization exhibits a polymodal distribution with multiple, well defined, and

39 plays a role in stimulus-response mapping in polymodal fashion.

40 ncapable of explaining the three-dimensional polymodal fault patterns that are widely observed in roc

41 sses, and can therefore account for observed polymodal fault patterns.

42 ere, we identify the molecular basis for the polymodal function of OCR-2 in its native cellular envir

43 eas attaining peak cortical thickness before polymodal, high-order association areas.

44 ntar injections of low dose STZ evoked acute polymodal hypersensitivities in mice.

45 udies show that most C-fiber nociceptors are polymodal (i.e., respond to multiple noxious stimulus mo

46 TRPV1 channels are polymodal in their function and exhibit multifaceted reg

47 The polymodal input from the perirhinal cortex (PR) is a maj

48 hin insular cortex provide the basis for its polymodal integration of all salient activity relevant t

49 receptor potential vanilloid 1 (TRPV1) is a polymodal ion channel involved in the detection of noxio

50 ensitivity and the proper biogenesis of this polymodal ion channel.

51 ressure affect activity of the prototypical, polymodal K(2P), K(2P)2.1 (KCNK2/TREK-1), at a common mo

52 rgets suggest that CGRP(+) SP(-) neurons are polymodal mechanoceptors.

53 The hypothesis that polymodal mechanoreceptors and capsaicin-sensitive affer

54 ntial vanilloid type 1 (TRPV1) receptor is a polymodal molecular integrator in the pain pathway expre

55 panding PRh involvement, consistent with the polymodal nature of PRh connections and results from pri

56 ivotal role in the generation of a systemic, polymodal neurohumoral response to a hyperosmotic challe

57 nels carry mechanotransduction currents in a polymodal neuron, where they act upstream of transient r

58 n wild type worms on the function of the ASH polymodal neuron.

59 rs is critical for encoding information from polymodal neurons.

60 ther nociceptive specific (NS, n = 20) or as polymodal nociceptive (HPC, responsive to heat, pinch an

61 pherally encoded in C-MIAs, and that primate polymodal nociceptive afferents form three functionally

62 inct subset of sensory neurons that transmit polymodal nociceptive information from the skin epidermi

63 ASH neurons are therefore hypothesized to be polymodal nociceptive neurons.

64 gans aversive behavior mediated by a pair of polymodal, nociceptive, ASH sensory neurons.

65 The capsaicin receptor VR1 is a polymodal nociceptor activated by multiple stimuli.

66 ound to have vasodilator actions were of the polymodal nociceptor afferent class, and fourteen (50%)

67 n both the rabbit and the rat, a subclass of polymodal nociceptor afferents form the majority of the

68 The afferent receptive fields of polymodal nociceptor afferents were mapped carefully usi

69 to analyse functional connectivity between a polymodal nociceptor and a command neuron that initiates

70 TRPV1 is a polymodal nociceptor for diverse physical and chemical s

71 major mechanotransduction channel in ASH, a polymodal nociceptor in Caenorhabditis elegans.

72 The vanilloid receptor VR1 is a polymodal nociceptor sensitive to capsaicin, protons, an

73 he capsaicin receptor TRPV1 ion channel is a polymodal nociceptor that responds to heat with exquisit

74 C polymodal nociceptor units do not appear to be involved

75 Stimulation of C polymodal nociceptor units never caused increases in blo

76 The receptive fields (RFs) of polymodal nociceptor units of canine testis consist of s

77 The vasoactive polymodal nociceptor units tend to have relatively low m

78 lass, and fourteen (50%) of the twenty-eight polymodal nociceptor units tested were vasoactive.

79 fibres were nociceptive and comprised seven polymodal nociceptor units, two heat nociceptor units an

80 eceptor potential cation channel family is a polymodal nociceptor.

81 family of non-selective cation channels is a polymodal nociceptor.

82 mal thresholds after regeneration, whereas C-polymodal nociceptors (CPMs) had lower heat thresholds.

83 ction and successful regeneration, cutaneous polymodal nociceptors (CPMs) lacking transient receptor

84 d on the responsiveness of cutaneous C-fiber polymodal nociceptors (CPMs) to sympathetic stimulation

85 Fewer than half the C polymodal nociceptors (CPMs) were positive.

86 t both in high threshold mechanoreceptor and polymodal nociceptors and also in units with either cuta

87 Polymodal nociceptors and mechanochemical receptors gave

88 In primates, C-fibre polymodal nociceptors are broadly classified into two gr

89 Polymodal nociceptors are one subclass of sensory neuron

90 Polymodal nociceptors detect noxious stimuli, including

91 igh-threshold CSNs and in a subpopulation of polymodal nociceptors expressing TRPM8, providing a gene

92 (MOPR) and delta opioid receptors (DOPR) in polymodal nociceptors have been recently challenged.

93 All C-polymodal nociceptors in glabrous (n = 4) but none in ha

94 Fifty-five C-polymodal nociceptors innervating hairy skin in human vo

95 It is concluded that a subpopulation of C-polymodal nociceptors is sensitive to noxious low temper

96 ion of corneal afferent neurons that are not polymodal nociceptors or cold-sensing neurons, and is li

97 ns are neurochemically distinct from corneal polymodal nociceptors or cold-sensing neurons.

98 receptors responding to mechanical stimuli; polymodal nociceptors responding to mechanical, noxious

99 t, but it also transforms a subpopulation of polymodal nociceptors signaling pain into neurons activa

100 Mechanical thresholds were higher in polymodal nociceptors than in either slowly adapting or

101 neurons of the Drosophila larva function as polymodal nociceptors that are necessary for behavioral

102 e we demonstrate that mechanically sensitive polymodal nociceptors that respond either quickly (QC) o

103 or population, C-mechanoheat fibres (C-MH or polymodal nociceptors) were markedly more responsive to

104 121 receptors recorded from 39 fish, 17 were polymodal nociceptors, 22 were mechanothermal nociceptor

105 sitive trigeminal nerve fibers, for example, polymodal nociceptors, rather than through taste buds.

106 in gene-related peptide (CGRP), a marker for polymodal nociceptors, suggesting that trigeminal genera

107 onin gene-related peptide [CGRP]) trigeminal polymodal nociceptors, which respond to numerous odorant

108 form sensory neurons with the properties of polymodal nociceptors.

109 ons was largely observed in C-mechanoheat or polymodal nociceptors.

110 es and subsequently desensitizes a subset of polymodal nociceptors.

111 the rate they inhibit action potentials from polymodal nociceptors.

112 elocity, as those of the pure mechano-heat C-polymodal nociceptors.

113 re NF200-IR, suggesting they are not corneal polymodal nociceptors.

114 rature-sensitive TRP channels to function as polymodal nociceptors.

115 y plays an important role in the function of polymodal nociceptors.

116 rminants between vertebrate and invertebrate polymodal nociceptors.

117 s that process afferent input from Mrgprd(+) polymodal nociceptors.

118 ulation of nonpeptidergic, TRPV1-negative, C-polymodal nociceptors.

119 hermal nociceptors were higher than those of polymodal nociceptors.

120 Mechanothermal, but not polymodal, nociceptors showed an increase in firing resp

121 that ammonia activates TRPV1, TRPA1 (another polymodal nocisensor), and other unknown receptor(s) exp

122 Localization and function of the polymodal non-selective cation channel TRPV1 (transient

123 e that Mrgprd influences the excitability of polymodal nonpeptidergic nociceptors to mechanical and t

124 r parietal cortex, higher-order auditory and polymodal processing regions in the superior temporal co

125 dorsal horn neurons and that, despite their polymodal properties, TRPV1+ and MrgprD+ nociceptors pro

126 tential vanilloid 1 (TRPV1) ion channel is a polymodal protein that responds to various stimuli, incl

127 TRPV1 channels and the relevance of accurate polymodal receptor biophysical characterization for drug

128 tential vanilloid 1 (TRPV1) ion channel is a polymodal receptor that mediates the flux of cations acr

129 We recently showed that the polymodal receptor transient receptor potential vanilloi

130 These membrane proteins are polymodal receptors that can be activated by cold or hot

131 Many primary sensory neurons are polymodal, responding to multiple stimulus modalities (c

132 Of ten multipolar cells, six were polymodal, responsive to heat, pinch and cold, and four

133 The carotid body (CB) is a polymodal sensor which increases its neural output to th

134 Various TRP channels act as polymodal sensors of thermal and chemical stimuli, but t

135 ential melastatin (TRPM) cation channels are polymodal sensors that are involved in a variety of phys

136 atures and defective trafficking of OSM-9, a polymodal sensory channel protein and a functional homol

137 ptive-specific inputs (PB-->CeA synapse) and polymodal sensory inputs (BLA-->CeA synapse) in the arth

138 ivity could result from increased numbers of polymodal sensory nerve fibres expressing TRPV1.

139 Polymodal sensory neurons detect a wide range of nocicep

140 C. elegans ASH neurons function as polymodal sensory neurons that generate a characteristic

141 enorhabditis elegans nervous system: the ASH polymodal sensory neurons, the AVA, AVD and AVE interneu

142 mination of a variety of repellents by these polymodal sensory neurons.

143 To understand the nature of polymodal sensory response and adaptation at the cellula

144 nsient receptor potential (TRP) channels are polymodal signal detectors that respond to a wide array

145 nsient receptor potential (TRP) channels are polymodal signal detectors that respond to a wide range

146 convertase provides additional evidence that polymodal signaling in C. elegans occurs via the differe

147 To investigate the mechanisms of this polymodal signaling, we have characterized the role of p

148 uggest that these receptors are expressed on polymodal, substance P-expressing neurons.

149 ient receptor potential isoform 4 (TRPV4), a polymodal swelling-sensitive cation channel.

150 Polymodal thermo- and mechanosensitive two-pore domain p

151 Adjacent to the channel gate, this polymodal thermoTRP channel displays a TRP domain, refer

152 se retina expresses mRNA and protein for the polymodal transient receptor potential vanilloid 4 (TRPV

153 experiments, we found that HA also modulates polymodal transient receptor potential vanilloid subtype

154 target side effect in clinical studies using polymodal TRPV1 antagonists has prompted companies to se

155 K(2P)2.1 (TREK-1) is a polymodal two-pore domain leak potassium channel that re

156 e dominant hemisphere were more likely to be polymodal, whereas those in nondominant hemisphere were