ライフサイエンスコーパス: polymorphic marker

1 LOH at 9p21-22 using eight different highly polymorphic marker.

2 17 through a pedigree, similar to a typical polymorphic marker.

3 All individuals were genotyped for 23 highly polymorphic markers.

4 pped by FISH or by loss of heterozygosity of polymorphic markers.

5 these clusters could be detected with linked polymorphic markers.

6 ed using six 18p11 and one 18q12.3 PCR-based polymorphic markers.

7 ned the entire autosomal genome by using 367 polymorphic markers.

8 mative mtDNA (haplogroups H and L) and Y Alu polymorphic markers.

9 ften necessary to genotype a large number of polymorphic markers.

10 les showed the same haplotype for these five polymorphic markers.

11 y, we developed 11 new STSs, including seven polymorphic markers.

12 ed to identify and provisionally localize 25 polymorphic markers.

13 characterized by using a panel of 10 highly polymorphic markers.

14 in a large U.S. kindred, using 312 different polymorphic markers.

15 th trinucleotide- and tetranucleotide-repeat polymorphic markers.

16 e idealized context of a dense set of highly polymorphic markers.

17 ng genetic map information for large sets of polymorphic markers.

18 rozygosity (LOH) was evaluated with multiple polymorphic markers.

19 rrounding the VHL locus using four different polymorphic markers.

20 tched normal DNA using 22 highly informative polymorphic markers.

21 , for LOH at all 41 chromosomal arms with 50 polymorphic markers.

22 R analysis was used to type four independent polymorphic markers.

23 Genotyping was performed using polymorphic markers.

24 a genome scan with 65 simple sequence length polymorphic markers.

25 n (order and distances) for any large set of polymorphic markers.

26 performed using >200 simple sequence-length polymorphic markers.

27 easure linkage disequilibrium between highly polymorphic markers.

28 sis was performed on 330 families, using 401 polymorphic markers.

29 ation of the defective gene by use of random polymorphic markers.

30 by low throughput and a lack of informative polymorphic markers.

31 nkage and linkage disequilibrium using known polymorphic markers.

32 clone onto which 71 markers were mapped: 23 polymorphic markers, 12 genes, 24 ESTs, and 12 random ge

33 B genes was constructed using 68 markers: 25 polymorphic markers, 15 known genes, 21 ESTs, and 7 rand

34 .CAST F2 female mice using a large number of polymorphic markers; (2) the generation of congenic subl

35 he B-NHL tumor panel, 24 additional 6q26-q27 polymorphic markers (21 mapping to the contig) further d

36 ns 200 PACs, 10 known genetic markers, 5 new polymorphic markers, 57 sequence tagged sites (STSs) gen

37 ple ascertainment of disease chromosomes and polymorphic markers, a genetic dominance model of diseas

38 Because palindromic insertions were used as polymorphic markers, a significant number of recombinant

39 Linkage disequilibrium was seen in six polymorphic markers across a 1 Mb interval.

40 milies affected by prostate cancer, using 17 polymorphic markers across a 98.5-cM segment of chromoso

41 Genome-wide scanning with polymorphic markers across the 19 murine autosomes was p

42 the extent of these microdeletions by using polymorphic markers afforded further refinement of this

43 ll show substantial allelic variation in the polymorphic marker among the racial-ethnic groups of gre

44 We have undertaken high-density polymorphic marker analysis in 30 matched normal and NSC

45 c loss in at least one of six microsatellite polymorphic markers analyzed.

46 Using polymorphic marker and phosphorimage densitometry analys

47 The STSs included 22 polymorphic markers and 20 transcripts, with the remaind

48 n a framework of 40 known and 3 newly cloned polymorphic markers and 37 new sequence-tagged sites.

49 epresented by 872 unique STSs, including 642 polymorphic markers and 957 bacterial artificial chromos

50 lineal multiplex pedigrees), using 10 highly polymorphic markers and a range of parametric and nonpar

51 rnative genetic maps as they can include non-polymorphic markers and are also powerful enough to orde

52 A catalog of 13,261 potential polymorphic markers and associated primer sets has been

53 uilibrium test to detect association between polymorphic markers and discrete or quantitative traits

54 osome 12 in 100 primary ALL samples using 22 polymorphic markers and identified two distinct smallest

55 cial chromosome contig that contains several polymorphic markers and is close to a polymorphic marker

56 200 STSs that include 25 dinucleotide repeat polymorphic markers and more than 80 expressed sequences

57 gene (LHCGR; 2p21), telomeric to the D2S123 polymorphic marker, and centromeric to the calmodulin-2

58 l between D19Umi1 and D19Mit9, developed new polymorphic markers, and mapped candidate genes by const

59 or the rapid and efficient identification of polymorphic markers, and through a World Wide Web site,

60 tion studies of candidate genes for which no polymorphic markers are available yet.

61 es, combinations of several phase-determined polymorphic markers, are extremely valuable for studies

62 members were recruited for the study, and 16 polymorphic markers around the AT3 gene were analyzed.

63 Additional analysis with other families and polymorphic markers as well as evaluation of potential c

64 The strong correlations demonstrated between polymorphic markers assessed by the four independent fin

65 urred, using polymerase chain reaction-based polymorphic markers at 11p13, 11p15, and 16q.

66 ozygosity (LOH) has been shown for anonymous polymorphic markers at 11q23 in adult leukemias.

67 129IR) and performed a genome-wide scan with polymorphic markers at a 20-cM resolution.

68 ly facilitates the identification of YACs or polymorphic markers at specific locations in the genome.

69 Linkage between diabetes and two polymorphic markers at the HNF-4gamma locus (D8S286 and

70 Using 360 polymorphic markers (average spacing 9.4 cM), we conduct

71 The polymorphic index content (PIC) of 55 polymorphic markers averaged 0.407, ranging from 0.033 t

72 hic clusters between diploid species, 47 116 polymorphic markers between cultivated and interspecific

73 also report the identification of eight new polymorphic markers between D19S406 and D19S912, which a

74 We have isolated and analyzed four novel polymorphic markers between DXS7117 and DXS559 and, by h

75 lication that automates the discovery of new polymorphic markers between ecotypes of Arabidopsis thal

76 argeted chromosomal regions for isolation of polymorphic markers, building bacterial artificial chrom

77 kb on chromosome 6 between D6S460 and a new polymorphic marker centromeric to D6S1707.

78 alyzed 94 progeny for the segregation of 301 polymorphic markers, consisting of 228 restriction site

79 lution, we performed haplotype analysis of 8 polymorphic markers covering 340 kb spanning the VHL gen

80 nkage map of chromosome 21q using 187 highly polymorphic markers covering almost the entire long arm;

81 Polymorphic markers covering the deletion and flanking r

82 GAAn were selected for analysis at anonymous polymorphic markers D11S1364 and D11S1356, which flank t

83 m typing analysis was also performed using a polymorphic marker, D14S1050, closely linked to the MJD1

84 nkage analysis using DNA from the family and polymorphic marker D14S288 in chromosome 14q12 produced

85 ximately 5 cM on chromosome 17p13 flanked by polymorphic markers D17S1810 and CHLC GATA7B03.

86 On the physical map, RIZ is adjacent to the polymorphic marker D1S228.

87 ion fraction 0, between the BO phenotype and polymorphic marker D1S2757 in the genetic region of chro

88 Sequence analysis places the polymorphic marker, D1S2803, within the RPE65 upstream r

89 1, 935B12, and 947B2), along with two nearby polymorphic markers (D1S426 and D1S194)).

90 Thus, these genes and the polymorphic marker D1Z2 are organized as follows: telome

91 Only one polymorphic marker, D22S429, segregated with decreased t

92 The genomic locus is positioned between polymorphic markers D22S944 and D22S941.

93 rresponds to the genetic interval flanked by polymorphic markers D2S119 and D2S378 and covers a genet

94 t a recombination fraction of .021, with the polymorphic marker D2S177.

95 10 in Whitehead contig WC861, along with the polymorphic markers D2S2236 and D2S2299.

96 he region of chromosome 2 encompassed by the polymorphic markers D2S378 (centromeric) and D2S391 (tel

97 LOH analysis using the polymorphic markers D3S1038 and D3S1110 that map to the

98 An adjacent locus defined by the polymorphic markers D3S1212 and D3S1245 has previously b

99 ified by polymerase chain reaction using the polymorphic markers D3S2452, D3S1110, D3S192, and D3S656

100 14B4, 951G9, 981D6, and 847B3), and a nearby polymorphic marker (D4S1538) on chromosome 4 was identif

101 Differences within intragenic polymorphic markers demonstrated that at least some muta

102 Two new CA/GT repeat polymorphic markers, designated KLK3f and KLK3g, that ha

103 It constitutes a resource for polymorphic marker discovery and association studies to

104 s tumours using a panel of 10 microsatellite polymorphic markers distributed along the length of the

105 e typing yielded identification of 127 novel polymorphic markers distributed throughout the class II

106 show that the crossover is between two novel polymorphic markers, DXS8349 and M6, both of which are p

107 that even a moderately spaced set of highly polymorphic markers (e.g., one every 0.8 cM) has high po

108 We typed 16 polymorphic markers encompassing the region of putative

109 es and five unaffected individuals, using 40 polymorphic markers evenly distributed throughout the X

110 children and the other from the parents, 161 polymorphic markers evenly spaced across the autosomal h

111 Typing of 21 polymorphic markers, evenly spanning the CD36 gene, reve

112 -stained slides for genetic evaluation using polymorphic markers flanking the APC gene locus.

113 locus by the lack of its cosegregation with polymorphic markers flanking the EDA locus in three of f

114 In this family, polymorphic markers flanking the GDF5 locus were found t

115 Haplotypes of polymorphic markers flanking the PRPH2 locus and sequenc

116 apped relative to other markers in 15q13 and polymorphic markers flanking tjp-1 were identified.

117 pped among hybrid F2s with single nucleotide polymorphic markers, followed by candidate gene sequenci

118 ng slowly and provides a particularly useful polymorphic marker for Chinese populations.

119 a history of extensive recombination between polymorphic markers for all six Or genes.

120 t microsatellites are a ubiquitous source of polymorphic markers for human adenoviruses and demonstra

121 show that AtPRIMER accurately found specific polymorphic markers for our linkage mapping project.

122 hysical map will facilitate the isolation of polymorphic markers for refinement of the disease gene r

123 egions harbouring putative TSG's between the polymorphic markers for the LPL gene-D8S298 (approximate

124 e, investigators can use POMPOUS to identify polymorphic markers for their research.

125 due to a founder effect, we identified five polymorphic markers (four diallelic markers and one CA r

126 of sporadic ductal carcinoma in situ with 18 polymorphic markers from 8p.

127 nce tagged site (STS) content using the five polymorphic markers from above, four novel STSs identifi

128 Polymorphic markers from chromosomes 1 and 10 that are n

129 Twenty-eight HCC cases were studied with polymorphic markers from different parts of the genome.

130 Segregation patterns of short tandem repeat polymorphic markers from four chromosomes revealed null

131 Genotyping was done with nine highly polymorphic markers from the 6p22.3-6p21.3 region.

132 Using polymorphic markers from the proximal symphalangism inte

133 We have used polymorphic markers from this region to examine leukemia

134 to map disease genes that, in a dense map of polymorphic markers, has considerably higher resolution

135 Highly polymorphic markers have become available throughout the

136 this region has been defined, and additional polymorphic markers have been isolated.

137 y map genes even in populations for which no polymorphic markers have been previously identified.

138 ar studies that use a large number of highly polymorphic markers have been undertaken to understand t

139 Three highly polymorphic markers (HLA-DR, D6S273 and TNFbeta) in the

140 e identified a unique simple sequence repeat polymorphic marker (hLMX1.2CA1) in a P1 genomic clone co

141 In every case, the SNPs and or polymorphic markers identified by the 3D VizStruct mappi

142 g rate, and refractoriness), genotyped at 70 polymorphic markers in 10 male reproductive genes, and m

143 lotype analysis on 105, using 15 consecutive polymorphic markers in 22q11.

144 by multipoint genetic linkage analysis of 22 polymorphic markers in 40 F2 progeny of Fischer (F344/N)

145 whole-genome scan was carried out using 119 polymorphic markers in 633 (MRLxSJL) F2 female mice.

146 d LOH for DNA sequences on 7q with 10 highly polymorphic markers in 92 matched normal/tumor samples r

147 laboratory findings and were genotyped with polymorphic markers in a candidate region on human chrom

148 Haplotypes, combinations of polymorphic markers in a chromosome, are critical for ge

149 The genetic mapping of polymorphic markers in a cross between two inbred plant

150 l statistical method for linkage analysis of polymorphic markers in a full-sib family of autotetraplo

151 ge analysis by use of simple sequence length polymorphic markers in an F2 intercross.

152 mic structure, chromosomal localization, and polymorphic markers in BARX2.

153 thesis is correct, then the genotypes of all polymorphic markers in CHMs should be homozygous.

154 PS gene, we present linkage analysis with 13 polymorphic markers in five families with a total of 69

155 Analysis of newly positioned polymorphic markers in recombinant individuals in two Us

156 These maps provide locations for genes and polymorphic markers in sequence and on genetic linkage,

157 Linkage and association of polymorphic markers in the chromosome 5q31-q33 cytokine

158 straight theta=.00) for the HGF phenotype to polymorphic markers in the genetic region of chromosome

159 Polymorphic markers in the hMRE11 gene, including the pr

160 Twenty-four polymorphic markers in the major histocompatibility comp

161 nscription units and ordered with respect to polymorphic markers in the region, resulting in a compre

162 ermined by simultaneously genotyping several polymorphic markers in the same reaction with a multiple

163 milies confirmed both significant linkage to polymorphic markers in this region and incomplete penetr

164 The use of polymorphic markers, in particular single nucleotide pol

165 The polymorphic markers include 12 microsatellites for 10 te

166 Using 12 polymorphic markers, including 2/1 and +/-, we have now

167 NTS is immediately proximal to four polymorphic markers, including D12S81 (AFM102xg9) and D1

168 everal polymorphic markers and is close to a polymorphic marker located at 95.8 cM on the Genethon li

169 Linkage between diabetes and two polymorphic markers located in this region (D13S285 and

170 s from an extensive MEN1 kindred using eight polymorphic markers located on chromosome 11q13, includi

171 with pseudoxanthoma elasticum (PXE) using 10 polymorphic markers located on chromosome 16p13.1.

172 the ODD locus was instigated and linkage to polymorphic markers located on chromosome 6q established

173 hin a subset of cysts for two closely linked polymorphic markers located within the PKD1 gene.

174 mating linkage disequilibrium (LD) between a polymorphic marker locus and any one of the loci affecti

175 Using the 12 polymorphic markers, LOH was found in all of the three s

176 e order of and physical distance between 180 polymorphic markers, many from the Genethon and CHLC gen

177 nalysis of 67 normal-tumor DNAs utilizing 20 polymorphic markers mapped to 12q22-q24, we identified t

178 normal-tumor DNAs from male GCTs assaying 24 polymorphic markers mapped to both the short and long ar

179 We have used polymorphic marker mapping to demonstrate that affected

180 individuals) has been completed using highly polymorphic markers (mean heterozygosity = .67).

181 This map includes 20 genes and 95 polymorphic markers, most of which have heterozygosity f

182 cludes the largest set, to our knowledge, of polymorphic markers (N=14,759) for which genotype data a

183 e families with acheiropodia, by means of 15 polymorphic markers, narrowed the critical region to 1.3

184 describe an approach for identifying highly polymorphic markers near candidate genes that utilizes t

185 haplotype incorporating 3 single-nucleotide polymorphic markers near the translocation break point o

186 In addition to studying how the polymorphic markers of interest are related to prostate

187 umours show loss of heterozygosity (LOH) for polymorphic markers on 11q13, the site of the MEN1 tumou

188 Polymorphic markers on 5q31 were identified using a high

189 he development of ovarian cancer, we used 23 polymorphic markers on 6q to examine allelic loss in 25

190 inoid tumors was assessed for LOH with eight polymorphic markers on chromosome 11q13.

191 lation (775 members of one village) using 22 polymorphic markers on chromosome 19.

192 putative tumor suppressor gene, we have used polymorphic markers on chromosome 3q to define the minim

193 ll 38 families were analyzed with additional polymorphic markers on chromosome 8p.

194 Only polymorphic markers on chromosome A01 showed co-segregat

195 nce of allelic imbalance at 5 microsatellite polymorphic markers on chromosomes 7q31-35, 8p12-21, 8p2

196 We have now examined polymorphic markers on every chromosome, some of which a

197 as used to determine the genotype at various polymorphic markers on the X chromosome.

198 Coupled with the recent development of new polymorphic markers on the Y, making it the best-charact

199 icrosatellite markers, resulting in multiple polymorphic markers on three chromosomes.

200 Two polymorphic markers, one located in intron 8 and another

201 cted relative pairs and dense sets of highly polymorphic markers or by emerging techniques such as ge

202 Ashkenazim, were genotyped with 10-14 highly polymorphic markers overlying each candidate region.

203 Both MI, detected by polymorphic markers (P=0.03), and an abnormal Alu/AP-PCR

204 ome-wide haplotypes and a dense map with one polymorphic marker per approximately 2.3 kilobases.

205 primer combinations, with an average of 4.8 polymorphic markers per SSR across 34 Peronosclerospora,

206 rial clones, but the placement of 25 ("CA")n polymorphic markers permits the ordering of contigs by c

207 l and NSCLC tumor samples using 11 PCR-based polymorphic markers positioned approximately every 2-3 c

208 te of programs, collectively called POMPOUS (polymorphic marker prediction of ubiquitous simple seque

209 gh millions of reads to distill high-quality polymorphic markers requires special algorithms tailored

210 Furthermore, 10 of the 12 polymorphic markers revealed LOH in the stroma at a dist

211 Microsatellite analysis using highly polymorphic markers revealed loss of heterozygosity and/

212 letion analysis of immortal segregants using polymorphic markers revealed the loss of a 2.9 Mbp inter

213 The haplotypes for polymorphic markers segregating with MSSE in non-Scottis

214 r gene prediction, radiation hybrid mapping, polymorphic marker selection and more.

215 bles direct molecular haplotyping of several polymorphic markers separated by as many as 24 kb.

216 ic association with the most common class of polymorphic markers, single-sequence repeats.

217 enia or schizoaffective disorder, 396 highly polymorphic markers spaced approximately 10 centimorgans

218 We initially typed 387 polymorphic markers spaced, on average, at 10 cM through

219 predisposition does not map to any of eight polymorphic markers spanning 1p36 by linkage analysis in

220 of these positive findings, eight additional polymorphic markers spanning a 63-cM region around AT1 l

221 t the results of a linkage analysis using 10 polymorphic markers spanning approximately 37 cM in the

222 pedigrees (259 individuals) genotyped for 13 polymorphic markers spanning chromosome 18.

223 ed for loss of heterozygosity (LOH) using 10 polymorphic markers spanning chromosome 6 including one

224 were assayed for LOH with 13 microsatellite polymorphic markers spanning chromosome band 1p36.

225 oss of heterozygosity (LOH) on 11q13 with 10 polymorphic markers spanning the area of the putative ME

226 rs with autoimmune thyroid disease for eight polymorphic markers spanning the cytotoxic T lymphocyte

227 -characterized BOR families with a set of 13 polymorphic markers spanning the D8S165-D8S275 interval

228 LOH analysis was performed using nine mapped polymorphic markers spanning the entire chromosomal arm.

229 diagnosed XLRP was scored with more than 34 polymorphic markers spanning the entire X-chromosome, in

230 The family were typed for polymorphic markers spanning the two genes known to caus

231 ients was studied for allelic deletions with polymorphic markers spanning the VHL gene locus.

232 We measured eight highly polymorphic markers spanning this positional candidate g

233 e chromosome 6 telomere was constructed, and polymorphic markers spanning this region were defined.

234 A panel of 26 polymorphic markers, spanning 15q12-15q22, were used to

235 Using 382 random polymorphic markers spread across 22 autosomes, we demon

236 for PCR amplification of short tandem repeat polymorphic markers (STRPs).

237 as the PCR template for short tandem repeat polymorphic markers (STRPs).

238 d penetrance has failed to show linkage with polymorphic markers, suggesting either locus heterogenei

239 We found linkage between TNS and polymorphic markers surrounding the MSX1 locus.

240 ge thin polyacrylamide gels and reveals more polymorphic markers than agarose gel electrophoresis.

241 COL5A3 is mapped to 19p13.2 near a polymorphic marker that should be useful in analyzing li

242 kage disequilibrium (MALD) requires a map of polymorphic markers that differentiate between the found

243 hort tandem repeat (STR) variants are highly polymorphic markers that facilitate powerful population

244 hed normal and breast tumor samples using 17 polymorphic markers that map to 11p15.5-15.4.

245 e selective AFLP primers and identified 1048 polymorphic markers that mapped to 468 unique loci on ni

246 from this family was genotyped with 6 highly polymorphic markers that span the DGI-II critical region

247 f newly identified transcribed sequences and polymorphic markers that will aid in linkage and linkage

248 ng, between a quantitative-trait locus and a polymorphic marker; this is achieved in the variance-com

249 Molecular analysis was performed with polymorphic markers throughout the 18q- region.

250 umented the increased density of potentially polymorphic markers throughout the genome.

251 ted males shared the same haplotype of eight polymorphic markers tightly linked to COL4A5, indicating

252 erminus was fine mapped with newly developed polymorphic markers to characterize the extent of the co

253 We used 106 polymorphic markers to perform simple sequence-length po

254 ric cancer progression, we used high-density polymorphic markers to screen for LOH in matched normal

255 enome-wide scan of short tandem repeat (STR) polymorphic markers was analyzed for linkage to COPD-rel

256 By this analysis, LOH for one or more polymorphic markers was detected in 17 of 52 sporadic pr

257 genomewide scan of short tandem repeat (STR) polymorphic markers was performed in 72 pedigrees (585 i

258 Using 39 polymorphic markers, we examined each chromosome arm, ex

259 Using additional polymorphic markers, we identified a novel gene locus on

260 Eighteen polymorphic markers were evaluated for five populations

261 Two polymorphic markers were genotyped in the vicinity of ea

262 A total of 390 polymorphic markers were genotyped, and multipoint linka

263 A total of 14 highly polymorphic markers were genotyped, combining anonymous

264 tandem repeat polymorphisms and 2 biallelic polymorphic markers were identified and included as STSs

265 Intragenic polymorphic markers were identified and typed in the prc

266 An ample number of candidate polymorphic markers were identified in the dataset provi

267 nkage analysis if the appropriate density of polymorphic markers were known and if the genotyping eff

268 Those polymorphic markers were used to further genotype a repr

269 To investigate this region, 29 polymorphic markers were used to genotype a combined set

270 ers for known ADC loci and other genome-wide polymorphic markers were used to map the gene; two-point

271 Sequence tagged sites (STS) and polymorphic markers were used to screen 117 lung cancer

272 Nearby polymorphic markers will be useful in testing the hypoth

273 Prism linkage mapping set which includes 350 polymorphic markers with an average spacing of 12 cM.

274 It can handle problems involving multiple polymorphic markers with missing data.

275 ew map, the Rutgers Map v.2, includes 28,121 polymorphic markers with physical positions corroborated

276 port a zebrafish genetic map comprising 4073 polymorphic markers, with more than twice the number of

277 sity (LOH) during tumor development, another polymorphic marker within GPx-1, which is frequently het

278 using DNA from the family and an intragenic polymorphic marker within the AT3 gene showed that the d

279 78 simplex and 350 multiplex families for 10 polymorphic markers within a genomic interval of approxi

280 ivated and interspecific hybrids, and 15 897 polymorphic markers within A. hypogaea germplasm.

281 mary adenocarcinomas of the ovary for LOH of polymorphic markers within and flanking the PTEN gene an

282 ealthy control subjects were genotyped for 6 polymorphic markers within and near NRAMP1 on chromosome

283 Analysis of polymorphic markers within and surrounding the PTEN gene

284 rkers across the MM locus, provided five new polymorphic markers within it and narrowed the locus to

285 to BRCA1, we constructed a haplotype of nine polymorphic markers within or immediately flanking the B

286 Polymorphic markers within the CTLA4 gene on chromosome

287 significant association only with the three polymorphic markers within the CTLA4 gene.

288 zygous for the same allele, for two adjacent polymorphic markers within the region segregating with t

289 LOH was not found at polymorphic markers within the same chromosome subband a

290 The physical order of the polymorphic markers within this radiation hybrid map is