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1 mers, cationic polysaccharides, and cationic polypeptides).
2 rchitectures have been reported for the same polypeptide.
3 enables robust ubiquitination of the nascent polypeptide.
4 tems, these proteins are fused into a single polypeptide.
5 h the surface along the entire length of the polypeptide.
6 in polysaccharide biosynthesis into a single polypeptide.
7 translationally incorporated into the parent polypeptide.
8 s when the domains are expressed as separate polypeptides.
9 tion of reaction centre and light-harvesting polypeptides.
10 unction in the presence of aggregation-prone polypeptides.
11 s in chaperone holdase activity for unfolded polypeptides.
12 form a disulfide bridge between two Siglec-E polypeptides.
13 re protein complexes formed by six different polypeptides.
14 n of cytochrome P450, family 7, subfamily b, polypeptide 1 (CYP7B1) and results in increased plasma l
16 r nuclear membrane protein lamina-associated polypeptide 1 (LAP1), are required for rearward nuclear
17 lipoprotein B mRNA-editing enzyme, catalytic polypeptide-1 (APOBEC1), together with its cofactor RBM4
18 that apolipoprotein B mRNA-editing catalytic polypeptide 3 expression and editing function was heat s
19 that apolipoprotein B mRNA-editing catalytic polypeptide 3A (A3A) and A3G expression levels were sign
20 l:betaGlcNAc beta-1,4-galactosyltransferase, polypeptide 5 (B4GALT5) expression in lung tissue (P = 1
22 cluding increased enzyme activity, increased polypeptide accumulation, and possibly reduced substrate
23 de variety of cargo including nucleic acids, polypeptides, adeno-associated viruses, and nanodots.
24 d dynamics of a self-assembling elastin-like polypeptide along its entire self-assembly pathway, from
26 genes found in C-fibers: calcitonin-related polypeptide alpha (Calca/Cgrpalpha), specific to pain-se
28 ntial enzymatic activities from a single Sde polypeptide: an ADP-ribosyltransferase and a nucleotidas
29 etween two polypeptides, or between a single polypeptide and a new molecule (polymer, small molecule,
30 d-beta, alpha synuclein, human islet amyloid polypeptide and prions, the peptides and proteins associ
31 ss to multiple activity states from the same polypeptide and transmission of that information across
32 to probe the mobility and density of the FG-polypeptides and embedded macromolecules within intact N
33 re the hydration water dynamics on different polypeptides and liposome surfaces and find the DW dynam
37 The RQC complex polyubiquitylates aberrant polypeptides and recruits a Cdc48 hexamer to extract the
38 amides, anionic polysaccharides, and anionic polypeptides) and polybases (e.g., polyamines, pyridine
39 n, vasoactive intestinal peptide, pancreatic polypeptide, and 24-hour urinary 5-hydroxyindoleacetic a
41 wers into iDR-NCs using PEG-grafted cationic polypeptides, and (4) physically loading neoantigen into
42 tified mitotic regulators, misfolded nascent polypeptides, and pathological Huntingtin variants as th
44 significant upregulation of fibrinogen gamma polypeptide, apolipoproteins A-Ib and A-II, galectin-1,
47 M) and closely related calmodulin-like (CML) polypeptides are principal sensors of Ca(2+) signals.
48 EGF Arg(1023) to citrulline with recombinant polypeptide arginine deiminase 4 (PAD4) abolished ADAMDE
50 o actin subunits connected by a single Lmod2 polypeptide, as reported in the original structure, the
51 NUCB1 inhibits aggregation of islet-amyloid polypeptide associated with type 2 diabetes mellitus, a-
54 RMM36m, with improved accuracy in generating polypeptide backbone conformational ensembles for intrin
59 mmarize the recent advances in the design of polypeptide-based supramolecular structures, including c
60 stem is developed to easily tune the size of polypeptide-based, thermoresponsive hydrogel particles,
61 e ribonucleoproteins (RNPs) with a family of polypeptides bearing different arrangements of cationic
62 ee protein subpopulations, including nascent polypeptides being translated and post-translationally m
63 ndependent growth, whereas its chaperone and polypeptide-binding functionalities are dispensable.
64 c understanding of the dynamic nature of the polypeptide-binding pocket in the Hsp70 chaperone cycle.
66 e RQC component, Rqc2p, modifies the nascent polypeptide by adding a carboxyl-terminal alanine and th
68 a partly conserved 40-residue nonstructural polypeptide, called the delta peptide, that is produced
69 d a paradigm by which lncRNAs encoding small polypeptides can modulate general biological pathways an
70 Using a combination of small molecule and polypeptide CCS calibrants, we successfully determined t
72 mical protein synthesis to prepare three ShK polypeptide chain analogues, each containing either an a
74 at of an overall extended and highly dynamic polypeptide chain comprising three helical segments and
78 donor to the asparagine residue of a nascent polypeptide chain is catalyzed by an oligosaccharyltrans
79 m a trefoil knot in the denatured state of a polypeptide chain of 120 residues is 5.8 +/- 1 kcal mol(
80 is is the first evidence that folding of the polypeptide chain precedes disulfide formation within a
81 tudied folding events at the early stages of polypeptide chain translocation into the mammalian ER us
82 le of hindered dihedral rotations within the polypeptide chain, with a proportionality coefficient b
83 known about spontaneous knot formation in a polypeptide chain-an event that can potentially impair i
87 plings between amino acids within and across polypeptide chains have allowed for inference of native
88 and allo-Ile, both l-allo-ShK and d-allo-ShK polypeptide chains were prepared by total chemical synth
90 Hsp70 that binds ribosome-associated nascent polypeptide chains, also binds to the TPR domain of Sec7
91 xpression of the corresponding complementary polypeptide chains, retain tetrameric architecture and a
92 MCM2-7 is a heterocomplex made of different polypeptide chains, the MCM complexes of many Archaea fo
95 a large channel that contains three types of polypeptide clamp sites: an alpha clamp, a phenylalanine
98 UN, ATP hydrolysis by the D2 ring moves the polypeptide completely through the double ring, generati
100 nit and the smallest of its kind, the 23-kDa polypeptide comprises a metallonuclease domain only.
102 Here, the authors show that control over a polypeptide conformation can be achieved by altering the
103 racellular fate of micelles of a recombinant polypeptide conjugated with doxorubicin via an acid-labi
104 esigned and tested simple de novo 98-residue polypeptides containing 7-residue repeats (AEEEXXX, wher
105 RPM6/7 are the only known examples of single polypeptides containing both an ion channel pore and a s
106 Our results suggest that an appropriate polypeptide context or other adequate structural element
108 in the -1 frame, and generate the 70 aa-long polypeptide CopA(Z), which helps cells survive toxic cop
109 e main fraction as well as small fraction of polypeptides could lower the denaturation of crayfish my
110 uch as with the erythropoietin protein, a V3 polypeptide derived from HIV-1 gp120, or a simple 9-fluo
111 V whole-virus (WV) particles and recombinant polypeptides derived from the four PEDV structural prote
112 evolution of inter-monomer distances within polypeptides deviates both from the predictions of those
114 gration, including the efficiency with which polypeptide domains integrate into the membrane, the var
116 i) to obtain a reduced dynamical model for a polypeptide dynamics in water and (ii) to identify diagn
117 N-myristoyltransferase with an elastin-like polypeptide (ELP) fused to a short recognition sequence
118 versus uncollapsed state of an elastin-like polypeptide (ELP), an uncharged thermoresponsive polymer
121 ymmetric structure within the homodimeric Fc polypeptide, enable completely selective binding to the
124 enylalanine, l-tyrosine, l-tryptophan) and a polypeptide (epsilon-poly-l-lysine) in prolonging the co
126 ound to also bind ribosomes near the nascent polypeptide exit tunnel, but the function of this SecA-r
128 heir activity, whereas vasoactive intestinal polypeptide-expressing interneurons increased their acti
131 Neither the l-allo-ShK nor the d-allo-ShK polypeptides folded, whereas both l-ShK and d-ShK folded
133 QC), which targets the partially synthesized polypeptide for proteasomal degradation through the acti
138 IkappaBalpha (nuclear factor of kappa light polypeptide gene enhancer in B-cell inhibitor, alpha), l
139 f exogenous glucose-dependent insulinotropic polypeptide (GIP) in the splanchnic region in 10 obese p
141 f clinical investigation, gastric inhibitory polypeptide (GIP), as proof-of-principle peptides to dem
142 rm of human glucose-dependent insulinotropic polypeptide (GIP), GIP(3-30)NH2, was recently identified
143 ghrelin, cholecystokinin, gastric inhibitory polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and
144 stability in de novo and naturally-occurring polypeptides, giving new insight into how single alpha-h
146 atelet preparation that concentrates various polypeptide growth factors and, therefore, has the poten
148 ations in multi-domain nuclear receptor (NR) polypeptides has remained challenging, with few crystal
150 est change in hepatitis B virus core antigen polypeptide (HBcAg/p21) synthesis, it mediates a dramati
151 Amyloid-beta (Abeta) and human islet amyloid polypeptide (hIAPP) aggregate to form amyloid fibrils th
153 or, human sodium-taurocholate cotransporting polypeptide (hNTCP), on macaque primary hepatocytes faci
155 GPCRs; these receptors are activated by long polypeptide hormones and constitute targets of drug deve
157 ression has come far since the 'one-gene one-polypeptide' hypothesis proposed by Beadle and Tatum.
162 (SHLP2), on the misfolding of islet amyloid polypeptide (IAPP), a critical pathogenic step in type 2
164 y effect on the aggregation of islet amyloid polypeptide (IAPP), a peptide which shares sequence simi
165 ded aggregates composed of the islet amyloid polypeptide (IAPP), its role in the disease is unknown.
166 sically disordered polypeptide islet amyloid polypeptide (IAPP), which is associated with type 2 diab
168 nt synthesis of a smaller number of cellular polypeptides illustrating a unique mode of action of the
169 diseases is that the level of amyloidogenic polypeptide in vivo is below the critical concentration
170 ue phase transition behavior of elastin-like polypeptides in bulk and within microfluidic-generated d
171 s) of myosin light-chain phosphatase partner polypeptides in regulation of vascular smooth-muscle cel
173 re of how Gnd(+) influences the stability of polypeptides in three distinct physical regimes by varyi
175 ranscript encoding a protein named AtC30Y, a polypeptide including most part of AtCPSF30 and a YT521B
176 The single Arf mRNA encodes two distinct polypeptides, including full-length p19(Arf) and N-termi
178 umulation is regulated and whether the ISG15 polypeptide influences HCMV replication remain unknown.
179 report that a systemic administration of the polypeptide insulin-like growth factor II (IGF-II) rever
181 hat brings N- and C-terminal segments of the polypeptide into proximity, high ionic strength that pro
182 translocates signal peptide-bearing nascent polypeptides into the endoplasmic reticulum (ER), and it
183 erse family of membrane-permeabilizing small polypeptides involved in replication and pathogenesis of
184 l translation of mRNA into the corresponding polypeptide is a complex multistep process, requiring ac
189 interaction of the intrinsically disordered polypeptide islet amyloid polypeptide (IAPP), which is a
190 tes I. scapularis organic anion transporting polypeptide, isoatp4056 and kynurenine amino transferase
191 ing ISG15 accumulation and whether the ISG15 polypeptide itself influences HCMV infection biology rem
192 tional and biorelated films like polymer and polypeptide layers, which is of topical interest for int
194 olipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) genes as an important source o
195 lipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) proteins are a family of cytid
196 olipoprotein B mRNA editing enzyme catalytic polypeptide-like APOBEC3A and APOBEC3B have emerged as k
200 etent states, as compared with a random-coil polypeptide, may contribute to the slow in vitro folding
202 ring amyloid fibril formation, amyloidogenic polypeptides misfold and self assemble into soluble pre-
203 found that the molecular structure of these polypeptides modulates the degree of PABP-mediated enhan
204 protein-conducting conduits that facilitate polypeptide movement in the opposite direction-from the
205 rions were generated in cells overexpressing polypeptide N-acetylgalactosaminyltransferase 1 (GalNAcT
206 catalytic subunit gamma gene PPP3CC and the polypeptide N-acetylgalactosaminyltransferase 4 gene GAL
207 is initiated by a large family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases (GalNAc-T
208 covery of sodium taurocholate cotransporting polypeptide (NTCP) as the hepatitis B virus (HBV) recept
210 s for the sodium-taurocholate cotransporting polypeptide (NTCP), which is a hepatocellular transporte
212 n wild-type (WT), organic anion transporting polypeptide (OATP) knockout mice (lacking Slco1a/1b isof
213 gated the role of organic anion transporting polypeptide (OATP) transporters to the disposition of do
214 uding 909 bp of coding region that encoded a polypeptide of 302 amino acids possessing all the charac
217 erized alpha-helical cytotoxic islet amyloid polypeptide oligomers which interact with cell membranes
218 formation of new covalent bonds between two polypeptides, or between a single polypeptide and a new
220 BNST pituitary adenylate cyclase activating polypeptide (PACAP) and its cognate PAC1 receptor transc
221 n of NUPR1, mapped by NMR, was a hydrophobic polypeptide patch at the 30s region of its sequence, as
222 ellular matrices as populations of assembled polypeptide phases ranging from particles to amyloid fib
223 ugh locomotion-induced vasoactive intestinal polypeptide positive (VIP) interneuron depolarization ca
225 tor (Y4R) and its cognate ligand, pancreatic polypeptide (PP), are involved in the regulation of ener
226 her-order functions in living systems (e.g., polypeptides, proteins, and nucleic acids) cannot occur
227 factor 7-like 2 (TCF7L2), gastric inhibitory polypeptide receptor (GIPR), caveolin 2 (CAV2), and pept
228 tive GLP-1, glucose-dependent insulinotropic polypeptide receptor (Gipr)-deficient mice receiving bac
229 upled pituitary adenylate cyclase-activating polypeptide receptor (PAC1R) is a potential therapeutic
232 n elaborate multidomain architectures, these polypeptides represent challenging targets for detailed
233 logical functions supported by these diverse polypeptides require them to have an amphipathic nature,
236 te was transcribed with 12 pure proteins (80 polypeptides): RNA polymerase II, six general transcript
237 Standard methods that rely on perturbing a polypeptide's sequence and evaluating impact on folding
241 us of the data analysis was on an 11-residue polypeptide segment in mouse [Formula: see text](121-231
242 he RodZ transmembrane domain dictate nascent polypeptide selection by SecA instead of the SRP machine
243 natural d-proline ((D)P) stereoisomer into a polypeptide sequence is a typical strategy to encourage
246 ,2,3-triazole groups, when incorporated onto polypeptide side-chains, serve as both H-bond donors and
248 se CRISPR/Cas9 engineering to develop a SPAR-polypeptide-specific knockout mouse while maintaining ex
250 ir venom such as conotoxins, which are short polypeptides stabilized by disulfide bonds, and conopept
251 and facilitate the in-register alignment of polypeptide strands that is characteristic of amyloid fi
255 in a cooperative manner from their unfolded polypeptide subunits, without biological chaperones.
258 , which is reversibly conjugated to numerous polypeptide targets, impacts the proteome and physiology
260 of insulin-like growth factor II (IGF-II), a polypeptide that crosses the blood-brain barrier and act
261 n insulin mRNA encoding a highly immunogenic polypeptide that is targeted by T cells in T1D patients.
262 tudy reveals a new source of nonconventional polypeptides that act as self-epitopes in clinical autoi
264 family of thermally responsive elastin-like polypeptides that exhibit temperature-triggered micelliz
265 ic phosphorylated tyrosine into the cationic polypeptide, the helical structure of AMPs was distorted
266 o drive the ligation of separately expressed polypeptides through a process termed protein trans-spli
267 cation channel for the movement of misfolded polypeptides through the endoplasmic reticulum membrane.
268 nd the global reconfiguration timescale of a polypeptide to be the sum of solvent friction and intern
270 ality control mechanisms eliminate defective polypeptides to ensure proteostasis and to avoid the tox
271 capture of increasingly complex motifs from polypeptides to single cell organisms and mammalian cell
274 s a subtle increase in cytoplasmic HBcAg/p21 polypeptide translation, which shifts the equilibrium fr
276 nt, indicating that both the beta-barrel and polypeptide transport-associated (POTRA) domains are req
277 Arabidopsis thaliana, revealing three tandem polypeptide transport-associated (POTRA) domains, with P
278 tion of segment 7 mRNA with NXF1, mutant NS1 polypeptides unable to promote mRNA export did neither.
279 ons of a collection of labeled and unlabeled polypeptides using smFRET and SAXS, we directly assessed
280 t a strategy to modulate the conformation of polypeptides utilizing donor-acceptor interactions emana
281 PAC1/2 receptor ligand vasoactive intestinal polypeptide (VIP) had no effect on plasma corticosterone
282 f mast cells (MCs) and vasoactive intestinal polypeptide (VIP) in barrier regulation in IBS and healt
283 ice, lower activity of vasoactive intestinal polypeptide (VIP) interneurons resulted in an increased
285 zation of the peptides vasoactive intestinal polypeptide (VIP), calcitonin-gene related peptide (CGRP
287 ional interactions between nucleic acids and polypeptides was a key transition in the origin of life
288 ntibody response, mainly directed against S1 polypeptides, was observed at days 7 to 10 postinfection
289 ymes, they appear as tandem repeats in large polypeptides we refer to as CSRPs (copper-only SOD-repea
290 ucagon-like peptide 1 and gastric inhibitory polypeptide were lower compared with PS-CF, and after 18
291 he three allo-Thr or allo-Ile-containing ShK polypeptides were able to fold into defined protein prod
292 ransport is an assembly of natively unfolded polypeptides, which contain phenylalanine-glycine (FG) b
293 DeActs, genetically encoded actin-modifying polypeptides, which effectively induce actin disassembly
294 rogress in the chemical design of functional polypeptides, which plays a crucial role to manipulate t
295 tu maturation of UQCRFS1 produces N-terminal polypeptides, which remain bound to holocomplex III.
296 osin alpha 1 (Talpha1)-a naturally occurring polypeptide with an excellent safety profile in the clin
297 a highly extended, intrinsically disordered polypeptide with unusually high polyproline type II heli
299 ns a large diversity of essentially isomeric polypeptides with the cationic and amphiphilic character
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