ライフサイエンスコーパス: polyphosphoinositide

1 Escherichia coli, and its activity requires polyphosphoinositides.

2 inases that phosphorylate the 3' position of polyphosphoinositides.

3 the synthesis of agonist-sensitive pools of polyphosphoinositides.

4 -bisphosphate and two 3-phosphate-containing polyphosphoinositides.

5 f phospholipase C, which hydrolyzes membrane polyphosphoinositides.

6 )P showed significantly less binding to most polyphosphoinositides.

7 rostatic effects for lateral organization of polyphosphoinositides.

8 h BSA had increased (4-5-fold) hydrolysis of polyphosphoinositides.

9 in the ability of the MARCKS-ED to sequester polyphosphoinositides.

10 e proteins to cell membranes through binding polyphosphoinositides.

11 This insulin-sensitive polyphosphoinositide 5'-phosphatase did not catalyze dep

12 The insulin-regulated polyphosphoinositide 5'-phosphatase was not immunoreacti

13 e observed previously that overexpression of polyphosphoinositide 5-phosphatase IV (5ptaseIV) that de

14 ge of HIV-1 in an A3.01 clone that expresses polyphosphoinositide 5-phosphatase IV (5ptaseIV), which

15 we examined the impact of overexpression of polyphosphoinositide 5-phosphatase IV (5ptaseIV), which

16 evious studies showed that overexpression of polyphosphoinositide 5-phosphatase IV (5ptaseIV), which

17 cell membrane (approximately 50 A(2)), only polyphosphoinositides achieve this threshold.

18 show that PLDbeta is stimulated by different polyphosphoinositides, among which PI(4,5)P2 is most eff

19 permeant synthetic 10-mer peptide that binds polyphosphoinositides and increases PI 3-kinase activity

20 The findings implicate D3 polyphosphoinositides and integrin signaling in PMA-medi

21 permeant synthetic 10-mer peptide that binds polyphosphoinositides and leads to activation of PI 3-ki

22 l significance of a PLD that is regulated by polyphosphoinositides and physiological concentrations o

23 gated the putative roles of phospholipase C, polyphosphoinositides, and inositol 1,4,5-trisphosphate

24 l, phosphatidylserine, phosphatidylinositol, polyphosphoinositides, and sphingosine 1-phosphate) show

25 ects of this diversity: the evolution of the polyphosphoinositides, and the synthesis and functions o

26 Polyphosphoinositides are among the most highly charged

27 Polyphosphoinositides are an important class of lipid th

28 Polyphosphoinositides are lipid signaling molecules gene

29 Polyphosphoinositides are needed for exocytosis, but it

30 Polyphosphoinositides are thought to be mediators of cel

31 PROPPINs (beta-propellers that bind polyphosphoinositides) are a family of PtdIns3P- and Ptd

32 PROPPINs (beta-propellers that bind polyphosphoinositides) are PtdIns3P and PtdIns(3,5)P2 bi

33 p85beta) of PI3K, an enzyme that generates 3-polyphosphoinositides at the plasma membrane.

34 ations of residues known to be essential for polyphosphoinositide binding in previously characterized

35 a heterogeneous gene family and that direct polyphosphoinositide binding is required for the activit

36 n-associated AP-2 adaptor protein is a major polyphosphoinositide-binding protein in mammalian cells.

37 This polyphosphoinositide binds the pleckstrin homology (PH)

38 increase in intracellular calcium levels and polyphosphoinositide bis phosphate (PIP2) hydrolysis.

39 Polyphosphoinositides both integrate signaling pathways

40 ed after phospholipase C activation, causing polyphosphoinositide breakdown, and was accelerated by e

41 Run-down of cellular polyphosphoinositides by concentrations of wortmannin th

42 of CD45 phosphatase/protein tyrosine kinase/polyphosphoinositide/Ca2+/protein kinase C pathway rathe

43 This connection to polyphosphoinositides, compounds whose levels are physio

44 This fraction is also enriched in polyphosphoinositides, containing approximately one-fift

45 ulates PLD by mediating its interaction with polyphosphoinositide-containing membranes; this might al

46 in cleaves actin filaments in a calcium- and polyphosphoinositide-dependent manner.

47 in dry seeds and mature leaves, whereas the polyphosphoinositide-dependent PLD activity was greater

48 The polyphosphoinositide-dependent PLD requires calcium for

49 myo-Inositol (Ins) and its polyphosphoinositide derivatives that are important in m

50 Results of previous work suggest that polyphosphoinositides disrupt this interaction and there

51 te a requirement for phospholipase C and for polyphosphoinositides for activation of capacitative cal

52 osphatidylinositol (PI) 3-kinase-mediated 3'-polyphosphoinositide generation and activation of Akt/pr

53 fied in Arabidopsis thaliana, and Ca(2+) and polyphosphoinositides have been suggested as key regulat

54 Polyphosphoinositides have many roles in cell signalling

55 tor expression and mGlu1/5 receptor-mediated polyphosphoinositide hydrolysis were also unchanged in t

56 to polybasic clusters known to interact with polyphosphoinositides identified in other ion channels.

57 ction, suggesting an important role for this polyphosphoinositide in vesicular trafficking.

58 This review emphasizes the role of polyphosphoinositides in recruiting signaling proteins t

59 useful to probe the location and function of polyphosphoinositides in vivo.

60 nositide-requiring PLDbeta and PLDgamma, and polyphosphoinositide-independent PLDalpha.

61 and HIP1-related (HIP1r), have an N-terminal polyphosphoinositide-interacting epsin N-terminal homolo

62 , a process that is known to be dependent on polyphosphoinositide lipids.

63 ositol-4-phosphate rather than a build-up of polyphosphoinositides or changes in the activity of phos

64 ate (PMA), did not alter the distribution of polyphosphoinositides or the polyphosphoinositide phosph

65 tool for pharmacological intervention in the polyphosphoinositide pathway and an important lead compo

66 seems causally related to alterations in the polyphosphoinositide pathway.

67 zymatic activity that defines a new class of polyphosphoinositide phosphatase (PPIPase).

68 ings suggest that polyphosphoinositides, the polyphosphoinositide phosphatase and protein kinase C pl

69 study, we have identified synaptojanin 2, a polyphosphoinositide phosphatase as a novel Rac1 effecto

70 Synaptojanin 1 is a polyphosphoinositide phosphatase concentrated in presyna

71 Inp53p contains a SacI polyphosphoinositide phosphatase domain, a 5-phosphatase

72 of FIG4, whose gene product contains a Sac1 polyphosphoinositide phosphatase domain, which suppresse

73 Ins(3,5)P(2) is mediated in part by the Sac1 polyphosphoinositide phosphatase family member Fig4.

74 Synaptojanin 1 is a polyphosphoinositide phosphatase implicated in synaptic

75 Synj1 is a polyphosphoinositide phosphatase important at convention

76 Synaptojanin 1 (SynJ1) is a polyphosphoinositide phosphatase involved in clathrin-me

77 Disruption of the presynaptically enriched polyphosphoinositide phosphatase synaptojanin 1 leads to

78 nes during endocytosis, or that it binds the polyphosphoinositide phosphatase synaptojanin and recrui

79 gh SH3 domain-mediated interactions with the polyphosphoinositide phosphatase synaptojanin and the GT

80 nzyme endophilin recruits and stabilizes the polyphosphoinositide phosphatase synaptojanin at nerve t

81 minals that binds the GTPase dynamin and the polyphosphoinositide phosphatase synaptojanin, two prote

82 Finally, depleting endogenous PIP2 with polyphosphoinositide phosphatase synaptojanin-1, known t

83 otein which binds the GTPase dynamin and the polyphosphoinositide phosphatase synptojanin.

84 Synaptojanin 2 is a ubiquitously expressed polyphosphoinositide phosphatase that displays a high de

85 Synaptojanin is a polyphosphoinositide phosphatase that is found at synaps

86 poral recruitment of synaptojanin 1 (SJ1), a polyphosphoinositide phosphatase, and its binding partne

87 We report here that the polyphosphoinositide phosphatase, but not several other

88 Synaptojanin 1, a polyphosphoinositide phosphatase, is expressed as two ma

89 wed that synaptojanin 1 (SJ1), a presynaptic polyphosphoinositide phosphatase, is required for normal

90 A polyphosphoinositide phosphatase, synaptojanin 1, was id

91 distribution of polyphosphoinositides or the polyphosphoinositide phosphatase.

92 osphate-5-Phosphatase F (INPP5F), one of the polyphosphoinositide phosphatases, is differentially exp

93 es in the cell membrane, and the most common polyphosphoinositide, phosphatidylinositol-4,5-bisphosph

94 sent studies, therefore, we examined whether polyphosphoinositide-phospholipase C-gamma (PI-PLC-gamma

95 s(1,4,5)P3, D-Ins(1,3,4,5)P4, and InsP6, and polyphosphoinositides PI(4,5)P2 and PI(3,4,5)P3, which c

96 yvitamin D3 (1,25[OH]2D3) rapidly stimulated polyphosphoinositide (PI) hydrolysis, raised intracellul

97 translocation in intact adipocytes, and the polyphosphoinositide, PI 4,5-(PO4)2, stimulated Rho tran

98 Polyphosphoinositides PI4-P and PI4,5P2 and cardiolipin

99 s of signal transduction, a process in which polyphosphoinositides play a central role.

100 suggest that attractive interactions between polyphosphoinositides, possibly mediated by hydrogen bon

101 Although chilling does not change polyphosphoinositide (ppI) levels, a ppI-binding peptide

102 particular interest in this context are the polyphosphoinositides (PPI's), especially phosphatidylin

103 Polyphosphoinositides (PPI) play crucial roles in cellul

104 how acute depletion of negatively charged PM polyphosphoinositides (PPIns) from the PM alters the int

105 Polyphosphoinositides (PPIs) affect the localization and

106 Polyphosphoinositides (PPIs) and in particular phosphati

107 , the susceptibility of membranes containing polyphosphoinositides (PPIs) to divalent cation-induced

108 the villin/gelsolin family are regulated by polyphosphoinositides (PPIs), and manipulation of cellul

109 sensitivity and is correlated with a fall in polyphosphoinositides (PPIs), including phosphatidylinos

110 The polyphosphoinositides (PPIs), phosphatidylinositol 3,4-b

111 arious lipid signaling molecules, designated polyphosphoinositides (PPIs).

112 agnesium on aggregation of PI4,5P2 micelles, polyphosphoinositides promote interactions with the tali

113 beta-propellers that bind polyphosphoinositides (PROPPINs), a eukaryotic WD-40 mot

114 P] 5-kinase responsible for synthesis of the polyphosphoinositide PtdIns(3,5)P(2).

115 ,5)P3, Ins(1,3,4,5)P4, and InsP6, and of the polyphosphoinositides PtdIns(3,4,5)P3, PtdIns(4,5)P2, an

116 via their predicted beta-propeller fold the polyphosphoinositides PtdIns3P and PtdIns(3,5)P(2) using

117 rgeting of their host proteins by binding to polyphosphoinositides; recent results have increased our

118 Polyphosphoinositides regulate numerous steps in membran

119 t intermediate for the synthesis of membrane polyphosphoinositides, regulators of multiple cellular f

120 ey exhibit two distinct types of activities: polyphosphoinositide-requiring PLDbeta and PLDgamma, and

121 cally to PtdIns 3-phosphate (PtdIns-3-P) and polyphosphoinositides, respectively, can direct such mem

122 Failure to catabolize polyphosphoinositides retards the fission process and en

123 Overexpressed pleckstrin can affect polyphosphoinositide second messenger-based signaling ev

124 ential participants in the generation of all polyphosphoinositide signaling molecules.

125 zation results in the biphasic activation of polyphosphoinositide-specific phospholipase C (PLC) acti

126 Ca(2+), alpha-latrotoxin does not stimulate polyphosphoinositide-specific phospholipase C. alpha-Lat

127 olysis of host PI and the activation of host polyphosphoinositide-specific PLC and host phospholipase

128 lta) are known to catalyze the hydrolysis of polyphosphoinositides such as phosphatidylinositol 4,5-b

129 Furthermore, when polyphosphoinositide synthesis was allowed to proceed in

130 a catalytic mechanism, because the amount of polyphosphoinositides synthesized greatly exceeded the m

131 rk, however, has highlighted the role of the polyphosphoinositide synthetic pathways in activated cel

132 inases is the first step in the synthesis of polyphosphoinositides, the lipid precursors of intracell

133 These findings suggest that polyphosphoinositides, the polyphosphoinositide phosphat

134 ein kinase, which interacts with membrane 3'-polyphosphoinositides through its pleckstrin homology (P

135 As polyphosphoinositides turn over rapidly and are exceptio

136 ts during target cell stimulation, including polyphosphoinositide turnover and tyrosine phosphorylati

137 nd intrinsic activity of phenethylamines for polyphosphoinositide turnover but not for arachidonic ac

138 Its requirement for polyphosphoinositides was further supported by its abili

139 vitro, although the other D5-phosphorylated polyphosphoinositides were also substrates.

140 y Rho-family GTPases such as Cdc42, membrane polyphosphoinositides, WIP/verprolin, and SH3 domain pro