ライフサイエンスコーパス: polyploid cell

1 e cytological nuclear abnormalities (even in polyploid cells).

2 quitination of histone-H2A at lysine-119) in polyploid cell.

3 of chromosome structure in both diploid and polyploid cells.

4 aryocytes, as well as an increased number of polyploid cells.

5 ribed changes with respect to development in polyploid cells.

6 from problems with chromosome segregation in polyploid cells.

7 g and functional analysis in post-mitotic or polyploid cells.

8 phology checkpoint to avoid the formation of polyploid cells.

9 ural chromosome instability of the resulting polyploid cells.

10 s in terminally differentiated larval midgut polyploid cells.

11 g cells replicate their DNA and propagate as polyploid cells.

12 ly in cells programmed to differentiate into polyploid cells.

13 bition by MK-0457, and preferentially killed polyploid cells.

14 le but skip late stages of mitosis to become polyploid cells.

15 s well as the endo cycle (S-G) that produces polyploid cells.

16 a reduced mitotic index and the presence of polyploid cells.

17 ns, failure of cytokinesis, and emergence of polyploid cells.

18 DNA synthesis resulted in the generation of polyploid cells.

19 kinase activity was largely abolished in the polyploid cells.

20 6 were haploinsufficient with an increase in polyploid cells, a reduction in cell proliferation, elev

21 in UV- and VP-16-treated cells and increases polyploid cells after VP-16 treatment.

22 ive stress promotes the appearance of highly polyploid cells, and antioxidant-treated NAFLD hepatocyt

23 Polyploid cells are a characteristic feature of certain

24 However, polyploid cells are found in many tumors, and the enhanc

25 In many developmental processes, polyploid cells are generated by a variation of the norm

26 In these circumstances, large polyploid cells are produced in organisms that are prima

27 t precursor, the megakaryocyte, matures to a polyploid cell as a result of DNA replication in the abs

28 In polyploid cells, Bik1 is required before anaphase to mai

29 ntial recognition of autophagy-competent and polyploid cells by the innate and cellular immune system

30 p53-mediated suppression of proliferation of polyploid cells can be averted by increased levels of on

31 Somatic polyploid cells can be mononucleate or multinucleate, an

32 In mammals, the development of polyploid cells can contribute to tissue differentiation

33 Polyploid cells can originate from cell fusion, endorepl

34 end points are preceded by the appearance of polyploid cells caused by the suppression of Aurora kina

35 The remaining 15 cells initiate a series of polyploid cell cycles to prepare for their role as nurse

36 ly degraded by acetylated Skp2, resulting in polyploid cell division, genomic instability, and oncoge

37 Normally, polyploid cells do not divide mitotically after initiati

38 meiosis-specific genes are expressed in the polyploid cells during depolyploidization.

39 While most cells maintain a diploid state, polyploid cells exist in many organisms and are particul

40 Concomitant with polyploid cell formation, we observed the appearance of

41 ulture with thrombopoietin failed to develop polyploid cells greater than 8N.

42 romotes the diploid-polyploid conversion and polyploid cell growth through the Akt-Skp2 axis.

43 Polyploid cells have genomes that contain multiples of t

44 p53 activity leads to a greater fraction of polyploid cells, higher mean and maximum ploidy, acceler

45 w cytometry confirmed a greater frequency of polyploid cells in basal zones of leaf blades, consisten

46 and the enhanced chromosomal instability of polyploid cells in culture suggests that such cells cont

47 0% in humans, the specialized role played by polyploid cells in liver homeostasis and disease remains

48 f p53 in 4pX-1 cells increases by 5-fold the polyploid cells in response to pX expression, indicating

49 o apoptosis and to allow for accumulation of polyploid cells in vitro.

50 The mitotic arrest occurring in these polyploid cells involves novel alterations in the cdk1/c

51 igenesis, primarily because cell division in polyploid cells is error-prone and produces aneuploid ce

52 Underreplication of specific regions in polyploid cells is proposed to be due to a slower S phas

53 Thus, disrupting genes in polyploid cell lines or when using poorly performing sgR

54 The polyploid cells lost the capacity for proliferation and

55 minichromosome Dp(1;f)1187 are shortened in polyploid cells of both the ovary and salivary gland but

56 ithin sequences that are underrepresented in polyploid cells of Drosophila melanogaster.

57 ocycles, as we find only the M-phase-capable polyploid cells of the papillae and female germline can

58 e mechanisms that lead to the development of polyploid cells, our current state of understanding of h

59 thout significant genetic instability (i.e., polyploid cell populations were not observed).

60 ra-nuclear protein translocation of FoxM1 in polyploid cells, respectively.

61 The accumulation of aneuploid or polyploid cells resulting from a disrupted mitotic spind

62 the formation of tetraploid or higher-order polyploid cells resulting from the culture of human colo

63 ergo cytokinesis, producing aploid cells and polyploid cells that contain multiple SPBs.

64 tion of Aurora-A in adult tissues results in polyploid cells that display a DNA-damage-like response

65 Megakaryocytes are large, polyploid cells that produce platelets.

66 ollectively as endoreplication, resulting in polyploid cells that support specific aspects of develop

67 o the sustained increase in the frequency of polyploid cells, the level of polyploidization was downr

68 In this study we employed sorted, pX-induced polyploid cells to investigate their growth and oncogeni

69 in diploid cells resulted in acquisition of polyploid cell traits.

70 ker gene expression, the appearance of large polyploid cells (trophoblast giant cells), and the expre

71 inantly enhance the dap phenotype in several polyploid cell types.

72 live cell-sorting, nearly 40% of pX-induced polyploid cells undergo apoptosis, whereas the surviving

73 ic checkpoint abnormality with production of polyploid cells when exposed to microtubule-targeting dr

74 e heterozygotes with such mutations generate polyploid cells when exposed to spindle depolymerizing a

75 mosome structure is a characteristic of some polyploid cells where several to thousands of chromatids

76 Polyploid cells, which contain more than two genome copi

77 cation remains unfinished in many Drosophila polyploid cells, which harbor disproportionately fewer c

78 d Kinesin-14 HSET increased the frequency of polyploid cells, which resulted from a failure in cytoki

79 because Aurora-A-deficient tumors accumulate polyploid cells with limited proliferative potential.

80 Given that mitochondrial genomes are polyploid, cells with advantageous levels of mtDNA mutat

81 are terminally differentiated, uncultivable polyploid cells, with remarkably elongated and even bran

82 ientation of individual chromosomes in large polyploid cells would not hamper reproductive success as

83 were specifically exposed on the surface of polyploid cells, yet lost upon passage of such cells thr