ライフサイエンスコーパス: polyploidization

1 and genome size variation, but likely not by polyploidization.

2 mber of cell cycling cells and in augmenting polyploidization.

3 d robust excision and an increased degree of polyploidization.

4 events may also contribute to the effects of polyploidization.

5 patterns of hybrid sterility and in rates of polyploidization.

6 panied by endoreduplication and consequently polyploidization.

7 igens, inhibition of cell proliferation, and polyploidization.

8 cytes from Stat1(-/-) mice were defective in polyploidization.

9 then enter an endocycle, resulting in their polyploidization.

10 first few million years after duplication or polyploidization.

11 ypothesized to represent abnormal hepatocyte polyploidization.

12 d into a cluster of cdc2-related genes after polyploidization.

13 elatives of wheat suggests that Ph1 arose on polyploidization.

14 n the maintenance of paralogs resulting from polyploidization.

15 than expected, given the age of the inferred polyploidization.

16 idy checkpoint acting to limit the degree of polyploidization.

17 ithin a single nuclear envelope, perpetuates polyploidization.

18 s and giant nuclei, consistent with roles in polyploidization.

19 iploidization occurred very slowly following polyploidization.

20 dergone extensive modification subsequent to polyploidization.

21 epeat families increased gradually following polyploidization.

22 ence from A. thaliana, likely as a result of polyploidization.

23 re duplicated along with the Hox clusters by polyploidization.

24 lenced during interspecific hybridization or polyploidization.

25 hepatocytes, indicating that miRNAs regulate polyploidization.

26 yclin B metabolism, cell cycle re-entry, and polyploidization.

27 metabolic differentiation, and 5) hepatocyte polyploidization.

28 nd proliferate between genomes subsequent to polyploidization.

29 ingle CD4(+) T cells undergoing a process of polyploidization.

30 and gene maps suggest that this occurred by polyploidization.

31 When added with TPO, IL-3 suppressed polyploidization.

32 ements in the hepatocyte's normal process of polyploidization.

33 IL-3 alone never increased the level of polyploidization.

34 rated, more autonomous growth contributes to polyploidization.

35 erscoring the critical role miR-122 plays in polyploidization.

36 hat miR-122 is required for complete hepatic polyploidization.

37 atterns of gene retention and loss following polyploidization.

38 vidence on the specific role of NMII-B on MK polyploidization.

39 DDEE), and speciation occurred subsequent to polyploidization.

40 replication and karyokinesis occur during MK polyploidization.

41 nsible for the specific role of NMII-B in MK polyploidization.

42 rganism for studying early changes following polyploidization.

43 ng cytokinesis, must be downregulated for Mk polyploidization.

44 ificance and agronomic relevance in terms of polyploidization.

45 on on the proteome is more important than is polyploidization.

46 anslational modifications of proteins during polyploidization.

47 ccurred subsequent to both hybridization and polyploidization.

48 ired megakaryocyte maturation, inhibition of polyploidization, abnormal proplatelet formation, and th

49 gene in megakaryocytes results in defective polyploidization accompanied by mitotic arrest and cell

50 osynthetic rate as diploids, indicating that polyploidization alone is likely not the reason for enha

51 Angiosperms show more frequent polyploidization and a higher degree of duplicate gene p

52 ossypium barbadense, were domesticated after polyploidization and are cultivated worldwide.

53 ppo signaling effector Yorkie modulates both polyploidization and cell fusion.

54 f Tnni3k in zebrafish promoted cardiomyocyte polyploidization and compromised heart regeneration.

55 in contrast to the synchronous inhibition of polyploidization and cytoplasmic maturation in adult MKs

56 the regulation of liver cell proliferation, polyploidization and death.

57 ical trials of MLN8237 and other inducers of polyploidization and differentiation in AMKL.

58 N8237, a selective AURKA inhibitor, promoted polyploidization and differentiation of megakaryocytes w

59 h significant loss of gene family members on polyploidization and domestication, and an abundance of

60 deficient megakaryopoiesis in mice, inducing polyploidization and expression of a subset of platelet-

61 ib), a selective inhibitor of AURKA, induced polyploidization and expression of mature megakaryocyte

62 is functionally important because when both polyploidization and fusion are blocked, wounds do not r

63 ot in sweet cherry (a diploid) suggests that polyploidization and gene duplication were indirectly re

64 e B inhibitors induce apoptosis secondary to polyploidization and have entered clinical trials as an

65 evolution-its members have undergone recent polyploidization and hybridization, with close relatives

66 Cs and contributes to vascular smooth muscle polyploidization and hypertrophy during hypertension.

67 tic spindle cell-cycle checkpoint, promoting polyploidization and hypertrophy.

68 rgo marked age- and blood pressure-dependent polyploidization and hypertrophy.

69 It regulates the proliferation, polyploidization and maturation of platelet precursors,

70 Similar effects on polyploidization and MK differentiation were seen with e

71 uration involve a series of steps, including polyploidization and proplatelet formation.

72 rs, although megakaryocytes showed decreased polyploidization and staining for acetylcholinesterase.

73 Ancient polyploidization and subsequent "diploidization" (loss)

74 Polyploidization and subsequent sub- and neofunctionaliz

75 that oxidative stress promotes pathological polyploidization and suggest that this is an early event

76 p53 during Mk differentiation is to control polyploidization and the transition to endomitosis by im

77 ne family whose evolution has been shaped by polyploidization and transposable element activity.

78 ce our understanding the mechanism of genome polyploidization and underpin genome-wide comparison res

79 osperms to undergo chromosomal duplication ('polyploidization') and subsequent gene loss ('diploidiza

80 mon origin, such as genome-wide duplication (polyploidization), and a concerted evolutionary process.

81 mentally unique uncoupling of proliferation, polyploidization, and cytoplasmic maturation.

82 an important regulator of megakaryopoiesis, polyploidization, and cytoskeletal dynamics in developin

83 s a higher frequency of small deletions post-polyploidization, and increased illegitimate recombinati

84 Shear forces promote DNA synthesis, polyploidization, and maturation in MKs, and platelet bi

85 adult morphogenesis program of enlargement, polyploidization, and proplatelet formation.

86 ential effector of megakaryocyte maturation, polyploidization, and proplatelet formation.

87 a developmental uncoupling of proliferation, polyploidization, and terminal differentiation.

88 iated events of megakaryocyte proliferation, polyploidization, and the expression of apoptotic marker

89 22 is both necessary and sufficient in liver polyploidization, and these studies will serve as the fo

90 was to identify novel signals that regulate polyploidization, and we focused on microRNAs (miRNAs).

91 plasia in the spleen; impaired megakaryocyte polyploidization; and increased reticulin fibrosis of th

92 Megakaryocyte maturation and polyploidization are critical for platelet production; a

93 of plants, the evolutionary consequences of polyploidization are not thoroughly understood.

94 aneuploid DNA histogram patterns and induced polyploidization as a result of successive rounds of cel

95 Our results highlight polyploidization as an important source for generating n

96 k2(-/-) megakaryocytes demonstrate increased polyploidization associated with alterations in beta1-tu

97 hirsutum L., an allotetraploid derived from polyploidization between AA and DD genome species, a res

98 onized megakaryocyte growth, maturation, and polyploidization but had no effect on erythroid developm

99 at the promegakaryocyte stage, after nuclear polyploidization, but before cytoplasmic maturation.

100 se data show that GATA-1 controls growth and polyploidization by regulating cyclin D-Cdk4 kinase acti

101 Polyploidization can precede the development of aneuploi

102 ATP, a chemotactic signal for myeloid cells, polyploidization can trigger endoplasmic reticulum stres

103 Hence, both autophagy and polyploidization cause the emission of adjuvant signals

104 (BCCIP) in HT1080 cells leads to chromosomal polyploidization, centrosome amplification and abnormal

105 ed MKlp2 knockdown in hepatoma cells induced polyploidization consistent with its essential function

106 us, a coincidence that would be explained if polyploidization directly contributed to speciation.

107 rrect, it would support Ohno's proposal that polyploidization drives evolution by generating the gene

108 o the understanding of the phenomena of VSMC polyploidization during hypertension.

109 uplication consistent with the hypothesis of polyploidization early in vertebrate history, both Ca(2+

110 ploidy is the best model to characterize the polyploidization effects in a highly controlled manner,

111 l evidence are consistent with the predicted polyploidization event and substantial homozygosity unde

112 tored to low copy number after a more recent polyploidization event in cotton.

113 pport to the possibility that a more ancient polyploidization event may have predated the A-D diverge

114 samples for many other taxa, suggests that a polyploidization event occurred approximately 70 million

115 , further supporting the hypothesis that the polyploidization event was common to sorghum and rice.

116 e-based Ks plot revealed at least one recent polyploidization event, consistent with fixed heterozygo

117 xtant genomes are the remnants of an ancient polyploidization event, rather than a result of successi

118 lication, possibly as a result of an ancient polyploidization event.

119 believed to have originated from an ancient polyploidization event; thus, each of these 28 loci was

120 r 10,000 years in B. napus) and more ancient polyploidization events (ca. 20 Myr for B. rapa and B. o

121 Polyploidization events are frequent among flowering pla

122 In the liver, physiological polyploidization events occur during both liver developm

123 e segments in mammals, it is likely that two polyploidization events occurred prior to the divergence

124 ure of plant genomes, but the nature of many polyploidization events remains to be elucidated.

125 Endomitotic polyploidization events were induced by alterations in c

126 We characterized two new polyploidization events, both occurring after the diverg

127 distinguish between tandem duplications and polyploidization events, nor whether independent duplica

128 entered through horizontal transfer or past polyploidization events.

129 gakaryocytes, which display reduced size and polyploidization, express nearly 10-fold less cyclin D1

130 hypothesis and supports the proposed role of polyploidization followed by genetic diploidizaton in th

131 p53 cooperate to allow rapid and progressive polyploidization following mitotic spindle damage.

132 The mechanism of polyploidization has been investigated extensively in Dr

133 Polyploidization has long been recognized as an importan

134 Such long-term karyotype stability after polyploidization has not been commonly observed in plant

135 Polyploidization has provided much genetic variation for

136 Polyploidization has repeatedly occurred during plant ev

137 Genome duplication (or polyploidization) has occurred throughout plant evolutio

138 Multimininucleation and subsequent polyploidization have been correlated with paclitaxel re

139 /-2 is necessary to support viability during polyploidization in a variety of tumor models and repres

140 pertrophic agent angiotensin II induced VSMC polyploidization in an Akt1-dependent manner.

141 these findings with regards to the origin of polyploidization in animal species.

142 These results suggest that polyploidization in C. bursa-pastoris enhanced its plast

143 cells demonstrated a high predisposition to polyploidization in culture and failed to maintain cycli

144 de DNA rereplication as a major mechanism of polyploidization in E7-expressing cells upon microtubule

145 We conclude that while polyploidization in Glycine has not driven a stable incr

146 Polyploidization in megakaryocytes (Mks), in contrast, i

147 Polyploidization in megakaryocytes is achieved by endomi

148 Here we investigate the properties of polyploidization in murine MKs and TGCs.

149 and are thought to be the result of ancient polyploidization in the Lamiales (> 50 mya).

150 potential role of flavoproteins in promoting polyploidization in this lineage.

151 d topologies inconsistent with two rounds of polyploidization in vertebrates.

152 miR397 and its targets as a result of genome polyploidization indicated their pivotal functions in re

153 l mass lost upon wounding can be replaced by polyploidization instead of mitotic proliferation.

154 The first step of polyploidization involves cell division with failed cyto

155 s remarkably common in the plant kingdom and polyploidization is a major driving force for plant geno

156 Although past polyploidization is a potential mechanism for the observ

157 Polyploidization is a prevalent mode of genome diversifi

158 Hybridization with polyploidization is a significant biological force drivi

159 Polyploidization is an abrupt speciation mechanism for e

160 Polyploidization is an important mechanism for introduci

161 We find no evidence that polyploidization is followed by an increase in net diver

162 enon in the Solanaceae where SC accompanying polyploidization is frequently due to the SC of heteroal

163 Polyploidization is one of the most dramatic changes tha

164 e, we have shown that the mechanism by which polyploidization is prevented in Mks lacking Mkl1, which

165 s, our current state of understanding of how polyploidization is regulated during liver growth, and i

166 , the increased SPG cell size resulting from polyploidization is required to maintain the SPG envelop

167 Polyploidization likely is a conserved strategy to coord

168 nt and recent polyploidy, together with post-polyploidization loss of many duplicated gene copies, co

169 Although plant TFs tend to be retained post polyploidization, many are lost within tens to hundreds

170 asudil (diMF, H-1152P) selectively increased polyploidization, mature cell-surface marker expression,

171 Recent evidence suggests that polyploidization may be accompanied by rapid genomic cha

172 Polyploidization may have been facilitated by environmen

173 estigated the possibility that autophagy and polyploidization might also affect the antigenicity of c

174 We demonstrate here that polyploidization neutralizes Mcl-1 function, rendering c

175 utionary events, implying that the pan-grass polyploidization occurred approximately 96 million years

176 sis that two rounds of genome duplication by polyploidization occurred early in vertebrate history.

177 To determine when this polyploidization occurred relative to speciation events

178 rounds of duplication of the entire genome (polyploidization) occurred early in vertebrate history (

179 .2) No whole-genome duplication event (i.e., polyploidization) occurred immediately prior to or after

180 Although polyploidization occurs in some types of human cells, th

181 Polyploidization occurs mainly during liver development,

182 Polyploidization occurs through failed cytokinesis, begi

183 ressed at 2-3 weeks, a period when extensive polyploidization occurs.

184 ted by induction of autophagy, as well as by polyploidization of cancer cells.

185 ryocyte progenitors, but is not required for polyploidization of committed megakaryocytes.

186 Polyploidization of diploids will allow the production o

187 se, a regulator of cytokinesis, improves the polyploidization of Fanca(-/-) MKs but greatly increases

188 ssociated with increased differentiation and polyploidization of megakaryocytes both in vivo and in v

189 o identify small-molecule probes that induce polyploidization of megakaryocytic leukemia cells and se

190 consistently inhibited TPO- and SCF-induced polyploidization of MK.

191 re, time-lapse videomicroscopy revealed that polyploidization of p53(-/-) HCT116 cells is frequently

192 hat this increased growth potential precedes polyploidization of the culture populations.

193 y to grow at low seeding densities, precedes polyploidization of these cultures.

194 Furthermore, polyploidization of wheat (both tetraploidization and he

195 TAT-p16 fusion peptide significantly blocked polyploidization of wild-type megakaryocytes.

196 We propose that large cells generated by polyploidization or cell fusion are essential because th

197 r lost either as an immediate consequence of polyploidization or on an evolutionary timescale.

198 cisplatin but does play a role in preventing polyploidization, or aberrant DNA reduplication, in the

199 Most gene duplicates arising from polyploidization (paralogs) are typically lost, although

200 f one of its diploid donors, suggesting that polyploidization plays little roles in the expansion of

201 ndings support a dynamic model of hepatocyte polyploidization, ploidy reversal and aneuploidy, a phen

202 s uncertain to what extent hybridization and polyploidization preceded domestication or were precipit

203 two successive whole-genome duplication(s) (polyploidizations) predating the origin of fishes, a vie

204 of fatty livers displayed alterations of the polyploidization process, including the presence of a la

205 ese indications of genic stasis accompanying polyploidization provide a sharp contrast to recent exam

206 e of their parental genomes, suggesting that polyploidization rather than hybridization induces genom

207 nhibitors in therapeutic strategies based on polyploidization regulators.

208 , the link between transcription factors and polyploidization remains undefined.

209 ne max) has undergone at least two rounds of polyploidization, resulting in a paleopolyploid genome t

210 It is well documented that, in addition to polyploidization, retrotransposon amplification has been

211 Alternatively, evidence of past polyploidization(s) may be masked by extensive chromosom

212 r-scale duplications and deletions following polyploidization(s).

213 oduced during interspecific hybridization or polyploidization serve as a buffer against the genomic s

214 tion of diploid gametes is a major route for polyploidization, speciation, and diversification in pla

215 o subgenomes were far less distinct prior to polyploidization, such that individual gene pairs, rathe

216 , its limited in vitro actions on human cell polyploidization suggest that additional megakaryocyte-a

217 Here, we determined that a pathological polyploidization takes place in nonalcoholic fatty liver

218 ive individuals and animals undergo dramatic polyploidization that contributes toward their hypertrop

219 the genus but did not experience any recent polyploidizations that could account for their high chro

220 ounds of duplication of the entire genome by polyploidization (the 2R hypothesis).

221 ncy of unreduced pollen in unilateral sexual polyploidization, the overall rate of neohexaploid forma

222 Together with more ancient polyploidizations, this conferred an aggregate 72x genom

223 Whole-genome duplication (WGD; polyploidization-ubiquitous in plant evolution [2]) prov

224 These allowed us to analyse both recent polyploidization (under 10,000 years in B. napus) and mo

225 This block in polyploidization was accompanied by increased expression

226 both cultured MSCs and primary hepatocytes, polyploidization was associated with a dramatic decrease

227 e frequency of polyploid cells, the level of polyploidization was downregulated on days 6 to 10, but

228 Of note, polyploidization was only modestly reduced in cyclin D1-

229 o determine whether survivin is required for polyploidization, we analyzed mice with a megakaryocyte-

230 gulation, cyclin B down-regulation, and VSMC polyploidization were evidenced at the smooth muscle of

231 Both long-term and immediate responses to polyploidization were implicated.

232 rrelated with increased MK DNA synthesis and polyploidization, which might explain the observed impac

233 , p53*; p53-/-, p53*), do not undergo normal polyploidization with aging and show an increase in the

234 y (MoAb)-fluorochrome conjugates and for DNA polyploidization with propidium iodide or 7-aminoactinom