ライフサイエンスコーパス: polyploidy

1 ore than two sets of homologous chromosomes (polyploidy).

2 me to find changes in soybean resulting from polyploidy.

3 on in genome size and different histories of polyploidy.

4 malities such as chromosomal aberrations and polyploidy.

5 merotelic attachments, anaphase lagging, and polyploidy.

6 essing unresolved problems about the role of polyploidy.

7 ts of a very common correlate of asexuality, polyploidy.

8 analysis of the evolutionary consequences of polyploidy.

9 ted in megakaryocyte endomitosis, leading to polyploidy.

10 ding to mitotic arrest and subsequently cell polyploidy.

11 works of kinases that regulate the switch to polyploidy.

12 ion and cell proliferation while inducing 8N polyploidy.

13 , followed by endomitosis and acquisition of polyploidy.

14 ition of LOX activity has no influence on MK polyploidy.

15 gents and promoting chemotherapeutic-induced polyploidy.

16 ging as a powerful new model system to study polyploidy.

17 abnormalities, which further result in cell polyploidy.

18 then replicate their DNA again, resulting in polyploidy.

19 tent spindle assembly checkpoint and reduces polyploidy.

20 mage checkpoint and DNA repair, resulting in polyploidy.

21 c of Aurora B inhibition is the induction of polyploidy.

22 ndergo an endomitotic cell cycle, leading to polyploidy.

23 rcation membrane systems, and have decreased polyploidy.

24 hat E7 may stimulate rereplication to induce polyploidy.

25 nism by which Aurora B inhibition results in polyploidy.

26 yocyte survival, and a stimulating effect on polyploidy.

27 7 expression induces a significant amount of polyploidy.

28 d rereplicated, unsegregated chromosomes and polyploidy.

29 ith HCV in vitro showed frequent chromosomal polyploidy.

30 ized in antimesometrial decidualization with polyploidy.

31 rrest in G(2), followed by rereplication and polyploidy.

32 e fusions, anaphase bridges, aneuploidy, and polyploidy.

33 moeologues) in soybean has changed following polyploidy.

34 nk between pX-induced DNA re-replication and polyploidy.

35 , indicating that p53 antagonizes pX-induced polyploidy.

36 w, and its subsequent absence contributes to polyploidy.

37 erefore, in plants, not only associated with polyploidy.

38 ion with a corresponding increase in p27 and polyploidy.

39 6 expression induces a significant amount of polyploidy.

40 identifying tumor subclonal populations and polyploidy.

41 le and cytokinesis defects, micronuclei, and polyploidy.

42 ycle oscillation frequency and the extent of polyploidy.

43 ion and returned to a physiological state of polyploidy.

44 ty of both wild-type and mutant E6 to induce polyploidy.

45 the DNA content in the nucleus and leads to polyploidy.

46 r to mitosis and concomitant upregulation of polyploidy.

47 ained duplicate genes from the ancient maize polyploidy.

48 rvening mitosis or cytokinesis, resulting in polyploidy.

49 ls to achieve repeated rounds of S phase and polyploidy.

50 ostmitotic checkpoint by HPV E6 that induces polyploidy.

51 thylation in regulating gene expression post polyploidy.

52 Polyploidy, a change whereby the entire chromosome set i

53 A defining feature of the mammalian liver is polyploidy, a numerical change in the entire complement

54 Our results revealed two rounds of polyploidy: a paleopolyploid event predating the African

55 Polyploidy (alias whole genome amplification) refers to

56 Polyploidy also frequently confers resistance to environ

57 nts defective in p53 degradation also induce polyploidy, although with lower efficiency.

58 tmitotic G1-like checkpoint that can lead to polyploidy, an early event during cervical carcinogenesi

59 ulation of pRb is important for E7 to induce polyploidy and abrogation of the postmitotic checkpoint.

60 issue, Rancati et al. report that extensive polyploidy and aneuploidy are the initial evolutionary c

61 promised nuclear envelope that is causal for polyploidy and aneuploidy in ovarian tumorigenesis.

62 Polyploidy and aneuploidy were common genetic alteration

63 zygous mutant embryos reveals high levels of polyploidy and aneuploidy, spindle defects, and a mitoti

64 ert's syndrome, which also involves cellular polyploidy and aneuploidy.

65 Here I review the sparse information on polyploidy and community context and then present a set

66 insights into the functional consequences of polyploidy and epigenetic regulation in plant genomes.

67 t economic potential, has become a model for polyploidy and evolutionary studies.

68 ne arrangements are complicated by recurring polyploidy and extensive genome rearrangement.

69 endoreduplication, which is associated with polyploidy and genome instability.

70 ed mechanisms that control the generation of polyploidy and have recently begun to provide clues to i

71 The mechanisms that induce polyploidy and how these mechanisms contribute to CIN ar

72 Because polyploidy and impaired DDRs can promote cancer, our fin

73 Polyploidy and interspecific hybridisation (with which i

74 With the evolution of extreme polyploidy and large cell size, Epulopiscium has acquire

75 frequency, age, and phylogenetic position of polyploidy and lineage separation events that have marke

76 during normal ageing and after injury led to polyploidy and multinucleation, but also to new diploid,

77 ited cells showed enhanced radiation-induced polyploidy and nuclear fragmentation, consistent with th

78 ude that Hippo-Yap signaling suppresses cell polyploidy and oncogenesis through Skp2.

79 -induced apoptosis, and increased pX-induced polyploidy and oncogenic transformation, suggesting ZNF1

80 agation of damaged DNA, resulting in partial polyploidy and oncogenic transformation.

81 Numerous hypotheses about the mechanism of polyploidy and parental genome donors have been proposed

82 e, thus revealing a unique mechanism linking polyploidy and retrotransposition.

83 of preferential gene retention or loss after polyploidy and reveals large variability of nucleotide s

84 eated with AZD1152 accumulated in a state of polyploidy and showed a senescent response to the drug,

85 ion in the fate/evolution of genes following polyploidy and speciation has not been fully explored.

86 Even though the connections between polyploidy and species interactions have been recognized

87 In flowering plants, polyploidy and subsequent reductions in chromosome numbe

88 TLR2 signaling promoted macrophage polyploidy and suppressed genomic instability by regulat

89 Polyploidy and the expansion of repetitive DNA, primaril

90 ing mitosis reportedly include prevention of polyploidy and transmission of aberrant chromosomes.

91 of the reproductive barriers observed (e.g., polyploidy and uniparental reproduction), however, may h

92 enetic program leading to cell cycle arrest, polyploidy, and apoptosis.

93 feration, triggering G2/M cell-cycle arrest, polyploidy, and apoptosis.

94 y, the potential contribution of DNA repair, polyploidy, and cell fusion to the measurement of myocyt

95 phase cyclin E, a cyclin associated with MK polyploidy, and its up-regulation restored most of the e

96 ly, the widespread species divergence, major polyploidy, and lineage separation events during Brassic

97 involving different plant families, kinds of polyploidy, and polyploids of different ages.

98 e mechanism by which cell growth, migration, polyploidy, and tumorigenesis are regulated may provide

99 reby driving cell proliferation, chromosomal polyploidy, and tumorigenesis.

100 naling in vitro leads to multinucleation and polyploidy, and we demonstrate that this is caused by al

101 aberrant centrosome content, DNA damage, and polyploidy/aneuploidy.

102 rs ago, followed by a genus Glycine-specific polyploidy, approximately 10 million years ago.

103 he genetic and morphological consequences of polyploidy are being rapidly elucidated, the effects on

104 Apomixis and polyploidy are closely associated in angiosperms, but th

105 Aneuploidy and polyploidy are hallmarks of radiation-induced mitotic ca

106 mine whether genetic changes associated with polyploidy are indeed adaptive.

107 Studies of the macroevolutionary legacy of polyploidy are limited by an incomplete sampling of thes

108 Chromosome losses and polyploidy are recovered as the main evolutionary mechan

109 eath following mitotic failure and increased polyploidy as a consequence of cellular inhibition of au

110 We see value in recognizing polyploidy as a key player in generating diversity in de

111 gulfment involving live cells, also leads to polyploidy, as internalized cells disrupt cytokinesis of

112 - tumors exhibit genomic instability but not polyploidy based on array comparative genomic hybridizat

113 sues within an organism it is termed somatic polyploidy, because it is distinct from the increase in

114 ion bursts in Zea may have been initiated by polyploidy, but the great majority of transposable eleme

115 ntitative evidence that in some environments polyploidy can accelerate evolutionary adaptation.

116 olution experiments to test directly whether polyploidy can accelerate evolutionary adaptation.

117 Polyploidy can also affect gene regulation by amplifying

118 volution of increased genome complexity, but polyploidy can also arise in somatic cells of otherwise

119 es in increasing cell size/metabolic output, polyploidy can also promote nonuniform genome, transcrip

120 Both aneuploidy and polyploidy can arise from multinucleate states after fai

121 Previous studies have shown that polyploidy can coincide with meiotic abnormalities and s

122 Polyploidy can lead to aneuploidy and tumorigenesis.

123 Polyploidy can occur because of cell fusion or abnormal

124 nomes (polyploidy), suggesting that study of polyploidy can reveal how cells with impaired DDRs/genom

125 els suggest that tetraploidy, one example of polyploidy, can promote tumorigenesis.

126 Inhibition of SPG polyploidy caused rupture of the septate junctions neces

127 ulted in apoptosis induction, G(2)-M arrest, polyploidy cells, and attenuation of cancer cell anchora

128 of cytokinesis, resulting in multinucleated, polyploidy cells.

129 In the absence of polyploidy, changes in the amount of repetitive DNA (tra

130 Polyploidy complicates genomics-based breeding of many c

131 Polyploidy confers postzygotic reproductive isolation an

132 rom a variety of animals and plants in which polyploidy controls organ size, the size and function of

133 We suggest that polyploidy could confer resource costs related to the di

134 Moreover, the polyploidy defect in Mir122 knockout mice was ameliorate

135 est that proper regional decidualization and polyploidy development requires FoxM1 signaling downstre

136 ion with perturbation of decidualization and polyploidy development, suggesting a role for Cbx4/Ring1

137 have led scientists to explore factors (e.g. polyploidy, developmental systems, floral evolution) tha

138 s, which may provide an alternative route to polyploidy, distinct from the one involving unreduced ga

139 rms, Brassicaceae, Poaceae), suggesting that polyploidy drives diversification.

140 variants of AURKC cause meiotic failure and polyploidy due to a failure in AURKC-CPC function that r

141 Polyploidy duplicates every gene in the genome, providin

142 The widespread use of polyploidy during cell differentiation makes it importan

143 ts, providing strong evidence that the gamma polyploidy event occurred early in eudicot evolution.

144 Although it is agreed that a major polyploidy event, gamma, occurred within the eudicots, t

145 event remains dominant through a subsequent polyploidy event.

146 (Glycine max L.) has undergone two separate polyploidy events (13 and 59 million years ago) that hav

147 cytogenetic approach to track occurrences of polyploidy events and to analyze their impact on the evo

148 We mapped the phylogenetic distribution of polyploidy events by both tree-based and distance-based

149 We identified 26 ancient and more recent polyploidy events distributed throughout Caryophyllales.

150 psis thaliana), which experienced two nested polyploidy events independent from the legume duplicatio

151 The impact of such polyploidy events is poorly understood, as is the fate o

152 f genes within gene families due to multiple polyploidy events, gene loss and fractionation, and diff

153 Following polyploidy events, genomes undergo massive reduction in

154 ver more than 100 million years and repeated polyploidy events.

155 d internal genetic turmoil such as recurrent polyploidy events.

156 seed plants and then expanded by subsequent polyploidy events.

157 Intraspecific hybridization and polyploidy exacerbate these defects, which segregate qua

158 Hybridization and polyploidy followed by genome-wide diploidization had a

159 Whole-genome duplication (WGD), or polyploidy, followed by gene loss and diploidization has

160 hermore, we found that c-Myc is required for polyploidy formation but not for cytoplasmic maturation

161 ation of the postmitotic checkpoint leads to polyploidy formation in E7-expressing human epithelial c

162 In addition, I highlight how polyploidy functions in wound healing and tissue regener

163 changing chromosome numbers (aneuploidy and polyploidy), genome size, (retro)transposable element mo

164 n in flowering plants is often punctuated by polyploidy, genome duplication events that fundamentally

165 mapping-by-sequencing to even poorly defined polyploidy genomes where chromosomes are incomplete and

166 line, we demonstrate that pX induces partial polyploidy (>4N DNA).

167 Genomic instability in the form of polyploidy has been demonstrated to play an important ro

168 Polyploidy has been reported in Thermococcales and P. fu

169 Polyploidy has contributed to the evolution of eukaryote

170 Polyploidy has extensive genetic, physiological, morphol

171 d some animal species and today we know that polyploidy has had a role in the evolution of all angios

172 Polyploidy has played a central role in plant genome evo

173 rences 66 Whole-genome duplication (WGD), or polyploidy, has important effects on the genotype and ph

174 ger-term genomic and epigenetic responses to polyploidy have become appreciated.

175 n, detailed comparative molecular studies on polyploidy have been confined to only a few species and

176 The genomic consequences of polyploidy have been extensively studied, but the mechan

177 The adaptive value of polyploidy, however, remains uncertain; ecologists have

178 ted, cyclin E is essential for megakaryocyte polyploidy; however, it has remained unclear whether up-

179 lacking an open reading frame, especially in polyploidy human cell lines.

180 hat introgressive hybridizations (diploid or polyploidy hybrid speciation) and/or a series of whole-g

181 nuclei range from 1N to >4N, with different polyploidies in the same cell and low levels of aneuploi

182 DNA re-replication, DNA damage, and partial polyploidy in a poorly differentiated, immortalized hepa

183 Effects of polyploidy in allohexaploid wheat (Triticum aestivum L.)

184 ther to increase the incidence of tetra- and polyploidy in early stages of tumorigenesis.

185 late from this to suggest that the rarity of polyploidy in gymnosperms may be due to slow diploidizat

186 The HPV E6 oncoprotein induces polyploidy in human keratinocytes, yet the mechanism is

187 dentified a phenotype of multinucleation and polyploidy in p27(CK-) mice not present in p27(-/-) anim

188 and transcriptional changes associated with polyploidy in plants and assess how these changes might

189 Although the prevalence of polyploidy in plants is well documented, the molecular a

190 dd to our understanding of the importance of polyploidy in plants.

191 cently found that HPV-16 E7 oncogene induces polyploidy in response to DNA damage; however, the mecha

192 It has been hypothesized that E7 induces polyploidy in response to mitotic stress by abrogating t

193 ce from fossil guard cell size suggests that polyploidy in Sequoia dates to the Eocene.

194 ues, suggesting that the main consequence of polyploidy in soybean may be at the regulatory level.

195 Following polyploidy in the Glycine lineage, NB-LRR genes have bee

196 rent study were to investigate the origin of polyploidy in the woody bamboos and examine putative hyb

197 ether up-regulated cyclin E is an inducer of polyploidy in vivo.

198 Therefore, Ph1 stabilises polyploidy in wheat by both promoting homologue pairing

199 ed the ubiquity of whole-genome duplication (polyploidy) in angiosperms, although subsequent genome s

200 We conclude that autophagy and polyploidy increase the immunogenicity of cancer cells m

201 Partial polyploidy induced by pX is not immediately associated w

202 Polyploidy is a central phenomenon in plant evolution, a

203 Polyploidy is a common characteristic of the mammalian l

204 Polyploidy is a common mode of evolution in flowering pl

205 er-than-diploid DNA content, suggesting that polyploidy is a common precursor to aneuploidy during tu

206 Polyploidy is a pervasive evolutionary feature of all fl

207 Polyploidy is an important aspect of the evolution of fl

208 Polyploidy is an important driver of eukaryotic evolutio

209 Polyploidy is an important driving force in angiosperm e

210 Polyploidy is an important feature of plant genomes, but

211 Polyploidy is an important force in the evolution of flo

212 oid progenitors, would seem to indicate that polyploidy is associated with evolutionary success in te

213 Megakaryocyte polyploidy is characterized by cytokinesis failure resul

214 Polyploidy is common and an important evolutionary facto

215 Polyploidy is common in plants and is also observed in a

216 Germline polyploidy is common in plants and occurs in some animal

217 Although polyploidy is common in plants and some animals, mechani

218 Although polyploidy is common, affecting approximately 90% of hep

219 Polyploidy is defined as an increase in genome DNA conte

220 In this regard, polyploidy is followed by subsequent locus loss.

221 Polyploidy is found in many plants and some animal speci

222 Polyploidy is generally not tolerated in animals, but is

223 Polyploidy is known to induce numerous genetic and epige

224 ution of agriculturally important traits via polyploidy is lacking.

225 he mechanism through which E7 contributes to polyploidy is not known.

226 Polyploidy is observed across the tree of life, yet its

227 Polyploidy is often an early event during cervical carci

228 Polyploidy is remarkably common in the plant kingdom and

229 Partial polyploidy is sometimes observed in humans (e.g. trisomy

230 One consequence of polyploidy is subfunctionalization, in which the ancestr

231 Polyploidy is thought to be an efficient method of incre

232 One route to polyploidy is through chromosome missegregation due to a

233 Whole-genome duplication resulting from polyploidy is ubiquitous in the evolutionary history of

234 etic and functional diversity resulting from polyploidy is unknown.

235 Summary Despite knowledge that polyploidy is widespread and a major evolutionary force

236 Our results suggest that polyploidy, lineage divergence, and complex reticulate e

237 Polyploidy may also affect adaptation independently of b

238 expression in S. halepense, suggesting that polyploidy may have offered new evolutionary potential t

239 e I use an experimental approach to test how polyploidy mediates ecological divergence in Achillea bo

240 enitor cells, is maximally present on large, polyploidy megakaryocytes, and near absent on platelets.

241 We hypothesized that hepatocyte polyploidy might be protective against TALEN-induced los

242 Polyploidy might therefore serve as a protective mechani

243 gnals that have been associated with hepatic polyploidy, miR-122 is the first liver-specific signal i

244 al report to test several predictions of the polyploidy model of gonococcal chromosome organization.

245 tic species, despite complications including polyploidy, multisomic inheritance, self-incompatibility

246 These data reflect increases in polyploidy observed 53BP1-/- deficient fibroblasts follo

247 In this Primer, we focus on why somatic polyploidy occurs and how cells become polyploid - the f

248 vation of VEGFR-3 impaired the transition to polyploidy of CD41+ cells in primary BM cultures.

249 milies, and gene duplications related to the polyploidy of maize; this avoided overidentification of

250 teria are known to possess multiple genomes, polyploidy of the magnitude observed in Epulopiscium is

251 Polyploidy often confers emergent properties, such as th

252 widespread occurrence, the direct effect of polyploidy on evolutionary success of a species is still

253 resolved questions about cause and effect of polyploidy on evolutionary success of a species.

254 The profound effects of polyploidy on gene expression appear to be caused more b

255 The effects of polyploidy on gene expression have been studied extensiv

256 loids and allopolyploids, but the effects of polyploidy on proteomic divergence are poorly understood

257 re direct connections between the effects of polyploidy on the genome and the responses this conditio

258 cytokinesis defects and formation of nuclear polyploidy or aneuploidy.

259 nship, as it is not driven by traits such as polyploidy or annual life history whose evolution is som

260 genome-wide sample properties, such as tumor polyploidy or polyclonality in cancer samples.

261 Polyploidy or whole genome duplication (WGD) provides ra

262 Polyploidy, or the presence of two or more diploid paren

263 Polyploidy, or whole genome duplication, has played a ma

264 The role of polyploidy, particularly allopolyploidy, in plant divers

265 l methods that cannot distinguish effects of polyploidy per se from genic differences that accumulate

266 However, it is unknown how polyploidy per se might affect plasticity in a plant's s

267 These studies demonstrate that cellular polyploidy plays important roles during normal developme

268 m, lineage-specific signaling with increased polyploidy proves possible and novel with phospho-regula

269 pectedly, chromosome fusions, aneuploidy and polyploidy rates in Mdm2 transgenic mice, but not chromo

270 that most homoeolog expression bias reflects polyploidy rather than domestication.

271 fusions and aneuploidy, but the frequency of polyploidy remained stable over time.

272 This allows an unusual tolerance to polyploidy resulting from failed mitosis, which is commo

273 tly inactivated in cells with extra genomes (polyploidy), suggesting that study of polyploidy can rev

274 MW-E induction led to failed cytokinesis and polyploidy, suggesting that LMW-E expression primes cell

275 Massive polyploidy supports the acquisition of unstable genetic

276 n between protein misfolding/aggregation and polyploidy that can be tested by future research.

277 ue to expanded wild introgressions following polyploidy that captured alleles outside of their geogra

278 ologous genomic regions from three rounds of polyploidy that contributed to the current Glycine max g

279 d frequencies of a number of processes (e.g. polyploidy) that have shaped the genomes of other vascul

280 Polyploidy, the condition of possessing more than two co

281 To achieve polyploidy, the S. meliloti cell cycle program must be a

282 ogenomic sampling, we show the propensity of polyploidy throughout the evolutionary history of Caryop

283 Aside from polyploidy, transposable elements are the major drivers

284 Polyploidy, usually whole-genome duplication, is propose

285 lihood of duplicate gene retention following polyploidy varies by functional properties (e.g. gene on

286 Polyploidy was first observed in plants more than a cent

287 Acute polyploidy was generated by knockdown of the essential r

288 In contrast, chromosome polyploidy was reduced in the presence of an activated M

289 o test whether miRNAs could regulate hepatic polyploidy, we examined livers from Dicer1 liver-specifi

290 ts into the molecular basis of adaptation to polyploidy, we investigated genome-wide patterns of diff

291 e evolution of centromeric repeats following polyploidy, we studied a model diploid progenitor (Gossy

292 d breaks, chromosome fusions, aneuploidy and polyploidy were increased in older Mdm2 transgenic mice

293 from high-risk HPVs have a high incidence of polyploidy, which has been shown to occur as an early ev

294 Failure in this process causes polyploidy, which in turn can generate chromosomal insta

295 al attention to the meiotic recombination in polyploidy, which is a common genomic feature for many c

296 Here we show that polyploidy, which is often observed in human cancers, le

297 may inhibit the mitotic checkpoint to induce polyploidy, which likely contributes to neoplastic trans

298 o the S phase of the cell cycle and promotes polyploidy, which may contribute to genomic instability

299 tion or knockdown of Plk1 reduced pX-induced polyploidy while increasing apoptosis.

300 g plants have experienced repeated rounds of polyploidy (whole-genome duplication), which has in turn