ライフサイエンスコーパス: polyposis coli

1 -containing protein 2), and APC (adenomatous polyposis coli).

2 synthase kinase 3beta, axin, and adenomatous polyposis coli.

3 ism associated with mutations in Adenomatous Polyposis Coli.

4 urine tumor model of spontaneous adenomatous polyposis coli.

5 a recessive phenotype, multiple adenomas, or polyposis coli.

6 In addition we identified adenomatous polyposis coli 1 (APC1) as an interaction partner of KHC

7 mline specific overexpression of Adenomatous Polyposis Coli 2 (APC2) rescued GSC loss in chic hypomor

8 cells for proper localization of Adenomatous polyposis coli 2 and E-cadherin at the hub-GSC interface

9 centrosomal proteins Ninein and adenomatous polyposis coli abolished this bias.

10 ors of beta-catenin, such as the adenomatous polyposis coli and Axin tumor suppressor proteins.

11 ignaling (RGS) domain that binds adenomatous polyposis coli and Galpha subunits, thereby providing a

12 ically associated with a loss of adenomatous polyposis coli and up-regulation of beta-catenin.

13 nsulin-like growth factor 2, and adenomatous polyposis coli) and other solid tumors (e.g., NOTCH3) an

14 synaptic density, among them the adenomatous polyposis coli, and 2) proteins with expression or funct

15 attributed to mutations in Axin, adenomatous polyposis coli, and beta-catenin that lead to constituti

16 cked differentiation markers and adenomatous polyposis coli antigen.

17 grafted OPCs differentiated into adenomatus polyposis coli (APC(+)) OLs, and CNTF significantly incr

18 lly expressed a mutant allele of adenomatous polyposis coli (APC(cKO)) in murine uterine stroma cells

19 hypoxia-induced PH, we used the adenomatous polyposis coli (Apc(Min/+)) mouse, where reduced APC cau

20 t a cancer causing truncation in adenomatous polyposis coli (APC) (APC(1-1450)) dominantly interferes

21 The tumor suppressor Adenomatous polyposis coli (APC) affects the function of microtubule

22 the rare inheritance of a mutant adenomatous polyposis coli (Apc) allele.

23 LPA to mice heterozygous for the adenomatous polyposis coli (Apc) allele.

24 n of the Wnt-regulating proteins adenomatous polyposis coli (APC) and APC2 in the pathogenesis of hum

25 pecific GSK3 substrates, such as adenomatous polyposis coli (APC) and collapsin response mediator pro

26 t two tumor suppressor proteins, adenomatous polyposis coli (APC) and Dlg1-SAP97, are required for th

27 le plus end-associated proteins, adenomatous polyposis coli (APC) and EB1, providing a potential link

28 nscriptional mechanisms and that adenomatous polyposis coli (APC) and GSK3beta, which are negative re

29 of the gut tumor suppressor gene adenomatous polyposis coli (Apc) and its role in the oligodendroglia

30 that mPar3 forms a complex with adenomatous polyposis coli (APC) and kinesin superfamily (KIF) 3A, p

31 lly, CBC stem cells deficient in adenomatous polyposis coli (Apc) and Math1 were able to promote inte

32 ith the tumor suppressor protein adenomatous polyposis coli (APC) and p150glued, a component of the d

33 lorectal cancer tumor suppressor adenomatous polyposis coli (APC) and that KLF4 repressed the Wnt/bet

34 d that both the tumor suppressor adenomatous polyposis coli (APC) and the ADP-ribose polymerase Tanky

35 py to image the tumor suppressor adenomatous polyposis coli (APC) and the formin mDia1 during filamen

36 pected loss in the expression of adenomatous polyposis coli (APC) and the transcriptional repressor B

37 ients with germline mutations in adenomatous polyposis coli (APC) are susceptible to stomach polyps a

38 AP) but further study identified adenomatous polyposis coli (APC) as responsible for FAP and the phys

39 The adenomatous polyposis coli (APC) binding site of axin involves resid

40 e find that the tumor suppressor adenomatous polyposis coli (APC) controls microtubule targeting to t

41 ith and blocks activation of the adenomatous polyposis coli (APC) destruction complex that targets fr

42 mice carrying the Min allele of Adenomatous polyposis coli (Apc) develop numerous adenomas along the

43 Mutations in adenomatous polyposis coli (APC) disrupt regulation of Wnt signaling

44 rs consistently contained mutant adenomatous polyposis coli (APC) DNA molecules in their plasma.

45 hat the tumor-suppressor protein adenomatous polyposis coli (APC) functions in localizing alpha3-nico

46 As Adenomatous Polyposis Coli (APC) functions in many of the same proce

47 g a heterozygote mutation in the adenomatous polyposis coli (APC) gene (Apc(Min/+) mice).

48 geted pigs with mutations in the adenomatous polyposis coli (APC) gene (APC) that are orthologous to

49 The adenomatous polyposis coli (Apc) gene also plays an important role i

50 dels involve modification of the adenomatous polyposis coli (Apc) gene and are excellent models for f

51 n cells with deficiencies in the adenomatous polyposis coli (APC) gene and in cells stimulated with t

52 Mutations in the adenomatous polyposis coli (APC) gene and K-ras occur in the majorit

53 We show that a deficiency in the adenomatous polyposis coli (APC) gene and subsequent activation of b

54 Mutations in the adenomatous polyposis coli (APC) gene are associated with an early o

55 Patients with mutations in the Adenomatous Polyposis Coli (APC) gene are at increased risk of devel

56 Somatic mutations of the adenomatous polyposis coli (APC) gene are initiating events in the m

57 Mutations in the adenomatous polyposis coli (APC) gene are pivotal in colorectal tumo

58 Genetic mutations in the adenomatous polyposis coli (APC) gene are thought to cause colon ade

59 Mutations in the human adenomatous polyposis coli (APC) gene are thought to initiate colore

60 l lines bearing mutations on the adenomatous polyposis coli (APC) gene as a model of FAP-related mali

61 The adenomatous polyposis coli (APC) gene encodes APC tumour suppressor

62 -LoxP strategy to inactivate the Adenomatous Polyposis Coli (Apc) gene in the murine renal epithelium

63 Since the Adenomatous Polyposis Coli (APC) gene is mutated in the majority of

64 The Adenomatous Polyposis Coli (APC) gene is mutated in the majority of

65 Although beta-catenin and adenomatous polyposis coli (APC) gene mutations are well established

66 Adenomatous polyposis coli (APC) gene mutations have been implicated

67 Mutations in the adenomatous polyposis coli (APC) gene occur in the vast majority of

68 al cancers have mutations of the adenomatous polyposis coli (APC) gene or the beta-catenin gene that

69 The adenomatous polyposis coli (APC) gene product is mutated in the vast

70 ce with inactivating mutation of adenomatous polyposis coli (APC) gene reduces intestinal adenomatous

71 Mutations in the adenomatous polyposis coli (APC) gene result in uncontrolled prolife

72 ng mutation in one allele of the adenomatous polyposis coli (Apc) gene that is similar to most mutati

73 operate with inactivation of the adenomatous polyposis coli (Apc) gene to accelerate intestinal tumou

74 eta-catenin or defective for the adenomatous polyposis coli (APC) gene to reinvestigated the identity

75 Mutations in the Adenomatous Polyposis Coli (APC) gene up-regulate Wnt signaling by s

76 r as conditional deletion of the adenomatous polyposis coli (Apc) gene within the adult bladder led r

77 The adenomatous polyposis coli (APC) gene, a member of the WNT pathway,

78 arcinogenesis is mutation of the adenomatous polyposis coli (APC) gene, which leads to activation of

79 ar inactivating mutations of the adenomatous polyposis coli (APC) gene, whose product is an important

80 tions in human CRC occurs in the adenomatous polyposis coli (APC) gene.

81 atic truncation mutations to the adenomatous polyposis coli (Apc) gene.

82 ith heterozygous mutation in the adenomatous polyposis coli (APC) gene.

83 be dominated by mutations in the adenomatous polyposis coli (APC) gene.

84 lasia caused by mutations of the adenomatous polyposis coli (Apc) gene.

85 associated with mutations in the adenomatous polyposis coli (APC) gene.

86 h loss of normal function of the Adenomatous polyposis coli (APC) gene.

87 ular, tumor suppressors TP53 and adenomatous polyposis coli (APC) gene.

88 mice lacking the beta-catenin or adenomatous polyposis coli (Apc) genes in osteoblasts.

89 e mouse tumor suppressor protein adenomatous polyposis coli (APC) has a role in AChR clustering and t

90 The adenomatous polyposis coli (APC) I1307K allele is found in 6% of the

91 enin pathway signaling following adenomatous polyposis coli (APC) inactivation.

92 utations in the tumor suppressor adenomatous polyposis coli (APC) initiate most colon cancers and hav

93 The tumor suppressor adenomatous polyposis coli (APC) is a crucial regulator of many stem

94 brain, and the tumor suppressor adenomatous polyposis coli (APC) is a key negative regulator of Wnt/

95 Adenomatous polyposis coli (APC) is a large multidomain protein that

96 Adenomatous polyposis coli (APC) is a microtubule plus-end scaffoldi

97 Adenomatous polyposis coli (APC) is a multifunctional tumour suppres

98 The tumor suppressor Adenomatous polyposis coli (APC) is a negative regulator of Wnt sign

99 Mutational inactivation of adenomatous polyposis coli (APC) is an early event in colorectal can

100 The tumor suppressor adenomatous polyposis coli (APC) is an essential negative regulator

101 The tumor suppressor adenomatous polyposis coli (APC) is an essential negative regulator

102 ASE of adenomatous polyposis coli (APC) is associated with pathogenesis of

103 Adenomatous polyposis coli (APC) is best known for its crucial role

104 Mutation of the tumor suppressor adenomatous polyposis coli (APC) is considered an initiating step in

105 The tumor suppressor adenomatous polyposis coli (APC) is implicated in regulating multipl

106 The tumor suppressor protein adenomatous polyposis coli (APC) is multifunctional - it participate

107 Adenomatous polyposis coli (APC) is mutated in colon cancers.

108 Adenomatous polyposis coli (APC) is one such MAP with a multifunctio

109 ing loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenom

110 Loss of tumor suppressor adenomatous polyposis coli (APC) is thought to initiate the majority

111 s of heterozygosity rates at the adenomatous polyposis coli (Apc) locus are unaffected by Atm loss.

112 Today, the tumor suppressor adenomatous polyposis coli (APC) may have the same complaint about a

113 Here, we show that adenomatous polyposis coli (APC) modulates microtubule (MT) severing

114 IP-Tag2 transgenic mouse tumors, adenomatous polyposis coli (apc) mouse adenomas, and implanted MCa-I

115 We report that adenomatous polyposis coli (APC) mutant zebrafish harbor an RA-defic

116 itiation of colorectal cancer by adenomatous polyposis coli (APC) mutation is mediated by dysregulati

117 Adenomatous polyposis coli (APC) mutation is the most common genetic

118 ulation of VEGF-A expression and adenomatous polyposis coli (APC) mutational status (activation of be

119 Adenomatous polyposis coli (APC) mutations are linked to human and m

120 In this study, we show that adenomatous polyposis coli (APC) mutations found in human colorectal

121 nin pathway activation caused by adenomatous polyposis coli (APC) mutations occurs in approximately 8

122 duals with heterozygous germline adenomatous polyposis coli (APC) mutations or familial adenomatous p

123 The tumor suppressor Adenomatous polyposis coli (APC) negatively regulates Wnt signaling

124 nitiating mutation occurs in the adenomatous polyposis coli (APC) or beta-catenin gene, activating th

125 been associated with loss of the adenomatous polyposis coli (APC) or constitutive activation of beta-

126 ynthase kinase 3beta (GSK-3beta)/adenomatous polyposis coli (APC) pathways.

127 The tumor suppressor adenomatous polyposis coli (APC) plays a critical role in the turnov

128 Adenomatous polyposis coli (APC) plays a critical role in the Wnt si

129 The tumor suppressor Adenomatous polyposis coli (APC) plays a key role in regulating the

130 essing NeuN positive neurons and adenomatous polyposis coli (APC) positive mature oligodendrocytes in

131 In interphase cells, the adenomatous polyposis coli (APC) protein accumulates on a small subs

132 In vitro data show that the adenomatous polyposis coli (APC) protein associates with the mitotic

133 SK-3beta and accumulation of the adenomatous polyposis coli (APC) protein at the plus ends of leading

134 rt that the expression status of adenomatous polyposis coli (APC) protein determines the relative sen

135 The adenomatous polyposis coli (APC) protein functions as a negative reg

136 The role of wild-type adenomatous polyposis coli (APC) protein in native epithelia is poor

137 Loss of the adenomatous polyposis coli (APC) protein is a common initiating even

138 Adenomatous polyposis coli (APC) protein is a large tumor suppressor

139 The adenomatous polyposis coli (APC) protein is inactivated in most colo

140 , and induces the interaction of adenomatous polyposis coli (Apc) protein with the plus ends of micro

141 CtBP interacts with adenomatous polyposis coli (APC) protein, and is stabilized in both

142 Fap1 also interacts with the adenomatous polyposis coli (Apc) protein, but the functional signifi

143 ses, beta-catenin, axin, and the Adenomatous Polyposis Coli (APC) protein.

144 iciencies in mismatch repair and adenomatous polyposis coli (APC) proteins, diet, inflammatory proces

145 ut allele in the gatekeeper gene Adenomatous polyposis coli (Apc) recapitulates familial colon cancer

146 The tumor suppressor protein adenomatous polyposis coli (APC) regulates cell protrusion and cell

147 Adenomatous polyposis coli (APC) regulates the activity of beta-cate

148 lly important for cell migration.Adenomatous polyposis coli (APC) regulates the localization of some

149 ing in mice, we demonstrate that adenomatous polyposis coli (APC) serves an essential function in the

150 The tumor suppressor protein adenomatous polyposis coli (APC) stabilizes microtubules both in vit

151 way the tumor-suppressor protein adenomatous polyposis coli (APC) targets RNAs to cell protrusions, f

152 ave defined a repeat sequence in adenomatous polyposis coli (APC) that binds to EB1's COOH-terminal d

153 responsive cells were defined by adenomatous polyposis coli (APC) time-of-flight mass cytometry (CyTO

154 Binding of adenomatous polyposis coli (APC) to the microtubule plus ends in pol

155 KIF17 participates in localizing adenomatous polyposis coli (APC) to the plus ends of a subset of MTs

156 The adenomatous polyposis coli (APC) tumor suppressor forms a complex wi

157 ed or inherited mutations in the adenomatous polyposis coli (APC) tumor suppressor gene are causally

158 The adenomatous polyposis coli (APC) tumor suppressor gene encodes a mul

159 Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene initiate a ma

160 The Adenomatous Polyposis Coli (APC) tumor suppressor gene is silenced b

161 Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene seem to under

162 ients harboring mutations in the adenomatous polyposis coli (APC) tumor suppressor gene.

163 The adenomatous polyposis coli (APC) tumor suppressor is a major regulat

164 The Adenomatous Polyposis Coli (APC) tumor suppressor is a multifunction

165 Inactivation of the adenomatous polyposis coli (APC) tumor suppressor is frequently foun

166 The adenomatous polyposis coli (APC) tumor suppressor is inactivated by

167 The adenomatous polyposis coli (Apc) tumor suppressor is involved in the

168 specific allelic deletion of the adenomatous polyposis coli (Apc) tumor suppressor locus, Ikkbeta(EE)

169 2A) and must be protected by the adenomatous polyposis coli (APC) tumor suppressor protein.

170 Mutation of the adenomatous polyposis coli (APC) tumor suppressor stabilizes beta-ca

171 tain truncating mutations in the adenomatous polyposis coli (APC) tumor suppressor, a negative regula

172 is negatively controlled by the adenomatous polyposis coli (APC) tumor suppressor, which induces pro

173 cleocytoplasmic shuttling of the adenomatous polyposis coli (APC) tumor suppressor.

174 the in vivo mutation rate of the adenomatous polyposis coli (APC) tumor-suppressor gene is presented.

175 etic pathway whereby loss of the adenomatous polyposis coli (APC) tumour suppressor and activation of

176 the granules associate with the adenomatous polyposis coli (APC) tumour suppressor and the fragile X

177 Mutations in the adenomatous polyposis coli (APC) tumour suppressor are the key initi

178 Mutations in Adenomatous polyposis coli (APC) underlie familial adenomatous polyp

179 Mutations in adenomatous polyposis coli (APC) underlie the earliest stages of col

180 dy, the tumor suppressor protein adenomatous polyposis coli (APC) was found to be important for the u

181 found that the tumor suppressor adenomatous polyposis coli (APC) was required for microtubule intera

182 h1 (Atoh1(Deltaintestine)), the adenomatosis polyposis coli (APC)(min) mutation, both mutations (Atoh

183 These mice were crossed with adenomatous polyposis coli (Apc)(min/+) mice, or given azoxymethane

184 ic relationship between MPC1 and Adenomatous polyposis coli (APC), a key tumor suppressor in colorect

185 Inactivating mutations within adenomatous polyposis coli (APC), a negative regulator of Wnt signal

186 uggest that the tumor suppressor adenomatous polyposis coli (APC), a regulator of Wnt signaling and t

187 Adenomatous polyposis coli (APC), a tumor suppressor commonly mutate

188 Adenomatous polyposis coli (Apc), a tumor suppressor gene conserved

189 Adenomatous polyposis coli (APC), a tumor suppressor gene that is co

190 Specific site of CpG islands of adenomatous polyposis coli (APC), a well studied tumor suppressor ge

191 The tumor suppressor adenomatous polyposis coli (APC), an essential negative regulator of

192 uction complex components Axin1, adenomatous polyposis coli (APC), and GSK3beta were also proteolytic

193 containing the proteins axin and adenomatous polyposis coli (APC), both of which bind directly to bet

194 plex with axin (axis inhibitor), adenomatous polyposis coli (APC), casein kinase 1alpha (CK1alpha), a

195 ic exchange factor stimulated by adenomatous polyposis coli (APC), contributing to colorectal cancer

196 with its direct binding partner adenomatous polyposis coli (APC), EB1 can stabilize microtubules.

197 ons in known driver genes [e.g., adenomatous polyposis coli (APC), KRAS, or PIK3CA] found in the prim

198 Individual crypt adenomatous polyposis coli (APC), p53, K-RAS, and 17p loss of hetero

199 y patients induced colon p53 and adenomatous polyposis coli (APC), reversing progrowth GH signals.

200 gainst beta-catenin (Ctnnb1) and adenomatous polyposis coli (Apc), two commonly mutated genes in hepa

201 naling by targeting the gene for Adenomatous Polyposis Coli (Apc), which controls Wnt signaling activ

202 hat the tumor suppressor protein adenomatous polyposis coli (APC), which is a known MT-associated pro

203 ion and activity using models of adenomatous polyposis coli (APC)- and chemotherapy-induced apoptosis

204 Two adenomatous polyposis coli (APC)-dependent proteasomal degradation p

205 eta-catenin is eliminated by two adenomatous polyposis coli (APC)-dependent proteasomal degradation p

206 beta-catenin through a conserved adenomatous polyposis coli (APC)-like domain.

207 Expression of eIF6 in adenomatous polyposis coli (APC)-mutant colon cancer cells, which ex

208 e cortical localizations of the adenomatosis polyposis coli (APC)-related protein APC2/E-APC and the

209 litis-associated and spontaneous adenomatous polyposis coli (APC)-related tumors of the intestinal ep

210 ansducin beta-like 1 (TBL1), and adenomatous polyposis coli (APC).

211 tations in the tumor suppressor, adenomatous polyposis coli (APC).

212 th myelin basic protein (MBP) and adenomatus polyposis coli (APC).

213 tubule plus end binding protein, adenomatous polyposis coli (APC).

214 get gene of the tumor suppressor adenomatous polyposis coli (APC).

215 cells correlated with status of adenomatous polyposis coli (APC).

216 umor suppressor proteins Axin and adnomatous polyposis coli (APC).

217 nthase kinase-3beta, axin-1, and adenomatous polyposis coli (APC).

218 tivation of the tumor suppressor adenomatous polyposis coli (APC).

219 function of the tumor suppressor Adenomatous polyposis coli (Apc).

220 sses beta-catenin activity in an adenomatous polyposis coli (APC)/glycogen synthase kinase-3 (GSK3)-i

221 esses colonic polyp formation in adenomatous polyposis coli (APC)min/+ mice.

222 We analyzed adenomatous polyposis coli (Apc)min/+/Sigirr-/- mice for polyps, mic

223 EGF1 mice were bred to Min mice (adenomatous polyposis coli [APC] +/-).

224 or suppressor candidate 33, N33; adenomatous polyposis coli, APC; mut-L homolog 1, MLH1; and O(6)-met

225 eted for proteolysis by the Axin/Adenomatous polyposis coli (Apc1 and Apc2)/Zeste-white 3 destruction

226 defect (POP-1)/TCF, APC related/adenomatosis polyposis coli (APR-1)/APC, and LIT-1/NLK (loss of intes

227 lloproteinases 1, 2, and 3, and adenomatosis polyposis coli) are known for their antiangiogenic funct

228 thway mutations, such as loss of adenomatous polyposis coli, are insensitive to this novel hypoxic ef

229 he destruction complex component adenomatous polyposis coli at a similar SLS motif to the effect that

230 lex, consisting of the proteins adenomatosis polyposis coli, Axin and glycogen synthase kinase 3beta

231 ynthase kinase 3beta (GSK3beta)- adenomatous polyposis coli-axin-mediated degradation pathway.

232 Because mutations in adenomatous polyposis coli, beta-catenin and other components of the

233 ted with colon cancer, including adenomatous polyposis coli, beta-catenin, p53, c-myc, cyclin D1, and

234 CCND1 gene and activated by the adenomatous polyposis coli-beta-catenin-T-cell factor/lymphoid enhan

235 umors driven by mutations in the adenomatous polyposis coli/beta-catenin pathway and activates AP-1.

236 even harboring mutations in the adenomatous polyposis coli/beta-catenin pathway.

237 lines harboring mutations in the adenomatous polyposis coli/beta-catenin pathway.

238 activated canonical signaling in adenomatous polyposis coli/beta-catenin wild-type colon cancer cells

239 n site family (WNT)/beta-catenin/adenomatous polyposis coli (CTNNB1/APC) pathway has been identified

240 In the context of APC (adenomatous polyposis coli) deficiency (Apc(Min/+) mice), loss of Fb

241 nization and capture dynamics in adenomatous polyposis coli-deficient radial progenitors.

242 Adenomatosis polyposis coli down-regulated 1 (APCDD1) has recently be

243 neoplasia (Min) mutation of the adenomatous polyposis coli gene (Apc) and homozygous for the tumor r

244 denomas acquire mutations in the adenomatous polyposis coli gene (APC) and show defects in APC-depend

245 e with germline mutations in the adenomatous polyposis coli gene (Apc) and/or DNA mismatch repair gen

246 Inactivating mutations of the adenomatous polyposis coli gene (APC) or activating mutations of the

247 rectal cancers, mutations in the adenomatous polyposis coli gene (APC) or CTNNB1 constitutively activ

248 d with reduced expression of the adenomatous polyposis coli gene (APC).

249 n family 1 gene RASSF1A, and the adenomatous polyposis coli gene APC in tumors and in histologically

250 rrying and non-sense mutation in Adenomatous polyposis coli gene at site R850, which designated Apc (

251 represent the homozygous loss of adenomatous polyposis coli gene function.

252 ause of germline mutation of the adenomatous polyposis coli gene is characterized by development of c

253 harboring an identical germline adenomatous polyposis coli gene mutation.

254 gative regulators, such as axin, adenomatous polyposis coli gene product (APC), and glycogen synthase

255 by inhibiting its binding to the adenomatous polyposis coli gene product and subsequent glycogen synt

256 rrier proteins like axin and the adenomatous polyposis coli gene product APC interact with beta-caten

257 ly rare missense variants in the adenomatous polyposis coli gene, which is responsible for familial a

258 e carrying the Min allele of the adenomatous polyposis coli gene.

259 d to control mice carry wildtype Adenomatous polyposis coli gene.

260 by inactivating mutations in the Adenomatous polyposis coli gene.

261 lineages by deletion of the Apc (adenomatous polyposis coli) gene causes spontaneous T cell activatio

262 through Disheveled (Dvl), Axin, adenomatous polyposis coli, glycogen synthase kinase 3beta, and case

263 hway regulatory genes, including adenomatous polyposis coli, GSK3beta, axin 1, beta-catenin, lymphoid

264 e tumor suppressor protein, APC (adenomatous polyposis coli), in the regulation of base excision repa

265 the Wnt repressor APC (encoding adenomatous polyposis coli) leads to a state of aberrant and unrestr

266 ned mutations in either the APC (adenomatous polyposis coli) locus or in an allele of beta-catenin.

267 g and glycogen synthase kinase-3/adenomatous polyposis coli-mediated beta-catenin activation.

268 al intestinal homeostasis and in adenomatous polyposis coli-mediated tumorigenesis.

269 Crossing Tfam(+/-) mice to the adenomatous polyposis coli multiple intestinal neoplasia (APC(Min/+)

270 Here, we demonstrate that adenomatous polyposis coli mutant APC(Min/+) mice, which have increa

271 ted and somatic mutations in the adenomatous polyposis coli occur in most colon cancers, leading to a

272 g functional mutations in either adenomatous polyposis coli or beta-catenin.

273 by loss of the tumor suppressor adenomatous polyposis coli or casein kinase 1alpha uncovered new reg

274 xamination of one or more of the adenomatous polyposis coli, p14ARF, p16INK4a, or death associated pr

275 formation about the roles of the adenomatous polyposis coli protein (APC) and its binding partner EB1

276 ated depletion of two kMAPs, the adenomatous polyposis coli protein (APC) and its binding partner, EB

277 in Axin and the tumor suppressor adenomatous polyposis coli protein (APC) are critical components of

278 We recently identified adenomatous polyposis coli protein (APC) as a key regulator of inter

279 eport that the tumour suppressor adenomatous polyposis coli protein (APC) directs the localization an

280 We propose that adenomatous polyposis coli protein (APC) is a key coordinator of pre

281 in requires interaction with the adenomatous polyposis coli protein but not with TCF for its function

282 des with both beta4-spectrin and adenomatous polyposis coli protein in the cytosol.

283 f a region similar to one in the adenomatous polyposis coli protein involved in EB1 binding blocks Ml

284 actin-nucleating ability of the adenomatous polyposis coli protein is required for disassembly of fo

285 We had shown that the APC (adenomatous polyposis coli) protein controls localization of some RN

286 i of the beta-catenin antagonist adenomatous polyposis coli results in the regeneration of a tail at

287 However, little is known about adenomatous polyposis coli's (APC's) role in the mammalian brain.

288 tably transformed with wild-type adenomatous polyposis coli showed decreased beta-catenin protein and

289 -catenin, a component of the Wnt-adenomatous polyposis coli signaling pathway, contribute to the deve

290 ifferent autoantigen, except for adenomatous polyposis coli that was recognized by sera of two patien

291 s the tumor suppressor gene APC (adenomatous polyposis coli), thereby affecting Wnt (Wingless-related

292 Germ line mutations in the Adenomatous polyposis coli tumor suppressor gene cause a hereditary

293 sed by germline mutations in the adenomatous polyposis coli tumor suppressor gene.

294 le motor cytoplasmic dynein, the adenomatous polyposis coli tumor suppressor protein (APC), and glyco

295 unction and cortically localized Adenomatous Polyposis Coli tumor suppressor protein to orient mitoti

296 Mutations in the APC (adenomatous polyposis coli) tumor suppressor gene cause uncontrolled

297 The APC gene encodes the adenomatous polyposis coli tumour suppressor protein, germline mutat

298 All patients were tested for the adenomatous polyposis coli variants I1307K and E1317Q, and variants

299 tivation of the tumor suppressor adenomatous polyposis coli, with the resultant activation of beta-ca

300 Disruption of Apc (adenomatous polyposis coli) within hepatocytes activates Wnt signall