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1 esis as the nascent proteins emerge from the polysome.
2 ctors may be constitutively localised to the polysome.
3 y and the association of the transcript with polysomes.
4 esent in all subpopulations of ER-associated polysomes.
5 se in the amount of grk mRNA associated with polysomes.
6 uces association of the UME6 transcript with polysomes.
7 s with the return of the stabilized mRNAs to polysomes.
8 3 translation and TP53 mRNA association with polysomes.
9 mRNAs into the active translation sites, the polysomes.
10 a2(I) mRNA is unrestrictedly loaded onto the polysomes.
11 p1 mutant for membrane-bound, but not total, polysomes.
12 ncreasing the loading of CBP/p300 mRNAs onto polysomes.
13 es with 40S ribosomal subunits and also with polysomes.
14 and it associates with mRNAs assembled into polysomes.
15 existing DHX33 mRNAs to actively translating polysomes.
16 of both PHO1;2 and cis-NATPHO1;2 toward the polysomes.
17 and the loading of CBP/p300 transcripts onto polysomes.
18 nally, IGFBP3 mRNA was found enriched to the polysomes.
19 onosomes and increased their target mRNAs in polysomes.
20 , of mRNAs encoding particular proteins from polysomes.
21 he cell coincident with their depletion from polysomes.
22 the tool to isolate coupled mitochondria and polysomes.
23 ap-dependent manner, were shifted to lighter polysomes.
24 te translation by actively recruiting RHA to polysomes.
25 lasm between the cytosol and the translating polysomes.
26 is present on many proteins that form active polysomes.
27 rotein synthesis rate and formation of large polysomes.
28 all of which are localized by membrane-bound polysomes.
29 ction motifs decrease LARP4 association with polysomes.
30 associated with cytosolic 80S ribosomes and polysomes.
31 transcript was present in RNA isolated from polysomes.
32 , and there was marked depletion of HuR from polysomes.
33 are detected in both ribonucleoproteins and polysomes.
34 PCBP 1 and 2, also cofractionated with viral polysomes.
35 ns uL4 or uL22 are still capable of entering polysomes.
36 cay (NMD), even though they were detected in polysomes.
37 ycolysis decreases TNF mRNA association with polysomes.
38 et of oxidative stress-responsive mRNAs into polysomes.
39 mammalian cells are in turn associated with polysomes.
41 in vitro, ribosome transit rates slowed, and polysomes accumulated in intact cells, suggesting defect
42 oping multicolor probes, we showed that most polysomes act independently; however, a small fraction (
43 subunits in sucrose gradients and repopulate polysomes after a short starvation-induced translational
45 This heightened association of miRNA with polysomes also elicits reduced degradation of target mRN
50 lational profiling by microarray analysis of polysome and monosome associated mRNAs in wild-type and
51 ighly hypoxia-induced mRNAs are recruited to polysomes and actively translated, whereas other cellula
52 . cerevisiae resulted in the accumulation of polysomes and an increase in ribosomal transit times.
54 e dynamics of messenger RNA association with polysomes and compared the transcriptome with the transl
55 l Ccr4-Not complex in yeast, associates with polysomes and contributes to the negative regulation of
56 levels of actb mRNA associated with synaptic polysomes and diminished levels of synaptic actb protein
57 liced c-myb transcripts were associated with polysomes and encoded a series of c-Myb proteins with id
58 the SMN mRNA from heavy polysomes to lighter polysomes and monosomes, suggesting that Gemin5 function
62 icient in loading uORF-containing mRNAs onto polysomes and stimulates translation in protoplasts, and
63 rent supra-ribosomal building blocks forming polysomes and suggest the presence of unexplored transla
65 tively translating mRNAs are associated with polysomes and the newly synthesized peptide chains are c
67 in annotated 5'-UTRs were overrepresented in polysomes and were as stable as canonical mRNA isoforms.
68 s are subject to differential recruitment to polysomes, and expose the importance of selective mRNA t
70 ssion, promotes cap-dependent translation in polysomes, and reduces the anti-proliferative effect of
71 messenger ribonucleoprotein for loading onto polysomes, and reduction of Cul4B expression shunts the
73 rmore, phosphorylated eIF4E relocates to the polysomes, and this contributes to changes in the transl
74 m a stable complex with the 70S ribosome and polysomes, and we demonstrate the proximity in vivo of r
75 iation of the mRNA with actively translating polysomes; and de novo MMP-9 protein synthesis were obta
76 n kinesin-3 and dynein-driven EEs, where the polysomes appeared to translate EE-associated mRNA into
81 multaneously translate the same mRNA strand (polysomes) are represented as freely jointed chains of h
82 on microscopy to image ex-vivo-derived human polysomes as a source of actively translating ribosomes.
84 ll organization of mRNA and ribosomes within polysomes, as well as the possible role of this organiza
86 crease in mRNA levels as well as a defect in polysome assembly that was independent of mRNA abundance
87 n about how proteins emerging from different polysomes associate to form hetero-oligomeric channels.
88 maydis, Higuchi et al. now demonstrate that polysomes associate with early endosomes that undergo ki
90 at the mRNA encoding plexin A remains highly polysome associated during stress and escapes degradatio
92 NA targeted mRNAs are invariably found to be polysome associated; observations that appear to be at f
94 Although psbA and rbcL mRNAs are normally polysome-associated in the mutant, petD-containing RNAs
96 tment did not change overall MOR transcript, polysome-associated mRNA declined in a let-7-dependent m
98 combinatorial biotin transfer system, where polysome-associated mRNAs are selectively recovered from
99 logy clustering showed that the functions of polysome-associated transcripts differed between dormant
101 anged following viral infection, whereas the polysome-associated tRNA population changes dramatically
102 delineated how a target mRNA passes through polysome association and Ago2 interaction steps on rough
104 and eIF4E2 are elucidated by observing their polysome association and the status of mammalian target
105 This novel combination results in increased polysome association of mda-7/IL-24 mRNA, activation of
108 as promoted by UPF1 depletion, which induced polysome association of PTC-containing mRNAs, increased
111 exes from target mRNAs, leading to increased polysome association, translation, and stability of miRN
112 und mRNAs, we found that La binds 34% of the polysome bound mRNAs and regulates the expression of a s
114 ling of the rpl4d mutant showed reduction in polysome-bound mRNA compared with wild-type, but no sign
116 a in the cytoplasm by microarray analysis of polysome-bound mRNAs, we found that La binds 34% of the
117 is influenced by ionizing radiation, we used polysome-bound RNA to generate gene translation profiles
118 impact on the association of HCMV mRNAs with polysomes but significantly diminished the translation e
119 so determines the specificity of neocortical polysomes by defining their combinatorial composition of
120 nt of elongation, TOP mRNAs are recruited on polysomes causing a relative increase in the synthesis o
122 on and are a result of its direct binding to polysomes, complex formation with cellular RNAs (which i
123 lyzing mRNAs that dynamically associate with polysome complexes as neocortical development progresses
124 a-up-regulated gene transcripts increased in polysome complexes during the stress, but the number of
125 f of the cellular mRNAs were restricted from polysome complexes during the stress, with little or no
127 s bind target mRNAs in high molecular weight polysome complexes, while inhibited miRNAs are stericall
129 as a shift of TDP-43 and FUS mRNAs away from polysomes, consistent with translational silencing.
132 show that active mRNA translation complexes (polysomes) contain ribosomal protein subsets that underg
133 location of longer 3' UTR mRNAs from RNPs to polysomes correlated with the production of new miRNAs t
135 a reduction in 40S subunits and translating polysomes, correlating with reduced overall cellular pro
139 K85R) mutant do not prevent arsenite-induced polysome disassembly, but fails to support the SG assemb
140 ation of SG proteins to VFs was dependent on polysome dissociation and occurred via association of th
141 y performing mRNA half-life measurements and polysome distribution analysis, we found that AUF1 assoc
142 es, including involucrin, are bound to heavy polysomes during differentiation, despite decreased gene
145 n and identified conditions that distinguish polysomes engaged in the translation of distinct cohorts
146 ly, the Sec61 complex was highly enriched in polysomes engaged in the translation of endomembrane org
147 as a direct HIF-1alpha target gene and that polysome enrichment of IGFBP3 mRNA may permit continuous
149 for translocation of viral RNA genome to the polysomes for efficient translation and replication.
150 upt protein synthesis and release mRNAs from polysomes for incorporation into P-bodies for degradatio
154 l of the large subunit (up to 17%), impaired polysome formation (appearance of half-mers), reduced tr
158 et mRNA stability, but decreased the size of polysomes forming on target transcripts and lowered the
159 of the actin cytoskeleton moved Wt1 off the polysome fraction in the cytoplasm, cancelled its nucleo
161 nd that decapping factors co-sediment in the polysome fraction of a sucrose gradient and do not alter
163 as indicated by luciferase reporter assays, polysome fractionation studies, and Western blot analysi
164 L-seq (TATL-seq), which combines TL-seq with polysome fractionation, enabled annotation of TLs, and s
166 creased viral messenger RNA association with polysome fractions and enhanced tolerance to begomovirus
168 omic analyses of HeLa cytosolic and ER-bound polysome fractions identified translocon components as s
171 ation, the distribution of chimeric mRNAs on polysome gradients and the steady-state levels of expres
173 mRNAs can be packaged in reversibly stalled polysome granules before their transport to distant syna
174 the cytoplasm, LARP6 does not associate with polysomes; however, overexpression of LARP6 blocks ribos
175 zation of RP transcripts led to retention of polysomes in a hog1Delta mutant, whereas stabilization o
180 s, capture distinct mobilities of individual polysomes in different subcellular compartments, and det
181 munopurification of transcripts engaged with polysomes in pollen tubes within self-fertilized florets
182 A decay, is critical for assembly of stalled polysomes in rat hippocampal neurons derived from embryo
184 O, there was a reduction in the formation of polysomes in the HFD mice relative to the LFD mice, sugg
185 -'UTR-shortened transcripts efficiently form polysomes in the mTOR-activated cells, leading to increa
188 nosines ((Cap)2G or (Cap)3G) are enriched on polysomes, indicating that RNAs synthesized from differe
190 ies with polysomes, and there is a subset of polysomes involved in myosin-dependent translation of co
193 strated that the transport of HCV RNA on the polysomes is Stau1-dependent, being mainly localized in
195 ly detected in multiple tissues, and also in polysome isolated from leaf, confirming active transcrip
198 the association of eIF2 subunits, diminished polysome levels, and increased GCN4 expression indicatin
199 HuR-dependent proteins, the association with polysomes likewise depends on the eukaryotic initiation
203 tantly, the fold induction of TNF-alpha mRNA polysome loading in response to LPS stimulation is reduc
206 inst even sudden changes in temperature, and polysome loading increases when the night temperature is
207 tion-polymerase chain reaction revealed that polysome loading remained high for much of the night in
210 nses of the metabolome and transcriptome and polysome loading, as a qualitative proxy for protein syn
213 med target mRNA localization to the ER-bound polysomes manifested as the earliest event, which is fol
215 Here we used a systems approach by combining polysome mRNA profiling and bioinformatics to identify R
217 ell line to fit thousands of images of human polysomes obtained by atomic force microscopy, from whic
219 The effect of Jak-Stat-Pim signaling on polysome occupancy and expression of GW182 protein was g
220 to maximize conformational entropy, and the polysomes occupy the empty space near the walls to maxim
222 ail lengths were similar for target mRNAs on polysomes or in non-translating mRNPs, and the presence
223 Cellular mRNAs can be actively translated in polysomes or physically sequestered in cytoplasmic proce
224 of Snail1 mRNA into the actively translated polysome pool accompanied by accumulation of the EMT tra
231 , we performed a genome-wide analysis of the polysome-profiled mRNAs by using an Affymetrix GeneChip
233 ein synthesis with one important difference: Polysome profiles observed immediately after eIF5A deple
238 -)), and two independent translation assays, polysome profiling and radiolabeled amino acid incorpora
245 blastoma to ionizing radiation (IR), we used polysome profiling to define the IR-induced translatomes
249 l oligopyrimidine motif) and TOP-like mRNAs, polysome-profiling indicated that MTOR also modulates tr
250 this regulation, we developed a genome-wide polysome-profiling strategy using stage-matched WT and e
251 In untreated conditions, Puf3p migrates with polysomes rather than ribosome-free fractions, but this
252 dependent 5'TOP mRNA translation repression, polysome release, and accumulation in stress granules.
253 R1 activation enhanced recruitment of RNA to polysomes, resulting in a marked increase in protein exp
254 , it facilitates association of MDR1 mRNA to polysomes, resulting in increased translation, and AEG-1
256 isoform mRNAs lost from the eif3ha morphant polysomes, revealing a mechanism by which lens developme
260 ng RatA showed that 70S ribosomes as well as polysomes significantly decreased with concomitant incre
262 -intact tissue culture cells, we performed a polysome solubilization screen and identified conditions
268 th retained U12-type introns can be found in polysomes, suggesting that splicing efficiency can alter
270 specific patterns of mRNA recruitment to the polysomes that are synchronized with the cell cycle.
271 decreasing the proportion of mef2ca mRNA in polysomes, the levels of Mef2c and slow myosin heavy cha
272 nge in the levels of Ribosomal protein L7 in polysomes, thereby regulating neocortical translation ma
275 Gemin5 redistributes the SMN mRNA from heavy polysomes to lighter polysomes and monosomes, suggesting
276 further examined their potency at converting polysomes to monosomes across other commonly used model
278 type cells and the shift in translation from polysomes to monosomes is attenuated, suggesting puf3Del
281 forms of recapping targets redistribute from polysomes to non-translating mRNPs, and recapping is all
282 he redistribution of target transcripts from polysomes to non-translating mRNPs, where they accumulat
284 futsch mRNA shift from actively translating polysomes to nontranslating ribonuclear protein particle
285 (Dc,60S = 0.311 microm(2)/s), whereas entire polysomes underwent long-range motility along microtubul
289 ation, the association of mRNAs and sRNAs to polysomes was characterized in roots of the model legume
292 -independent manner, were shifted to heavier polysomes whereas mRNAs encoding GAPDH, actin, L32, and
293 ment of early endosomes randomly distributes polysomes, which may ensure the even distribution of the
294 ated through decreased mRNA association with polysomes, which requires microRNA23b (miRNA23b), a spec
295 s C), but did not influence global levels of polysomes, which were minimally perturbed by above freez
296 on results in decreased RHA association with polysomes while increasing Lin28 expression leads to ele
300 F correlated with alterations in the size of polysomes with ribosomes present every 250 to 500 nucleo
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