ライフサイエンスコーパス: polytopic

1 The polytopic 5-domain multidrug resistance protein 1 (MRP1/

2 SRP pathway also affected the insertion of a polytopic AcrB-AP fusion.

3 l proteins; polymeric IgA receptor (pIgA-R), polytopic apical, and basolateral resident distributions

4 ontain the active site of gamma-secretase, a polytopic aspartyl protease involved in the transmembran

5 eavage is effected by Presenilin, an unusual polytopic aspartyl protease that apparently cleaves Notc

6 protease complex and its similarity to other polytopic aspartyl proteases.

7 e electron transport by distinct families of polytopic b cytochromes.

8 The MOFs reported herein are of polytopic carboxylates and contain one of Zn, Pb, Co, Cd

9 ed by mutations in SLC4A1, which encodes the polytopic chloride-bicarbonate exchanger AE1 that is nor

10 form of F protein inserted in membranes in a polytopic conformation with both the amino-terminal end

11 itine palmitoyltransferase (CPT) 1A adopts a polytopic conformation within the mitochondrial outer me

12 previously that the membrane integration of polytopic connexin polypeptides can be accompanied by an

13 cation-binding abilities of these mono- and polytopic crown ethers have been probed through picrate

14 e distribution of encoded known and putative polytopic cytoplasmic membrane transport proteins within

15 d, suggesting that pCytf, in contrast to the polytopic D1 protein, does not require cpSRP for targeti

16 Tsc13p is a polytopic endoplasmic reticulum (ER) membrane protein th

17 olesterol homeostasis is mediated by Scap, a polytopic endoplasmic reticulum (ER) protein that transp

18 The polytopic endoplasmic reticulum (ER)-localized enzyme 3-

19 SREBP cleavage-activating protein (SCAP), a polytopic endoplasmic reticulum membrane protein.

20 sses depend on interactions of TLR9 with the polytopic endoplasmic reticulum-resident protein UNC93B1

21 are comparable with those measured for other polytopic ER integral membrane proteins.

22 terol-dependent binding to the following two polytopic ER membrane proteins: sterol regulatory elemen

23 ER hemoproteins, CYP2C11 and CYP3A4, and the polytopic ER protein HMGR attest to the remarkable mecha

24 One polytopic ER protein subjected to ER-associated degradat

25 ata suggest that p97 recruits proteasomes to polytopic ER proteins even before they are extracted fro

26 We show that two polytopic ERAD substrates, mutated transporter of the ma

27 al type 1 glycoprotein, while the other is a polytopic form in which approximately 200 amino acids of

28 milar predictions do not appear to apply for polytopic G protein-coupled receptors.

29 -Pick C1 (NPC1) protein is predicted to be a polytopic glycoprotein, and it contains a region with ex

30 We describe the NMR structure of DsbB, a polytopic helical membrane protein.

31 ve monotopic P450 enzyme, in common with the polytopic HMGR, required the function of certain HRD (HM

32 Most ion transport proteins are polytopic, however, and little is known of the signals r

33 The OxlT amino acid sequence specifies a polytopic hydrophobic protein of 418 residues with a mas

34 single open reading frame (ORF), encoding a polytopic hydrophobic protein, LjN70, with a predicted m

35 to address the sequence requirements of the polytopic hydrophobic transmembrane domain for LMP-1's s

36 y intermediate between exported proteins and polytopic IMPs.

37 he presence of a truncated derivative of the polytopic inner membrane protein, TetA.

38 bution of Agrobacterium tumefaciens VirB6, a polytopic inner membrane protein, to the formation of ou

39 required for the efficient insertion of many polytopic inner membrane proteins (IMPs) into the Escher

40 ly blocked the membrane insertion of several polytopic inner membrane proteins (IMPs) that were predi

41 The two open reading frames encode predicted polytopic inner membrane proteins with 61% amino acid id

42 Thus, polytopic inner membrane proteins, which lack an NH2-ter

43 bed for a series of purified variants of the polytopic integral membrane protein diacylglycerol kinas

44 Recently, mutations in the novel polytopic integral membrane protein PfCRT were shown to

45 Ghrelin O-acyltransferase (GOAT) is a polytopic integral membrane protein required for activat

46 rly-onset familial Alzheimer's disease, is a polytopic integral membrane protein that is endoproteoly

47 nt anion channel (VDAC-1) as an example of a polytopic integral membrane protein.

48 ty of NMR for functional characterization of polytopic integral membrane proteins and provide insight

49 ins associated with HycC and HycD, which are polytopic integral membrane proteins believed to anchor

50 rticular, the subunit stoichiometry of these polytopic integral membrane proteins has not been unequi

51 O-acyltransferase (MBOAT) family, a group of polytopic integral membrane proteins involved in lipid-b

52 The presenilin (PS) proteins are polytopic integral membrane proteins that are critically

53 librative nucleoside transporters (ENTs) are polytopic integral membrane proteins that transport nucl

54 Rhomboids form a family of polytopic intramembrane serine proteases.

55 membrane proteins with multiple TM segments (polytopic) is still incomplete.

56 on, we show that the proper insertion of the polytopic MalF protein (synthesized without a signal seq

57 sterol-sensing domain, which is part of the polytopic membrane attachment region of SCAP.

58 y sterols, which appear to interact with the polytopic membrane domain of SCAP.

59 Gaa1 is a polytopic membrane glycoprotein with a cytoplasmic N ter

60 -dependent bile acid transporter (Asbt) is a polytopic membrane glycoprotein, which is specifically e

61 hese results pinpoint RhCG and Rhcg as novel polytopic membrane glycoproteins that may function as ep

62 protein (NGEP-S) and a long form encoding a polytopic membrane protein (NGEP-L).

63 al integration of a eukaryotic multispanning polytopic membrane protein (PMP), its hydrophilic loops

64 g green fluorescent protein (GFP) fused to a polytopic membrane protein (SpoIVFB) that is involved in

65 e human MDR3 P-glycoprotein (Pgp) as a model polytopic membrane protein and expressed it in a coupled

66 P-glycoprotein (Pgp)1 is a polytopic membrane protein and functions as an energy-de

67 esents the first reported semisynthesis of a polytopic membrane protein and highlights the potential

68 s covalent linkage between a G protein and a polytopic membrane protein appears, to our knowledge, to

69 The pathway by which segments of a polytopic membrane protein are inserted into the membran

70 The polytopic membrane protein BfpE appears to be a central

71 vivo and in vitro demonstrate that Akr1p, a polytopic membrane protein containing a DHHC cysteine-ri

72 The data demonstrate that mPRA1 is a polytopic membrane protein containing four TM segments.

73 1 cleavage, apparently by interacting with a polytopic membrane protein designated SREBP cleavage-act

74 each latent transmembrane segment (TMS) in a polytopic membrane protein emerges from the ribosome, it

75 PC1 is a complex polytopic membrane protein expressed in cilia that under

76 Here we show that the polytopic membrane protein FeoB, which is essential for

77 ed in prostate (NGEP) is a prostate-specific polytopic membrane protein found at high concentrations

78 he SLC26A family of anion transporters, is a polytopic membrane protein found in outer hair cells (OH

79 rod Na(+)/Ca(2+),K(+) exchanger (RodX) is a polytopic membrane protein found in photoreceptor outer

80 gamma-Glutamyl carboxylase (GC), a polytopic membrane protein found in the endoplasmic reti

81 The 1278-amino acid, polytopic membrane protein has not been purified, and it

82 g the intracellular trafficking of a complex polytopic membrane protein in yeast.

83 e, to determine whether YidC plays a role in polytopic membrane protein insertion and/or folding.

84 equential, cotranslational model of archaeal polytopic membrane protein insertion in vivo.

85 use of the assay to monitor the kinetics of polytopic membrane protein insertion in vivo.

86 The prevailing model of polytopic membrane protein insertion is based largely on

87 The final destination of this polytopic membrane protein is the Golgi apparatus, where

88 li, the major cytoplasmic domain (C6) of the polytopic membrane protein lactose permease (LacY) is ex

89 a molecular chaperone in the folding of the polytopic membrane protein lactose permease (LacY) of Es

90 However, the topology and function of the polytopic membrane protein lactose permease of Escherich

91 apical targeting information and can direct polytopic membrane protein localization.

92 hinese hamster ovary cells and shown to be a polytopic membrane protein localized in the endoplasmic

93 understand cellular response to a misfolded polytopic membrane protein of the secretory pathway, we

94 Presenilin-1 (PS1), a polytopic membrane protein primarily localized to the en

95 These data suggest that this large polytopic membrane protein requires multiple signals for

96 Lamin B receptor (LBR) is a polytopic membrane protein residing in the inner nuclear

97 These studies directly demonstrate polytopic membrane protein retrotranslocation during ERA

98 The polytopic membrane protein SCAP transports sterol regula

99 al that SpoIIQ resides in a complex with the polytopic membrane protein SpoIIE.

100 e for studying static and dynamic aspects of polytopic membrane protein structure and function.

101 P-Glycoprotein (Pgp) is a polytopic membrane protein that consists of a tandem rep

102 the G-protein-coupled receptor family, is a polytopic membrane protein that does not encode a cleave

103 nsmembrane conductance regulator (CFTR) is a polytopic membrane protein that functions as a Cl(-) cha

104 Scap is a polytopic membrane protein that functions as a molecular

105 TM4SF20 (transmembrane 4 L6 family 20) is a polytopic membrane protein that inhibits proteolytic pro

106 osphate includes the HK protein UhpB and the polytopic membrane protein UhpC, a UhpT homolog which is

107 Here we show that the function of the polytopic membrane protein UNC93B1 is to deliver the nuc

108 ility studies support a model for VirB6 as a polytopic membrane protein with a periplasmic N terminus

109 er, these data support a model of FATP1 as a polytopic membrane protein with at least one transmembra

110 SLY41 encodes a polytopic membrane protein with homology to a class of s

111 sa aurealis insertion in SAV2335, encoding a polytopic membrane protein with predicted protease domai

112 f the nir operon, which is predicted to be a polytopic membrane protein with six membrane-spanning he

113 r such studies because it is a very abundant polytopic membrane protein, and its localization and act

114 of Escherichia coli (LacY), a highly dynamic polytopic membrane protein, catalyzes stoichiometric gal

115 In contrast, TM3 and TM4 of another polytopic membrane protein, cystic fibrosis transmembran

116 SdpI, a polytopic membrane protein, is encoded by a two-gene ope

117 protein, which was previously found to be a polytopic membrane protein, is secreted by the Dot/Icm t

118 us mutations affect membrane assembly of the polytopic membrane protein, MalF.

119 ntroduced at 55 independent sites in a model polytopic membrane protein, TM0026.

120 entified ttsA, a chromosomal gene encoding a polytopic membrane protein.

121 s, we identified TMEM129, an uncharacterized polytopic membrane protein.

122 amino acids in the helix interfaces of four polytopic membrane proteins (cytochrome c oxidase, bacte

123 Transmembrane topology of polytopic membrane proteins (PMPs) is established in the

124 subunit complexes, often composed of several polytopic membrane proteins and cytosolic proteins.

125 should be useful for studying biogenesis of polytopic membrane proteins and GPCR signaling mechanism

126 Unlike most other proteases, they are polytopic membrane proteins and specialize in cleaving t

127 Most polytopic membrane proteins are believed to integrate in

128 Eukaryotic polytopic membrane proteins are cotranslationally insert

129 Polytopic membrane proteins are essential for cellular u

130 Once inserted, transmembrane segments of polytopic membrane proteins are generally considered sta

131 Polytopic membrane proteins are inserted cotranslational

132 Structural studies of polytopic membrane proteins are often hampered by the va

133 ppears in both antiparallel helical pairs of polytopic membrane proteins as well as the parallel heli

134 s to the quality control of non-glycosylated polytopic membrane proteins by binding to misfolded or u

135 e energetics and structural specificities of polytopic membrane proteins by using a battery of in sil

136 These data indicate that polytopic membrane proteins can be extracted from the ER

137 of amino acids into transmembrane helices of polytopic membrane proteins disrupt helix-helix interact

138 omain (DHHC-CRD), is a diverse collection of polytopic membrane proteins extending through all eukary

139 nobutyric acid (GABA) transporter family are polytopic membrane proteins found endogenously in both e

140 s that predict the transmembrane topology of polytopic membrane proteins identify 10-12 putative memb

141 Dysregulation of these polytopic membrane proteins impacts the redox signaling

142 e high-resolution structure determination of polytopic membrane proteins in a detergent-free, near-na

143 residues mediate helix-helix interactions in polytopic membrane proteins in a fashion similar to that

144 feasibility of determining the structures of polytopic membrane proteins in their native phospholipid

145 hem, the TIM22 complex mediates insertion of polytopic membrane proteins into the inner membrane, and

146 The import of polytopic membrane proteins into the mitochondrial inner

147 The membrane assembly of polytopic membrane proteins is a complicated process.

148 Insertion and folding of polytopic membrane proteins is an important unsolved bio

149 The topology of polytopic membrane proteins is determined by topogenic s

150 The topology of most eukaryotic polytopic membrane proteins is established cotranslation

151 tein (Pgp) suggested that the topogenesis of polytopic membrane proteins is likely more complicated t

152 The encoded enzymes are polytopic membrane proteins of 298 and 272 amino acids,

153 xamined 199 transmembrane alpha-helices from polytopic membrane proteins of known structure.

154 mily of DHHC cysteine-rich domain (DHHC-CRD) polytopic membrane proteins shown recently in yeast to r

155 Polytopic membrane proteins subjected to endoplasmic ret

156 TbSLSs are polytopic membrane proteins that are essential for viabi

157 resenilin 1 (PS1) and presenilin 2 (PS2) are polytopic membrane proteins that are mutated in the majo

158 PS1 and PS2 are homologous polytopic membrane proteins that are processed endoprote

159 multiple hydrophobic segments, suggestive of polytopic membrane proteins that are targeted to the sec

160 S2P defines a new family of polytopic membrane proteins that contain an HEXXH sequen

161 P(1B)-type ATPases are polytopic membrane proteins that couple the hydrolysis o

162 Presenilins (PSs) are polytopic membrane proteins that have been implicated as

163 PS1 and PS2 are polytopic membrane proteins that undergo endoproteolytic

164 ABC transporters are polytopic membrane proteins that utilize ATP binding and

165 D family members, represent rare examples of polytopic membrane proteins with an intrinsic additional

166 The GXGD proteases are polytopic membrane proteins with catalytic activities ag

167 e" may be an important folding mechanism for polytopic membrane proteins, and it is regulated by the

168 mpt to investigate further the biogenesis of polytopic membrane proteins, I used the human MDR3 P-gly

169 Two polytopic membrane proteins, NarK and NarU, are assumed

170 Functional overexpression of polytopic membrane proteins, particularly when in a fore

171 aspartyl proteases are a homologous group of polytopic membrane proteins, some of which function in i

172 pholipids in the topological organization of polytopic membrane proteins, the function and assembly o

173 For polytopic membrane proteins, those with multiple transme

174 Presenilin 1 and presenilin 2 are polytopic membrane proteins, whose genes are mutated in

175 emented to predict membrane dipping loops in polytopic membrane proteins.

176 cal sterol-sensing domain found in six other polytopic membrane proteins.

177 ly to multiple signals to drive packaging of polytopic membrane proteins.

178 hould be applicable to a number of different polytopic membrane proteins.

179 nces must be considered when epitope tagging polytopic membrane proteins.

180 nd the molecular mechanism of topogenesis of polytopic membrane proteins.

181 e because of the complexity and diversity of polytopic membrane proteins.

182 e earliest steps of tertiary folding of five polytopic membrane proteins.

183 ties to study the cotranslational folding of polytopic membrane proteins.

184 tides (including dimers), and TM segments of polytopic membrane proteins.

185 ntermembrane space, involved in transport of polytopic membrane proteins.

186 ures of transmembrane helical interfaces and polytopic membrane proteins.

187 ns express markedly different pheromones and polytopic membrane receptor proteins.

188 Rhomboid, a polytopic membrane serine protease, represents a unique

189 Lactose permease of Escherichia coli is a polytopic membrane transport protein containing 12 membr

190 of a defined apical localization signal in a polytopic membrane transport protein, and suggest that t

191 g that reentrance loops are unlikely in this polytopic membrane transport protein.

192 a membrane protein does not resemble that of polytopic membrane transporters for other substrates.

193 Yeast Doa10 is a polytopic membrane ubiquitin ligase (E3) that along with

194 different sub-branches of a larger family of polytopic membrane-associated aspartyl proteases.

195 y effect on the cell surface distribution of polytopic membrane-associated proteins, suggesting that

196 identify GOAT (Ghrelin O-Acyltransferase), a polytopic membrane-bound enzyme that attaches octanoate

197 m lysosomes requires two lysosomal proteins, polytopic membrane-bound Niemann-Pick C1 (NPC1) and solu

198 T) for investigating the interactions of the polytopic membrane-bound oligosaccharyl transferases (OT

199 f the dopamine transporter, as well as other polytopic membrane-bound proteins, including G protein-c

200 ptable central lipid-filled chamber, wherein polytopic membrane-proteins could fold, sheltered from a

201 There is evidence that the polytopic membrane-spanning proteins, presenilin 1 and 2

202 oundaries of MP insertion and the folding of polytopic MPs in vivo.

203 on of p97 in degrading immature forms of the polytopic, multi-domain protein CFTR (cystic fibrosis tr

204 association require the function of LMP-1's polytopic multispanning transmembrane domain, a domain t

205 The polytopic PGT superfamily, represented by MraY and WecA,

206 ternary complex mechanisms of representative polytopic PGTs.

207 Interestingly a polytopic plasma membrane protein, Fig1p, was required f

208 rates two separate Ig domain proteins from a polytopic precursor.

209 nd S2P appear to be members of a new type of polytopic protease with an intramembranous active site.

210 ssay to examine the insertion pathway of the polytopic protein bacterioopsin, the apoprotein of Halob

211 A defining feature of eukaryotic polytopic protein biogenesis involves integration, foldi

212 During polytopic protein biogenesis, multiple transmembrane seg

213 hey are presented in rapid succession during polytopic protein biogenesis.

214 to conventional cotranslational pathways of polytopic protein biogenesis.

215 ht be oriented and integrated during nascent polytopic protein biogenesis.

216 Presenilin-1 (PS-1) is a polytopic protein comprised of six to eight transmembran

217 uration factor 1 (LMF1) is predicted to be a polytopic protein localized to the endoplasmic reticulum

218 Scap is a polytopic protein of endoplasmic reticulum (ER) membrane

219 Scap is a polytopic protein of the endoplasmic reticulum (ER) that

220 Lamin B receptor (LBR) is a polytopic protein of the nuclear envelope thought to con

221 F2 (transmembrane 6 superfamily member 2), a polytopic protein of unknown function, is associated wit

222 uman RHAG locus encodes Rh50 glycoprotein, a polytopic protein that modulates expression of Rh antige

223 Polytopic protein topology is established in the endopla

224 ransmembrane conductance regulator (CFTR), a polytopic protein with 12 predicted transmembrane segmen

225 s of LmPOT1 predicted an unusual 803-residue polytopic protein with 9-12 transmembrane domains.

226 ne protein with the C terminus outside, or a polytopic protein with both termini inside.

227 e recently analyzed the GPIT subunit Gaa1, a polytopic protein with seven transmembrane (TM) spans, t

228 TolQ is a polytopic protein with three membrane-spanning regions.

229 membrane protein, in actinobacteria, it is a polytopic protein with three transmembrane domains.

230 s, we established that Arabidopsis CCDA is a polytopic protein with within-membrane strictly conserve

231 b(0,+) amino acid transporter (b(0,+)AT), a polytopic protein, and the helper, related to b(0,+) ami

232 complex structure-function relationships of polytopic proteins and for drug discovery.

233 These polytopic proteins are confined to the erythroid lineage

234 Polytopic proteins are synthesized in the endoplasmic re

235 atterns of specific transporters and unknown polytopic proteins during microgametogenesis provides ne

236 tingly, TbPT family permeases are related to polytopic proteins from plants but not to characterized

237 , the principles governing folding of native polytopic proteins have not yet been elucidated.

238 , required for the insertion of at least two polytopic proteins into the inner membrane, but not for

239 tero-oligomeric complex (TIM10) that escorts polytopic proteins into the mitochondrial inner membrane

240 plex, required for the insertion of imported polytopic proteins into the mitochondrial inner membrane

241 m22p machinery that facilitates insertion of polytopic proteins into the mitochondrial inner membrane

242 Tim17p complex) and one for the insertion of polytopic proteins into the mitochondrial inner membrane

243 ted to sterol-sensing domains found in other polytopic proteins involved in sterol interactions or st

244 Transmembrane topology of most eukaryotic polytopic proteins is established cotranslationally at t

245 egation of nascent transmembrane segments of polytopic proteins is prevented by chaperones present in

246 Thus, the early folding landscape of polytopic proteins is shaped by a spatially restricted e

247 suggest a model in which the degradation of polytopic proteins such as CFTR is coupled to retrograde

248 able to mutations in one of two presenilins, polytopic proteins that contain the catalytic site of th

249 variations in cotranslational folding enable polytopic proteins to acquire and/or maintain primary se

250 Tested on 60 non-redundant polytopic proteins using a strict leave-one-out cross-va

251 orters, when fused to periplasmic domains of polytopic proteins, produces fusions with high AP activi

252 from the transmembrane-spanning segments of polytopic proteins.

253 cess is regulated, especially in the case of polytopic proteins.

254 ABC transporters are polytopic proteins.

255 agr (accessory gene regulator) operon uses a polytopic receptor, AgrC, activated by an autoinducing p

256 s a conformational change in the intervening polytopic sequence separating loops 1 and 7.

257 phenotype of the diseases and the predicted polytopic structure of the protein, it has been suggeste

258 translocon, we devised a self-ubiquitinating polytopic substrate (Hmg1-Hrd1p) that undergoes ERAD in

259 ual membrane-spanning domains within LMP-1's polytopic transmembrane domain.

260 n, albeit less potently than does the entire polytopic transmembrane domain.

261 distinct and separable activities of LMP-1's polytopic transmembrane domain.

262 By using a classification of polytopic transmembrane domains into families, we examin

263 Niemann-Pick C1-like 1 (NPC1L1) is a polytopic transmembrane protein containing a sterol-sens

264 Niemann-Pick C1-Like 1 (NPC1L1) is a polytopic transmembrane protein localized at the apical