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3 l proteins; polymeric IgA receptor (pIgA-R), polytopic apical, and basolateral resident distributions
4 ontain the active site of gamma-secretase, a polytopic aspartyl protease involved in the transmembran
5 eavage is effected by Presenilin, an unusual polytopic aspartyl protease that apparently cleaves Notc
9 ed by mutations in SLC4A1, which encodes the polytopic chloride-bicarbonate exchanger AE1 that is nor
10 form of F protein inserted in membranes in a polytopic conformation with both the amino-terminal end
11 itine palmitoyltransferase (CPT) 1A adopts a polytopic conformation within the mitochondrial outer me
12 previously that the membrane integration of polytopic connexin polypeptides can be accompanied by an
13 cation-binding abilities of these mono- and polytopic crown ethers have been probed through picrate
14 e distribution of encoded known and putative polytopic cytoplasmic membrane transport proteins within
15 d, suggesting that pCytf, in contrast to the polytopic D1 protein, does not require cpSRP for targeti
17 olesterol homeostasis is mediated by Scap, a polytopic endoplasmic reticulum (ER) protein that transp
20 sses depend on interactions of TLR9 with the polytopic endoplasmic reticulum-resident protein UNC93B1
22 terol-dependent binding to the following two polytopic ER membrane proteins: sterol regulatory elemen
23 ER hemoproteins, CYP2C11 and CYP3A4, and the polytopic ER protein HMGR attest to the remarkable mecha
25 ata suggest that p97 recruits proteasomes to polytopic ER proteins even before they are extracted fro
27 al type 1 glycoprotein, while the other is a polytopic form in which approximately 200 amino acids of
29 -Pick C1 (NPC1) protein is predicted to be a polytopic glycoprotein, and it contains a region with ex
31 ve monotopic P450 enzyme, in common with the polytopic HMGR, required the function of certain HRD (HM
33 The OxlT amino acid sequence specifies a polytopic hydrophobic protein of 418 residues with a mas
34 single open reading frame (ORF), encoding a polytopic hydrophobic protein, LjN70, with a predicted m
35 to address the sequence requirements of the polytopic hydrophobic transmembrane domain for LMP-1's s
38 bution of Agrobacterium tumefaciens VirB6, a polytopic inner membrane protein, to the formation of ou
39 required for the efficient insertion of many polytopic inner membrane proteins (IMPs) into the Escher
40 ly blocked the membrane insertion of several polytopic inner membrane proteins (IMPs) that were predi
41 The two open reading frames encode predicted polytopic inner membrane proteins with 61% amino acid id
43 bed for a series of purified variants of the polytopic integral membrane protein diacylglycerol kinas
46 rly-onset familial Alzheimer's disease, is a polytopic integral membrane protein that is endoproteoly
48 ty of NMR for functional characterization of polytopic integral membrane proteins and provide insight
49 ins associated with HycC and HycD, which are polytopic integral membrane proteins believed to anchor
50 rticular, the subunit stoichiometry of these polytopic integral membrane proteins has not been unequi
51 O-acyltransferase (MBOAT) family, a group of polytopic integral membrane proteins involved in lipid-b
53 librative nucleoside transporters (ENTs) are polytopic integral membrane proteins that transport nucl
56 on, we show that the proper insertion of the polytopic MalF protein (synthesized without a signal seq
60 -dependent bile acid transporter (Asbt) is a polytopic membrane glycoprotein, which is specifically e
61 hese results pinpoint RhCG and Rhcg as novel polytopic membrane glycoproteins that may function as ep
63 al integration of a eukaryotic multispanning polytopic membrane protein (PMP), its hydrophilic loops
64 g green fluorescent protein (GFP) fused to a polytopic membrane protein (SpoIVFB) that is involved in
65 e human MDR3 P-glycoprotein (Pgp) as a model polytopic membrane protein and expressed it in a coupled
67 esents the first reported semisynthesis of a polytopic membrane protein and highlights the potential
68 s covalent linkage between a G protein and a polytopic membrane protein appears, to our knowledge, to
71 vivo and in vitro demonstrate that Akr1p, a polytopic membrane protein containing a DHHC cysteine-ri
73 1 cleavage, apparently by interacting with a polytopic membrane protein designated SREBP cleavage-act
74 each latent transmembrane segment (TMS) in a polytopic membrane protein emerges from the ribosome, it
77 ed in prostate (NGEP) is a prostate-specific polytopic membrane protein found at high concentrations
78 he SLC26A family of anion transporters, is a polytopic membrane protein found in outer hair cells (OH
79 rod Na(+)/Ca(2+),K(+) exchanger (RodX) is a polytopic membrane protein found in photoreceptor outer
83 e, to determine whether YidC plays a role in polytopic membrane protein insertion and/or folding.
88 li, the major cytoplasmic domain (C6) of the polytopic membrane protein lactose permease (LacY) is ex
89 a molecular chaperone in the folding of the polytopic membrane protein lactose permease (LacY) of Es
90 However, the topology and function of the polytopic membrane protein lactose permease of Escherich
92 hinese hamster ovary cells and shown to be a polytopic membrane protein localized in the endoplasmic
93 understand cellular response to a misfolded polytopic membrane protein of the secretory pathway, we
102 the G-protein-coupled receptor family, is a polytopic membrane protein that does not encode a cleave
103 nsmembrane conductance regulator (CFTR) is a polytopic membrane protein that functions as a Cl(-) cha
105 TM4SF20 (transmembrane 4 L6 family 20) is a polytopic membrane protein that inhibits proteolytic pro
106 osphate includes the HK protein UhpB and the polytopic membrane protein UhpC, a UhpT homolog which is
108 ility studies support a model for VirB6 as a polytopic membrane protein with a periplasmic N terminus
109 er, these data support a model of FATP1 as a polytopic membrane protein with at least one transmembra
111 sa aurealis insertion in SAV2335, encoding a polytopic membrane protein with predicted protease domai
112 f the nir operon, which is predicted to be a polytopic membrane protein with six membrane-spanning he
113 r such studies because it is a very abundant polytopic membrane protein, and its localization and act
114 of Escherichia coli (LacY), a highly dynamic polytopic membrane protein, catalyzes stoichiometric gal
117 protein, which was previously found to be a polytopic membrane protein, is secreted by the Dot/Icm t
122 amino acids in the helix interfaces of four polytopic membrane proteins (cytochrome c oxidase, bacte
124 subunit complexes, often composed of several polytopic membrane proteins and cytosolic proteins.
125 should be useful for studying biogenesis of polytopic membrane proteins and GPCR signaling mechanism
130 Once inserted, transmembrane segments of polytopic membrane proteins are generally considered sta
133 ppears in both antiparallel helical pairs of polytopic membrane proteins as well as the parallel heli
134 s to the quality control of non-glycosylated polytopic membrane proteins by binding to misfolded or u
135 e energetics and structural specificities of polytopic membrane proteins by using a battery of in sil
137 of amino acids into transmembrane helices of polytopic membrane proteins disrupt helix-helix interact
138 omain (DHHC-CRD), is a diverse collection of polytopic membrane proteins extending through all eukary
139 nobutyric acid (GABA) transporter family are polytopic membrane proteins found endogenously in both e
140 s that predict the transmembrane topology of polytopic membrane proteins identify 10-12 putative memb
142 e high-resolution structure determination of polytopic membrane proteins in a detergent-free, near-na
143 residues mediate helix-helix interactions in polytopic membrane proteins in a fashion similar to that
144 feasibility of determining the structures of polytopic membrane proteins in their native phospholipid
145 hem, the TIM22 complex mediates insertion of polytopic membrane proteins into the inner membrane, and
151 tein (Pgp) suggested that the topogenesis of polytopic membrane proteins is likely more complicated t
154 mily of DHHC cysteine-rich domain (DHHC-CRD) polytopic membrane proteins shown recently in yeast to r
157 resenilin 1 (PS1) and presenilin 2 (PS2) are polytopic membrane proteins that are mutated in the majo
159 multiple hydrophobic segments, suggestive of polytopic membrane proteins that are targeted to the sec
165 D family members, represent rare examples of polytopic membrane proteins with an intrinsic additional
167 e" may be an important folding mechanism for polytopic membrane proteins, and it is regulated by the
168 mpt to investigate further the biogenesis of polytopic membrane proteins, I used the human MDR3 P-gly
171 aspartyl proteases are a homologous group of polytopic membrane proteins, some of which function in i
172 pholipids in the topological organization of polytopic membrane proteins, the function and assembly o
189 Lactose permease of Escherichia coli is a polytopic membrane transport protein containing 12 membr
190 of a defined apical localization signal in a polytopic membrane transport protein, and suggest that t
192 a membrane protein does not resemble that of polytopic membrane transporters for other substrates.
195 y effect on the cell surface distribution of polytopic membrane-associated proteins, suggesting that
196 identify GOAT (Ghrelin O-Acyltransferase), a polytopic membrane-bound enzyme that attaches octanoate
197 m lysosomes requires two lysosomal proteins, polytopic membrane-bound Niemann-Pick C1 (NPC1) and solu
198 T) for investigating the interactions of the polytopic membrane-bound oligosaccharyl transferases (OT
199 f the dopamine transporter, as well as other polytopic membrane-bound proteins, including G protein-c
200 ptable central lipid-filled chamber, wherein polytopic membrane-proteins could fold, sheltered from a
203 on of p97 in degrading immature forms of the polytopic, multi-domain protein CFTR (cystic fibrosis tr
204 association require the function of LMP-1's polytopic multispanning transmembrane domain, a domain t
209 nd S2P appear to be members of a new type of polytopic protease with an intramembranous active site.
210 ssay to examine the insertion pathway of the polytopic protein bacterioopsin, the apoprotein of Halob
217 uration factor 1 (LMF1) is predicted to be a polytopic protein localized to the endoplasmic reticulum
221 F2 (transmembrane 6 superfamily member 2), a polytopic protein of unknown function, is associated wit
222 uman RHAG locus encodes Rh50 glycoprotein, a polytopic protein that modulates expression of Rh antige
224 ransmembrane conductance regulator (CFTR), a polytopic protein with 12 predicted transmembrane segmen
227 e recently analyzed the GPIT subunit Gaa1, a polytopic protein with seven transmembrane (TM) spans, t
229 membrane protein, in actinobacteria, it is a polytopic protein with three transmembrane domains.
230 s, we established that Arabidopsis CCDA is a polytopic protein with within-membrane strictly conserve
231 b(0,+) amino acid transporter (b(0,+)AT), a polytopic protein, and the helper, related to b(0,+) ami
235 atterns of specific transporters and unknown polytopic proteins during microgametogenesis provides ne
236 tingly, TbPT family permeases are related to polytopic proteins from plants but not to characterized
238 , required for the insertion of at least two polytopic proteins into the inner membrane, but not for
239 tero-oligomeric complex (TIM10) that escorts polytopic proteins into the mitochondrial inner membrane
240 plex, required for the insertion of imported polytopic proteins into the mitochondrial inner membrane
241 m22p machinery that facilitates insertion of polytopic proteins into the mitochondrial inner membrane
242 Tim17p complex) and one for the insertion of polytopic proteins into the mitochondrial inner membrane
243 ted to sterol-sensing domains found in other polytopic proteins involved in sterol interactions or st
244 Transmembrane topology of most eukaryotic polytopic proteins is established cotranslationally at t
245 egation of nascent transmembrane segments of polytopic proteins is prevented by chaperones present in
247 suggest a model in which the degradation of polytopic proteins such as CFTR is coupled to retrograde
248 able to mutations in one of two presenilins, polytopic proteins that contain the catalytic site of th
249 variations in cotranslational folding enable polytopic proteins to acquire and/or maintain primary se
251 orters, when fused to periplasmic domains of polytopic proteins, produces fusions with high AP activi
255 agr (accessory gene regulator) operon uses a polytopic receptor, AgrC, activated by an autoinducing p
257 phenotype of the diseases and the predicted polytopic structure of the protein, it has been suggeste
258 translocon, we devised a self-ubiquitinating polytopic substrate (Hmg1-Hrd1p) that undergoes ERAD in
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