ライフサイエンスコーパス: polyvalent

1 Previous measurements demonstrate that the polyvalent acidic lipid phosphatidylinositol 4,5-bisphos

2 quely synergistic system with which to study polyvalent adhesion of bacteria to biologically relevant

3 tion of the surface BCR into polarized caps, polyvalent Ag-induced BCR caps persisted.

4 Although both paucivalent and polyvalent Ags induced the redistribution of the surface

5 lent anthranilic acid catalysts operating on polyvalent aldehyde substrates were used with PAMAM dend

6 g of multivalent ligands within a mixture of polyvalent amphiphiles provides, in principle, a simple

7 hesion has been difficult both because it is polyvalent and because bacterial adhesins often recogniz

8 larly, all 21 serum samples were positive in polyvalent and class-specific ELISAs with whole-cell B.

9 -cell biology and provided evidence of their polyvalent and important role in gut homeostasis.

10 Polyvalent and Monovalent-89.6) (P = 0.039).

11 rophysiology of Bot1 detects Na(+)-dependent polyvalent anion transport in a Nernstian manner with ch

12 The polyvalent anions sulfate and phosphate were found to be

13 g of either flavin mononucleotide (FMNH2) or polyvalent anions.

14 ach, we study the DNA-mediated adsorption of polyvalent anisotropic nanoparticles on surfaces and exp

15 sis of hydrazone ligation were observed when polyvalent anthranilic acid catalysts operating on polyv

16 etection of viral nucleoprotein binding to a polyvalent anti-influenza aptamer by monitoring the surf

17 The results indicate that polyvalent antibodies predominantly directed against V3

18 1D2-Ig alpha tp (abbreviated as D1D2-IgP), a polyvalent antibody construct that presents dodecameric

19 Polyvalent antibody responses to a recombinant fusion pr

20 creased, analogous to the precipitation of a polyvalent antigen by divalent antibodies.

21 ell line, or consistent patterns of M. canis polyvalent antigen distribution in canine meningoencepha

22 sm was deconstructed and a minimal composite polyvalent antigen was engineered, delivering a designed

23 ng antigen-specific IgE were aggregated with polyvalent antigen, they became rapidly phosphorylated a

24 is an important determinant of ADCC and that polyvalent antigen-specific Abs are required for a robus

25 as reliant on detergent-mediated exposure of polyvalent antigen.

26 -methionyl-leucyl-phenylalanine and IgE plus polyvalent antigen.

27 recombinant ALVAC vectors represent powerful polyvalent antigenic stimuli for activation and expansio

28 B lymphocytes preferentially capture polyvalent antigens, which are capable of eliciting a co

29 was selectively immunoprecipitated by rabbit polyvalent antiserum generated against the predicted uni

30 Our simulations show how polyvalent apical membrane Ag-1 vaccination alters the s

31 This bias, together with polyvalent attachment to cell surface antigen, would ens

32 However, the correlation between polyvalent avidities and solution affinities is poor.

33 ate ligands in solution correlate with their polyvalent avidities.

34 ctions can be stabilized by a combination of polyvalent binding and the enhanced macromolecular crowd

35 Polyvalent binding inhibitors have potential as antivira

36 Polyvalent binding is possible at all surface densities

37 We propose that the polyvalent binding mode characterized for UBXD1-N is a m

38 Here, we examined the role of polyvalent binding of GM(1) in CT action by producing ch

39 RING bodies form polyvalent binding surfaces and scaffold multiple partne

40 e interactions in a manner characteristic of polyvalent binding.

41 In trivalent (and more generally, polyvalent) binding, dissociation occurs in stages, and

42 Therefore, as a prototype of polyvalent bionanoparticles, TYMV can be used as scaffol

43 The paper demonstrates that polyvalent, biospecific, noncovalent interactions betwee

44 on as well as type of cation (monovalent and polyvalent) can significantly influence thermal stabilit

45 A therapeutic polyvalent cancer vaccine (Canvaxin vaccine; CancerVax C

46 Polyvalent cancer vaccines targeting the entire antigeni

47 The results suggest that monovalent or polyvalent carbohydrate or glycoprotein mimetics that in

48 nition signals in nature, as well as for how polyvalent carbohydrate-protein interactions should be s

49 model systems for cell surfaces to evaluate polyvalent carbohydrate-protein interactions.

50 roach to synthesize solid-phase libraries of polyvalent carbohydrates, one can rapidly address key is

51 ecificity in recognition processes involving polyvalent carbohydrates.

52 creased in the presence of increased aqueous polyvalent cation concentrations or decreased pH.

53 lts indicate that charge neutralization by a polyvalent cation is sufficient to promote formation of

54 We report that the polyvalent cation ruthenium red (RR) directly evokes rap

55 Extracellular calcium/polyvalent cation-sensing receptors (CaR) couple to G pr

56 To determine whether calcium polyvalent cation-sensing receptors (CaRs) are salinity

57 bilize the native fold of RNA, whereas other polyvalent cationic ligands can act to both stabilize or

58 Exposure of HL-60 cells to polyvalent cationic metals results in a dramatic and sus

59 ETH-129 transports polyvalent cations according to the selectivity sequence

60 re we compare the characteristics of several polyvalent cations and Mg(2+) to block monovalent MIC cu

61 , intracellular Mg-nucleotides, divalent and polyvalent cations and pH.

62 Screening negative charges with polyvalent cations antagonized the effect.

63 characteristics and block of MIC channels by polyvalent cations from the outside.

64 Other polyvalent cations had similar effects, including La(3+)

65 We find that polyvalent cations like Ca(2+) and the trivalent cobalt

66 We conclude that polyvalent cations not only alter the net mobility but a

67 vesicle loaded with chelator/indicators for polyvalent cations show that ionomycin transports divale

68 e the unopened phage capsid upon addition of polyvalent cations to the host solution, in agreement wi

69 ot aggregate at low pH or in the presence of polyvalent cations, and can be used to solubilize membra

70 Here we show that Ca2+, or certain other polyvalent cations, binds to an extracellular site on ra

71 example, the bundle formation of F-actin by polyvalent cations, including divalent metal ions such a

72 iments involving intracellular dialysis with polyvalent cations, inhibition of PIP2 synthesis kinases

73 ing evasins, and use it to identify 10 novel polyvalent CC-chemokine binding evasin-like peptides fro

74 Dog tick saliva contains polyvalent CC-chemokine binding peptides termed evasins

75 The alpha-tosyloxy ketones produced are polyvalent chiral synthons.

76 cpF should be considered as a component of a polyvalent cholera vaccine formulation.

77 hypothesize how the unique properties of the polyvalent chromatin fiber and associated effectors may

78 These results demonstrate the potential of polyvalent coacervate as a new controlled delivery platf

79 eved robust angiogenesis using an injectable polyvalent coacervate of a polycation, heparin, and fibr

80 Here we report the development of polyvalent complexes of CD1b proteins and carbohydrate b

81 in pathways that involve homo-oligomeric or polyvalent components.

82 ation of the amino group or the synthesis of polyvalent compounds by attachment to an activated polya

83 d to study the interactions of the mono- and polyvalent compounds with XL35.

84 eumococcus in the post-vaccine era, use of a polyvalent conjugated meningococcal vaccine, and influen

85 Combinatorial polyvalent contacts of histone-binding domains or reader

86 hievement of a critical density that permits polyvalent contacts.

87 ween two mechanisms (polyfluoride anions and polyvalent Cs cations) allows CsF2 and CsF4 compounds to

88 decoys, but the structural context of these polyvalent decoys remains unclear, and it has been argue

89 ngly, the animals in the Monovalent-DH12 and Polyvalent-DH12 vaccine groups were more resistant to th

90 nt); (ii) LAI, RF, 89.6, AD8, Bal, and DH12 (Polyvalent-DH12); (iii) 89.6 (Monovalent-89.6); and (iv)

91 The polyvalent display of carbohydrate groups found on cell

92 s of enthalpy and entropy in the affinity of polyvalent DNA nanostructure interactions, which exhibit

93 ross-subtype ADCC and ADCP activities when a polyvalent DNA prime-protein boost vaccine formulation w

94 ridization in the context of an aggregate of polyvalent DNA-Au NP conjugates occurs in three dimensio

95 ivity is attributed to the interplay between polyvalent electrostatic and non-covalent interactions t

96 We attribute these properties to polyvalent engagement between the dendrimer surface grou

97 vaccine phase I trial, the DP6-001 trial, a polyvalent Env DNA prime-protein boost formulation could

98 ein (MBP) fusion peptide, as an antigen in a polyvalent enzyme-linked immunosorbent assay (ELISA).

99 borreliosis, respectively, were analyzed in polyvalent enzyme-linked immunosorbent assays (ELISAs) w

100 tested with human sera in class-specific and polyvalent enzyme-linked immunosorbent assays (ELISAs).

101 ing concentrations of antivenin (Crotalidae) polyvalent (equine origin) and either Crotalus atrox (We

102 ved when the saccharides were presented in a polyvalent fashion.

103 y human volunteers confirms the value of the polyvalent formulation in this HIV vaccine design.

104 Polyvalent, generation 4 (G4) SA-conjugated polyamidoami

105 esting that vaccination schemes that include polyvalent, genetically divergent immunogens may generat

106 val of cell-surface gal-3 from CD45 with the polyvalent glycan inhibitor GCS-100 rendered DLBCL cells

107 The synthesis of polyvalent glycopeptides containing three different anti

108 Unlike lysine, the polyvalent guanidyl group of arginine is capable of both

109 The yeast C-8,7 sterol isomerase contains a polyvalent high-affinity drug binding site similar to ma

110 y, nucleation potential, and low complexity, polyvalent, highly charged nature-could contribute to or

111 t with substrates important for adhesion via polyvalent hydrophobic interactions.

112 munoglobulin G (IgG)-opsonized particles and polyvalent IgG immune complexes, respectively.

113 Polyvalent IgG replacement therapy might not fully compe

114 ein(s) from (i) LAI, RF, 89.6, AD8, and Bal (Polyvalent); (ii) LAI, RF, 89.6, AD8, Bal, and DH12 (Pol

115 ations of different TLR ligands to stimulate polyvalent immune responses.

116 el skin electroporation microarray can drive polyvalent immunity in macaques, and offers protection f

117 ectively for 2 years while receiving similar polyvalent immunoglobulin replacement therapies.

118 ensation mechanisms, and oxidation states of polyvalent impurities in complex multiphase mineral syst

119 thesis that increasing virus input titres in polyvalent inactivated HRV vaccine may result in broad n

120 inst many rhinovirus types can be induced by polyvalent, inactivated HRVs plus alhydrogel (alum) adju

121 can be inhibited by a synthetic, polymeric, polyvalent inhibitor in vivo.

122 , we designed monodisperse polypeptide-based polyvalent inhibitors of anthrax toxin in which multiple

123 attern matching also enhanced the potency of polyvalent inhibitors of cholera toxin.

124 f the heterodivalent compounds suggests that polyvalent inhibitors that can target multiple regions o

125 g the valency and linker length, we designed polyvalent inhibitors that were over four orders of magn

126 In the case of the polyvalent interaction between the hexakisBMP25C8 cluste

127 This polyvalent interaction is significantly stronger than th

128 In both instances K(POLY) for the polyvalent interaction was found to be approximately 2 o

129 binding and that BAZ2B PHD-BRD establishes a polyvalent interaction with H3K14ac.

130 By determining K(AVE) for the polyvalent interaction, it was possible to calculate an

131 interactions are strengthened by pronounced polyvalent interactions catalyzed by the surface itself.

132 ty of nanorods originate from the balance of polyvalent interactions that favor adhesion and entropic

133 5 free cysteine residues could contribute to polyvalent interactions with the Ag clusters and serve a

134 chieved by means of nonspecific low-affinity polyvalent interactions.

135 , along with my decade-long involvement with polyvalent iodine chemistry, especially alkynyliodonium

136 ordinate, I(III), and pentacoordinate, I(V), polyvalent iodine compounds have been known for over a c

137 In the last twenty years, new polyvalent iodine reagents have been introduced along wi

138 Stimulation of mast cells with immobilized polyvalent ligand resulted in typical levels of degranul

139 f the basement membrane and is known to be a polyvalent ligand, possessing sequences bound by the alp

140 fically, high molecular weight, polydisperse polyvalent ligands are effective inhibitors of Con A bin

141 egrin CR3 that requires divalent cations and polyvalent ligands for activation of the receptor.

142 The widespread occurrence of flexible polyvalent ligands in biological systems suggests that t

143 the interaction of polyvalent receptors with polyvalent ligands-in unnatural systems is outlined.

144 tenin and actin, and together they provide a polyvalent linkage directing the topographic assembly of

145 ), MARCKS-(151-175), laterally sequester the polyvalent lipid PI(4,5)P2 in the plane of a bilayer mem

146 Pattern-matched polyvalent liposomes inhibited anthrax toxin in vitro at

147 ract with carbohydrate-binding proteins in a polyvalent manner.

148 change approach for preparing compact, dense polyvalent mannose-capped quantum dots (QDs) has been de

149 dy (sdAb) that is both captor and tracer for polyvalent Marburgvirus nucleoprotein.

150 An allogeneic polyvalent melanoma cell vaccine (PMCV) has been shown t

151 Wayne Cancer Institute, Santa Monica, CA), a polyvalent melanoma cell vaccine (PMCV), might be correl

152 observed in melanoma patients treated with a polyvalent melanoma cell vaccine containing TRP-2.

153 pigmentation and had improved survival after polyvalent melanoma cell vaccine had significantly augme

154 receiving postoperative immunotherapy with a polyvalent melanoma cell vaccine increased sensitivity a

155 Polyvalent melanoma cell vaccine treatment enhanced anti

156 in melanoma patients (n = 23) pre- and post-polyvalent melanoma cell vaccine treatment.

157 The potential for ligand bridging by polyvalent metal ions is proposed to be an important fac

158 Thus, a polyvalent, minigene-based vaccine can simultaneously in

159 e as models to study the binding behavior of polyvalent molecules and gain insight into how small cha

160 f liposomal surfaces as well as detection of polyvalent molecules and removal of targeted substances

161 tegy for the rational design of monodisperse polyvalent molecules may not only be broadly applicable

162 The design of polyvalent molecules, presenting multiple copies of a sp

163 ivity relationships and for designing potent polyvalent molecules.

164 Polyvalent mosaic antigens therefore represent a promisi

165 Polyvalent mosaic HIV immunogens offer a potential solut

166 Polyvalent mosaic immunogens derived by in silico recomb

167 ne constructs expressing either consensus or polyvalent mosaic proteins.

168 Polyvalent 'mosaic' antigens, in contrast, are designed

169 intermolecular cross-links among the arrayed polyvalent mucin mimetics.

170 The polyvalent nature of nucleocapsid borne NP and display o

171 ism of alpha-toxins prevents production of a polyvalent neutralizing antiserum, whereas the determina

172 These findings indicate that polyvalent neutralizing MAb formulations targeting epito

173 is Communication, we describe a new class of polyvalent nucleic acid nanostructures (PNANs), which ar

174 ntibody clone was both captor and tracer for polyvalent nucleoprotein (NP).

175 Polyvalent O and O1 antiserum sensitivity and specificit

176 specificity were >90%, with the exception of polyvalent O1 antiserum, for which sensitivity was 88.9%

177 of the pattern-recognition ability of these polyvalent oligomers.

178 Amine-functionalized polyvalent oligonucleotide gold nanoparticles (DNA-Au NP

179 for human telomerase activity that relies on polyvalent oligonucleotide nanoparticle conjugates as di

180 Polyvalent oligonucleotide-nanoparticle conjugates posse

181 Enhanced inhibitory potencies of polyvalent over monovalent forms of oligosaccharide inhi

182 inding selections using FcepsilonRIalpha and polyvalent peptide-phage libraries yielded a dominant 18

183 oponin I (TnI), previously identified from a polyvalent phage displayed library, has been immobilized

184 agnitude higher than that calculated for the polyvalent phage particles (K(D) = 2.5 +/- 0.1 nM).

185 Here we compare the efficacy of polyvalent phage PEf1 versus coliphage T4 in suppressing

186 Overall, this study shows that polyvalent phages can propagate in soil bacteria and sig

187 mportant PM lipids including cholesterol and polyvalent phosphoinositides, further demonstrating PS s

188 tibody concentrations were immunised with 23 polyvalent pneumococcal and tetanus-haemophilus conjugat

189 acterial polysaccharides used to formulate a polyvalent pneumococcal polysaccharide vaccine.

190 ide powders to be used in preparation of the polyvalent pneumococcal vaccine PNEUMOVAX 23.

191 disease, and both types are included in the polyvalent pneumococcal vaccine.

192 l P-selectin inhibitors were created using a polyvalent polymer nanoparticle capable of displaying mu

193 ver, because the derivatized beads mimic the polyvalent presentation of cell surface carbohydrates, t

194 signal transduction methods for detection of polyvalent proteins have been developed by directly coup

195 barcodes, one can screen for multiple target polyvalent proteins simultaneously in one solution.

196 erpesvirus 1 (BHV-1) gI and gE proteins with polyvalent rabbit serum specific for gI or gE.

197 the study of polyvalency-the interaction of polyvalent receptors with polyvalent ligands-in unnatura

198 Moreover, these polyvalent responses proved to be tumor-suppressive and

199 ev molecules, it would be useful to generate polyvalent Rev decoys that could bind multiple Rev molec

200 . A. Sharp originally constructed functional polyvalent Rev decoys, but the structural context of the

201 Furthermore, treatment of cells with polyvalent RGD peptides or pre-polymerized fibronectin d

202 report the synthesis and characterization of polyvalent RNA-gold nanoparticle conjugates (RNA-Au NPs)

203 ble than mG RSV to monovalent G-specific and polyvalent RSV-specific antibodies, whereas susceptibili

204 We have reported that polyvalent SA attachment induces lysis of biotinylated R

205 in polyvalent salt solutions at small enough polyvalent salt concentrations.

206 ced expanded --> condensed DNA transition in polyvalent salt solutions at small enough polyvalent sal

207 A solutions for monovalent salts to that for polyvalent salts and sheds some light on the complicated

208 n effort to mimic the high-affinity binding, polyvalent scaffolds that contain multicomponent display

209 mbly creates bodies that act structurally as polyvalent scaffolds, thermodynamically by amplifying ac

210 The relative capacity of murine polyvalent sera produced following infection, recovery,

211 igen argue for the inclusion of rCFP-10 in a polyvalent serodiagnostic test for detection of active T

212 n be evaluated for glycan interactions using polyvalent soluble glycan probes and for protein interac

213 concatenated conserved protein regions, and polyvalent strategies that improve coverage of epitope d

214 The avidities of polyvalent sugar-coated virus particles for immobilized

215 sure) liquid chromatography was applied to a polyvalent system composed of both reactive and nonreact

216 y, we show that trifunctional bsAbs induce a polyvalent T-cell response and, therefore, a vaccination

217 able, but reversible specific recognition of polyvalent targets.

218 ker region also bind with higher affinity to polyvalent than monovalent phosphoinositides on nitrocel

219 cal pattern matching enhances the potency of polyvalent therapeutics.

220 tumor cell destruction in situ may provide a polyvalent tumor vaccine without a requirement for knowl

221 ll affinity maturation during monovalent and polyvalent vaccinations that predicts the fine specifici

222 eive Canvaxin (CancerVax Corp, Carlsbad, CA) polyvalent vaccine (PV) immunotherapy for metastatic mel

223 ant.Our results indicate that an inactivated polyvalent vaccine against RABV filoviruses is achievabl

224 We have designed new polyvalent vaccine antigens comprised of sets of 'mosaic

225 his approach to predict the Ab response to a polyvalent vaccine based on the highly polymorphic malar

226 d HLA-A*02+ melanoma patients immunized to a polyvalent vaccine containing multiple Ags, including MA

227 ty, and outline the rationale behind several polyvalent vaccine design strategies that are currently

228 on, diagnostics, surveillance and ultimately polyvalent vaccine development.

229 , globo H will constitute one component of a polyvalent vaccine for evaluation in high-risk breast ca

230 bsence of any detectable NAb, animals in the Polyvalent vaccine group, but not those immunized with M

231 Animals in the two polyvalent vaccine groups developed NAbs against more HI

232 NTHI-mediated otitis media, development of a polyvalent vaccine reflecting the variability of P1 woul

233 for continued clinical investigation of this polyvalent vaccine strategy in the treatment of metastat

234 The development of a polyvalent vaccine targeted against the most pathogenic

235 virus type 1 (HIV-1), it is probable that a polyvalent vaccine will also be needed for protection fr

236 o a broad array of HIV-1 primary isolates, a polyvalent vaccine will be needed containing representat

237 rain-specific epitopes and demonstrate how a polyvalent vaccine with a small number of strains and on

238 However, to understand how to construct a polyvalent vaccine, serotypes or immunotypes of HIV must

239 immunogen and similar T-cell responses to a polyvalent vaccine.

240 cell-mediated immune response induced by the polyvalent vaccine.

241 that exhibit significant genetic variation, polyvalent vaccines are needed.

242 Polyvalent vaccines may therefore be required to provide

243 Polyvalent vaccines use a mixture of Ags representing di

244 than genotypic classification for designing polyvalent vaccines, studies were undertaken to determin

245 oss-reactivity may be a universal feature of polyvalent vaccines.

246 iants that should be included or excluded in polyvalent vaccines.

247 nesis that results from treatment with these polyvalent VEGF-mimetic nanofibers.

248 he safety, activity, and immunogenicity of a polyvalent Wilms tumor gene 1 (WT1) peptide vaccine in p

249 These preliminary data suggest that this polyvalent WT1 peptide vaccine can be administered safel