ライフサイエンスコーパス: poorly characterized

1 ntal aspects of AAV's capsid assembly remain poorly characterized.

2 PCs, and their functions in the plant remain poorly characterized.

3 incRNAs, their synthesis and turnover remain poorly characterized.

4 its restricted basal ganglia distribution is poorly characterized.

5 verning peroxisome emergence from the ER are poorly characterized.

6 RhoB, RhoC of which RhoB and RhoC have been poorly characterized.

7 on coding, but inhibition among glomeruli is poorly characterized.

8 cells, and the INM-specific proteome remains poorly characterized.

9 ry enhancer elements in solid tumours remain poorly characterized.

10 lular processes underpinning this switch are poorly characterized.

11 hat the drivers of MERS-CoV epidemics remain poorly characterized.

12 of PLK1 beyond cell cycle regulation remain poorly characterized.

13 Nevertheless, cooking emissions remain poorly characterized.

14 tal cortical long-range connectivity remains poorly characterized.

15 c compartmentalization develop in tumors are poorly characterized.

16 sible quality control (QC) mechanisms remain poorly characterized.

17 ular coordinators of their activities remain poorly characterized.

18 r source of nutrients for C. elegans, remain poorly characterized.

19 rn this metastatic colonization event remain poorly characterized.

20 and chromatin modification/remodeling remain poorly characterized.

21 been proposed, but its contribution remains poorly characterized.

22 However, muscle-based NST in mammals remains poorly characterized.

23 t the underlying oncogenic mechanism remains poorly characterized.

24 the maternal and fetal immune system remain poorly characterized.

25 connections mediating these functions remain poorly characterized.

26 mechanism is not well-understood and remains poorly characterized.

27 ts role in CNS biology in other organisms is poorly characterized.

28 sorder (ASD), but their dysfunction is often poorly characterized.

29 ratory distress syndrome in this setting are poorly characterized.

30 ll surface expression of GABAB receptors are poorly characterized.

31 immunity; however, the channels involved are poorly characterized.

32 ommunities in urban green space soils remain poorly characterized.

33 by which blood cells sense shear stress are poorly characterized.

34 c determinants of circulating AMH levels are poorly characterized.

35 <3 mum particulate bound mercury (PBM), are poorly characterized.

36 rophils, its function in these cells remains poorly characterized.

37 How cells sense cellular P(i) levels is poorly characterized.

38 aches to adult patients with ETP-ALL/LBL are poorly characterized.

39 d the underlying regulatory networks, remain poorly characterized.

40 f antigen presenting machinery genes, remain poorly characterized.

41 However, the exact mechanisms are poorly characterized.

42 al tissues from lean and obese mice, remains poorly characterized.

43 The reaction cycle of P5-ATPases is poorly characterized.

44 he reaction pathway and precursors have been poorly characterized.

45 ng this interplay on the molecular level are poorly characterized.

46 hanisms that repair damaged epithelia remain poorly characterized.

47 its on-target and off-target activity remain poorly characterized.

48 ections by nontyphoidal Salmonella (NTS) are poorly characterized.

49 papillomavirus 16 (HPV16) infection remains poorly characterized.

50 gnancy and infant birth weight (BW) is still poorly characterized.

51 atients from perioperative complications are poorly characterized.

52 in widespread neurodegeneration that remains poorly characterized.

53 ion, but the outcomes of those who do remain poorly characterized.

54 red with conventional photon irradiation are poorly characterized.

55 erlying GLI1-increased activity in DLBCL are poorly characterized.

56 seizures and their functional impact remain poorly characterized.

57 r according to setting of drug initiation is poorly characterized.

58 programs contributing to this process remain poorly characterized.

59 yotes (heterotrophic protists and fungi) are poorly characterized.

60 mediate their transport to mitochondria are poorly characterized.

61 however, mTORC2 function in renal tubules is poorly characterized.

62 However, most of these targets are still poorly characterized.

63 wever, its effects on beta cell function are poorly characterized.

64 (HCV) particles from infected cells remains poorly characterized.

65 iseases, while broadly acknowledged, remains poorly characterized.

66 er of discrete groups whose function remains poorly characterized.

67 ith the initiation of impaired cognition are poorly characterized.

68 to ensure long-term skill retention remains poorly characterized.

69 nction and maintenance of blood pressure are poorly characterized.

70 Yet CO2/HCO3 (-) sensing mechanisms remain poorly characterized.

71 tions of RNA viruses with host miRNAs remain poorly characterized.

72 well known in animal cells, while CORVET is poorly characterized.

73 ion and pharmacokinetic properties have been poorly characterized.

74 c factors that regulate ILC responses remain poorly characterized.

75 the molecular basis for this defect remains poorly characterized.

76 relative to accelerating climate changes are poorly characterized.

77 ic roles of NRP1 in tumor progression remain poorly characterized.

78 cell (NS cell) self-renewal has so far been poorly characterized.

79 ruses are challenging to study and therefore poorly characterized.

80 inning production of IL-10 by these cells is poorly characterized.

81 e specific contribution of VSMC Akt1 remains poorly characterized.

82 gulating striatal pathway development remain poorly characterized.

83 twork, but its upstream regulators are still poorly characterized.

84 the ultimate fate of those waste streams is poorly characterized.

85 follicle (HF) cycle and skin homeostasis is poorly characterized.

86 ements for IL-36R signal transduction remain poorly characterized.

87 ins, and their structure and function remain poorly characterized.

88 Rab GTPase in the endocytic pathway remains poorly characterized.

89 he multiple oral pathogens involved is still poorly characterized.

90 and additional inflammatory pathways remains poorly characterized.

91 oxidans and Stenotrophomonas maltophilia, is poorly characterized.

92 s on long-term patterns of AAA expansion are poorly characterized.

93 lecular basis for this heterogeneity remains poorly characterized.

94 responsible for liver stage development are poorly characterized.

95 al bacteria that promote plant growth remain poorly characterized.

96 volved in nitrogen signaling pathways remain poorly characterized.

97 whereas its function in MSCs in vivo remains poorly characterized.

98 nism behind this atypical regulation remains poorly characterized.

99 ic and autophagy pathways with lysosomes are poorly characterized.

100 s, the infected RBC surface proteome remains poorly characterized.

101 r subsequent neural crest development remain poorly characterized.

102 t response to intracellular bacteria remains poorly characterized.

103 The optimal albumin dose remains poorly characterized.

104 hat lead to ILC-lineage specification remain poorly characterized.

105 basis of their neutralizing activity remains poorly characterized.

106 osis on adhesion-dependent signaling remains poorly characterized.

107 man T-cell leukemia virus type 1 (HTLV-1) is poorly characterized.

108 but the contribution of inherited factors is poorly characterized.

109 rmation play key roles in biology and remain poorly characterized.

110 metal across the host vacuolar membrane are poorly characterized.

111 endogenous target genes is regulated remains poorly characterized.

112 on in the disturbed intestinal ecosystem are poorly characterized.

113 ponents of marine ecosystems, they are still poorly characterized.

114 jor effects are modulated by interactions is poorly characterized.

115 lization by gut microbiota members are still poorly characterized.

116 role in tumor microenvironment regulation is poorly characterized.

117 yonic and early seedling development remains poorly characterized.

118 Ras senescence pathways remain poorly characterized.

119 tocyte restoration or HCC development remain poorly characterized.

120 tis C virus replicates its RNA genome remain poorly characterized.

121 tion (hereafter, "latent infection") remains poorly characterized.

122 tivity, but the underlying mechanisms remain poorly characterized.

123 non-structural protein (NSs), which remains poorly characterized.

124 on blood-brain barrier (BBB) function remain poorly characterized.

125 rt with initial cell fate commitment remains poorly characterized.

126 with treatment failure and relapse, yet are poorly characterized.

127 feeding insects, particularly aphids, remain poorly characterized.

128 wever, their role in skeletal muscle remains poorly characterized.

129 tus and ensuing CD4+ T-cell polarization are poorly characterized.

130 aberrantly activate oncogenes have remained poorly characterized.

131 al human antiviral responses, yet it remains poorly characterized.

132 r functional connections and substrates, are poorly characterized.

133 gaged during locomotion or immobility remain poorly characterized.

134 ined in animals, but low zinc homeostasis is poorly characterized.

135 kinetics of the two-state reaction, remains poorly characterized.

136 (RBPs) that govern cancer stem cells remains poorly characterized.

137 rst reported 70 years ago, but which remains poorly characterized.

138 et their indoor occurrence and abundance are poorly characterized.

139 air quality, but its global distribution is poorly characterized.

140 atic colonization, but its mechanisms remain poorly characterized.

141 lic health, but actual emission rates remain poorly characterized.

142 n waters, their sources and transport remain poorly characterized.

143 associated myocardial infarction and remains poorly characterized.

144 n GPCRs and the underlying mechanism remains poorly characterized.

145 d cancer, but its molecular function remains poorly characterized.

146 microbial-animal digestive associations, yet poorly characterized.

147 ers (PFDs) are genetically heterogeneous and poorly characterized.

148 lative performance in real-word scenarios is poorly characterized.

149 ics and their ability to harbour life remain poorly characterized.

150 ion, effects over successive generations are poorly characterized.

151 ion of Galphas in this sorting step is still poorly characterized.

152 els, their differential pathogenesis remains poorly characterized.

153 are mostly unknown, and their functions are poorly characterized.

154 genes on growth and muscle quality traits is poorly characterized.

155 al effects of most axon guidance cues remain poorly characterized, a prevailing model posits that att

156 by a clinically recognized, but biologically poorly characterized, accelerated phase (AP).

157 ific over the past 2,000 y, but these remain poorly characterized across most of the ocean where long

158 ulates phosphorylation of both sites via the poorly characterized AGC-family kinase Ypk3 and the PP1

159 Severe asthma remains poorly characterized, although it likely consists of at

160 s affecting ACV formation and release remain poorly characterized; although in some cell types, the g

161 r basis for this length control has remained poorly characterized and controversial.

162 Ebola virus (EBOV) transmission is currently poorly characterized and is thought to occur primarily b

163 apidly during development and have thus been poorly characterized and modeled to date.

164 me-linked long non-coding RNAs (lncRNAs) are poorly characterized and the potential link between thes

165 ver, the commensal bacteria bound by IgA are poorly characterized and the type of humoral immunity th

166 de range of nanofluidic systems, yet remains poorly characterized and understood due to the enormous

167 Vertebrate ocular microbiomes are poorly characterized and virtually unexplored in wildlif

168 evalence and importance of enhancers remains poorly characterized, and demonstrates the power of usin

169 he pathogenesis of cryptosporidiosis remains poorly characterized, and interventions for the disease

170 ssues other than dedicated storage organs is poorly characterized, and its function is not well under

171 However, soluble Tim-3 (sTim-3) is poorly characterized, and its role in HIV disease is unk

172 titial cells with EPO-producing capacity are poorly characterized, and the role of the PHD/HIF-2 axis

173 Genetic determinants of cognition are poorly characterized, and their relationship to genes th

174 IFN in restricting human enteric viruses are poorly characterized as a result of the difficulties in

175 However, RTK heterodimers remain poorly characterized, as compared with homodimers, becau

176 is shared between cells and tissues remains poorly characterized, as does the degree to which incomp

177 zation of organelles within the cell remains poorly characterized, as fluorescence imaging approaches

178 response to growth factor stimulation remain poorly characterized; as a result, the biological mechan

179 stions and enhance our understanding of this poorly characterized aspect of wall dynamics and metabol

180 s still an enigmatic multifunctional protein poorly characterized at the molecular level.

181 al specificity phosphatase 12 (DUSP12), is a poorly characterized atypical dual specificity phosphata

182 Several atypical chain types have remained poorly characterized because the enzymes mediating their

183 Di-nitrogen (N2) emissions are still poorly characterized, both in terms of the processes inv

184 Deep groundwater aquifers are poorly characterized but could yield important sources o

185 The protein encoded by TMEM106B is poorly characterized but is reported to have a role in r

186 Early industrial trace metal loadings are poorly characterized but potentially substantial sources

187 checkpoint blockade in mesenchymal tumors is poorly characterized, but immunogenomic dissection of th

188 The targeting mechanism of ExoU is poorly characterized, but it was recently found to bind

189 with a majority belonging to the category of poorly characterized by Cluster of Orthologous Groups cl

190 However, such movements are poorly characterized by existing biomechanical metrics.

191 ase states and to determine the functions of poorly characterized cell populations.

192 r maturation and release is an important but poorly characterized cell separation event.

193 several discrete steps in the assembly of a poorly characterized class of virulence factors.

194 f organic material with a highly complex but poorly characterized composition.

195 However, the as-yet poorly characterized contribution of host responses duri

196 rdered, noncrystalline U(IV) species remains poorly characterized despite their prevalence in biostim

197 tic spine morphogenesis among members of the poorly characterized DOCK family of RhoGEFs, we performe

198 omaly (MCA) and the Little Ice Age (LIA) are poorly characterized due to a lack of evidence from the

199 is an emerging, nosocomial pathogen that is poorly characterized due to a paucity of genetic tools a

200 rmenting herbivores, but their physiology is poorly characterized due to few representative axenic cu

201 chemical compositions of these emissions are poorly characterized due to their highly complex molecul

202 Signal peptide peptidase-like 3 (SPPL3) is a poorly characterized endoplasmic reticulum (ER)-localize

203 rd elucidating the specific function of this poorly characterized enzyme.

204 of histone H3 at lysine 23, an abundant but poorly characterized epigenetic mark.

205 ia coli and, to a lesser extent, on the more poorly characterized eukaryotic chaperonin CCT/TRiC.

206 Here we report that FBXW2, a poorly characterized F-box, is a substrate of beta-TrCP1

207 of becoming a dominant taxon in response to poorly characterized factors.

208 ing new insights into the life cycle of this poorly characterized family of viruses.

209 ts, a large portion of mouse genome is still poorly characterized for cellular functions and associat

210 ection coefficients - quantities that remain poorly characterized for current genomic data sets.

211 ion, tissue-specific innate immunity remains poorly characterized for hepatitis C virus (HCV) infecti

212 Less frequent mutations in Ras are poorly characterized for their oncogenic potential.

213 n sequentially arranged genes (US12-21) with poorly characterized function.

214 ions, while genes in large gene families and poorly characterized genes show a greater incidence of m

215 C3405G,A3696G (termed SA13/JFH1orig), of the poorly characterized genotype 5a, to Huh7.5 cells, yield

216 Cancer testis antigens (CTAs) represented a poorly characterized group of proteins whose expression

217 The Go-opsins form an ancient and poorly characterized group retained only in marine inver

218 lopment, but this large enzymatic complex is poorly characterized, hampering drug development efforts

219 ay be toxic, and many others have unknown or poorly characterized health effects.

220 the core helicase domain with the conserved, poorly characterized HRDC domain.

221 escribe the initial functional analysis of a poorly characterized human lncRNA (LINC00657) that is in

222 istal structures, their cell biology remains poorly characterized, impeding our understanding of how

223 he underlying molecular mechanisms are still poorly characterized, impending the development of thera

224 tastasis, and cell-cycle progression, but is poorly characterized in hematologic malignancies.

225 ed mechanoreceptors described in animals are poorly characterized in humans.

226 ver, organ- or tissue-specific promoters are poorly characterized in many cases.

227 of multidrug-resistant (MDR) tuberculosis is poorly characterized in molecular epidemiologic studies.

228 nual N and P loads from urban watersheds are poorly characterized in northern cities because monitori

229 of transgene susceptibility to silencing is poorly characterized in plants; thus, we evaluated sever

230 -CEA-DA neuron path to the striatum has been poorly characterized in primates.

231 spite this curious presentation, MCV is very poorly characterized in terms of host-pathogen interacti

232 role of NO as a signaling molecule has been poorly characterized in the context M. tuberculosis infe

233 for effective immunity and tolerance, remain poorly characterized in the developing fetus.

234 he flow of carbon through food webs, yet are poorly characterized in the marine environment.

235 the tumor microenvironment over time remains poorly characterized in these models.

236 ory responses among defined OB cell types is poorly characterized in vivo Here, we used cell-type-spe

237 of DNA-bound transcription factors has been poorly characterized in vivo.

238 There is limited, poorly characterized information about adverse events oc

239 Recent studies have documented a direct yet poorly characterized interaction between p53 and RNA pol

240 thy individuals had low fungal loads, mostly poorly characterized Malasezziales.

241 unctional in patients with cirrhosis through poorly characterized mechanisms.

242 (GBPs), which themselves dock to PVs through poorly characterized mechanisms.

243 centriole-derived basal body (BB) via as yet poorly characterized mechanisms.

244 Nek5 is a poorly characterized member of the NIMA-related kinase f

245 NLRC3 (also known as CLR16.2 or NOD3) is a poorly characterized member of the NLR family and was id

246 te adipocyte differentiation by engaging the poorly characterized membrane protein PGRMC2.

247 ed by this motif and encode a diverse set of poorly characterized membrane proteins have roles in met

248 YIPF4 is also a poorly characterized membrane spanning protein.

249 ur data revealed a significant increase in a poorly-characterized MK protein, myristoylated alanine-r

250 latin targets, cellular RNAs remain the most poorly characterized molecules.

251 type lectin-like domain (CTLD) followed by a poorly characterized neck region coupled to a transmembr

252 he majority of pri-miRNAs are transcribed as poorly characterized noncoding RNAs that are 10's to 100

253 n thousands of parameters, many of which are poorly characterized or unknown.

254 he etiology of acute watery diarrhea remains poorly characterized, particularly after rotavirus vacci

255 The role of DILI in these fatalities is poorly characterized, particularly when fatalities occur

256 Aichi virus (AiV), an unusual and poorly characterized picornavirus, classified in the gen

257 ever, cyanobacterial Sfp-type PPTases remain poorly characterized, posing a significant barrier to th

258 ar and biological roles associated with this poorly characterized posttranslational modification and

259 ist as a result of differential splicing and poorly characterized posttranslational processing.

260 cause of cancer patient deaths and remains a poorly characterized process.

261 resulting in mixed regulatory circuits with poorly characterized properties.

262 ectin domain family 3 member A (CLEC3A) is a poorly characterized protein belonging to the superfamil

263 an N-terminally bound glyoxylyl group-in the poorly characterized protein secernin-3.

264 monstrate that GCN5, RARalpha/gamma, and the poorly characterized protein TACC1 form a complex in the

265 ated protein on chromosome 22 (GAR22beta), a poorly characterized protein that interacts with actin a

266 We focused our attention on FAU, a poorly characterized protein with unknown function.

267 To explore the function of this poorly characterized protein, we performed HMGB2 ChIPseq

268 rovides functional insights into hundreds of poorly characterized proteins while enhancing network-ba

269 man silencing hub) complex, comprising three poorly characterized proteins, TASOR, MPP8, and periphil

270 To begin defining the functions of such poorly characterized proteins, we used mass spectrometry

271 pulmonary dysplasia (BPD) is a prevalent yet poorly characterized pulmonary complication of premature

272 ge conventional wisdom and define a hitherto poorly characterized reaction class forming complex orga

273 after an acute myocardial infarction (MI) is poorly characterized regarding its determinants or its e

274 This dramatic reorganization involves a poorly characterized reorientation of the apicobasal pol

275 e gH/gL complex plays an essential but still poorly characterized role in membrane fusion and cell tr

276 Ltn1p-mediated ubiquitination depends on the poorly characterized RQC component Rqc1p, and that the p

277 This gene encodes MAPKBP1, a poorly characterized scaffolding protein for JNK signali

278 from patients with acute MI and discovered a poorly characterized secreted protein, EMC10 (endoplasmi

279 dy, an exquisitely selective inhibitor for a poorly characterized serine hydrolase (PNPLA4, patatin-l

280 cal analyses for annotating the functions of poorly characterized signaling proteins.

281 Here, we have studied the poorly characterized SNX20 and its paralogue SNX21, whic

282 rogenitors of crops, orphan crops, and other poorly characterized species such as those of ecological

283 The deep dorsal horn is a poorly characterized spinal cord region implicated in pr

284 Intriguingly, mammalian genomes encode many poorly characterized SR-like proteins, including subunit

285 The nodule functioning is still a poorly characterized step of the symbiotic interaction,

286 o nt-pairings at the junction of R and U5, a poorly characterized structure upstream of the character

287 ovides the first structural analysis of this poorly characterized subfamily of SNX proteins, highligh

288 NDUFB11 encodes one of 30 poorly characterized supernumerary subunits of NADH:ubiq

289 detes and Proteobacteria, as well as several poorly characterized taxa.

290 5 of them in the mouth, several abundant but poorly characterized Tenericutes species in gastric flui

291 Although catharanthine biosynthesis remains poorly characterized, the biosynthesis of vindoline from

292 wn to bind FA, but this interaction has been poorly characterized to date.

293 pulmonary epithelial differentiation, these poorly characterized transcriptional networks may underl

294 rom healthy human lung, these subsets remain poorly characterized transcriptionally and phenotypicall

295 Together, they delimit a poorly characterized transitory phase between the attack

296 arge fraction of the human MT family remains poorly characterized, underscoring the need for new tech

297 eral, the distribution of iodine intakes was poorly characterized when food iodine concentrations wer

298 The natural history of TTR-CM is poorly characterized, which presents difficulties for th

299 s an emerging global affliction that remains poorly characterized with few treatment options.

300 Among 502 poorly characterized Z. mobilis genes, we identified a s