ライフサイエンスコーパス: pore

1 sor movement and current through the channel pore.

2 e once the capsid interacts with the nuclear pore.

3 he trypanosomal analogue of the Tom40 import pore.

4 an concur simultaneously in the hERG channel pore.

5 Pase rings (D1 and D2) surrounding a central pore.

6 in the setting of a narrow, cation-selective pore.

7 t, unlike the DNA, does not pass through the pore.

8 n that is then also translocated through the pore.

9 t with an impact on conformation of the KCNQ pore.

10 ate unfolding by threading through a central pore.

11 n, the influenza proton channel, and the MCU pore.

12 l saturation (ROS) and the fraction of micro-pores.

13 membranes without oligomerizing into visible pores.

14 s exclusively on the internal surface of the pores.

15 n clays include interlayer and interparticle pores.

16 TMEM16A forms a dimer with two pores.

17 hen concentrated as they are in pit membrane pores.

18 ese channels are composed of the ion-forming pore alpha1 and auxiliary subunits (beta and alpha2delta

19 cesses by conducting a time-resolved pore-by-pore analysis of the local curvature and capillary press

20 dopts a non-domain-swapped attachment to the pore and contacts the cytoplasmic Ca(2+)-binding domain

21 These structures reveal the ion permeation pore and represent different functional states.

22 process crudely controls the aperture of the pore and thus the flux of molecules between cells.

23 Their pores and cavities act as hosts of diverse guests rangin

24 hiral sequences, assemble into antimicrobial pores and form contiguous helices that are biologically

25 he SILM, one in the IL phase in the membrane pores and the other in the supporting membrane polymer.

26 ytoplasm, docking of the capsid at a nuclear pore, and release of the viral genome into the nucleus.

27 ure-stable Ni-MOF-74 members with adjustable pore apertures, which exhibit excellent sorption capabil

28 stomatal responsiveness and larger range of pore apertures.

29 with 3D printing, and indicate that scaffold pore architecture is a critical variable in additively m

30 ies of MOFs and can significantly change the pore architecture.

31 lve translocation of peptides through capsid pores are associated with a subtle conformational change

32 Instead the majority of stomatal pores are entirely covered over by a continuous fusion o

33 ations of the IL (spectral diffusion) in the pores are slower than in the bulk IL by approximately 2-

34 Interlayer equivalent pores are small pores in compressed clay stones that are

35 th the Mlp1/2 role in gene gating to nuclear pores, artificial tethering to the nuclear periphery of

36 at when the proximity to the surface and the pore aspect ratio were included the actual initiating de

37 Our experiments reveal that the pore assembly proceeds via a membrane-bound prepore inte

38 To elucidate the pathways of perforin pore assembly, we carried out real-time atomic force mic

39 ntiviral drug, amantadine, at the N-terminal pore at low pH did not convert all histidines to the neu

40 microwells by fluid flow through small open pores at the bottom of the porous well arrays.

41 basigin, a step linked to the formation of a pore between merozoites and erythrocytes.

42 f Nef inhibits the formation of small fusion pores between viruses and cells.

43 The identification of this pore binding site sheds light on the mechanism of barbit

44 sing on structures with methane-inaccessible pores blocked away from the main adsorption channels.

45 ndent and competes with that by amiloride, a pore blocker of ASICs.

46 e influx was inhibited by MK-801, a specific pore blocker of N-Methyl-D-aspartic acid receptor (NMDAR

47 This idea was tested by applying the pore blocker toxin maurocalcine on the cytoplasmic side

48 hese processes by conducting a time-resolved pore-by-pore analysis of the local curvature and capilla

49 thene-containing MOFs, the properties of the pore can be changed via an optical trigger without the p

50 urther demonstrate how the geometry of these pores can be altered beyond triangular by changing beam

51 sly (seconds) convert into rapidly expanding pores causing membrane lysis (minutes).

52 ewise, the tomato CATION EXCHANGER 1 and TWO-PORE CHANNEL 1 (SlTPC1), key genes for Ca(2+) fluxes to

53 ophysical feedback mechanisms acting through pore characteristics and microbial accessibility.

54 Here, we show that these pores clearly function as an entry pathway into infected

55 Binding of the capsid to the nuclear pore complex (NPC) is mediated by the capsid protein pUL

56 plasm to the periplasm via an inner-membrane pore complex (TraC and TraG) with homology to type IV se

57 t al. (2017) describe defects in the nuclear pore complex and impaired nucleocytoplasmic transport in

58 is expressed in cells of the developing air pore complex and the morphogenesis of the complex is def

59 Moreover, we provide evidence that a nuclear pore complex associates with the duplicating SPB and hel

60 The nuclear pore complex controls the passage of molecules via hydro

61 e explore the hypothesis that the P2X7-PANX1 pore complex is a critical determinant of spreading depo

62 interacts with key components of the nuclear pore complex.

63 Nuclear pore complexes (NPCs) are multiprotein channels connecti

64 Transport through nuclear pore complexes (NPCs) during interphase is facilitated b

65 requires Nup2, suggesting a role for nuclear pore complexes.

66 transcription complexes and show how nuclear pore composition changes can be exploited to regulate ge

67 Two levels of the pore conductance and two dwell closed times of the pore

68 ductivity for the case with aligned circular pores, confirming a significant thermal transport degrad

69 space, pore type, sample size and associated pore connectivity, as well as theoretical base and inter

70 ediate state to the activated state, the VSD-pore coupling has less efficacy in opening the pore, pro

71 ent mechanisms, other than the canonical VSD-pore coupling, are at work in voltage-dependent ion chan

72 he averages of the seven measurements from 8-pore devices are contrasted to single measurements from

73 jor challenge is to extrapolate these single-pore devices into macroscopic materials.

74 age of the improved size resolution of the 8-pore devices to analyze in real time the assembly of Hep

75 are contrasted to single measurements from 2-pore devices.

76 hollow fibers not only possess a small mean pore diameter of 1.0-1.3 nm with a molecular weight cuto

77 to their difference in measurable ranges of pore diameter, pore space, pore type, sample size and as

78 Multi-scale (five pore-diameter intervals) inaccessible porosity to N2 was

79 rge value of inaccessible porosity occurs at pore diameters <10 nm, which we attribute to low connect

80 ances for porous copper inverse opals having pore diameters from 300 to 1000 nm by measuring the capi

81 capped PLGA displayed an osmotically induced/pore diffusion mechanism based on confocal micrographs o

82 vidence that, contrary to the time-dependent pore dilation model, ATP binding opens an NMDG(+)-permea

83 Here we show that transplanting the pore domain of TRPV1 into Shaker gives rise to functiona

84 Two-pore domain potassium (K2P) channel ion conductance is r

85 detergent and liposomes, for residues at the pore domain that agree with their location in the TRPV1

86 This pore-domain chimera is permeable to Na(+), K(+), and Ca(

87 arly counterbalance hypokalaemia-induced two pore-domain K(+) channel isoform 1 (K2P1) leak cation cu

88 fies the interface between the catalytic and pore domains of CFTR and that this modification facilita

89 5 linker connects nearby voltage-sensing and pore domains to produce a non-domain-swapped transmembra

90 or non-swapped arrangements of the S1-S4 and pore domains.

91 t the brine-oil interface jumps from pore-to-pore during imbibition at an approximately constant loca

92 yed a key role in preventing the collapse of pores during DMF evaporation.

93 show a strain-independent failure of fusion pore enlargement among H2 (A/Japan/305/57), H3 (A/Aichi/

94 f 1.25 x 10(-8) cm(2) s(-1) due to the small pore entrance of the DNA@ZIF-8 membranes.

95 mbrane helices can control ion access to the pore even in the NBD-dimerized conformation.

96 line nanoparticles, as a function of micelle pore expander concentration or stirring rate.

97 ns which help lower the energetic barrier to pore expansion.IMPORTANCE Influenza A virus is an airbor

98 w (groundwater), with larger, well-connected pores filling before finer pore spaces, unlike groundwat

99 in a characteristically different pattern of pore-filling than wetting from below (groundwater), with

100 n which capillary forces saturate the finest pores first.

101 of the characteristic dye-permeable membrane pore for molecules up to 900 Da.

102 r, the molecular mechanisms for how stomatal pores form and how guard cell walls facilitate dynamic s

103 haviors and establish a link between peptide pore formation and both lipid-peptide charge and topolog

104 ts of ATP synthase that could participate in pore formation are e, f, g, diabetes-associated protein

105 of exogenous substrates upon inner membrane pore formation by alamethicin or Ca(2+)-induced PTP open

106 the founding member of this class, prevents pore formation by destabilizing the prepore into a poorl

107 tricts HIV-1 fusion at a step prior to small pore formation by selectively inactivating sensitive Env

108 the plasma membrane might facilitate fusion pore formation during exocytosis.

109 In particular, the keyhole pore formation is experimentally revealed with high spat

110 Here we show that the process of MOM pore formation is sensitive to the type of OxPls species

111 in the MAC, hints at their putative roles in pore formation or receptor interactions.

112 ting oligomerization, membrane insertion and pore formation.

113 nel is closed by a constriction of the inner pore formed by criss-crossing of the S6 segments at a co

114 vents of single-channel currents through the pore formed by recombinant ATOM40 were detected in elect

115 lts indicated that AG can be used as a novel pore-former, hydrophilizing and antifouling agent, as we

116 Ammonium carbonate was used as a pore-forming agent since it decomposed with volatile dur

117 recursor and introducing phenanthroline as a pore-forming agent.

118 Interestingly, the pore-forming alpha subunit of KCa1.1 coimmunoprecipitate

119 e-activated K(+)(BK) channel consists of the pore-forming alpha subunits (BKalpha) and auxiliary subu

120 Voltage-gated CaV2.1 channels comprise a pore-forming alpha1A subunit with auxiliary alpha2delta

121 ated potassium channels (BK) are composed of pore-forming BKalpha and auxiliary beta1 subunits in art

122 oL1 has been hypothesized to function like a pore-forming colicin and has been reported to have perme

123 Retigabine binds to the pore-forming domain, causing a hyperpolarizing shift in

124 osis requires cleavage and activation of the pore-forming effector protein gasdermin D by inflammator

125 rst evidence, to our knowledge, that StII, a pore-forming protein from a marine eukaryotic organism,

126 ed endosome-disrupting agent composed of the pore-forming protein Perfringolysin O (PFO), potent sile

127 ated DNA to encode either a fluorescent or a pore-forming protein.

128 anisms from all kingdoms of life, only a few pore-forming proteins have been successfully reconstitut

129 sins (CDCs) represent a family of homologous pore-forming proteins secreted by many Gram-positive bac

130 form a channel complex with the K(+) channel pore-forming subunit Kv4.3 in a subset of nociceptors to

131 The K(+) channel pore-forming subunit Kv4.3 is expressed in a subset of n

132 Lysenin is a pore-forming toxin from the earthworm Eisenida foetida,

133 of toxins may represent a common feature of pore-forming toxins.

134 Hydathodes are water pores found on leaves of a wide range of vascular plants

135 o the configuration where the DNA enters the pore from the open reservoir.

136 s are mediated mainly by modulation of KCNQ1 pore function.

137 is important for communications between the pore gate and the voltage sensor during deactivation.

138 occurs as a result of reconfiguration of the pore gate upon opening by a mechanism that is influenced

139 data also demonstrate that the mechanisms of pore gate-opening-induced and relaxation-induced voltage

140 anking residues (132 to 140), and Leu-122, a pore-gating residue.

141 yamide groups, open metal sites, appropriate pore geometry and cooperative binding between guest mole

142 orous hydrogel scaffolds to test how varying pore geometry, accomplished by manipulating the advancin

143 Several aromatic and hydrophobic residues in pore helix 1, helices S5 and S6, and helix S6 of a neigh

144 silicon wafers can be prepared with tubular pores imbedded in a silicon matrix.

145 in bacteria by opening a large, water-filled pore in response to changes in membrane tension.

146 liposomes, forms an intrinsic dye-permeable pore in the absence of other cellular components.

147 his depends on activation of the RyR1 Ca(2+) pore in the SR, under control of conformational changes

148 on of the diffusion barrier, an array of 100 pores in 0.2cm(2) area of nail permitting a 10(3)-fold i

149 Interlayer equivalent pores are small pores in compressed clay stones that are small enough to

150 mmunity, did not induce closure of hydathode pores in contrast to stomata.

151 Stomata, microscopic pores in leaf surfaces through which water loss and carb

152 audin-4) as receptors to form Ca2+-permeable pores in the membrane, damaging epithelial cells in smal

153 based on confocal micrographs of percolating pores in the polymer, not previously observed in vitro.

154 n diffuse easily through air- and gas-filled pores in the soil and likely play an important role in l

155 These materials can sustain nanoscale pores in their rigid lattices and due to their minimum p

156 of organic matter-hosted and clay-associated pores in these shales.

157 ed to monitor the shape and dimension of the pores in which water is confined, thus boosting the info

158 Extension is largest in small pores, increasing >10-fold but remaining 30-fold shorter

159 Pore inhibitors elevate the electrical threshold for spr

160 ll wall and is enriched at sites of stomatal pore initiation in cotyledons.

161 nts caused lipid bilayer destabilization and pore instability, limiting the total number of recorded

162 Recent proposals suggest that the pore is associated with the ATP synthase complex and spe

163 ete assembly intermediates and show that the pore is most probably a helix barrel that contains eight

164 rs adopt a depolarized conformation, and the pore is open.

165 selectivity is provided by highly conserved, pore-lining amino acids.

166 to induce changes that lead to asynchronous pore-lining M2 helix movements.

167 conformation, the extracellular-half of the pore-lining M2 is splayed open, reminiscent of the open

168 adiol interaction with hERG mutations in the pore loop containing G604 or with common TdP-related blo

169 MCM pore loops touch both the Watson and Crick strands, cons

170 atives bound to the stem part of the aqueous pore lumen.

171 ermined by measuring their flux across large pore membranes and using dynamic light scattering, with

172 challenge the "drift and diffusion through a pore" model that dominates conventional explanatory sche

173 er size of only 82 amino acids, resemble the pore module of all complex K(+) channels in terms of str

174 ains, we found that SMIT1 binds to the KCNQ2 pore module.

175 of the mitochondrial permeability transition pore (MPTP).

176 in the vicinity of the gating region of the pore, namely between residues E90, E123, D253, N258, and

177 molecules allowed their movement through the pore network to be reconstructed.

178 t thermal fluctuations enable rate-dependent pore nucleation, driving the dynamics of the swell-burst

179 We also observed that the duration of the pore obstruction event is more controlled by the knot tr

180 sing channel gating rather than blocking the pore of heterologously expressed human BK channels.

181 tive tarantula toxin that binds to the outer pore of the channel.

182 ught to unfold substrate through the central pore of their hexameric structures, but how this process

183 (GIP) is stored as an adsorbed phase in fine pores of coal matrix, the nano-pore structure directly i

184 es under transmission electron microscopy in pores of intervessel pit membranes and deposited on vess

185 the melting temperature of the polymer, the pores of the nanofibers collapse due to the nanofibers'

186 e attack complex (MAC), which forms a lethal pore on the cellular surface of pathogenic bacteria.

187 xchange that is controlled by stomata, small pores on plant leaves and stems formed by guard cells.

188 ively in the opposite leaflet, resolution of pore opening and content release was lost.

189 e-binding site of complex II (site IIf); (b) pore opening in the inner membrane resulting in rapid ef

190 oach of kiri-kirgami, and their actuation of pore opening via both mechanical stretching and temperat

191 cate that G100V/C103V retards initial fusion-pore opening, hinders its expansion and leads to prematu

192 turn slowing correlated with the kinetics of pore opening.

193 ymorphic activated forms with very different pore openings, markedly different gas-adsorption capacit

194 ctions either by conducting ions through the pore or by phosphorylating downstream proteins via its k

195 on after ATP washout, and makes the receptor pore permeable to NMDG+, a large organic cation.

196 oscale have been explored in depth on single-pore platforms.

197 s approach, we discovered that a pair of two-pore potassium channel (K2P) subunits, largely dispensab

198 ke CP structure that occlude substrate entry pores, preventing unregulated degradation of substrates

199 re coupling has less efficacy in opening the pore, producing inactivation.

200 h altered gating kinetics, pharmacology, and pore properties.

201 y target of the compounds as the T3SS needle pore protein EspD, which is essential for effector prote

202 Nuclear pore proteins (Nups) interact with chromosomes to regula

203 centerline approximation leads to an optimum pore radius of about 8-12A, depending on the model chose

204 ese motions result in a minimum open-channel pore radius of approximately 3 A formed by Gln-4933, rat

205 The impacts by individual parameter such as pore radius, half cone angle, and surface charges are sy

206 We develop a pore recognition approach to quantify similarity of pore

207 ANLAAF motif orient toward the center of the pore region and most likely lead to disturbance of the g

208 tively charged Arg-1119 in the extracellular pore region in repeat III of CaV1.2.

209 pectedly, the extracellular mouth of the ion pore remains closed, indicating that local movements of

210 SE structure, especially of the pore-rich end walls, has a direct effect on translocatio

211 Here we demonstrate that pore-scale wetting patterns interact with antecedent soi

212 antecedent soil moisture conditions to alter pore-scale, core-scale, and field-scale C dynamics.

213 cific OprP and the diphosphate-specific OprO pores show structural differences in their binding sites

214 Molecularly sized pores significantly enhance the association between hydr

215 the lumen a function of the substrate entry pore size and the bulkiness of the gating residues.

216 ing flexibility, depending on the material's pore size characteristics.

217 uring radiation, and their shrinkage rate is pore size dependent.

218 99.6%), light weight (5 mg/cm(3)) and narrow pore size distribution ( 2 to 5 nm), the ECF anode exhib

219 icroscopic characteristics of the substrate (pore size distribution, porosity, permeability, and depo

220 showed that this transition occurs when the pore size is <3x the maximum of molecular dimensions.

221 When the pore size is on the nm scale, as the porosity increases,

222 In contrast, the calculated pore size of a brain metastasis of breast cancer was app

223 Aspects such as pore size or stiffness of the matrix influence the selec

224 ferent electrolyte composition and effective pore size to elucidate their influence on separation mec

225 Pore size tunability between 500 nm-10 microm is establi

226 ith an event size of the order of an average pore size, again much smaller than the large bursts seen

227 These MOFs exhibit similar pore size, pore surface, and surface area (around 3000 m

228 uit additional prepore oligomers to grow the pore size.

229 ons during CO2 sequestration will change the pore-size distribution and pore surface characteristics,

230 el is presented that incorporates a range of pore sizes to more accurately predict the capillary tran

231 In conjunction with a tight control over pore sizes, inverse opal scaffolds have found widespread

232 Despite the relatively large pore sizes, the complete orientational randomization of

233 Despite the relatively large pore sizes, the measurements reveal that the reorientati

234 Both genotypes showed decreasing pore space between 0.8 and 0.1 mm from the root surface.

235 taneous shift toward greater accumulation of pore space in larger aggregates.

236 tion, with larger aggregates containing less pore space than under control conditions, and water rete

237 rence in measurable ranges of pore diameter, pore space, pore type, sample size and associated pore c

238 t-like layers in the narrower regions of the pore space.

239 Pore spaces in clays include interlayer and interparticl

240 ods, due to the ability of neutrons to probe pore spaces inaccessible to N2 and mercury.

241 rmeability sediments that are sequestered in pore spaces too small for cell passage can be reduced by

242 r, well-connected pores filling before finer pore spaces, unlike groundwater rise in which capillary

243 cation, and what is the relationship between pore structure and function?

244 phase in fine pores of coal matrix, the nano-pore structure directly influences gas storage and trans

245 s have quantified the alteration of the nano-pore structure due to ME-CBM treatment.

246 oth the structure of root hairs and the soil pore structure in plant-soil microcosms.

247 Based on our results, we postulate that the pore structure of many mineral soils could undergo N-dep

248 ach method probes a unique aspect of complex pore structure of shale, the discrepancy between pore st

249 structure of shale, the discrepancy between pore structure results from different methods is explain

250 ly affected the crystallinity, surface area, pore structure, and luminescence properties of the polym

251 re the influence of the building material on pore structure, dynamics and function.

252 is is proposed based on the evolution of the pore structure.

253 cognition approach to quantify similarity of pore structures and classify them using topological data

254 nanocarbon-based materials with controllable pore structures and hydrophilic surface show great poten

255 work for visualization and quantification of pore structures in a wide variety of materials.

256 ratory experiments on mixed micro- and macro-pore suggest that there is a systematic relationship bet

257 n will change the pore-size distribution and pore surface characteristics, complicating permeability

258 These MOFs exhibit similar pore size, pore surface, and surface area (around 3000 m(2) g(-1) )

259 between discrete organic molecules or on the pore surfaces of MOFs, in a very fast (1-2 s) and contin

260 ted biochar that covers the outer and inner (pore) surfaces of biochar particles using high-resolutio

261 nel gating coupling junction and the channel pore (T288N), which are functionally coupled during rece

262 ases has changed to form an enclosed aqueous pore that is largely shielded from the membrane.

263 molecular docking a binding site in the ion pore that we confirm by site-directed mutagenesis.

264 leased through fluctuating exocytotic fusion pores that can flicker open and shut multiple times.

265 Partial ablation of the nail created pores that extended to a range of depths; the nail mater

266 -negative bacteria by forming size-selective pores that permeabilized bacterial membranes.

267 cell integrity by forming membrane-spanning pores that ultimately lead to their death.

268 Once inside the pore, the sugar release rate (koff) from the affinity si

269 Like the smart human sweating pores, the flaps can close automatically after the persp

270 olved within each monomer with a constricted pore; this is likely to correspond to a closed state, be

271 cting ACT segments, a proteolipidic toroidal pore through which AC domain transfer could directly tak

272 nts exit the bacterial cell through the ComE pore through which the NTHI type IV pilus is expressed.

273 ied by incorporating Ni(2+) cations into the pores through coordination to the amino groups, and the

274 imilarly, standard deviations of the pore-to-pore time distributions decrease by 3.2-fold when the av

275 show that the brine-oil interface jumps from pore-to-pore during imbibition at an approximately const

276 Similarly, standard deviations of the pore-to-pore time distributions decrease by 3.2-fold whe

277 molecular dynamics simulations to study the pore translocation of 10-kbp-long DNA rings that are kno

278 surable ranges of pore diameter, pore space, pore type, sample size and associated pore connectivity,

279 ulate and retain AITC molecules within their pores under low (30-35%) relative humidity (RH) conditio

280 e-selectivity in terms of smooth cylindrical pores using the centerline approximation leads to an opt

281 ere, we probed the dilation of single fusion pores using v-SNARE-reconstituted 23-nm-diameter discoi

282 ngs rotate, resulting in an increase in both pore volume and content.

283 Pore volume as well as shape in the cathodes were easily

284 lates with the cavity size and mass-specific pore volume in pristine ZIFs.

285 lev's equations afforded the evaluation of a pore volume variation from 10 to 110 cm(3)/g by cobalt i

286 ed, which showed higher surface area, larger pore volume, stronger acidity and higher surface area co

287 tributed 7 A micropores, and ever most polar pore walls.

288 ates that low chloride concentrations in the pore water of the corresponding sediments can only be ex

289 nd the thermal conductivity greatly affected pore water signals.

290 The tests without soil (simulating pore-water exposure) revealed higher toxicity, with LC50

291 The sediment pore waters of PPR wetlands contain some of the highest

292 d unexpectedly low DOC concentrations in the pore waters, reflecting the combined effect of thermal d

293 experiments on controlled migration through pores, we show that squeeze-out of the fluid, and hence

294 onductance and two dwell closed times of the pore were found.

295 This is due to reshaping of the M2 pore when N31 is present, which, in contrast to wild-typ

296 Guard cells shrink and close stomatal pores when air humidity decreases (i.e. when the differe

297 ct can increase protein concentration inside pores, which enables crystal nucleation even under condi

298 hannel constitutes the actual protein-import pore wide enough to allow the passage of polypeptides wi

299 O, -OH) polyhedra supporting one-dimensional pores with apertures and internal diameters of 7.8 and 9

300 ablish the metastable nature of the inserted pore, yielding a force profile with barriers for membran