ライフサイエンスコーパス: pore-forming

1 barrel arrangement that we named beta-barrel pore-forming Abeta42 oligomers (betaPFOsAbeta42).

2 Here, we report on the use of the pore-forming abilities of heat shock cognate 70 (Hsc70)

3 bacterial membranes are consistent with the pore-forming activities of AMPs previously observed in l

4 ggest the relative independence between StII pore-forming activity and its immunomodulatory propertie

5 umolysin-induced MIF production required its pore-forming activity and phosphorylation of p38-MAPK in

6 These data suggest that the pore-forming activity and the ISVP*-promoting activity o

7 protein responsible for the 0.6-nanosiemens pore-forming activity in the outer membrane of B. burgdo

8 se-containing membranes, indicating that its pore-forming activity is specific and not promiscuous.

9 Both activities are attributed to the pore-forming activity of the ESX-1-secreted substrate ES

10 their mechanism of action-plasmatic membrane pore-forming activity selective for bacteria.

11 Lipopolysaccharide inhibits RegIIIalpha pore-forming activity, explaining why RegIIIalpha is bac

12 the borrelial OMP P66, a known adhesin with pore-forming activity, forms a beta-barrel in the B. bur

13 ns of the Cry protein, and in particular its pore-forming activity.

14 ted with plasma membrane damage due to LLO's pore-forming activity.

15 directed exposure of individual cells to the pore-forming agent alpha-hemolysin, we have controlled t

16 Ammonium carbonate was used as a pore-forming agent since it decomposed with volatile dur

17 e Ga- or Zn-complexes, using an incorporated pore-forming agent, poly(ethylene glycol) (PEG).

18 recursor and introducing phenanthroline as a pore-forming agent.

19 geting nucleic acids, proteins or membranes (pore-forming agents).

20 nd control of cell surface expression of the pore forming alpha-subunits.

21 Interestingly, the pore-forming alpha subunit of KCa1.1 coimmunoprecipitate

22 excitable cell types and with or without the pore-forming alpha subunit present.

23 e-activated K(+)(BK) channel consists of the pore-forming alpha subunits (BKalpha) and auxiliary subu

24 ltage-gated potassium (Kv) channels comprise pore-forming alpha subunits and a multiplicity of regula

25 els are heteromeric proteins consisting of a pore-forming alpha(1) subunit and auxiliary alpha(2)delt

26 mice with a genetic ablation of the Ca(v)2.1 pore-forming alpha(1A) subunit (alpha(1A)(-)/(-)) encode

27 Kcnq1, which encodes for the pore-forming alpha-subunit of a voltage-gated potassium

28 ewise, OHCs of BKalpha(-/-) mice lacking the pore-forming alpha-subunit of BK channels have longer IP

29 utations in SCN5A, the gene encoding for the pore-forming alpha-subunit of the cardiac sodium channel

30 ther-a-go-go-related gene (hERG) encodes the pore-forming alpha-subunit of the rapidly activating del

31 te the ER exit and surface expression of the pore-forming alpha-subunit, whereas beta4-subunits that

32 tion mutations in either Navbeta-subunits or pore-forming alpha-subunits is epilepsy.

33 ltage-gated K(+) (Kv) channel comprises four pore-forming alpha-subunits, and only members of the sam

34 hannels are formed by the co-assembly of the pore-forming alpha-subunits, Kv4.2 and Kv4.3, together w

35 n of PMN number and function and the role of pore-forming alpha-toxin (AT), a virulence factor that c

36 nnels reflect the tetrameric assembly of Kv4 pore-forming (alpha) subunits, and previous studies sugg

37 multisubunit protein complexes composed of a pore-forming alpha1 and auxiliary beta and alpha2delta s

38 caused by a gain-of-function mutation in the pore-forming alpha1 subunit of CaV 2.1 (P/Q-type) calciu

39 We show that the main body of the pore-forming alpha1 subunit of neuronal L-type VGCCs, Ca

40 alleled by changes in phosphorylation of the pore-forming alpha1 subunit of the cardiac voltage-gated

41 divisions of calcium channel, defined by the pore-forming alpha1 subunit, the CaV 1, CaV 2 and CaV 3

42 age-gated Ca(2+) (CaV) channels consist of a pore-forming alpha1 subunit, which determines the main f

43 The pore-forming alpha1-subunit comprises four repeated doma

44 ta, 14-3-3, calmodulin and CaMKII) that bind pore-forming alpha1-subunits can be converted into calci

45 tions in the CACNA1A gene, which encodes the pore-forming alpha1A subunit of the CaV2.1 voltage-gated

46 Voltage-gated CaV2.1 channels comprise a pore-forming alpha1A subunit with auxiliary alpha2delta

47 ved by manipulating expression of the 6.6 kb pore-forming alpha1C-subunit in adult cardiomyocytes.

48 Sperm lacking CaV2.3's pore-forming alpha1E subunit showed altered Ca(2+) respo

49 Both pore forming and nitrogen doping simultaneously proceed

50 Ion channels composed of pore-forming and auxiliary subunits control physiologica

51 Mitochondrial calcium uniporter (MCU) is the pore-forming and Ca(2+)-conducting subunit of the unipor

52 tifier (I(KS)) channel is composed of KCNQ1 (pore-forming) and KCNE1 (auxiliary) subunits, and functi

53 Perforin-2 (MPEG1) is a pore-forming, antibacterial protein with broad-spectrum

54 Microcin E492 (Mcc) is a pore-forming bacteriotoxin.

55 This pore-forming behavior is strong evidence that Aibm (m >/

56 ment of C9 molecules that yield an 88-strand pore-forming beta-barrel.

57 revealed that bacterial invasion and the GBS pore-forming beta-hemolysin/cytolysin (beta-h/c) trigger

58 S. aureus encodes pore-forming bi-component leukotoxins that are toxic tow

59 ated potassium channels (BK) are composed of pore-forming BKalpha and auxiliary beta1 subunits in art

60 Arterial myocytes express both pore-forming BKalpha and auxiliary beta1 subunits, which

61 K(+) (BK) currents and the expression of the pore-forming BKalpha protein were normal.

62 e attributed to the specific geometry of the pores, forming cages built with phenyl rings and enriche

63 Gasdermin D (GSDMD), the pore-forming caspase-1 substrate required for efficient

64 nels, Cav1.4 channels are composed of a main pore-forming Cav1.4 alpha1 subunit and auxiliary beta an

65 nnels are oligomeric complexes formed by the pore-forming CaValpha1 with the auxiliary CaVbeta and Ca

66 ytes exist as heteromeric complexes with the pore-forming CaValpha1, CaVbeta, and CaValpha2delta1 sub

67 elation between the total amount of the LTCC pore-forming Cavalpha1.2 and the Akt-dependent phosphory

68 ) was tested using perfringolysin O (PFO), a pore-forming cholesterol-dependent cytolysin.

69 etry upon the conformational behavior of the pore-forming, cholesterol-dependent cytolysin perfringol

70 oL1 has been hypothesized to function like a pore-forming colicin and has been reported to have perme

71 h the threshold for oligomerization into the pore-forming complex.

72 ible mechanisms, including the production of pore-forming complexes that permeabilize membranes.

73 Tom40 is the pore forming component of the complex.

74 which the receptor complex combines with the pore-forming component to assemble a new translocase for

75 e and other Tat components, notably the Tha4 pore-forming component.

76 t among these toxins are the membrane-active pore-forming cytolysin alpha-toxin (Hla) and the amphipa

77 the transcription factor PrfA, including the pore-forming cytolysin listeriolysin O (LLO), two phosph

78 e phagocyte cell death through the action of pore-forming cytolysins.

79 Among these molecules are pore-forming cytolytic toxins, including Panton-Valentin

80 Pneumolysin, a pore-forming cytotoxin and major virulence determinant,

81 Staphylococcus aureus employs numerous pore-forming cytotoxins to injure host immune cells and

82 echanotransduction complex that contains the pore-forming degenerin/epithelial sodium channel (DEG/EN

83 by interaction of the C terminus with a Cx37 pore-forming domain able to open as a GJC.

84 mic N-terminal domain and smaller C-terminal pore-forming domain comprising six transmembrane helices

85 GC-35 evolved from GABA-A receptors, but the pore-forming domain contains novel molecular determinant

86 Lo-like domain of HELLP is homologous to the pore-forming domain of MLKL, the cell death-execution pr

87 e based on expression of a chimera between a pore-forming domain of the mechanically insensitive ASIC

88 Retigabine binds to the pore-forming domain, causing a hyperpolarizing shift in

89 ell death-inducing protein containing a HeLo pore-forming domain, is activated through amyloid templa

90 lamydial ORFan protein and bacterial colicin pore-forming domain.

91 ic moiety of the TMalpha5 that is a probable pore-forming domain.

92 involves global changes in structure of the pore-forming domains transduced by interactions of the p

93 ng domains transduced by interactions of the pore-forming domains with either the NT, CT, or both, wi

94 acNavs contain conserved voltage-sensing and pore-forming domains, but they are homotetramers of four

95 osis requires cleavage and activation of the pore-forming effector protein gasdermin D by inflammator

96 During pyroptosis, GSDMD (gasdermin D), the pore-forming effector protein, is cleaved, forms oligome

97 H. pylori secretes a pore-forming exotoxin known as vacuolating toxin (VacA).

98 Burst drug release occurred followed by pore forming from the exterior to the core of both micro

99 ne model to evaluate the contribution of the pore-forming GBS beta-hemolysin/cytolysin (betaH/C) to v

100 drophobic pockets between the peripheral and pore-forming helices to which amantadine or rimantadine

101 ransmembrane helices do not pack against the pore-forming helices, creating an apparent void.

102 odel invokes STIM1 binding directly to Orai1 pore-forming helix.

103 necessity for direct STIM1 contact with the pore-forming helix.

104 pathway and, when activated, transform into pore-forming homo-oligomers that permeabilize the mitoch

105 nexpected similarities uncovered between the pore-forming "hotspots" of TcdB and the well-characteriz

106 It encodes the pore-forming human CaV3.3 alpha1 subunit, a subtype of v

107 l activity by coexpression of members of the pore-forming inward rectifier gene family (Kir6.1, KCNJ8

108 Co-expression of Neto1 and 2 with pore-forming kainate receptor subunits also increases th

109 tive potassium (KATP) channels comprise four pore-forming Kir6.2 subunits and four modulatory sulfony

110 f-function (GOF) mutations in genes encoding pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9)

111 Kv4 channels are ternary complexes including pore-forming Kv4 subunits and two types of auxiliary sub

112 Kv4 channels are ternary complexes including pore-forming Kv4 subunits, K(+) channel-interacting prot

113 Bicomponent pore-forming leukocidins are a family of potent toxins s

114 can produce up to five different bicomponent pore-forming leukotoxins that lyse immune cells by formi

115 of virulence factors including bi-component pore-forming leukotoxins.

116 at Asn-988 (Trpm4b-N988Q), located near the pore-forming loop between transmembrane helices 5 and 6,

117 ents (the lipid binding PlyA protein and the pore-forming MACPF component PlyB).

118 -expressed gene 1, Mpeg1), which possesses a pore-forming MACPF domain, reduces the viability of bact

119 Furthermore, another distantly related pore-forming MACPF protein, pleurotolysin (from the oyst

120 beta), each of which comprises an N-terminal pore-forming MACPF/CDC domain, a central focal adhesion-

121 The uniporter is composed of the pore-forming MCU protein, the gatekeeping MICU1 and MICU

122 ly, there are tantalizing hints that the CDC pore-forming mechanism is more sophisticated than previo

123 ins) suggests that the toxins have a similar pore-forming mechanism of action involving alpha-helices

124 e make the unexpected finding that SNTX is a pore-forming member of an ancient branch of the Membrane

125 rned through direct interactions between the pore-forming Orai proteins and the endoplasmic reticulum

126 K(+) channel sequence signature-containing, pore-forming P loop.

127 assay that relies on the conductance of the pore-forming peptide gramicidin A to monitor PLD activit

128 rs under conditions where melittin and other pore-forming peptides do not.

129 w that conformational fine-tuning of helical pore-forming peptides is a powerful way to modulate thei

130 lP5 are unique as neither melittin nor other pore-forming peptides release macromolecules significant

131 D by highlighting similarities with secreted pore-forming peptides, and by suggesting that PopB/PopD

132 embrane defects that permit the insertion of pore-forming peptides.

133 e contents--granzyme (Gzm) proteases and the pore-forming perforin (PFN)--into the infected cell.

134 Here we show that pore-forming properties of human and rodent P2X7 recepto

135 Ls kill by secreting toxic proteases and the pore forming protein perforin into the synapse.

136 in has recently been solved, showing it is a pore-forming protein (viroporin).

137 rst evidence, to our knowledge, that StII, a pore-forming protein from a marine eukaryotic organism,

138 to avoid this hurdle, sticholysin (St) II, a pore-forming protein from the Caribbean Sea anemone Stic

139 tage-dependent anion channel (VDAC), a major pore-forming protein in the outer membrane of mitochondr

140 ss-of-function mutations in the CRAC channel pore-forming protein ORAI1 or the Ca(2+) sensing protein

141 teraction molecule 1 (STIM1) and the channel pore-forming protein Orai1.

142 The pore-forming protein perforin is essential for delivery

143 ic T lymphocytes enhance the function of the pore-forming protein perforin, thereby leading to more e

144 ed as inhibitors of the lymphocyte-expressed pore-forming protein perforin.

145 ed endosome-disrupting agent composed of the pore-forming protein Perfringolysin O (PFO), potent sile

146 Equinatoxin II (EqtII) is a soluble, 20 kDa pore-forming protein toxin isolated from the sea anemone

147 erall scheme of the archetypical beta barrel pore-forming protein toxin mode of action, in which the

148 nithine rhamnolipid pigment and not due to a pore-forming protein toxin.

149 in that belongs to the family of beta barrel pore-forming protein toxins.

150 specialized lysosomes containing perforin, a pore-forming protein, and granzymes, which are proteases

151 ediated cytotoxicity in conjunction with the pore-forming protein, perforin.

152 ated DNA to encode either a fluorescent or a pore-forming protein.

153 Pore-forming proteins are weapons often used by bacteria

154 In pathogenic Yersinia, the T3SS pore-forming proteins are YopB and YopD.

155 ives can be utilized as anti-infectives with pore-forming proteins as the targets.

156 way requires activation of the mitochondrial pore-forming proteins BAK or BAX.

157 anisms from all kingdoms of life, only a few pore-forming proteins have been successfully reconstitut

158 that have advanced the field of transport by pore-forming proteins of bacterial origin.

159 sins (CDCs) represent a family of homologous pore-forming proteins secreted by many Gram-positive bac

160 ) proteins constitute a major superfamily of pore-forming proteins that act as bacterial virulence fa

161 ct effector proteins termed Yops, as well as pore-forming proteins that comprise the translocon itsel

162 Both toxins are pore-forming proteins that form oligomeric structures th

163 The ability of pore-forming proteins to interact with various analytes

164 Pore-forming proteins, deployed by both hosts and pathog

165 proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity

166 te and harbor in their membranes a number of pore-forming proteins.

167 gondii expanded the functional diversity of pore-forming proteins.

168 ed that the mutation is localized within the pore forming region of InsP3R2 and abrogates Ca2+ releas

169 nserved residue leucine 29 to alanine in the pore-forming region increased its single-channel conduct

170 eported a hypothetical structure of the RyR1 pore-forming region, obtained by homology modeling and s

171 a peptide corresponding to the hERG-channel pore-forming region.

172 ctly binding to an external site outside the pore-forming region.

173 s in the structural elements of K(+) channel pore-forming regions and postulated equivalent regions o

174 embers have a unique topology comprising two pore-forming regions per subunit.

175 to this pathway, and mutations of homologous pore-forming residues had analogous effects on GltPh sim

176 ns by mutagenesis into the inner half of the pore-forming second transmembrane domain of the receptor

177 amino acid residues in or near the S5 and S6 pore-forming segments of NALCN, highlighting the functio

178 rsibly activates BK channels composed of the pore-forming Slo1 subunit and the auxiliary subunit beta

179 of VSV-TMD on the initial-intermediate- and pore-forming steps of PEG-mediated fusion derives from i

180 smooth muscle cell is a complex containing a pore-forming subunit (Kir6.1) and a sulfonylurea recepto

181 cular components of CRAC channels, the Orai1 pore-forming subunit and the STIM1-activating subunit ha

182 rted the unexpected finding that CaV1.2, the pore-forming subunit in a well-characterized voltage-gat

183 Kv4.2 is a major pore-forming subunit in somatodendritic subthreshold A-t

184 form a channel complex with the K(+) channel pore-forming subunit Kv4.3 in a subset of nociceptors to

185 The K(+) channel pore-forming subunit Kv4.3 is expressed in a subset of n

186 l calcium uptake 1 (MICU1) and MICU2 and the pore-forming subunit mitochondrial calcium uniporter (MC

187 otein 16A (TMEM16A), also known as ANO1, the pore-forming subunit of a Ca(2+) -dependent Cl(-) channe

188 neuron-specific misexpression of TRP-4, the pore-forming subunit of a mechanotransduction channel, s

189 y NOMPC mutation, indicating that NOMPC is a pore-forming subunit of a mechanotransduction channel.

190 KCNQ1 is the pore-forming subunit of cardiac slow-delayed rectifier p

191 IM1 or Orai1, the activating subunit and the pore-forming subunit of CRAC channels, respectively, abo

192 The beta-subunit associates with the alpha1 pore-forming subunit of high voltage-activated calcium c

193 CaVbeta binds to the alpha1 pore-forming subunit of L-type channels and augments cal

194 Orai1 comprises the pore-forming subunit of the Ca(2+) release-activated Ca(

195 culum (ER) Ca(2+) sensor STIM1 to Orai1, the pore-forming subunit of the Ca(2+) release-activated Ca(

196 tations of the CACNA1A gene that encodes the pore-forming subunit of the human Cav2.1 (P/Q-type) volt

197 d by mutations in CACNA1A, which encodes the pore-forming subunit of the neuronal voltage-gated calci

198 ther-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed r

199 ther-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed r

200 hese analyses establish that MCU encodes the pore-forming subunit of the uniporter channel.

201 However, the identity of the pore-forming subunit remains to be established, since kn

202 sing this system, we confirm that MCU is the pore-forming subunit, define the minimal genetic element

203 Manipulation of the pore-forming subunit, MCU, in PASMCs was achieved throug

204 These channels consist of a primary alpha(1) pore-forming subunit, which is associated with an extrac

205 eavage of the channel within the core of the pore-forming subunit.

206 docytosis motif of the K(ATP) channel Kir6.2 pore-forming subunit.

207 of AMPA receptors (AMPARs) is observed when pore-forming subunits coassemble with or without auxilia

208 K+ channels containing Kv4.2 and Kv4.3 pore-forming subunits mediate most of the subthreshold-o

209 Two mammalian genes, Kcnt1 and Kcnt2, encode pore-forming subunits of Na(+)-dependent K(+) (KNa) chan

210 ne (polyQ) within the C terminus (CT) of the pore-forming subunits of P/Q-type Ca(2+) channels (Cav2.

211 of evidence is consistent with these TMCs as pore-forming subunits of the long-sought hair-cell trans

212 The principal pore-forming subunits of voltage-gated sodium and calciu

213 However, the identity of the pore-forming subunits of VRAC and how the channel is gat

214 I(Ks) channels are composed of KCNQ1 (Q1) pore-forming subunits that carry S4 voltage-sensor segme

215 tion channels with two non-equivalent tandem pore-forming subunits that dimerize to form quasi-tetram

216 IKs channels are comprised of four KCNQ1 pore-forming subunits, two KCNE1 accessory subunits, and

217 ding domain (LBD) is essential for gating by pore-forming subunits, whereas a conserved motif on the

218 els are tetrameric complexes consisting of 4 pore-forming subunits.

219 ising from the homo-tetrameric core of their pore-forming subunits.

220 AMPA-Rs consist of four pore-forming subunits.

221 There was decreased induction of the pore-forming tight junction protein claudin-2 in STAT6(-

222 crease in the level of the cation-selective, pore-forming TJ protein claudin-2 was observed after cel

223 Cytolysin A (ClyA) is an alpha-pore forming toxin from pathogenic Escherichia coli (E.

224 the 4th domain of intermedilysin (rILYd4), a pore forming toxin secreted by Streptococcus intermedius

225 inetics for the well-characterized bacterial pore-forming toxin aerolysin in single cells in real tim

226 via bacterial N-formylated peptides and the pore-forming toxin alpha-haemolysin, through distinct me

227 The alpha-pore-forming toxin Cytolysin A (ClyA) is responsible for

228 Lysenin, a pore-forming toxin extracted from the earthworm E. fetid

229 Lysenin is a pore-forming toxin from the earthworm Eisenida foetida,

230 e-threatening wound infections, secretes the pore-forming toxin hemolysin II (HlyII).

231 aining 3 (NLRP3) and ASC due to the secreted pore-forming toxin hemolysin.

232 ape the phagosome in host cells by using the pore-forming toxin listeriolysin O (LLO) and two phospho

233 The pore-forming toxin listeriolysin O (LLO) is a major viru

234 We studied L. monocytogenes and its secreted pore-forming toxin listeriolysin O (LLO) to identify key

235 or virulence factor of L. monocytogenes, the pore-forming toxin listeriolysin O (LLO), is sufficient

236 some of the host cells via the action of the pore-forming toxin listeriolysin O (LLO).

237 cardiac damage was entirely dependent on the pore-forming toxin pneumolysin only for D39.

238 ne and can be stimulated by the heterologous pore-forming toxin pneumolysin, suggesting that LLO acts

239 e cytosolic compartment via the pneumococcal pore-forming toxin pneumolysin.

240 NetB is a pore-forming toxin produced by Clostridium perfringens a

241 hylococcus aureus leukotoxin ED (LukED) is a pore-forming toxin required for the lethality associated

242 alpha-Hemolysin (Hla), a pore-forming toxin secreted by S. aureus and a major con

243 The pore-forming toxin SLO was directly visualized entering

244 Intermedilysin (ILY), a cytolytic pore-forming toxin that is secreted by Streptococcus int

245 emolysin (VCC) is an amphipathic 65-kDa beta-pore-forming toxin with a C-terminal beta-prism lectin d

246 membrane, we engineered a natural SM-binding pore-forming toxin, equinatoxin II (Eqt), into a nontoxi

247 testinal pathogen Vibrio cholerae secretes a pore-forming toxin, V.cholerae cytolysin (VCC), which co

248 nd transgenic overexpression, we show that a pore-forming toxin-like (PFT) gene at Fhb1 confers FHB r

249 ional changes occurring in a large cytolytic pore-forming toxin.

250 alpha-Pore-forming toxins (alpha-PFTs) are ubiquitous defense

251 beta-Barrel pore-forming toxins (beta-PFT), a large family of bacter

252 elongs to the aerolysin family of small beta-pore-forming toxins (beta-PFTs), some members of which a

253 beta-Barrel pore-forming toxins (betaPFTs) form an obligatory oligom

254 Pore-forming toxins (PFTs) are a class of pathogen-secre

255 Pore-forming toxins (PFTs) are abundant bacterial virule

256 Bacterial pore-forming toxins (PFTs) are structurally diverse path

257 the mechanisms of other important classes of pore-forming toxins and proteins across the kingdoms of

258 strategy that safely delivers non-disrupted pore-forming toxins for immune processing.

259 Pore-forming toxins form a family of proteins that act a

260 pid and evolutionarily conserved response to pore-forming toxins in the gut, involving cytoplasm ejec

261 Secreted pore-forming toxins of pathogenic Gram-negative bacteria

262 The staphylococcal bicomponent pore-forming toxins Panton-Valentine leukocidin LukSF-PV

263 sin AB and CB (HlgAB, HlgCB) are bicomponent pore-forming toxins present in almost all human S. aureu

264 n important class of such protein complexes, pore-forming toxins start their journey as soluble monom

265 nism that is relevant to understanding other pore-forming toxins that also require CD59.

266 rol-dependent cytolysins (CDCs), a family of pore-forming toxins that form gigantic pores in cell mem

267 cholesterol-dependent cytolysins (CDCs) are pore-forming toxins that have been exclusively associate

268 senin is a member of the aerolysin family of pore-forming toxins that includes many representatives f

269 belong to a small family of potent cnidarian pore-forming toxins that includes two other C. fleckeri

270 This is different from beta-pore-forming toxins that often form beta-barrel pores vi

271 I) is an archetypal example of alpha-helical pore-forming toxins that porate cellular membranes by th

272 peratures as measured by hypersensitivity to pore-forming toxins that target PS (papuamide A) or PE (

273 Many pathogenic bacteria produce pore-forming toxins to attack and kill human cells.

274 investigated the contribution of bicomponent pore-forming toxins to the ability of USA300 to withstan

275 venom of sea anemones, actinoporins are the pore-forming toxins whose toxic activity relies on the f

276 f epithelial cells to sublytic quantities of pore-forming toxins, and VLY-induced epithelial cell mem

277 lium-based drugs, cyclodextrin inhibitors of pore-forming toxins, anti-fungals that deal with biofilm

278 ata support the emerging paradigm shift that pore-forming toxins, including CDCs, have cellular recep

279 ow that NLRP3 activators including bacterial pore-forming toxins, nigericin, ATP, and particulate mat

280 ongated shape, which resembles those of beta-pore-forming toxins, such as Aerolysin, but is devoid of

281 e bacterial pathogens that secrete cytotoxic pore-forming toxins, such as Staphylococcus aureus and S

282 ng of pore formation by other aerolysin-like pore-forming toxins, which often represent crucial virul

283 gnificant structural similarity to bacterial pore-forming toxins.

284 of toxins may represent a common feature of pore-forming toxins.

285 sponds to Gram-negative bacteria and certain pore-forming toxins.

286 tivation signal from purinergic receptors or pore-forming toxins.

287 a variety of injuries and diseases caused by pore-forming toxins.

288 egulatory and agonist-binding domains to the pore-forming trans-membrane domain (TMD), and validated

289 Pseudomonas aeruginosa, the chaperone of the pore-forming translocator proteins is PcrH.

290 First, the pore-forming translocators are released.

291 ed tip complex responsible for assembly of a pore-forming translocon in the host cell membrane.

292 f antagonism, and complete structures of the pore-forming transmembrane domains of these receptors re

293 The pore-forming transmembrane helices in these channels are

294 of the stalk helix, which propagates to the pore-forming transmembrane helix TM1.

295 Potassium channels are pore-forming transmembrane proteins that regulate a mult

296 contains two constrictions, one each in the pore-forming upper and lower gates.

297 Helicobacter pylori secretes a pore-forming VacA toxin that has structural features and

298 y measurements in order to investigate how a pore-forming, virucidal peptide destabilizes lipid vesic

299 determined not only by the properties of the pore-forming voltage-gated Na(+) channel (VGSC) alpha su

300 determined not only by the properties of the pore-forming voltage-gated Na+ channel (VGSC) alpha subu