ライフサイエンスコーパス: pose

1 ng mode and other thermodynamically relevant poses.

2 eneous contents associated with these models pose a challenge for toxicological assays to accurately

3 ity and relationships in this wealth of data pose a challenge in interpretation.

4 r of degrees of freedom and lack of symmetry pose a challenge to studying the chemical details of the

5 Food allergies pose a considerable world-wide public health burden with

6 he onset of biological invasions before they pose a continental-wide threat.

7 Vascular malformations pose a diagnostic and therapeutic challenge due to the b

8 hat increased drought frequency and severity pose a formidable challenge to maintaining soybean yield

9 dynamic of identity-protective cognition to pose a friendly challenge to Jussim (2012).

10 ewater releases from New Delhi hospitals may pose a greater AR exposure risk to residents than believ

11 ds, our study shows that microplastic fibers pose a greater risk to C. dubia, with reduced reproducti

12 regions of the world, mosquito-borne viruses pose a growing threat to human health.

13 nome-wide binding data, but at the same time pose a hard computational inference problem.

14 Some camel-related activities may pose a higher risk of MERS-CoV infection, as may cross-b

15 Damaged mitochondria pose a lethal threat to cells that necessitates their pr

16 ureus infections of the skin and soft tissue pose a major concern to public health, largely owing to

17 metal content.Carbapenem-resistant bacteria pose a major health threat by expressing metallo-beta-la

18 ly polymeric molecule of peptidoglycan (PG), pose a major problem for the release of progeny virions.

19 Abs) against adeno-associated viruses (AAVs) pose a major, unresolved challenge that restricts patien

20 sults suggest that CIV-H3N2 reassortants may pose a moderate risk to public health and that the canin

21 d our observations strongly suggest that LCs pose a more severe danger to human health than cigarette

22 g a new standard of care, these two articles pose a number of important questions for future investig

23 ChIP-seq, these high throughput experiments pose a number of unique quality control and analysis cha

24 Endothelial dysfunction may pose a particularly significant risk factor in the devel

25 oalkyl substances (PFASs) contained in AFFFs pose a potential environmental and health risk, critical

26 mmals without prior adaptation and therefore pose a potential public health risk.

27 the mitochondrial and nuclear genomes could pose a problem for mitochondrial replacement therapy (MR

28 ther mito-nuclear interactions are likely to pose a problem for MRT.

29 These sparse but robust observations pose a problem in that the coesismic uplifts of the foot

30 n cystathionine beta-synthase deficiency may pose a problem.

31 Cells producing virus pose a risk for reinitiating infection within niches ina

32 e not in sufficiently high concentrations to pose a risk of intoxication.

33 tential endocrine-disrupting properties, may pose a risk to early embryonic development and cellular

34 g from natural excretion and medical use may pose a risk to fish.

35 susceptible to these emerging strains, which pose a risk to global wheat production, because the fung

36 barium-based phenological research, but also pose a serious challenge regarding efficient data collec

37 s for the extraction of tantalum and niobium pose a serious threat to human beings and the environmen

38 Heat waves and air pollution episodes pose a serious threat to human health and may worsen und

39 rs can modulate antibiotic activity and thus pose a significant challenge to antibiotic treatment.

40 c particles resulting from traffic emissions pose a significant risk to human health and also contrib

41 lel, contaminants in the air that we breathe pose a significant threat to human health.

42 otential use as instruments of bioterrorism, pose a significant threat to the developed and the devel

43 development and shows that CNT and asbestos pose a similar health hazard.

44 ng behavior of organoids and gastruloids may pose a slight challenge to this novel ethical approach.

45 These biases pose a source of uncertainty in environmental analyses,

46 rulent pathogen strains such as 'Ug99' (5,6) pose a threat from long-distance dispersal out of East A

47 ases spreading over large agricultural areas pose a threat to food security.

48 ndogenous sources and chemotherapeutics, and pose a threat to genome stability and cell survival.

49 le for substantial crop losses each year and pose a threat to global food security and agricultural s

50 As infectious diseases pose a threat to host integrity, eukaryotes have evolved

51 f antigenically distinct H3N2 variants which pose a threat to public health.

52 d that environmental and metabolic aldehydes pose a threat to these individuals by promoting degradat

53 These asymmetric responses pose a tractable challenge to process-based models attem

54 Brain motion in these recordings pose a unique challenge.

55 materials by cosmic rays and neutrons, which pose a variety of hazards through atomic displacements f

56 This virus has spread rapidly and has posed a significant public health threat since the outbr

57 expectorating infectious cough aerosols, and posed a threat of transmission of extensively drug-resis

58 In vivo detection of DA poses a challenge due to the low concentration and high

59 This poses a challenge for centers that may not be ready to h

60 Their repetitive nature poses a challenge for genome assembly and makes progress

61 This under-determinedness poses a challenge for the quantitative characterization

62 n of material dimensions to the atomic scale poses a challenge for traditional measurement and interf

63 ontaneously metastasizing tumor models still poses a challenge requiring highest sensitivity and exce

64 This poses a challenge to single molecule image analysis.

65 ular resources to viral replication, it also poses a challenge to the maintenance of cellular functio

66 istance to the EGFR-targeting drug cetuximab poses a challenge to their effective clinical management

67 This variability in streamflow responses poses a challenge to water resource management in the no

68 e telecommunication wavelength of 1.3 microm poses a challenge, as the growth mechanism for axial con

69 difficult, so that food authentication often poses a challenge.

70 However, the use of allogeneic CAR T cells poses a concern in that it may increase risk of the occu

71 ural variant frontotemporal dementia (bvFTD) poses a daunting challenge for clinicians but will be cr

72 ated, evolving landscape of cancer mutations poses a formidable challenge to identify cancer genes am

73 nplanar samples in ambient mass spectrometry poses a formidable challenge.

74 tic bands from the various components, which poses a fundamental problem to this analytical technique

75 cted to nearest neighbours are observed, and poses a fundamental question of how complex interactions

76 phenotype as two complex objects, this also poses a general statistical problem of testing associati

77 ively generated in the past few years, which poses a great challenge to data interpretation.

78 Antimicrobial resistance poses a growing threat to public health and the provisio

79 udy conclusively establish that ATM activity poses a major barrier to oncogenic transformation in the

80 The development of drug resistance in cancer poses a major clinical problem.

81 y affects patients' quality of life but also poses a major economic burden to the health care system.

82 art et al. contend that general intelligence poses a major evolutionary puzzle.

83 te vascularization of engineered dental pulp poses a major hurdle towards successful implementation o

84 ears to develop in higher organisms, it also poses a major obstacle for CNS repair later in life.

85 spread of drug-resistant bacterial pathogens poses a major threat to global health.

86 n the malaria parasite Plasmodium falciparum poses a major threat to the control and elimination of m

87 e storms-mesoscale convective systems (MCSs)-poses a particular challenge, because they organize dyna

88 noise that fluctuates in intensity over time poses a particular challenge.

89 rophic water containing cyanobacteria toxins poses a potential risk to soil animals.

90 Therefore, ER stress poses a promising target in colorectal cancers, which de

91 e Zika virus (ZIKV) epidemic in the Americas poses a public health emergency that requires a swift re

92 on and an indoor or outdoor environment that poses a risk of increases in body core temperature and/o

93 f Zika virus in the male reproductive system poses a risk of sexual transmission.

94 waters; however, whether this pharmaceutical poses a risk to aquatic organisms is debated.

95 od chains due to the rapid industrialization poses a serious threat on the environment.

96 n warming, acidification, and deoxygenation, poses a serious threat to marine organisms.

97 common waterhemp (Amaranthus tuberculatus), poses a serious threat to sustained crop production.

98 nt of antimicrobial-resistant (AMR) bacteria poses a serious worldwide health concern.

99 ) outbreak in the Americas and South Pacific poses a significant burden on human health because of ZI

100 Acute sore throat poses a significant burden on primary care and is a sour

101 low-band-gap photoelectrocatalytic materials poses a significant challenge for the generation of chem

102 Tumour heterogeneity poses a significant challenge for treatment stratificati

103 Behavioral resilience in mosquitoes poses a significant challenge to mosquito control.

104 ce conservation of the 120 human SH2 domains poses a significant challenge to selectively perturb the

105 transdermal delivery of protein therapeutics poses a significant challenge.

106 ls to flexible, thin, or low-cost substrates poses a significant challenge.

107 This poses a significant clinical dilemma because DAPT interr

108 This poses a significant contribution to the North Sea methan

109 ds, particularly in the diabetic population, poses a significant healthcare burden.

110 Obesity poses a significant risk of developing type II diabetes

111 which not only harms living beings but also poses a significant risk to damage materials placed in c

112 catalytic CO2 conversion to useful chemicals poses a significant scientific challenge.

113 This intratumor genetic heterogeneity poses a substantial challenge for the implementation of

114 g individual patients and among communities, poses a substantial challenge to efforts to interrupt tr

115 This poses a substantial problem of self-regulation that main

116 are resistant to existing antifungal agents poses a substantial threat to human health.

117 d processes of living cells at the nanoscale poses a unique analytical challenge, as cells are dynami

118 ed host community composition and structure, posing a grave threat to all amphibian populations.

119 he phase and amplitude of scattered light is posing a great challenge.

120 croalgae that can accumulate in the foodweb, posing a health threat to human seafood consumers and wi

121 infected resting CD4+ T cells (rCD4 cells), posing a major barrier to curing HIV-1 infection.

122 nic mycotoxins may contaminate food and feed posing a public health issue.

123 fp-type PPTases remain poorly characterized, posing a significant barrier to the exploitation of cyan

124 ciparum parasites lacking this protein, thus posing a significant public health problem, which could

125 ity that might confound the study results or pose additional risk to the patient.

126 of network data increases dimensionality and poses additional challenges for common machine learning

127 everted back to near-native crystallographic poses after being perturbed.

128 pe and biopersistent properties and thus may pose an asbestos-like inhalation hazard.

129 Neurodegenerative diseases pose an extraordinary threat to the world's aging popula

130 Drug-resistant bacterial pathogens pose an urgent public-health crisis.

131 Therefore, our findings indicate that BCA2 poses an additional barrier to HIV-1 infection: not only

132 troguanidine determination in water and soil poses an analytical challenge due its high hydrophilicit

133 However, too much IKs under basal conditions poses an arrhythmogenic risk.

134 the diversity and functionality of proteins poses an enormous challenge, as this requires large, pre

135 of short-chain chlorinated paraffins (SCCPs) poses an exceptional challenge to analytical chemists.

136 coupled with a shortage of available donors, poses an urgent clinical need for the development of inn

137 n the nonconcentrated water extract that was posing an antiandrogenic activity equal to 45.5 (+/-13.7

138 rtality among immunocompromised individuals, posing an urgent need for new antifungal therapeutic str

139 with Brd4 for determining the ligand binding pose and rationalizing subsequent structure-activity dat

140 We pose and solve a statistical mechanical model of gas ads

141 ed that these ligands adopt distinct binding poses and engage different subsets of residues, despite

142 proposed 4D biofabrication process does not pose any negative effect on the viability of the printed

143 al dispersion of repolarization, which could pose arrhythmogenic risk in LQTS patients.

144 Synthetic somatostatin analogs have been posed as a potential source of error in somatostatin rec

145 atopoietic stem cell transplantation (HSCT), posing as a significant barrier against the widespread u

146 the donor pool and ensures organ donation is posed at every end-of-life care pathway.

147 cs of the adult central nervous system (CNS) pose barriers to axonal regeneration and functional reco

148 near-native structures from a set of docked poses based on their calculable properties.

149 ity and activity patterns under the pressure posed by a pandemic threat.

150 information to evaluate the combined threat posed by climate change and invasions to existing PAs an

151 ionary theories about the two major problems posed by cooperation: generating and distributing benefi

152 We address questions posed by experiments that show small-chain alcohols redu

153 iginal cohort established the cardiac threat posed by high blood pressure, high cholesterol, smoking,

154 The present article reviews the challenges posed by infective endocarditis and outlines current and

155 re are limited data on the burden of disease posed by influenza in low- and middle-income countries.

156 information technology and target challenges posed by needs of quantum and neuromorphic computing.

157 ion via the mucosal route, but that the risk posed by oral secretions from individuals with a typical

158 t the reproductive opportunities and threats posed by potential mates and rivals.

159 The results highlight the challenge posed by quantitative single cell analysis and the impli

160 The question most commonly posed by researchers across multiple communities was: wh

161 impact was evaluated using sample questions posed by researchers retrieved from Biostars, a site foc

162 tems, and associated risks for food security posed by rumen fluke infection, it is imperative that we

163 re, we explore the risk of accidental spread posed by self-propagating gene drive technologies, highl

164 to navigate the opportunities and challenges posed by such recurrent interactions.

165 nstructing a cell mimic is a major challenge posed by synthetic biologists.

166 The challenge posed by the competition of nonnative stabilization agai

167 cus on the potentially greater health threat posed by the covert search for performance-enhancing age

168 both pushed to their limits by the challenge posed by the highly flexible tetranitromethane molecule.

169 ns open to question, owing to the challenges posed by the highly variable host star and the low spect

170 Due to the atomic coordinate errors posed by the limitations of low-resolution RNA three-dim

171 the magnitude of the public health challenge posed by the prolonged mechanical ventilation population

172 commentary, we highlight a crucial challenge posed by the proposal of Lake et al. to introduce key el

173 In response to the global health emergency posed by the Zika virus (ZIKV) outbreak, brain organoids

174 ity composition and that the relative threat posed by these two fundamental drivers varies across eco

175 nds region, but the ecotoxicological hazards posed by this complex bitumen-derived material-including

176 To estimate risk posed by this pathway, neonicotinoid residues were analy

177 ollectively, these data highlight the threat posed by TOP2-induced DSBs during transcription and demo

178 ow to address challenges to causal inference posed by wealth's cumulative nature and how to operation

179 mpanzees [2], we tested the alternative view posed by Wrangham et al.[1] in the chimpanzee population

180 ibiting spatial and temporal variations that pose challenges for designing robust therapies.

181 Rare cancers pose challenges for diagnosis, treatments, and clinical

182 This may pose challenges to achieving optimal efficacy, safety, a

183 ear cell type that requires Clrn1 expression pose challenges to therapeutic investigation.

184 guidance with remarkable specificity, but it poses challenges for determining the precise binding int

185 This poses challenges for labeled line theories of informatio

186 trimeric (gp160)3, cleaved to (gp120/gp41)3] poses challenges for vaccine development.

187 s, as well as the hydrophobic nature of Wnt, poses challenges to laboratory-based investigations of i

188 illions of candidates is in high demand, but poses challenges.

189 follow-up duration, and vaccine composition posing challenges for public health decision making.

190 s' hopes for healing were often unrealistic, posing challenges for the clinicians caring for them.

191 captured by typical thin-section histology, posing challenges for the study of tissue physiology and

192 pericardial disease in cancer patients also posed clinical challenges.

193 If a substantial number of low energy docked poses cluster in a narrow vicinity of the native structu

194 the complexity of the pathogenesis, however, pose considerable challenges to researchers.

195 Silicic volcanic eruptions pose considerable hazards, yet the processes leading to

196 Adverse drug reactions (ADRs) pose critical public health issues, affecting over 6% of

197 At 1 minute, no meter result from ICUs posed dangerous or significant risk by error grid analys

198 T term was wrong, and three crystallographic poses differed from both predictions.

199 protecting groups at C17-OH and C18-OH have posed difficult challenges.

200 ve and of limited mechanistic insight, which poses difficulties for reliable distinction between true

201 widespread nature of peri-implant bone loss poses difficulties in the management of biological compl

202 tially eligible patients were treated, which poses dilemmas for policymakers, payers, and society.

203 Contaminated sites pose ecological and human-health risks through exposure

204 ollowing its legalization in some countries, poses emergent oral and periodontal health concerns.

205 public health emergencies and disasters may pose ethical challenges.

206 However, this approach poses ethical problems, given that the donor is exposed

207 ing these fragments surpasses the challenges posed even by the construction of the parent drug scaffo

208 lows the prediction of the bioactive binding pose for this series of GluN2C-selective positive allost

209 accurately (<1-A rmsd) the crystal structure poses for four known heparin-protein structures.

210 odern cities fueled largely by fossil energy poses formidable challenges for establishing a sustainab

211 Cs in adult injured CNS is not well defined, posing fundamental questions about the design and implem

212 arming and freeze-thaw cycle (FTC) frequency pose great ecological challenges to organisms in alpine

213 Heterogeneity of protein glycosylation poses great challenges for analysis that is key to under

214 ilitates whole genome methylation study, yet posing great challenges for differential methylation det

215 mmalian genome, certain genomic loci/regions pose greater challenges to the DNA replication machinery

216 eat depression in older adults, they tend to pose greater risk for adverse events because of multiple

217 oamides (e.g., DCAM), and therefore they may pose greater risks to drinking water consumers given the

218 aternal intervention or treatment that might pose harm to the fetus.

219 d, atmospheric ultrafine particles (<100 nm) pose health risks because of, e.g., their capability to

220 eception of the consumer but also because it poses health risks e.g. from possible methanol admixture

221 ded us of the threat tropical cyclones (TCs) pose in the eastern North Pacific (ENP) and the importan

222 and prevent the long-term effects generally posed in source zones.

223 This attenuated response may pose increased risks on typical brain development result

224 Positive-sense RNA viruses pose increasing health and economic concerns worldwide.

225 This broad set of ligand-bound poses is then used to investigate general properties of

226 agonists, rituximab, or mycophenylate, which pose known or unknown risks to the fetus.

227 d islet survival and their impaired function pose limitations to this approach.

228 ures considered to be aerosol-generating may pose little infection risk to HCP.

229 are likely to provoke seizures, while others pose little or no risk.

230 nd around the world because they continue to pose major public health challenges.

231 ysically isolated biopsies of a single tumor poses major barriers to the identification of biomarkers

232 rare disease, adolescent type 2 diabetes now poses major challenges to paediatric and adult diabetes

233 airborne respirable crystalline silica (RCS) poses major health risks in many industrial environments

234 nt staphylococci and streptococci infections posing major threats to human health.

235 of an "energy funnel", the carotenoids still pose many open questions.

236 linked RecQ4 is the least studied because it poses many technical challenges.

237 that can engage their target using alternate poses may enable productive structure-based optimization

238 n addition, the emergence of drug resistance poses new threats to longer-term use and highlights the

239 a known toxin, when in fact the protein may pose no real danger.

240 By contrast, leader males pose no threat to each other and congregate in large gro

241 That this poses no significant problem for the neonate, but does f

242 re research will build on these findings and pose novel questions about how to continue to reduce the

243 ic infection by the Epstein-Barr virus (EBV) poses numerous health risks, such as infectious mononucl

244 other emerging influenza viruses continue to pose pandemic threats.

245 d mortality annually, while emerging viruses pose potential pandemic threats.

246 onsumer goods, from which they can leach and pose potential threats to human health.

247 Chronic methamphetamine use poses potentially devastating consequences for directly

248 ng explicit rate constants results in an ill-posed problem with a vast number of potential solutions.

249 However, this is in most cases an ill-posed problem, as the affiliation of a node to a single

250 rated by random genomic insertion approaches pose problems of unreliable expression, and thus there i

251 This may pose problems with managing adverse effects and the desi

252 ften suffer from contamination by homodimers posing purification challenges.

253 ence of an intriguing regulatory network and poses questions as to the functional compatibility and s

254 of new vaccines and immunotherapy approaches poses questions regarding the mechanism by which the mam

255 sequencing (WGS) are entering clinical use, posing questions about their incremental value compared

256 tions for treatment of severe agitation that poses risk to patient or staff safety or threatens inter

257 by centralized waste treatment (CWT) plants pose risks to aquatic and human health.

258 ethyl carbamate through wine consumption may pose risks to consumer health, since calculated MOE valu

259 Mercury contamination in food can pose serious health risks to consumers and coal-fired po

260 these contaminated vegetables and grains may pose serious health risks.

261 ociated bleeding and pathological thrombosis pose serious risks to hospitalized patients.

262 ace weather' events caused by solar activity pose serious risks to human health, safety, economic act

263 not only driving species to extinction, they pose serious threats to human health and wellbeing.

264 deficits in rodents and humans and therefore poses serious health hazards around the world.

265 a Rh-allyl intermediate.Reduction of allenes poses several challenges in terms of chemo-, regio- and

266 This poses several challenges similar to those encountered in

267 Extreme biotic and climatic events pose severe hazards to tropical rainforests.

268 It has also been shown that AgNPs can pose significant burdens to the environment from life cy

269 Although these conditions collectively pose significant health care problems, drug companies se

270 Fibres of a similar nature may pose significant health risks to humans.

271 tion (MR) is a complex valve lesion that can pose significant management challenges for the cardiovas

272 he complex nature of long-distance dispersal poses significant challenges for quantitative research (

273 expected impacts of climate change on kelp, poses significant risks for the persistence of kelp fore

274 Ongoing climate change poses significant threats to plant function and distribu

275 pensive, labor intensive and time consuming, posing significant limitations to their wide-scale explo

276 A multidisciplinary panel posed six clinical questions in a Population, Interventi

277 matics and the paucity of commercial sources pose some obstacles to the general use of these reactive

278 However, mecC-harboring MRSA strains pose special difficulties in their detection.

279 sis of data produced by bisulfite-sequencing poses statistical challenges owing to low and uneven seq

280 Intra-tumor heterogeneity poses substantial challenges for cancer treatment.

281 We conclude that each scenario poses substantial threats.

282 o the creation of new targets, many of which posed synthetic challenges that required the invention o

283 In this paper, we pose the following working hypothesis: in humans, transc

284 enges of predicting which viral variants may pose the greatest threats for zoonotic and pandemic emer

285 In this paper we pose the question to what extent sequence- and structure

286 nary embolus, and mental status change cases posed the greatest difficulty for student learners.

287 ependent activation of p38 MAP kinase, which posed the important question of how Epac2 engages p38 wi

288 he seven major serotypes of BoNT/A-G, BoNT/A poses the most serious threat to humans because of its h

289 pread of bacterial resistance to antibiotics poses the need for antimicrobial discovery.

290 This poses the question of how NBP35 (Nucleotide-Binding Prot

291 al distribution of different cell types, and poses the question of whether alternative networks could

292 Wrapping of genomic DNA into nucleosomes poses thermodynamic and kinetic barriers to biological p

293 ang Province, the major grain base of China, posing threats to food security in the context of growin

294 The hazard plastic debris poses to biodiversity is well established, but mitigatio

295 rane-bound bitopic protein-protein complexes pose tremendous challenges for structural studies by cry

296 Menninghaus et al. pose two open-ended questions: To what extent do formal

297 range contraction as abundance declines may pose unexpectedly large extinction risks to harvested sp

298 cyanographene, aminographene, graphene acid pose unique and well defined chemical and physical prope

299 nct from functional) tricuspid regurgitation pose unique challenges.

300 that predicted by GIST, for one of these the pose without the GIST term was wrong, and three crystall