ライフサイエンスコーパス: positive charge

1 uckminster Fuller have exactly 12 pentagons (positive charges).

2 ining aqueous nanodroplets that carry excess positive charge.

3 nge on the 6'-substituent and the drug's net positive charge.

4 probably by neutralization of its side chain positive charge.

5 ransition state, with an overall decrease in positive charge.

6 clude a hydrophobic region followed by a net positive charge.

7 her sites in the pore to host this important positive charge.

8 n of an oxygen atom to 1 and the loss of one positive charge.

9 (0) depends primarily upon the presence of a positive charge.

10 was tolerated, suggesting participation of a positive charge.

11 water is uniquely proficient in delocalizing positive charge.

12 n which the oxygen is under the influence of positive charge.

13 ively charged amino acids to interact with a positive charge.

14 or near the Mg(2+) site, due to its high net positive charge.

15 LNA with 2'-glycylamino-LNA, contributing a positive charge.

16 ed by, but does not require, the presence of positive charge.

17 f our detection method for transmitters with positive charge.

18 recovery only for peptides that carried net positive charge.

19 , peptides react to contain fixed, permanent positive charges.

20 fications of intracellular proteins that add positive charges.

21 dual ability to stabilize both negative and positive charges.

22 but not for a mutant with extreme clustered positive charges.

23 actin analogues with an increasing number of positive charges.

24 de chain cyclodepsipeptide that contains two positive charges.

25 specific regions within Ssb characterized by positive charges.

26 s a potential candidate for counterbalancing positive charges.

27 iched in aromatic residues and surrounded by positive charges.

28 s were nanoparticulate (199nm) with a slight positive charge (21.82mV); CLG-shAnx2 was of similar siz

29 tes were long MWNT-OVA (~386nm), bearing net positive charge (5.8mV), or short MWNTs-OVA (~122nm) of

30 strongly affected by the graphene charge: a positive charge accelerates the motion, whereas a negati

31 t analysis of the reaction kinetics revealed positive charge accumulation in the transition state (rh

32 Moving the positive charge also restored open-channel blocker inter

33 sting of a cyclopentadienyl cation bearing a positive charge and a negatively charged BF3 unit.

34 while maintaining a proper distance between positive charge and aromatic ring (Me13) or with homolog

35 This modification leads to the loss of a positive charge and reduction in hydrogen-bonding abilit

36 lpha-helical 30-residue sequence, with a net positive charge and several aromatic amino acids, as a p

37 substitutions were used to determine if the positive charge and susceptibility to posttranslational

38 predicted by the presence of domains of high positive charge and that PRC1 components from a variety

39 ar localization of SF2/ASF and that both the positive charge and the methylation state are important.

40 Further analysis reveals that positive charge and volume of residue 436 are determinan

41 is in partially oxidized form-it is bearing positive charges and its emission is quenched.

42 bosomal proteins by neutralizing unfavorable positive charges and thus facilitate their transports.

43 ccepting capabilities), ammonium (preserving positive charge), and methylene (preserving neither pi-a

44 oximately 320 amino acids long with dominant positive charge, and its interaction with sulfated GAG-p

45 AMPs differ in length, composition, and net positive charge, and the tested bacteria include two wil

46 When a binding event occurs, positive charges are formed in the nanosphere, leading t

47 he negative deviation observed when the four positive charges are replaced by four negative charges b

48 We found that only 3 positive charges are similarly positioned and essential

49 heir lack of a ribose moiety, phosphate, and positive charge as present in m7-GMP.

50 atibility with proteins bearing considerable positive charge as well as modulation of molecular align

51 and identify symmetry-related clustering of positive charges as one mechanism by which HSPG binding

52 e charge, while Lu, Hgamma, and Sibeta carry positive charges; as the number of O-based ligands incre

53 hesized with the aim to decrease the overall positive charge associated with these molecules and incr

54 formed by Asp313 and Glu341 to stabilize the positive charge at C2.

55 egative charge at the substrate C(alpha) and positive charge at C4' of the cofactor, consistent with

56 ber of O-based ligands increases so does the positive charge at Lu, which in turns shortens the Lu...

57 Removal of the positive charge at Lys544 or a negative charge in the C-

58 Histidine carries a partial positive charge at neutral pH, and so our result suggest

59 odified activated carbon (ZrOx-AC) possesses positive charge at pH lower than 7, and FTIR analysis de

60 directed mutagenesis, we demonstrated that a positive charge at position 435 is required but not suff

61 and R75V) at this position suggest that the positive charge at position 75 in Cx32 is required for n

62 port the idea that Arg at position 295 and a positive charge at positions 141 and 363 are required fo

63 ations at R175 are active, indicating that a positive charge at R175 is not necessary.

64 abilization of intermediates that accumulate positive charge at the acetal carbon atom.

65 tion of a lysine isosteric residue bearing a positive charge at the appropriate position leads to the

66 his shows that there is a strong, developing positive charge at the benzylic position in the transiti

67 Membrane permeabilization is enhanced by a positive charge at the carboxy terminus of the peptide,

68 The compensating positive charge at the exposed surface of GTO charge dis

69 Introducing a positive charge at the Glu-68 site (the E68R mutation) i

70 were introduced per subunit to increase the positive charge at the inner surface of the capsid.

71 therefore, better able to support incipient positive charge at the locus of reaction.

72 exon9 charge-changing mutations, providing a positive charge at the substituted amino acid residue, w

73 The positive charge at the vacuum surface that compensates t

74 conformation in this variant is caused by a positive charge at this site in the protein.

75 -aminoproline (amp), was used to specify the positive charges at the Xaa positions of (Xaa-Yaa-Gly) t

76 electively labeled at their N-termini with a positive charge-bearing group, are subjected to controll

77 two chlorophylls was found to be broken, the positive charge being preferentially located on P(D1).

78 K mutant features an overall accumulation of positive charges between helices H-IV and H-II.

79 II binding motif PXXPXRpXR, where additional positive charges between the two constant arginine resid

80 transition state that has considerably less positive charge buildup on the incoming nucleophile and

81 he smaller tip sizes for proteins with a net positive charge but not for proteins with a net negative

82 Redistribution of positive charges by placing three Lys residues at both t

83 The positive charge carrier (hole) mobility in TIPS-pentacen

84 for applications such as lasers because the positive-charge carriers (holes) have a large thermal ac

85 ged fatty acid ligands to neutralize the net positive charges caused by the excess monolayer of Cd io

86 engths, the former being stronger due to the positive charge centralized on the pyridyl nitrogen, N-H

87 s captured by the nanoparticles owing to its positive charge (chitosan coating).

88 ulomb energy as a result of bringing the two positive charges closer together in the folded structure

89 paration of soluble and insoluble subsets by positive charge clustering (area under the curve for a R

90 ucture-based mutational studies revealed two positive-charge clusters, near the center and apex of th

91 ty of the AAD band increases with increasing positive charge, consistent with a greater population of

92 free-OH stretch red-shift with increasingly positive charge, consistent with a Stark effect as a res

93 ioning of hydrophobic moieties while keeping positive charges constant.

94 A hole is a site of positive charge created when an electron is removed.

95 ly through a hydrogen bond network using net positive charges created upon oxidation of a heme iron (

96 This leads to greater positive-charge delocalization in the superelectrophiles

97 )O(6)(+) entity that defines the boundary of positive-charge delocalization.

98 of the two nitrogen atoms, and a state with positive charge delocalized over both nitrogen atoms.

99 yaniline frameworks, which provide large net positive charge densities, excellent structural stabilit

100 fferent groups of anti-HS peptides with high positive charge densities.

101 re problems for its toxicity due to the high positive charge density and non-degradability although t

102 Thus, ions of increasing positive charge density increasingly distort the E2 bind

103 tions in the C-terminal cluster reducing the positive-charge density completely abolished binding of

104 lenges, such as how to decrease the multiple positive charges derived from basic amino groups, which

105 ation/reduction, C1-O1 bond orientation, and positive charge development around the anomeric carbon.

106 ids and thus may moderate the combined local positive charge, diminishing tropomyosin-actin interacti

107 Thirty positive charges distributed throughout the mature domai

108 4) while electrostatic repulsion and loss of positive charge due to destruction of oxonium and pyridi

109 BMV mutants with decreased positive charges encapsidated lower amounts of RNA while

110 e, coupled to the surrounding region of high positive charge, explain the remarkable ability of SNM1A

111 arges impact CRY2 homo-oligomerization, with positive charges facilitating oligomerization and negati

112 inker forms a straight alpha-helix, with the positive charges facing the lipid phosphates of the inne

113 or its recognition and binding by SRP, while positive charges fine-tune the SRP-signal sequence affin

114 nium chloride) (PDDA) was used to create net positive charge for carbon atoms in the nanotube carbon

115 embrane-active small molecules featuring two positive charges, four nonpeptidic amide groups, and var

116 Because of their positive charge, 'free' (non-chromatin associated) histo

117 The acpcPNA probe contains a single positive charge from the lysine at C-terminus and causes

118 Ultrafast transfer of positive charge from the molecular assembly to a metal o

119 ein-mediated signal transduction, removal of positive charge from this residue produced a signalling-

120 protein receptors requires the removal of a positive charge from water.

121 In addition, a string of consecutive positive charges generally had a more significant effect

122 more pathogenic mutations involving loss of positive charge have been identified in the S4 segments

123 cales of the evolution of the photogenerated positive charge (hole) and the subsequent proton transfe

124 d correlation exists among the extent of the positive charge, hydrophobicity, and amphipathicity of a

125 enotypically associated with reduced surface-positive charge, (iii) this net reduction in surface-pos

126 However, engineering an increasingly positive charge in a critical phosphorylation site, S318

127 Introducing a second positive charge in addition to that at K95 did not incre

128 ipathicity is at least as important as their positive charge in enabling them to participate in innat

129 charge, (iii) this net reduction in surface-positive charge in graR and vraG mutants, in turn, corre

130 Both Caf20p and Eap1p contain stretches of positive charge in regions of predicted disorder.

131 aller tip sizes for proteins that have a net positive charge in solution, and additional high-charge-

132 ization of negative charges or addition of a positive charge in the Cx26 equivalent region reduced th

133 roA's catalytic strategy is to stabilize the positive charge in the EPSP cation.

134 We further show that the threshold of positive charge in the mutant CALR C terminus influences

135 ine substitution (G347R), which introduces a positive charge in the ninth transmembrane domain (TMD)

136 ates with SUMO1 and not SUMO2, due to a more positive charge in the SUMO1-loop.

137 of the C-S bond cleavage an increase of the positive charge in the trityl moiety and of the spin den

138 compensates energetically for the absence of positive charge in their structures.

139 e, glutamate, and lysine demonstrated that a positive charge in this position prevents alpha-conotoxi

140 Mutation of a conserved patch of positive charges in FtsN(Cyto) to negative charges aboli

141 ovirus coinfection suggested that additional positive charges in NLS regions restrict mobilization in

142 inserted into the membrane to position more positive charges in the cytoplasm, suggesting an interpl

143 The rPrP mutant without positive charges in the middle region reduced the amount

144 Thus, additional positive charges in the phage RuvC binding site apparent

145 The positive charges in the signal sequence helped it to ove

146 We find that mutation to remove positive charges in these residues in STIM1 prevents its

147 utational modeling shows that the introduced positive charge interacts with PI(4,5)P2 in TRPV6.

148 sign strategy has led to the introduction of positive charges into the vicinity of the heme edge thro

149 Both functions require the lysine's positive charge; intriguingly, the positive charge of K1

150 ted that electrostatic repulsion between the positive charge introduced at position 124 and the sodiu

151 tated by the high density of extra framework positive charge introduced by the dicationic structure d

152 tion in monomers and dimers (most of the net positive charge is equally distributed among the TTF gro

153 pose that although the exact location of the positive charge is not crucial for normal pore propertie

154 gesting that the exact location of the fixed positive charge is not crucial to support high conductan

155 According to XPS and Raman, the positive charge is proposed to transfer from MB to GONR

156 proteoliposomes, indicating a reaction where positive charge is rapidly displaced into the proteolipo

157 a modified Tat-based CPP (Tatm) with reduced positive charge is secreted efficiently, but its transdu

158 tion of the initial state, i.e., whether the positive charge is smeared over the molecule or localize

159 That the positive charge is the main effector of transition state

160 Subsequently, positive charge is transported out of the cell associate

161 izing them to contain a net fixed, permanent positive charge, is described.

162 t the PAH is associated with only 70% of the positive charges it could hold while the AH remains most

163 t the physiological pH sphingosine has a net positive charge, its interaction with negatively charged

164 consistent with occurring between the upper positive charge layer and the negative screening layer a

165 n of the mutant (AaLS-pos) revealed that the positive charges lead to the uptake of cellular RNA duri

166 termined the relative energy of a state with positive charge localized on one of the two nitrogen ato

167 interest as antiinfectives) bind with their positive charge located in the same region as the cyclop

168 propose that a surface of H3 with an excess positive charge may be the binding site for heparin.

169 stry, and a more extensive delocalization of positive charge may need to be incorporated into descrip

170 ased from 4.0 to 6.0, indicating that higher positive charges (measured trough zeta potential) in the

171 change by AdiC is strongly electrogenic with positive charge moved outward, and thus that AdiC mainly

172 we demonstrate that ion beams, due to their positive charging nature, may be used to observe and tes

173 enzymes, demonstrating that simply placing a positive charge near N5 of the flavin does not guarantee

174 cent work has focused on the importance of a positive charge near N5 of the reduced flavin.

175 or coordination with Mg(2+), accumulation of positive charge near N7 of guanine can stabilize the exp

176 ater interfaces can 'snorkel', placing their positive charge near negatively charged phospholipid hea

177 specificity, most notably the necessity of a positive charge near the end of TMH1 in the C-terminal d

178 The high positive charge not only modulates specific HVR binding

179 eoretical calculations indicate that induced positive charge occurs in the Au atoms which are adjacen

180 The positive charge of Arg-436, located within the HA stretc

181 bined data indicate that the positioning and positive charge of Arg-61 synergistically contribute to

182 e Arg155, interacts with the PB and that the positive charge of Arg155 plays a key role in photoprote

183 From these results, we propose that the positive charge of arginine 193 in the SH3-like domain o

184 basic proteins by SPR, wherein the naturally positive charge of basic protein was utilized to immobil

185 Because of the positive charge of CPZ, the presence of negatively charg

186 lysine's positive charge; intriguingly, the positive charge of K100 can be neutralized by acetylatio

187 The positive charge of Lys53 is critical for flavin reductio

188 omain of Set9 with RelA, we propose that the positive charge of lysine 310 is critical for the bindin

189 ion efficiency, which may correlate with the positive charge of most CPPs, has emerged as one of the

190 A reduction in the net positive charge of myelin basic protein (MBP) via deimin

191 vely high Hamaker constant combined with the positive charge of Pu(IV) colloids under typical groundw

192 Mutation of these residues increases the positive charge of the active site and is expected to af

193 al in vivo, indicating the importance of the positive charge of the arginine/lysine residue for dimer

194 The positive charge of the Cu-NPs imparted by the PEI allowe

195 Increasing the positive charge of the cytoplasmic surface of the N-term

196 Correlation between the increased positive charge of the D + 2 and T + 2 side chains and f

197 The overall positive charge of the HBR was needed for the interactio

198 Critically, the positive charge of the lysine residues was necessary for

199 rkable correlation was found between the net positive charge of the peptides and their capacity to in

200 e chains, resulting in a decrease in the net positive charge of the protein.

201 lation with lysine mutations (preserving the positive charge of the residue) increased the turnover r

202 Positive charges of acetylable lysine residues in the N-

203 When positive charges of lysines were eliminated by acetic an

204 This suggests that the positive charges of residues 126, 160, and 187 are requi

205 e hydrated electrons will reduce the overall positive charges of the CTA(+) covered Au NPs and decrea

206 Acetylation-mediated neutralization of the positive charges of the lysine residues in the N-termina

207 ses, that reversible titration of the excess positive charges of the reflectins, comparable with that

208 phospholipid vesicles can enhance the local positive charge on a membrane and attract RNA polynucleo

209 s, the negative charge of the NA exceeds the positive charge on capsid.

210 ticle formation and reactivity, and that the positive charge on CO increases due to the stronger adso

211 n incorporation into MTs by neutralizing the positive charge on K252 and allowing tubulin heterodimer

212 8) for elevated stability and 2) addition of positive charge on MB (RC5K) for greater DNA associabili

213 That the 6-bromo substituent increased the positive charge on selenium was confirmed by NPA-analysi

214 the iodide and cyanide ions and the partial positive charge on the alpha carbon in the gas phase tra

215 oth DMF and DMA that increases the extent of positive charge on the amide, leading to C-H bond deacti

216 support into acceptor molecules results in a positive charge on the Au.

217 stabilizes the canonical resonance form with positive charge on the beta-nitrogen and negative charge

218 ng pocket and the other lobes coordinated by positive charge on the cysteine-rich head region and res

219 The adsorbed polyelectrolytes create a positive charge on the fiber surface that physically att

220 hromosome congression in cells also requires positive charge on the Hec1 tail to facilitate microtubu

221 With loss of the positive charge on the K42H side chain at high pH, the e

222 figuration is nonrepulsive, despite the high positive charge on the molecules.

223 te that increased stabilization of a partial positive charge on the nitro-substituted carbon in both

224 hat intramolecular hydrogen bonding and high positive charge on the nitronyl carbon could facilitate

225 light scattering established the presence of positive charge on the prepared nanocomposite.

226 d a sweeter mutant Y65R, containing an extra positive charge on the protein surface, in conditions mi

227 hifts suggest that the delocalization of the positive charge on the side arm over the three nitrogens

228 Guanidinium groups and increasing positive charge on the side chain enhance affinity and a

229 upport a model in which the local effects of positive charge on the translocation kinetics dominate o

230 The positive charge on two of these lysines, Lys(49) and Lys

231 ently exposed to 185-nm UV light to generate positive charges on Au surfaces, and their activities we

232 hanging the surface friction by immobilizing positive charges on the constriction's walls primarily a

233 This liberates positive charges on the histone tail and allows for tigh

234 ys(620), and Lys(660), which form a triad of positive charges on the NOSoxy surface.

235 Positive charges on the PCL fibrous substrate were estab

236 he effects of the number and distribution of positive charges on the transport time and transport eff

237 harge, and we noticed a correlation between (positive) charge on the catalytic domain and bacteriolyt

238 of this complex pointed to delocalization of positive charge onto both the beta-silyl groups and the

239 greater ability of FHCs 3 and 4 to stabilize positive charges opposed to Cp 2 favors a stepwise mecha

240 Transport of positive charge or holes in DNA occurs via a thermally a

241 The ability of DNA to transport positive charges, or holes, over long distances is well-

242 mately 24% of the unit-cell volume as highly positive-charged organic templates were manipulated to c

243 n of helical segments into the membrane, and positive charges orient the protein with respect to the

244 The high surface area with a positive charge over the neutral pH range (pH 5-8) of Ol

245 amounts of RNA while mutants with increased positive charges packaged additional RNAs up to approxim

246 ospholipids and add an excess of up to three positive charges per phosphate group.

247 ding interface is highly electrostatic, with positive charge present on both C2 epitopes and compleme

248 is preoxidized, caused by the oxygen-induced positive charge produced on the perimeter Au atoms.

249 In vivo, positive charge promoted liver uptake.

250 uadruplex serves as an effective conduit for positive charge rather than as a hole trap when inserted

251 by which Arg methylation and the associated positive charge regulate the activities of SF2/ASF and e

252 minor polypeptides and exhibits an increased positive charge relative to Hbb(s) due to the net loss o

253 Abolishing either positive charge restored surface expression.

254 An intragenic suppressor introducing a positive charge restores membrane binding after mutating

255 ations that block methylation and remove the positive charge result in the cytoplasmic accumulation o

256 his, coupled with the presence of C-terminal positive charges, results in abortive insertion of this

257 ntaining predicted disordered segments, with positive charge runs, are enriched for nucleic acid bind

258 and Fe(III) tetraphenylporphyrins with their positive charges seemed likely to bind up to two axial C

259 Analogues with five positive charges show the lowest activity.

260 and convert the polymer from a neutral to a positive-charged state, hence triggering the negative-ch

261 ructures of the CiOi(SiI) cluster result for positive charge states in dramatically distinct electron

262 ts, high-exposed surface coverage sites, and positive charge streams in saline.

263 r character of 1 that derives from its three positive charges substantially increases the intrinsic p

264 a typical MBL-beta-CASP domain, a region of positive charge surrounds the active site of SNM1A, whic

265 ere we show that jumping droplets gain a net positive charge that causes them to repel each other mid

266 arization of the core electrons by the added positive charge that impacted the intraparticle charge d

267 nding site is located near a local pocket of positive charge that is complementary to the negatively

268 its hydration sphere and takes on a residual positive charge that promotes its binding to endogenous

269 of HufH19-20 as a template showed a loss of positive charge that protrudes at the C terminus of doma

270 phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA th

271 ee-base or zinc porphyrin bearing peripheral positive charges ((TMPyP(+))M (tetrakis(4-N-methylpyridy

272 es hydride shift pathways to translocate the positive charge to a remote position and enables ring fo

273 en binding site, allowing for an increase in positive charge to enhance the interaction with the nega

274 xclusive use of arginine over lysine for the positive charge to neutralize DNA.

275 gnal enhancing tag that imparted a permanent positive charge to the vitamin and reduced the limit of

276 rearrangements resulting in the exposure of positive charges to bulk solvent rather than to lipid ph

277 The maximum number of positive charges to maintain the activity are three to f

278 pid membranes in response to the addition of positive charges to membrane surfaces.

279 mphipathic polypeptides with substantial net positive charges to translocate across lipid membranes i

280 t these materials do not obey a conventional positive charge-transfer picture, but instead exhibit a

281 ium ether formation, and the resulting fixed positive charge triggers a characteristic fragmentation,

282 f the R262 sidechain in CaiT indicates how a positive charge triggers the change between outward-open

283 rings led to an increase in the guest total positive charge up to 4+ and simultaneously generated tw

284 oated Ad complex significantly increases net positive charge upon exposure to hypoxic tumor microenvi

285 an M412K point mutation in TMC1 that adds a positive charge, we found that Ca(2+) permeability and c

286 ed state, primarily changing from +13 to +17 positive charges, whereas beta-casein had charge states

287 f symmetry, presumably producing a region of positive charge which can interact with the negatively c

288 rocarbon groups at these sites bear a slight positive charge, which enhances anion binding without di

289 Inner-shell photoionization creates positive charge, which is initially localized on the iod

290 reveals the presence of a cluster of exposed positive charges, which potentially explains the affinit

291 mechanism for unfolding and a novel role for positive charges, which we propose chaperone negative ch

292 Thus, mutations that ablate the arginine's positive charge while retaining the hydrophobic contacts

293 has been reported that nanoparticles with a positive charge will bind more efficiently to negatively

294 se peptide or protein ions carrying multiple positive charges with either free low-energy (~1 eV) ele

295 effect to the Coulombic interaction of these positive charges with the negative charge borne by the i

296 ne, and that sequential reduction of the net positive charge within the first EF-hand domain of PLCze

297 function is EB1-independent but requires net positive charges within Ctail which essentially contribu

298 We also find that accumulation of positive charges within the auxiliary motif can diminish

299 ing that the membrane interaction depends on positive charges within the linker.

300 Neutralization of the positive charges within the sequence (121)KRWRK(125), wh