ライフサイエンスコーパス: positive inotropic

1 ation of IGF binding protein-3 blocked IGF-1-positive inotropic action in ferret papillary muscles.

2 te sympathetic tone, effects that mirror the positive inotropic action of AM in the heart.

3 est that the same signal responsible for the positive inotropic action of ouabain, i.e. net influx of

4 The positive inotropic actions of IGF-1 were not associated

5 reduction, P=0.005), to receive intravenous positive inotropic agents (31% risk reduction, P<0.001),

6 The positive inotropic agents EMD 57033 or CGP 48506 (1 micr

7 linical guidelines recommend targeted use of positive inotropic agents in highly selected patients, b

8 o determine hospital variation in the use of positive inotropic agents in patients with heart failure

9 -CMs display robust contractile responses to positive inotropic agents, such as myofilament calcium s

10 gery and is generally modified by the use of positive inotropic agents, volume resuscitation, and pac

11 ay become a lead compound for a new class of positive inotropic agents.

12 ought to assess the effects of combined oral positive inotropic and beta-blocker therapy in patients

13 neously beating isolated heart caused marked positive inotropic and chronotropic effects, respectivel

14 inhibitor that acts rapidly and exerts both positive inotropic and direct vasodilator effects in pat

15 Thus, HNO/NO(-) has positive inotropic and lusitropic action, which unlike N

16 Ca2+-dependent binding to troponin C, exerts positive inotropic and lusitropic effects in failing hum

17 (ANG) type 1A receptor (AT(1A)R) results in positive inotropic and lusitropic effects in isolated ad

18 the primate heart, thyroid hormone produces positive inotropic and lusitropic effects in the resting

19 nduced phospholamban phosphorylation and the positive inotropic and lusitropic responses in cardiomyo

20 1A)R-deficient knockout (KO) mice, exhibited positive inotropic and lusitropic responses to both ANG

21 Lipid emulsion exerts rapid, positive inotropic and positive lusitropic effects in bo

22 protein kinase A (PKA) pathway, resulting in positive inotropic and relaxant effects in the heart.

23 iability and are known to be associated with positive inotropic, but not toxic, effects of ouabain in

24 r were receiving intravenous vasodilators or positive inotropic drugs were excluded.

25 l/L) markedly inhibited the beta1-AR-induced positive inotropic effect and increase in cAMP but alone

26 Cardiac glycosides exert a positive inotropic effect by inhibiting sodium pump (Na,

27 indings suggest that levosimendan exerts its positive inotropic effect by mechanisms that do not invo

28 ence that diacylglycerol can induce a strong positive inotropic effect in mammalian ventricular muscl

29 Endogenous ET-1 has a tonic positive inotropic effect in normal subjects, independen

30 ol, another beta2-AR agonist, induced a full positive inotropic effect in SHR myocytes even in the ab

31 ffect of sotalol has a reverse use-dependent positive inotropic effect in the intact heart.

32 Endogenous NO has a small baseline positive inotropic effect in the normal human heart, whi

33 role of the P2X(4) receptor in mediating the positive inotropic effect of ATP.

34 in a paracrine mechanism whereby the direct positive inotropic effect of beta(1)-adrenergic stimulat

35 These effects were attributed both to the positive inotropic effect of beta-stimulation, which was

36 The widely accepted model to explain the positive inotropic effect of cardiac glycosides invokes

37 activators and "deep" release mimicking the positive inotropic effect of ET-1.

38 , heterologous PKD expression suppressed the positive inotropic effect of ET1 seen in control cells,

39 ed in the absence of an effect of CCh on the positive inotropic effect of ISO in eNOSnull myocytes.

40 LPS treatment significantly reduced the positive inotropic effect of isoproterenol in NTG myocyt

41 esults show that lack of IP3R2 abolishes the positive inotropic effect of neurohumoral stimulation wi

42 and (d) it may be possible to dissociate the positive inotropic effect of ouabain from its growth-rel

43 The increase in net work was due to the positive inotropic effect of phenylephrine, which was si

44 ed by an increase in DeltaGATP, and that the positive inotropic effect of pyruvate can be explained b

45 ostulated cellular mechanisms underlying the positive inotropic effect of pyruvate, however, are cont

46 or APJ constitute a signaling pathway with a positive inotropic effect on cardiac function and a vaso

47 ge-dependent sodium channels, resulting in a positive inotropic effect on the heart.

48 hibits Na+-H+ exchange, ET-1 did not cause a positive inotropic effect or intracellular alkalinizatio

49 iacylglycerol in cardiac tissues, produced a positive inotropic effect that was similar to the respon

50 9) on isolated cardiomyocytes demonstrated a positive inotropic effect via increasing calcium transie

51 gnaling which, in turn, negates cAMP-induced positive inotropic effect via inhibiting sarcolemmal Ca2

52 In contrast, in work-loop contractions, the positive inotropic effect was accompanied by a reduced d

53 This positive inotropic effect was dose dependent, stereospec

54 In vivo SSA78 infusion in mice results in a positive inotropic effect with enhanced contractile func

55 the prediction that allopurinol would have a positive inotropic effect without increasing energy expe

56 After this initial positive inotropic effect, rhTNF-alpha treatment led to

57 CHF, Ang II (10(-6) mol/L) produced a slight positive inotropic effect.

58 ation, which contributes to the NOS1-induced positive inotropic effect.

59 hances atrial Ca(2+) signalling and exerts a positive inotropic effect.

60 ation of APD by sotalol is associated with a positive inotropic effect.

61 =10), allopurinol (200 mg IV) caused a small positive inotropic effect; (dP/dt)(max) increased from 3

62 t study is the first to show that apelin has positive inotropic effects in vivo in both normal rat he

63 -ATPase activity probably contributes to the positive inotropic effects observed at EGCG concentratio

64 Thus, we conclude that the positive inotropic effects of both beta1- and beta2-AR s

65 The positive inotropic effects of IGF-1 were not associated

66 VES preserves the positive inotropic effects of isoproterenol that are oth

67 sarcolemmal Ca2+ fluxes responsible for the positive inotropic effects of solutions with reduced Na+

68 s controversial whether the sympatholytic or positive inotropic effects of these agents is the mechan

69 ular failure, enhanced CaTs during ECC exert positive inotropic effects on atrial contractility which

70 beta-Adrenergic signalling induces positive inotropic effects on the heart that associate w

71 nd 3 both reduce arterial pressure and exert positive inotropic effects on the heart.

72 rgic receptor (beta-AR) stimulation leads to positive inotropic effects, it can also induce arrhythmo

73 gain mechanistic insights into Akt-mediated positive inotropic effects, transcriptional profiles in

74 that lipid emulsion infusion exerts direct, positive inotropic effects.

75 ac output state, suggesting it has important positive inotropic effects.

76 bpm; P < .01) responses and abolition of the positive inotropic (left ventricular dP/dt: first dose,

77 nitroxyl (HNO) donor, Angeli's salt, exerts positive inotropic, lusitropic, and vasodilator effects

78 rdiovascular function, combining concomitant positive inotropic, lusitropic, and vasodilator properti

79 re, we report the cardiac effects of a novel positive inotropic peptide isolated from the toxin of th

80 The myocyte response was biphasic with a positive inotropic phase (39% increase in twitch amplitu

81 ardiac muscle to diacylglycerol, including a positive inotropic phase and a complex responsiveness to

82 depolarize the cell membrane eliminated the positive inotropic phase, but the negative inotropic res

83 rtmannin-sensitive pathway displays distinct positive inotropic properties by sensitizing the myofila

84 g the adenosine A2a receptor (A2aR)-mediated positive inotropic response and to define its contractil

85 left ventricular dP/dt max, the predominant positive inotropic response being due to the concomitant

86 by marked attenuation of beta(1)-AR-mediated positive inotropic response in isolated perfused hearts

87 led beta2- but not beta1-AR to induce a full positive inotropic response in SHR myocytes.

88 bit this activity and consequently produce a positive inotropic response in the heart.

89 uxotonically loaded ssTnI hearts whereas the positive inotropic response of isovolumic hearts or unlo

90 indicate that cTnI has a pivotal role in the positive inotropic response of the murine heart to beta-

91 ontractility but does not inhibit the native positive inotropic response of the right ventricle to in

92 ke graded "moderately reduced" or better, or positive inotropic response on dobutamine MRI.

93 uch "detubulated" cardiac myocytes showed no positive inotropic response to 20 nM ET-1, despite retai

94 h response to field stimulation and a robust positive inotropic response to 20 nm isoproterenol.

95 Inhibition of cardiac NO augments the positive inotropic response to beta-adrenergic receptor

96 PLB expression in hESC/iPSC-vCMs restores a positive inotropic response to beta-adrenergic stimulati

97 of PKA-dependent cTnI phosphorylation in the positive inotropic response to beta-adrenergic stimulati

98 hat inhibition of cardiac NO potentiates the positive inotropic response to beta-adrenergic stimulati

99 that cardiac nitric oxide (NO) inhibits the positive inotropic response to beta-adrenergic stimulati

100 WT mice maintained a positive inotropic response to dobutamine 8 weeks after

101 of neuronostatin significantly decreased the positive inotropic response to endothelin-1 (ET-1).

102 In contrast, the positive inotropic response to excitation of the aortic

103 Furthermore, a significantly greater positive inotropic response to high extracellular Ca2+ (

104 However, the positive inotropic response to isoprenaline was also blu

105 S1P inhibits the positive inotropic response to isoproterenol and this re

106 pharmacological features of the ATP-induced positive inotropic response were similar to those of the

107 on (EFS) of the atrial preparations evoked a positive inotropic response which is known to be mediate

108 tentiating effect on the beta(2)-AR-mediated positive inotropic response.

109 Hyperglycemia diminishes positive inotropic responses to agonists that activate p

110 Mammalian hearts exhibit positive inotropic responses to beta-adrenergic stimulat

111 The positive inotropic responses were mediated via the sympa

112 tion-contraction coupling, and the effect of positive inotropic stimulation on the spatial profile of

113 gnificantly lower in-hospital mortality than positive inotropic therapy in patients hospitalized with

114 The addition of a beta-blocker to positive inotropic therapy might attenuate this adverse

115 nts a short time after starting CPR prompted positive inotropic therapy.