ライフサイエンスコーパス: positive selection

1 d evolution (RDE2) screen that negates false-positive selection.

2 n them, were found to be the main targets of positive selection.

3 networks that have likely been influenced by positive selection.

4 unoglobulin genes, exhibiting antigen-driven positive selection.

5 development, whereas weak TCR signals induce positive selection.

6 dulating Runx3d induction rates during MHC I positive selection.

7 large census population sizes, and frequent positive selection.

8 selection, avian HSPA2 has been subjected to positive selection.

9 identify genomic regions that have undergone positive selection.

10 ow several canonical signatures of recurrent positive selection.

11 T cell numbers due to impaired negative and positive selection.

12 wing the identification of 1,318 genes under positive selection.

13 g in their interaction showing signatures of positive selection.

14 ture thymocytes caused by impaired thymocyte-positive selection.

15 Erk signaling and increased the threshold of positive selection.

16 roevolution standpoint, these are subject to positive selection.

17 resented relative to random chance, implying positive selection.

18 transit from double-negative stage 4 through positive selection.

19 quences that does not require peak shifts or positive selection.

20 t occur independently and sequentially after positive selection.

21 Viscum, indicative of highly relaxed if not positive selection.

22 e-receptor binding affinities are targets of positive selection.

23 gned to these same traits showed evidence of positive selection.

24 ecies and show no evidence of being fixed by positive selection.

25 with the idea that these epitopes are under positive selection.

26 substitutions in haDHSs are attributable to positive selection.

27 d Tanzania and to exhibit a strong signal of positive selection.

28 tal of 6810 gene trees have some evidence of positive selection.

29 t and approximate coalescent simulation with positive selection.

30 ivision of labor to be enriched for signs of positive selection.

31 l block at the pre-TCR checkpoint and during positive selection.

32 ne expression is rapidly extinguished during positive selection.

33 s, whereas TRC miRNAs appear to evolve under positive selection.

34 uced in DKO mice, implying defects in thymic-positive selection.

35 dicating the basal translation rate is under positive selection.

36 te of specific genes that are actively under positive selection.

37 ired to transmit weak TCR signals leading to positive selection.

38 lopment in the thymus, a phenomenon known as positive selection.

39 ereby sustaining Themis expression following positive selection.

40 tified 187 genes showing strong evidence for positive selection across all branches of the primate ph

41 our results provide compelling evidence for positive selection acting on some somatic mtDNA mutation

42 d trimers can be purified successfully via a positive-selection affinity column using the bNAb PGT145

43 of this arms race is better characterized by positive selection altering specific functions instead o

44 ed with stronger evidence for evolving under positive selection, although this varied between functio

45 We used coevolutionary and positive-selection analyses to characterize the genotypi

46 Positive-selection analysis and direct examination of pr

47 tations identified in genes putatively under positive selection and associated with virulence might h

48 evolutionary rates; and (iii) signatures of positive selection and coevolution of the extracellular

49 jor histocompatibility complex (MHC) undergo positive selection and differentiate into naive T cells

50 oteins VP1, p48 (NS1-2), and p22 (NS4) under positive selection and expands the known targets of noro

51 als that land plant TAL genes have undergone positive selection and gained several introns following

52 rchaeal species, suggesting they result from positive selection and have a functional role.

53 d that TSSP deficiency resulted in deficient positive selection and induced deletion of the BDC-6.9 a

54 sed in double-positive thymocytes undergoing positive selection and is sustained in immature single-p

55 T-cell receptor (TCR) signals by undergoing positive selection and lineage differentiation into sing

56 c variants that harbour signatures of recent positive selection and may facilitate physiological adap

57 he potential need to switch peptides between positive selection and negative selection to avoid the t

58 conclusions about the relative importance of positive selection and neutral drift in clonal evolution

59 elopment gene INNER NO OUTER (INO) was under positive selection and potentially contributed to the de

60 e substitutions were in genes evolving under positive selection and putatively associated with a mari

61 4(+)CD8(+) thymocytes, has a crucial role in positive selection and T cell development.

62 Both positive selection and the rate of copy-error mutations

63 across all gene categories, arguing against positive selection and toward genetic drift with relaxat

64 velopment occurred around the checkpoints of positive selection and, unexpectedly, negative selection

65 ers, are more often located in regions under positive selection, and are significantly enriched among

66 OXTR amino acid sites are under positive selection, and intramolecular and intermolecula

67 curring during thymopoiesis: beta-selection, positive selection, and negative selection.

68 nd the relative importance of genetic drift, positive selection, and relaxed purifying selection in t

69 tions in our study show signs of being under positive selection, and that these duplications are like

70 tion with divergence of one paralog and weak positive selection appear to underlie hidden orthology i

71 bears; nine of the top 16 genes under strong positive selection are associated with cardiomyopathy an

72 rotein structure; (ii) covarying sites under positive selection are enriched in resistant viruses; (i

73 ions are immediately beneficial and fixed by positive selection are most relevant to explain the long

74 ons, learning and cognition in regions under positive selection, as well as increased CpG methylation

75 ocus analysis, we found nominal evidence for positive selection at 14 of the loci.

76 rger young adult pools, and it was driven by positive selection at advanced ages in the presence of m

77 tation and detect 57 high-scoring signals of positive selection at innate immunity genes, variation i

78 There was no detectable signal of positive selection at species-specific GR binding sites,

79 Host-pathogen co-evolution and positive selection at the interfaces of host-pathogen co

80 pulations, and we found strong signatures of positive selection at the locus.

81 abling thymocytes to reach the threshold for positive selection, avoiding death by neglect.

82 Selectome is a database of positive selection, based on a branch-site likelihood te

83 across strains, and we identify codons under positive selection, both important considerations for th

84 B) kinase (IKK) kinase TAK1 underwent normal positive selection but exhibited a specific block in fun

85 etic membrane-targeted allele allows limited positive selection but is associated with proinflammator

86 analysis identifies other loci under recent positive selection, but a limited number of changes at t

87 product of various mutational processes and positive selection, but might also be shaped by negative

88 ptor (TCR) signaling in the thymus initiates positive selection, but the CD8(+)-lineage fate is thoug

89 Thus, THEMIS facilitates thymocyte positive selection by enhancing the T cell antigen recep

90 hus, this study proves that signaling during positive selection by lineage-specifying cytokines is re

91 CHMP5 enabled positive selection by promoting post-selection thymocyte

92 Instead, selective sweeps caused by positive selection can reduce diversity level more sever

93 However, following positive selection, CD31 expression differs dramatically

94 Here we report the creation of a new positive-selection cloning vector dubbed pKILLIN, which

95 cids into proteins; our method uses parallel positive selections combined with deep sequencing and st

96 demonstrate that the observed signatures of positive selection correlate better with the presence of

97 functional change; the results implied that positive selection could have targeted mtDNA.

98 ifferent fungal lineages, and residues under positive selection could provide targets for further exp

99 enhancers can be associated with genes under positive selection, demonstrating the power of this appr

100 Resistant cancer cells thus arise from a positive selection driven by BCL-XL modulation of RAS-in

101 ing clones featuring high plasticity undergo positive selection during consecutive stages of multiste

102 ected site and that A3Z3 hap V is subject to positive selection during evolution.

103 Residue 283, which has undergone positive selection during the evolution of human KIRs, a

104 nism responsible for increased productivity: positive selection effect in nonnative communities and p

105 Deltabiomass, indicating complementarity or positive selection effects.

106 etion efficiency and significantly increased positive selection efficiency.

107 these 'lineage-specifying cytokines' during positive selection eliminated Runx3d expression and comp

108 lf pMHC) to avoid autoimmune diseases, while positive selection ensures the survival and maturation o

109 ably, multiple cancer genes are under strong positive selection even in physiologically normal skin,

110 es self-tolerant T-cell generation following positive selection events that take place in the cortex.

111 The cells that stimulate positive selection express specialized proteasome beta-s

112 of strongly relaxed purifying selection and positive selection, followed by fixation and conservatio

113 ry with protease (chymotrypsin), followed by positive selection for binding via mRNA display.

114 ncestral primates were subjected to enhanced positive selection for bright-light vision and relativel

115 he ancestral amniotes, which featured strong positive selection for bright-light vision.

116 stor of the extant Mammalia was dominated by positive selection for dim-light vision, supporting the

117 tochondrial dynamics machinery and observe a positive selection for dynamin-related protein 1 (DRP1),

118 Positive selection for E. coli O157:H7 across the farms

119 evolutionary analysis revealed signatures of positive selection for FGF3 and FGF11, genes related to

120 The A or At genome may have undergone positive selection for fiber traits.

121 We detect signals of positive selection for genes involved in peroxidase and

122 ile sites from regions showing signatures of positive selection for homozygous deletions and identify

123 in this genetic region, with indications of positive selection for its variants, we decided to compa

124 For SCk1772, positive selection for K627 over E627 was observed in fe

125 al transcriptome sequencing, we found strong positive selection for low-light vision genes in owls, w

126 uggested that increased virulence arose from positive selection for mutations found in known and puta

127 However, positive selection for plasmid-encoded antibiotic resist

128 This apparent positive selection for reduced mitochondrial function in

129 and dN/dS ratios consistent with neutral and positive selection for several genes.

130 ificant age-related accumulation, suggesting positive selection for specific alleles at specific posi

131 isolates of L. pneumophila have a potential positive selection for the ER-retention KNKYAP motif.

132 Using a structure-function approach and positive selection for transgenic C. elegans, we explore

133 The IgG3-H435 allele may be under positive selection, given its relatively high frequency

134 es of modern humans and to determine whether positive selection has acted on these fragments.

135 The structural basis for positive selection has long been debated.

136 propose that illegitimate recombination, not positive selection, has driven the divergence of rpoA.

137 g(R)) plasmid, pQBR57, both with and without positive selection [i.e., addition of Hg(II)].

138 ential mutations are only accessible through positive selection if they are fixed simultaneously.

139 ical requirement for THEMIS during thymocyte positive selection, implicating THEMIS in signaling down

140 mpendium of genes that potentially underwent positive selection in >1 of these six species consisted

141 eas alleles within supertypes are subject to positive selection in a Red Queen arms race.

142 was found between likelihood convergence and positive selection in all three marine lineages.

143 Both the lack of signatures of positive selection in AMPs and lack of association betwe

144 related to genetic signatures ascribable to positive selection in Arctic or Antarctic mammalian spec

145 the functions of genes showing evidence for positive selection in B. taurus are enriched for neurobi

146 Further, we provide evidence for positive selection in bat Mx1 genes that might explain s

147 We found signatures of positive selection in bat NPC1 concentrated at the virus

148 homeostasis, has been suggested to be under positive selection in both European and Asian population

149 fied many cerQTLs that have undergone recent positive selection in different human populations, and s

150 r genes, wherein, these genes have undergone positive selection in eudicots, but not in grasses.

151 We find evidence of positive selection in genes encoding antiviral responses

152 We found signatures of positive selection in genes involved in chemoreception,

153 Detecting positive selection in genomic regions is a recurrent top

154 rlapping reading frames, which is subject to positive selection in genotypes 3 and 4.

155 mino acid substitutions occur at sites under positive selection in high-altitude catfishes, located a

156 In the first genome-scale analysis of positive selection in HSV-1, we found signs of selection

157 ood, we found evidence of similarly enhanced positive selection in human carriers of the PTPN22 C1858

158 ons that are likely to have undergone recent positive selection in humans (i.e., with a low NSS score

159 d in PDXs, indicating that events undergoing positive selection in humans can become dispensable duri

160 ancer activity and colocalizes with peaks of positive selection in humans.

161 which have been claimed to harbor signals of positive selection in Inuit populations due to adaptatio

162 The candidate genes potentially under positive selection in Jeju black pig support previous re

163 compare and identify putative signatures of positive selection in Jeju black pig, the true and pure

164 though pQBR57 survived both with and without positive selection in P. fluorescens, it was lost or rep

165 has experienced gene duplication and likely positive selection in paralogs of Or67b in D. melanogast

166 entify genomic regions showing signatures of positive selection in present-day Zoroastrians that migh

167 positive selection, similar to the block in positive selection in RORgammat transgenic mice.

168 ance that have been subjected to independent positive selection in several species; to determine prom

169 Maturation initiates after positive selection in single-positive thymocytes and con

170 f MHC class I-specific thymocytes undergoing positive selection in situ.

171 osomiasis susceptibility, resulting in their positive selection in sub-Saharan Africa.

172 of specific RSV genes revealed high rates of positive selection in the attachment (G) gene.

173 stical tests have failed to find evidence of positive selection in the epitopes targeted by CD8(+) T

174 We also detected 87 loci under positive selection in the expanded groups.

175 the relative importance of genetic drift vs. positive selection in the fixation of new gene duplicate

176 haplotype at the OAS locus was subjected to positive selection in the human population.

177 African populations; yet, strong evidence of positive selection in the OAS region is still lacking.

178 l domain of the protein was remodified under positive selection in the primate lineage; and (iv) MUC7

179 Thus, during positive selection in the spleen, BCR signaling causes i

180 also implicated in conferring flexibility to positive selection in the thymus, in controlling the mag

181 sess the presence of candidate signatures of positive selection in their genome, with the aim to prov

182 We detected hallmarks of positive selection in these evolved regulatory and codin

183 The identification of genes under positive selection in this fish reveals potential candid

184 We are the first to detect positive selection in this overlap region.

185 Several aging genes are under positive selection in this short-lived fish and long-liv

186 This suggests recent positive selection in three different species, and model

187 Twelve of them showed traces of positive selection in three species.

188 enotypic trait by scanning for signatures of positive selection in whole-genome sequencing data.

189 These results demonstrate a novel aspect of positive selection, in which TCR affinity for positively

190 admixture selection at traits evolving under positive selection, including skin color, lactase persis

191 cancers show particularly strong signals of positive selection, indicated by higher proportions and

192 of sites across the PLV genome evolve under positive selection, indicating that host-imposed selecti

193 chains and various MHC alleles, we show that positive selection-induced MHC bias of T cell receptors

194 ot restore iNKT cell numbers or the block in positive selection into the iNKT cell lineage in CD4-cre

195 to the earliest characterized block in post-positive selection intrathymic maturation of CD4 T cells

196 Positive selection is detected in the bindin coding regi

197 On the whole, our study suggests that positive selection is less pervasive in these butterflie

198 of evidence to show that the signal of FADS-positive selection is not restricted to the Arctic but i

199 e-TCR mediated selection, its role in thymic positive selection is unclear.

200 One locus of positive selection is unusual in that it encodes two dis

201 s demonstrate that NOD1 and NOD2 promote the positive selection/maturation of CD8 single-positive thy

202 carcinogenic potential and/or that are under positive selection may have important implications for v

203 mino acid substitutions inferred to be under positive selection may modulate coupling efficiency and

204 Positive selection occurs in the thymic cortex, but crit

205 ntigen receptor (TCR) engagement facilitates positive selection of a useful T cell repertoire.

206 ceptor programs, leading to broadly enhanced positive selection of B cells at two discrete checkpoint

207 ated family member 2 (Themis2) increased the positive selection of B1 cells and germinal center B cel

208 Positive selection of CD8 single-positive thymocytes was

209 r histocompatibility complex class I (MHC I) positive selection of CD8(+) T cells in the thymus requi

210 nd reproducible in vitro differentiation and positive selection of conventional human T cells from al

211 Both positive selection of cross-linked conformers using the

212 Positive selection of diverse yet self-tolerant thymocyt

213 ous girls might be the driving force for the positive selection of G6PD deficiency alleles.

214 The positive selection of immature CD4(+)CD8(+) double-posit

215 Thymoproteasome-independent positive selection of monoclonal CD8(+) T cells results

216 We find evidence for positive selection of mutations in transcription factor

217 We hypothesize that positive selection of novel phosphorylation sites in the

218 emia (BCL)6 by a functional pre-BCR mediates positive selection of pre-B cells that have passed the c

219 We observed positive selection of pre-LT variants and the appearance

220 xtremes by PAG corals was facilitated by the positive selection of preadapted symbionts.

221 , negative selection of effector T cells and positive selection of regulatory T cells.

222 are sufficient to alter B cell tolerance via positive selection of self-reactive transitional B cells

223 AChR-MG was further characterized by reduced positive selection of somatic mutations in the VH CDR an

224 These data, in combination with evidence of positive selection of the allele encoding p.Arg457Gln, s

225 faster germination may be implicated in the positive selection of the ancient PAPhy gene duplication

226 lloantigen that participates in negative and positive selection of the T cell repertoire.

227 o acids in the CDRH3s in both species showed positive selection of tyrosines and glycines, and negati

228 ained V/K/E polymorphism at PB2 residue 627, positive selections of E627 and K627 were observed in ch

229 Although positive-selection of recombinants in DNA cloning seems

230 We also found evidence for lineage-specific positive selection on a subset of genes related to trans

231 ent, early loss of arginine biosynthesis and positive selection on chitinase pathways.

232 pMap Project, we confirmed the signatures of positive selection on HFE in Asian populations and ident

233 We also identify signatures of positive selection on immune-related genes in the ancien

234 tolerance, indicating a more recent onset of positive selection on lactose tolerance than previously

235 and that optimal TCR responsiveness requires positive selection on major histocompatibility complex c

236 has revealed widespread footprints of recent positive selection on standing genetic variation.

237 in amino acid properties provide evidence of positive selection on the ND2 and ND5 genes against a ba

238 ndependent lines of evidence indicate strong positive selection on the region and suggest these high-

239 reover, we detected widespread signatures of positive selection on young male-biased genes.

240 -nucleotide variants (SNVs) all demonstrated positive selection or accelerated evolution in primates.

241 s sampling of the peptides within MHC during positive selection or T-cell activation is undefined.

242 n can only be performed either for affinity (positive selection) or for specificity (negative selecti

243 likelihood-based method for detecting recent positive selection, or selective sweeps.

244 Unlike species evolution, positive selection outweighs negative selection during c

245 eased proliferation of LCLs and demonstrated positive selection over time.

246 Our observations also indicated that positive selection played a crucial role on this bacteri

247 trypsin that may have evolved in response to positive selection pressure.

248 alyses found only a few strong signatures of positive selection, primarily in replication- and transc

249 gest that this relentless competition drives positive selection, promoting change in the sequences in

250 y approximately 4 coding substitutions under positive selection, ranging from <1/tumor in thyroid and

251 Mechanistically, positive selection resulted in the stabilization of CHMP

252 ockout (cKO) mice (HDAC3-cKO) was blocked at positive selection, resulting in few CD4 and CD8 T cells

253 e acquisition of mutations and antigen-based positive selection, resulting in retention of the highes

254 Furthermore, a CRISPR-UMI positive-selection screen uncovered new roadblocks in re

255 se molecules and suggest new concepts of TCR positive-selection signaling.

256 Some are subject to neutral drift or positive selection, similar to coding regions.

257 -related orphan receptor (ROR) gammat during positive selection, similar to the block in positive sel

258 ir natural host to human; 3) Six out of nine positive selection sites detected in spike (S) protein a

259 ring MERS-CoV's evolutionary history and the positive selection sites in MERS-CoV's S protein might e

260 compensatory substitutions without invoking positive selection, speculative mechanisms, or implausib

261 al situation, mature naive B cells undergo a positive selection step driven by self-antigens, kept in

262 Although we find some evidence of positive selection, substitution rate is negatively corr

263 f genomic regions that possess signatures of positive selection, suggesting adaptive geographical div

264 id residue in EKC viruses shows evidence for positive selection, suggesting that evolutionary pressur

265 he native glareolus mtDNA evolved under past positive selection, suggesting that mtDNA in this system

266 The influence of positive selection sweeps in human evolution is increasi

267 ptxD/Phi has proven to be a very efficient, positive selection system for the generation of transgen

268 polar bear lineage have been under stronger positive selection than in brown bears; nine of the top

269 ing selection and (ii) undergo less frequent positive selection than other genes.

270 ion can drive adaptations of immune genes by positive selection that erodes genetic variation (Red Qu

271 l lineages from different hosts can identify positive selection that is otherwise obscured by strong

272 ogenetic relationship, revealing patterns of positive selection that suggest a coevolution with viral

273 om the depleted sample displayed evidence of positive selection, the lambda genes in sIgkappa(+) cell

274 ates presented signatures of retention under positive selection, the majority of retained duplicates

275 netic mosaicism provides evidence for strong positive selection, the sequences of PorB serotypes comm

276 tral tolerance due to its expression by post-positive selection thymocytes, and expression of its lig

277 romotes medullary entry of the earliest post-positive selection thymocytes, as well as efficient inte

278 ice, demonstrating that HDAC3 is required at positive selection to downregulate RORgammat.

279 nificance that influenza virus evolves under positive selection to escape T cells.

280 We show that positive selection triggered by T cell help activates th

281 ividual methods implemented so far to detect positive selection under specific selective scenarios.

282 We show how positive selection via adhesion can be transformed into

283 A consistent signal of positive selection was detected in the Cebidae family, a

284 The strongest evidence of positive selection was in the glycosylated membrane prot

285 vents and found that the overall duration of positive selection was similar for all CD8(+) thymocytes

286 Using signatures of positive selection, we identify a small motif on rodent

287 T cells enriched by streptamer-based serial-positive selection were activated by CD3/CD28 engagement

288 Signatures of positive selection were also investigated.

289 bally relaxed at LSE genes, and codons under positive selection were detected in 50% of them.

290 At CYP3A5, strong signatures of positive selection were detected, though not connected t

291 Several candidate genes potentially under positive selection were involved in fatty acid transport

292 ike (S) protein of MERS-CoV was under strong positive selection when MERS-CoV transmitted from their

293 -76), for example, cause an arrest of T cell positive selection, whereas a synthetic membrane-targete

294 ensitive SWS2, were found to be under strong positive selection, which may be linked to the spectral

295 selected at least 4 times and is under rapid positive selection, which shows that dairy consumption h

296 In addition, reQTLs are enriched for recent positive selection with an evolutionary trend towards en

297 n to model the probabilities of mutation and positive selection with cell divisions.

298 ht on interesting global and local events of positive selection, with particular emphasis on the evol

299 e other species, we find strong evidence for positive selection within promoters of this species.

300 While a defect in positive selection would reflect an inability to generat