ライフサイエンスコーパス: post mortem

1 of sudden death medication-free individuals post mortem.

2 gh-resolution mapping of expression patterns post-mortem.

3 , and histology used to identify NK-92 cells post-mortem.

4 eurons of ALS patients carrying mutations at post-mortem.

5 e was diagnosed during life and confirmed at post-mortem.

6 ed at population level from extracted skulls post-mortem.

7 Tissues were collected post mortem (2012-2016), and histopathological images we

8 n Alzheimer's disease (AD) mouse model and a post-mortem AD case, confirming known plaque constituent

9 ses of 5hmC in DNA from prefrontal cortex of post-mortem AD patients, and RNA-Seq to correlate change

10 Here we address this issue by using post-mortem adult human brain and spinal cord samples or

11 and filamin were shown to break down during post mortem ageing of meat.

12 dorsi and their degradation products during post mortem ageing were investigated by gel electrophore

13 has the potential to be applied to identify post-mortem aging of chicken meat samples.

14 lues were also declined with the increase of post-mortem aging showing the presence of ample tenderne

15 utase 1-overexpressing mice as well as human post-mortem ALS spinal cord-derived astrocytes induce mo

16 Previous evidence from post-mortem Alzheimer disease (AD) brains and drug (espe

17 ing assay and in vitro autoradiography using post-mortem Alzheimer's disease brain tissue.

18 omparing Pittsburgh compound-B thresholds to post-mortem amyloid burden are lacking.

19 When compared to post-mortem amyloid burden, low proposed thresholds were

20 nic mice, which we further corroborated with post-mortem analyses in these animals as well as in huma

21 cts regularly consume alcohol (ethanol), and post-mortem analyses of opioid overdose deaths have reve

22 bout DCX-associated lissencephaly comes from post-mortem analyses of patient's brains, mainly since a

23 Post-mortem analysis has revealed reduced levels of the

24 roscale impact have hitherto been limited to post-mortem analysis of impacted specimens, which does n

25 Post mortem and real-time tissue distribution studies di

26 Gross post-mortem and histological findings were indistinguish

27 s different psychiatric disorders, including post-mortem and in-vivo studies in humans and experiment

28 a range of studies using diverse designs and post-mortem and in-vivo techniques show impairments of t

29 Both post-mortem and neuroimaging studies have identified abn

30 Post-mortem and neuroimaging studies suggest that the se

31 Taken together, these post-mortem and preclinical findings identify TG2 as a c

32 present both at Day 14 in vivo and at Day 28 post-mortem) and marked and long-lasting sensorimotor de

33 onsistent with and expand upon findings from post-mortem, animal and cerebrospinal fluid studies, and

34 Taphonomic processes affecting bone post mortem are important in forensic, archaeological an

35 Experimentally produced faults, observed post-mortem, are sealed by fluid-bearing micro-pseudotac

36 enting a validated consensus approach to the post-mortem assessment and scoring of cerebrovascular di

37 here are no generally accepted protocols for post-mortem assessment in cases of suspected vascular co

38 g and validation of the criteria, by blinded post-mortem assessment of brain tissue from 113 individu

39 nificantly enriched for genes upregulated in post-mortem autistic brain, including astrocyte and micr

40 ologists for decades because verification on post-mortem autopsy is not possible.

41 The post-mortem autoradiographic data showed that 18F-AV-145

42 Using post-mortem badger body weight records from 15 878 indiv

43 Post mortem biochemical staging of Alzheimer's disease i

44 Post-mortem blood was tested by serology.

45 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Post-mortem Braak staging of neurofibrillary tau tangle

46 ay approach for gene expression profiling in post mortem brain samples from patients with cirrhosis w

47 measures of correlated gene expression in a post mortem brain tissue data set.

48 oups, though, as with any method for imaging post mortem brain tissue, care should be taken when inte

49 mble changes observed in human schizophrenia post mortem brain tissues.

50 hesis has gained indirect support from human post-mortem brain analyses and genetic studies, little i

51 Post-mortem brain analyses and some genetic studies have

52 Six patients had post-mortem brain analysis available for assessment of n

53 been informed by both direct analysis of the post-mortem brain and by study of the biological consequ

54 AD using samples from four independent human post-mortem brain cohorts.

55 d no reliable method of diagnosis other than post-mortem brain examination.

56 Two patients underwent post-mortem brain examination.

57 Additionally, post-mortem brain extracts from patients with Alzheimer

58 ines and demonstrate its upregulation in the post-mortem brain from 15q11-13 duplication patients for

59 scovery and proteomics approach by comparing post-mortem brain material from schizophrenia patients a

60 le of the immune system in a large sample of post-mortem brain of patients with schizophrenia: RNA se

61 ) to measure metabolites and metals in seven post-mortem brain regions of nine AD patients and nine c

62 ression Consortium involving 12 human frozen post-mortem brain regions.

63 ripotent stem cell-derived motor neurons and post-mortem brain samples from ALS patients.

64 ed these to a series of fibroblast lines and post-mortem brain samples from individuals with either a

65 tant HTT and its oligomeric intermediates in post-mortem brain samples from patients with Huntington'

66 e-wide DNA methylation was quantified in 262 post-mortem brain samples, representing tissue from four

67 to examine mRNA expression of parvalbumin on post-mortem brain sections.

68 A series of post-mortem brain tissue and in vitro experiments sugges

69 Neuropathological analysis of post-mortem brain tissue demonstrated that pIRE1alpha is

70 f alpha-synuclein with PSEN1 was detected in post-mortem brain tissue from cognitively normal cases a

71 In a blinded study with post-mortem brain tissue from patients with Parkinson's

72 istant aggregates, which are also present in post-mortem brain tissue from patients.

73 We examined post-mortem brain tissue from six patients with lacunar

74 Tof-MS) and chemometrics for the analysis of post-mortem brain tissue from subjects with Alzheimer's

75 ongitudinal retrospective study, we analysed post-mortem brain tissue of all individuals with an Alzh

76 ously been employed to biochemically profile post-mortem brain tissue, and the novel methods describe

77 we conducted whole transcriptome analysis of post-mortem brain tissues (cingulate cortex) from SCZ, B

78 Post-mortem brain tissues from post-stroke dementia and

79 parate neuronal and glial DNA fractions from post-mortem brain tissues.

80 o define the tau PTM landscape present in AD post-mortem brain.

81 r from an independent (Oxford, UK) cohort of post-mortem brains (n = 74), we confirmed the significan

82 and TRIM33 in the human prefrontal cortex of post-mortem brains between subjects with and those witho

83 ation of GFAP and AQP4 immunoreactivities in post-mortem brains from adult baboons with cerebral hypo

84 Studies of post-mortem brains from Alzheimer disease patients sugge

85 motor cortex, hippocampus and cerebellum of post-mortem brains from HD individuals, particularly in

86 ide microRNA (miRNA) expression profiling in post-mortem brains from individuals with ASD and control

87 We analysed post-mortem brains obtained from a cohort of 85 subjects

88 VDAC1 is overexpressed in post-mortem brains of Alzheimer disease (AD) patients.

89 cortical, limbic and subcortical areas, from post-mortem brains of familial Alzheimer's disease (n =

90 Alcohol-dependent rats as well as post-mortem brains of human alcoholics and controls were

91 L), enhanced production of which is found in post-mortem brains of Parkinson disease patients.

92 Analysis of three independent data sets of post-mortem brains revealed signs of increased methylati

93 required to form the aggregates observed in post-mortem brains.

94 r 24 weeks of age, inflammation was assessed post-mortem by determining colon length and histological

95 deer that were analyzed for prion infection post-mortem by immunohistochemistry (IHC).

96 It is defined at post-mortem by the loss of dopamine neurons in the subst

97 tochemical experiments to detect epitopes in post-mortem CADASIL brains (n=8), control brains, and ce

98 ypt (LEC), limbus, cornea and conjunctiva of post-mortem cadaver eyes with laser microdissection (LMD

99 In 136 human forensic corpses, a post-mortem cardiac MR examination was carried out prior

100 In this post-mortem case series, we investigated several feature

101 ed in the cortex of R6/2 mice and HD patient post-mortem caudate tissue compared with controls.

102 climbing fibre-Purkinje cell synapses using post-mortem cerebellar tissue of essential tremor cases

103 Post-mortem cerebrospinal fluid and dissected cerebral l

104 Distinguishing ante-mortem pathology from post-mortem change has been a major constraint in diagno

105 ution NMR technique has been used to monitor post-mortem changes in salmon (Salmo salar) fillets upon

106 PSE was induced by incubation of post-mortem chicken carcasses at 37 degrees C for 200min

107 death, but data on the role of nonselective post-mortem CIED (pacemaker or defibrillator) analysis i

108 Post-mortem CIED analysis was clinically useful in assis

109 port were all cataloged in the Johns Hopkins Post-mortem CIED Registry.

110 Post mortem, cochlear gain disappeared.

111 A post-mortem cohort of pathologically confirmed cases wit

112 In age-matched post-mortem cohorts of Alzheimer's disease (n = 49), vas

113 This definitive, multi-centre study uses post-mortem confirmed cases as the gold standard to: (i)

114 lly, we show that Gomafu is downregulated in post-mortem cortical gray matter from the superior tempo

115 Implementation of post-mortem CT (PMCT), enhanced with targeted coronary a

116 Standard post-mortem CT methods were used to assess rib end morph

117 We then scanned the skeleton with whole-body post-mortem CT.

118 ong DNA templates and is limited by the fast post-mortem cytosine deamination rates of methylated epi

119 f cytosine to thymine mismatches, typical of post-mortem damage.

120 bly similar to profiles obtained from mature post-mortem DaNs.

121 Growing clinical, neuro-imaging and post-mortem data have implicated the cerebellum as playi

122 Extrapolation of post-mortem data predicts that a approximately 30% decli

123 SZ signal and increased the concordance with post-mortem data sets.

124 ty of 73.3% (95%CI: 61.9, 82.9%) relative to post-mortem detection.

125 caveats, and results of the TMA analysis of post mortem diagenesis in bone are discussed, and implic

126 Of these 64 athletes, 47 had a confirmed post-mortem diagnosis; the most common were hypertrophic

127 inal significance (P<0.05) in an independent post-mortem DLPFC data set (182 schizophrenia and 212 co

128 -sequencing on neuronal nuclei isolated from post-mortem dlPFC of cocaine addicts and healthy control

129 ned with DNA metabarcoding and assessment of post-mortem DNA damage allowed us to authenticate ancien

130 stid DNA metabarcoding and the assessment of post-mortem DNA damage.

131 simulates the entire molecular process from post-mortem DNA fragmentation and DNA damage to experime

132 array of tissues in a large number of human post-mortem donors.

133 data in a wide variety of tissue types from post-mortem donors.

134 In the post-mortem dorsolateral prefrontal cortex (DLPFC), we f

135 d by comparison with a grain map obtained by post-mortem electron backscatter diffraction (EBSD).

136 All subjects underwent detailed post-mortem evaluation, including histological analysis

137 Post-mortem evaluations of healthy grafted tissue in suc

138 Based on accumulating post-mortem evidence of abnormalities in Purkinje cell b

139 -demented individuals before death but whose post-mortem examination demonstrated significant amounts

140 ho did not have post-mortem examination, but post-mortem examination provided data that were otherwis

141 tive reactors to the skin test with positive post-mortem examination results (phenotype 1); ii) posit

142 tive reactors to the skin test regardless of post-mortem examination results (phenotype 2) and iii) a

143 ive reactors to the skin tests with positive post-mortem examination results (phenotype 3).

144 As a group, subjects who had post-mortem examination were not significantly different

145 In foxes with no evidence of ICH on post-mortem examination, 29 of 154 (18.8%) red foxes had

146 tly different from patients who did not have post-mortem examination, but post-mortem examination pro

147 In subjects who had post-mortem examination, older age (odds ratio = 1.13; 9

148 For those who had post-mortem examination, sudden unexpected death in epil

149 he three subjects who additionally underwent post-mortem examination.

150 t Centre for Epilepsy: 122 had comprehensive post-mortem examination.

151 ppearances and neurodegenerative features on post-mortem examination.

152 spp.) were determined in faecal samples from post mortem examinations performed on 42 males, includin

153 Post-mortem examinations in three patients confirmed neu

154 In all cases, circumstantial evidence and post-mortem examinations indicated drowning to be the mo

155 is and neuronal loss in two patients who had post-mortem examinations.

156 At 48h post-mortem, export quality loins were aged at -1.7 degr

157 ization, but contrast with known patterns of post-mortem Fe mineralization.

158 Additionally, pancreas samples obtained post mortem from a separate cohort of 21 children/adoles

159 genomic analysis of 2,693 samples collected post mortem from lung and extrapulmonary biopsies of 44

160 hat cytokine production by splenocytes taken post mortem from patients who died of sepsis is profound

161 By analyzing post-mortem gene expression data from the Allen Brain At

162 d the clinical utility and combined yield of post-mortem genetic testing (molecular autopsy) in cases

163 Evidence from post-mortem, genetic, neuroimaging, and non-human animal

164 Here, through post-mortem genome-wide transcriptome analysis of the la

165 with ER stress markers was observed in human post-mortem glaucomatous TM tissues.

166 ressed HTT protein in peripheral tissues and post-mortem HD brain tissue, as well as in tissues from

167 vation of increased type I IFN signalling in post-mortem hippocampal brain sections from patients wit

168 nalyzed the global gene expression data from post-mortem hippocampal tissue of 25 old (age >/= 60 yrs

169 tlas constructed from ultra-high resolution, post-mortem hippocampal tissue was used to label seven h

170 The present study is a preliminary post-mortem histological analysis of the effects of CR o

171 resonance imaging have been validated versus post-mortem histology in humans.

172 an primate model remains to be studied using post-mortem histopathologic techniques.

173 e first time and in contrast to the previous post mortem HRTEM observations, a sharp (010) phase boun

174 melanopsin-expressing ganglion cells in four post mortem human donor retinas.

175 d levels of active p38 MAPK were detected in post-mortem human ALS-FUS brain tissues.

176 eurodegeneration and support earlier work in post-mortem human brain that suggested loss of calcium b

177 ted glycoprotein to proteolipid protein 1 in post-mortem human brain tissue correlates with the degre

178 NT2 specifically labeled pathological tau in post-mortem human brain tissue from Pick disease, progre

179 s bind to amyloid-beta plaques in samples of post-mortem human brain tissue.

180 Finally, post-mortem human brain tissues of alpha-Syn(G51D) cases

181 hout the life span of various AD mice and in post-mortem human brain.

182 riant affecting gene regulation in cells and post-mortem human brain.

183 haracterized animal model of depression, and post-mortem human brains.

184 functional borders across species, including post-mortem human brains.

185 sh single mouse cortical cells and to frozen post-mortem human cortical nuclei, matching the performa

186 of their metabolites could be identified in post-mortem human kidney and muscle tissue based on simu

187 Anatomical investigations in animals and post-mortem humans have established that cerebro-cerebel

188 putamen, but not cerebral cortex samples, of post-mortem Huntington's disease patients when compared

189 ticography to identify epileptic animals and post-mortem immunohistochemistry to confirm blood-brain

190 y to ascertain the burden of tuberculosis at post mortem in medical inpatients at a tertiary care hos

191 We then identified GbbLCV-1 in post-mortem infant lung tissues demonstrating histopatho

192 ted Abeta proteoforms did not correlate with post-mortem interval, suggesting they are not artefacts.

193 chnical sources, such as sequencing date and post-mortem interval, we also identified several biologi

194 hich addressed the consent process, pre- and post mortem interventions, the determination of death, p

195 pmMRI should be considered as a feasible post-mortem investigation technique for the deceased pat

196 in conjunction with other minimally invasive post-mortem investigations (minimally invasive autopsy),

197 The gold standard of post-mortem investigations should include both PMCT and

198 curacy of PMCTA as a first-line technique in post-mortem investigations.

199 neuronal cell bodies, in accordance with the post-mortem literature.

200 This study aimed to investigate post-mortem magnetic resonance imaging (pmMRI) for the a

201 Post-mortem material was examined from two patients with

202 D1-type receptors has been conducted only on post-mortem material, with no differences in methampheta

203 sequencing of the viral genome directly from post-mortem material.

204 ly fatal pelvis injury was probably received post mortem, meaning that the most likely injuries to ha

205 Our findings demonstrate the potential of post-mortem measurement of myelin proteins and mediators

206 nd below, cracking in TiN was suppressed and post mortem measurements indicated a reduction in layer

207 spectroscopy measurements were performed in post-mortem mice brains using a flexible probe with an e

208 areas and 83 areas previously reported using post-mortem microscopy or other specialized study-specif

209 Monte Carlo simulations estimated post-mortem migration of Anisakis from viscera to flesh

210 vantages, researchers are often skeptical of post mortem MRI scans because of uncertainty about wheth

211 a thorough comparative study of in vivo and post mortem MRI scans in healthy male Wistar rats at thr

212 We assessed the accuracy of whole-body, post-mortem MRI for detection of major pathological lesi

213 Post-mortem MRI is a potential diagnostic alternative to

214 n of mucosal-associated invariant T cells in post-mortem multiple sclerosis brain white matter active

215 e connections between the redox imbalance in post-mortem muscle, early protein oxidation and the onse

216 expressed in Hfe(-/-) x Tfr2(mut) brain and post-mortem NBIA basal ganglia.

217 erns have been difficult to quantify through post-mortem neuropathology or in vivo scanning alone.

218 ted the primary motor cortices isolated from post-mortem normal control subjects, patients with famil

219 e, we examined genome-wide RNA expression in post-mortem nucleus accumbens from donors (N=26) with kn

220 IC1 expression in chronic brain lesions from post-mortem of patients with progressive multiple sclero

221 Clinical blood and plasma samples and post mortem oral swabs submitted to the Liberian Institu

222 ss-sectional distribution of tau reported in post-mortem pathology studies, in that the most commonly

223 s was prominent in end-stage SMA mice and in post-mortem patient spinal cords.

224 ted in the substantia nigra pars compacta of post-mortem PD brains as compared with age-matched contr

225 e retrieval was performed within 36 hours of post-mortem period.

226 o found that TG2 levels are increased in the post-mortem PFC of depressed suicide subjects relative t

227 o this, we conducted a systematic search for post-mortem, pharmacological, functional magnetic resona

228 ility of the method is first demonstrated on post-mortem porcine tissue.

229 d with results from a proteomic profiling of post-mortem prefrontal cortex from SCZ patients and with

230 e properties of the peptides released during post-mortem proteolysis of myofibrillar proteins.

231 Alongside post-mortem Pt determination in the tissues, the biodist

232 Murine and human WNV neuroinvasive disease post-mortem samples exhibit loss of hippocampal CA3 pres

233 rgeted or untargeted xenobiotic screening of post-mortem samples is normally conducted.

234 analyses revealed that liver, lung and heart post-mortem samples were marked by tissue abnormalities,

235 Evidence obtained from human post-mortem samples, of both variant Creutzfeldt-Jakob d

236 was acquired, followed by perfusion and two post mortem scans at two different MRI facilities.

237 illustrate the validity and utility of using post mortem scans in volumetric neurobiological studies.

238 In contrast, post mortem scans offer improved image quality and incre

239 he image quality is dramatically improved in post mortem scans.

240 22 anatomical structures between in vivo and post mortem scans.

241 We review post-mortem, serum-biomarker, CSF-biomarker, and neuroim

242 The trends revealed from experimentation on post-mortem skin are then used to identify the parameter

243 le that contains up to 3.5% ISF in 3.1s from post-mortem skin.

244 RI scans can be acquired from either live or post mortem specimens.

245 to demonstrate S-acylation of SOD1 in human post-mortem spinal cord homogenates from ALS and non-ALS

246 om four sequential respiratory samples and a post-mortem spleen sample of a woman presenting with bro

247 proteolysis of myofibrillar proteins during post-mortem storage, may be an indicator of the textural

248 Post mortem studies demonstrated that loss of RAB39B res

249 gamma oscillations, are reduced in number in post mortem studies of bipolar disorder and schizophreni

250 sed by animal models and confirmed by recent post mortem studies.

251 dict a growing convergence between hiPSC and post-mortem studies as both approaches expand to larger

252 Post-mortem studies have not identified an association b

253 Structural brain imaging and post-mortem studies in individuals with ataxia-telangiec

254 is disorder and new in vivo neuroimaging and post-mortem studies makes it timely to review this theor

255 Post-mortem studies of the anterior insula showed that t

256 Findings from post-mortem studies of the brain and from genomic and in

257 With respect to neurodegeneration after TBI, post-mortem studies on the long-term neuropathology afte

258 Post-mortem studies revealed (i) micrencephaly without p

259 Recent genetic, molecular and post-mortem studies suggest impaired dopamine (DA)-D2 re

260 ed notion by bringing together findings from post-mortem studies, non-invasive imaging (including stu

261 a modest reduction of Purkinje cells in some post-mortem studies, Purkinje cell axonal swellings (tor

262 In the post-mortem study we found that tyrosine hydroxylase sta

263 In a post-mortem study, a semi-quantitative analysis of tyros

264 s Evaluation of Advanced Cancer Environment) post-mortem study.

265 ot and immunohistochemical analysis of human post-mortem substantia nigra from Parkinson's disease su

266 ment of sepsis had unresolved septic foci at post mortem, suggesting that patients were unable to era

267 At post-mortem, surprisingly, the total number of N-methyl

268 myocardial infarction and hypointensities on post-mortem T2-weighted images as a possible method for

269 Through a combination of in vivo and post-mortem techniques, we aimed to characterize vascula

270 rvation method, with donor age </= 88 years, post-mortem time </= 63 h, overall preservation time </=

271 rs were mean aged 67.4 +/- 12.5 years with a post-mortem time of 20.7 +/- 14.7 h and ECD of 2641.0 +/

272 Main donor tissue parameters included age), post-mortem time, overall preservation time, preservatio

273 Post-mortem tissue analyses showed autolysis and retenti

274 Post-mortem tissue analysis indicates BBB damage in Alzh

275 First, in post-mortem tissue CYFIP2 expression was reduced by appr

276 th nuclear membrane markers, probably due to post-mortem tissue delay and fixation.

277 on-sensitive and disease-related proteins in post-mortem tissue from Alzheimer's disease, vascular de

278 the 18F-AV-1451 autoradiographic binding in post-mortem tissue from patients with Alzheimer's diseas

279 conducted in nigral dopaminergic cells from post-mortem tissue from patients with schizophrenia (n =

280 receptor subunits have been observed in the post-mortem tissue of autistic individuals [8, 9], and G

281 ith alpha-synuclein in amyloid aggregates in post-mortem tissue of patients with sporadic Parkinson d

282 x project is designed to serve as a data and post-mortem tissue resource to the research community.

283 tages of multiple sclerosis lesions in human post-mortem tissue revealed high levels of endothelin re

284 ugs of abuse as well as their metabolites in post-mortem tissue samples.

285 e explored the composition of Lewy bodies in post-mortem tissue using electron microscopy and immunog

286 The PET images matched ligand binding in post-mortem tissue, and histological markers of dopamine

287 WSB1 is in Lewy bodies in human PD post-mortem tissue.

288 ex vivo specimens, biopsy samples, and fixed post-mortem tissue.

289 defined using cytochrome-oxidase staining of post-mortem tissue.

290 resulting from partial RNA fragmentation in post-mortem tissues has a marked impact on global expres

291 rmalities reported in RPE cells studied from post-mortem tissues of affected m.3243A > G mutation car

292 Analysis of post-mortem tissues reveals reduced axonal dystrophy in

293 ed RNA samples, such as those collected from post-mortem tissues, can result in distinct expression p

294 d glaucoma, primary human TM cells and human post-mortem TM tissues, we show that increased ECM accum

295 in-5 in the brains of schizophrenic patients post mortem was observed compared to age-matched control

296 y (on both magnetic resonance imaging and at post-mortem) was evident in one patient.

297 fibular junction of 15 week-old C57BL/6 mice post mortem, we show the bone cortical porosity simultan

298 ective validation study, we did pre-autopsy, post-mortem, whole-body MRI at 1.5 T in an unselected po

299 A subset of older adults present post mortem with Alzheimer disease (AD) pathologic featu

300 emical differentiation of protein aggregates post-mortem would be advantageous for the insight into t