ライフサイエンスコーパス: post-transcriptional

1 n on transcriptional (expression levels) and post-transcriptional (3' RNA processing) regulation acro

2 Post-transcriptional adenosine-to-inosine RNA editing me

3 is pathway, such as alternative splicing and post transcriptional and translational modifications.

4 Here, we provide new insights into complex post-transcriptional and -translational hierarchies that

5 nd provides insight into co-transcriptional, post-transcriptional and cytoplasmic RBP functions for c

6 and differentiation at the transcriptional, post-transcriptional and epigenetic levels.

7 ves the way for characterizing the impact of post-transcriptional and post-translational modification

8 Post-transcriptional and post-translational regulation o

9 to an intricate network of transcriptional, post-transcriptional and translational processes.

10 COX-2 can be regulated at transcriptional, post-transcriptional and/or post-translational levels.

11 U6 RNA processing enzyme Usb1, reconstitute post-transcriptional assembly of yeast U6 snRNP in vitro

12 We reconstitute the post-transcriptional assembly of yeast U6 snRNP in vitro

13 link between ribosome heterogeneity and the post-transcriptional circuitry of gene expression.

14 ption of long genes and uncovered widespread post-transcriptional compensation at the cellular level.

15 the primary regulatory region that mediates post-transcriptional control by microRNAs and RNA-bindin

16 Post-transcriptional control by small regulatory RNA (sR

17 l regulators are subject to sRNA regulation, post-transcriptional control by sRNAs allows multiple en

18 the prevalence and functional impact of this post-transcriptional control layer requires technologies

19 pands our understanding of the combinatorial post-transcriptional control of gene expression at the 3

20 ding proteins (RBPs) play important roles in post-transcriptional control of gene expression, includi

21 shock domains, has several specific roles in post-transcriptional control of gene expression.

22 Such transposon-mediated post-transcriptional control of miR171 levels is conserv

23 Post-transcriptional control of mitochondrial gene expre

24 proteins (RBPs) play important roles in the post-transcriptional control of RNAs.

25 ction in mechanisms beyond microRNA-mediated post-transcriptional control, playing roles in DNA repai

26 teins have evolutionarily conserved roles in post-transcriptional coordination of pro-growth gene exp

27 w challenges emerge in the identification of post-transcriptional coregulatory modules and the geneti

28 Mechanistically, we show that inhibition of post-transcriptional cytosine-5 methylation locks tumour

29 ts, by inducing transcriptional silencing or post-transcriptional decay of mRNAs.

30 Transcription of TEs leads to their post-transcriptional degradation into siRNAs, and it has

31 Post-transcriptional deregulation is a defining feature

32 regulated by tissue-specific enhancers or by post-transcriptional differences in stability between th

33 upregulated by Cu deficiency and mediate the post-transcriptional downregulation of transcripts that

34 upregulated by Cu deficiency and mediate the post-transcriptional downregulation of transcripts that

35 2 associated death promoter (BAD) protein by post-transcriptional downregulation.

36 Finally, the variation of post-transcriptional editing patterns across diplonemids

37 development, thus indicating an unsuspected post-transcriptional effect on cancer genes.APE1 plays a

38 d genes, in line with this phenotype being a post-transcriptional event.

39 instead of CpG sites to study the effects of post-transcriptional events in mapping eQTL.

40 part, regulated by CDK9 dependent co- and/or post-transcriptional events involving SPT5 and ICP27.

41 eins (RBPs) are master regulators of co- and post-transcriptional events; however, their role in GBM

42 chain (Igk) and, furthermore, regulated the post-transcriptional expression switch from the membrane

43 ms regulating these events are well studied, post-transcriptional factors functioning in this cell fa

44 and U2 snRNPs, splicing regulators and other post-transcriptional factors in differentiated cells.

45 3'-untranslated regions (UTRs) specify post-transcriptional fates of mammalian messenger RNAs (

46 oforms with 3'-UTRs of different lengths and post-transcriptional fates.

47 initial signal transduction from subsequent post-transcriptional feedback events.

48 e propose that the main function of m(6)A is post-transcriptional fine-tuning of gene expression.

49 Although its functions in the regulation of post-transcriptional gene expression are beginning to be

50 of lncRNAs in regulating transcriptional and post-transcriptional gene expression during HIV infectio

51 thylation of eukaryotic nuclear RNA controls post-transcriptional gene expression, which is regulated

52 (miRNAs) are sequence-specific inhibitors of post-transcriptional gene expression.

53 proteins (RBPs) control multiple aspects of post-transcriptional gene regulation and function during

54 binding protein Hu Antigen-R (HuR), controls post-transcriptional gene regulation and undergoes stres

55 Before the MZT, post-transcriptional gene regulation by RNA-binding prot

56 further examine roles for cotranscriptional/post-transcriptional gene regulation during development.

57 The role of post-transcriptional gene regulation in human brain deve

58 gs demonstrate an important role for RppH in post-transcriptional gene regulation in pathogenic Epsil

59 only contributes to overall understanding of post-transcriptional gene regulation in roots of P. noto

60 Post-transcriptional gene regulation is critical for ade

61 y regulatory molecules involved primarily in post-transcriptional gene regulation of RNAs.

62 MicroRNAs (miRNA) play an important role in post-transcriptional gene regulation of several physiolo

63 NA metabolism, including the coordination of post-transcriptional gene regulation that allows organis

64 ing is a finely tuned, dynamic mechanism for post-transcriptional gene regulation that has been thoro

65 ss of RNA chaperones could play key roles in post-transcriptional gene regulation throughout bacteria

66 MicroRNAs (miRNAs) are known to mediate post-transcriptional gene regulation, but their role in

67 racterize the landscape of rapamycin-induced post-transcriptional gene regulation.

68 suggesting that it plays broader role(s) in post-transcriptional gene regulation.

69 mammals, small RNAs are important players in post-transcriptional gene regulation.

70 ly being recognized as an important layer of post-transcriptional gene regulation.

71 e factor may use two independent pathways of post-transcriptional gene regulation.

72 Splicing regulation is an important step of post-transcriptional gene regulation.

73 that directly link signal transduction with post-transcriptional gene regulation.

74 MicroRNAs form an essential class of post-transcriptional gene regulator of eukaryotic specie

75 studied, non-coding, evolutionary conserved, post-transcriptional gene regulators of genome, microRNA

76 Post-transcriptional gene silencing is a promising thera

77 DNA methylation and post-transcriptional gene silencing play critical roles

78 results strongly suggest that miRNA-mediated post-transcriptional gene silencing relies primarily on

79 ns in eukaryotes are known as key players in post-transcriptional gene silencing(1), while recent stu

80 MicroRNAs (miRNAs) are post-transcriptional gene suppressors and potential medi

81 sable role for ZFP36L1 as the regulator of a post-transcriptional hub that determined the identity of

82 , careful consideration of the complexity of post-transcriptional immune regulation is needed.

83 ion is negatively regulated by KhpA/B at the post-transcriptional level and that FtsA overproduction

84 These devices operate at the post-transcriptional level and use an extended RNA trans

85 transthyretin in preeclampsia occurs at the post-transcriptional level and while preeclamptic nano-v

86 L1 life cycle at the transcriptional or the post-transcriptional level in a manner that can depend o

87 e signatures both at the transcriptional and post-transcriptional level in breast cancer.

88 -dependent Cox-1 up-regulation occurs at the post-transcriptional level via the Fes-Akt-mTORC axis.

89 mechanism to regulate gene expression at the post-transcriptional level, and suggests that blocking t

90 iRNAs), that regulate gene expression at the post-transcriptional level, are altered in experimental

91 (+KTS) isoform, which acts presumably on the post-transcriptional level, did not.

92 en the study of transcriptome changes at the post-transcriptional level, such as alternative splicing

93 At the post-transcriptional level, the expression of the adm cl

94 a-related target genes exhibit repression at post-transcriptional level.

95 ay be responsible for ceRNA crosstalk at the post-transcriptional level.

96 sting that BET proteins are regulated at the post-transcriptional level.

97 sion, control circadian gene expression at a post-transcriptional level.

98 e expression at both the transcriptional and post-transcriptional level.

99 nt signaling pathway, probably acting at the post-transcriptional level.

100 s methylamine-dependent and regulated at the post-transcriptional level.

101 y regulates bacterial gene expression at the post-transcriptional level.

102 expression as key negative regulators at the post-transcriptional level.

103 thus promoting MYC mRNA stabilization at the post-transcriptional level.

104 nt regulation step of gene expression at the post-transcriptional level.

105 1 regulation both at the transcriptional and post-transcriptional level.

106 MiRNA biogenesis is highly regulated at the post-transcriptional level; however, the role of sequenc

107 f c-Fos/AP-1 activity at transcriptional and post transcriptional levels in OA chondrocytes.

108 is regulated by CK2, at transcriptional and post-transcriptional levels.

109 led KRT7 expression at both the mRNA and the post-transcriptional levels.

110 e these processes at the transcriptional and post-transcriptional levels.

111 ls tightly controlled at transcriptional and post-transcriptional levels.

112 ta-siRNAs) mainly inhibit gene expression at post-transcriptional levels.

113 Post-transcriptional m(6)A methylation of RNA has profou

114 However, the post-transcriptional mechanism for the development of th

115 -inosine (A-to-I) RNA editing is a conserved post-transcriptional mechanism mediated by ADAR enzymes

116 These data establish a post-transcriptional mechanism that can fine-tune gene e

117 RNA editing is a widespread post-transcriptional mechanism that can make a single ba

118 ed levels of SR-B1 in Caco-2/TC7 cells via a post-transcriptional mechanism that involves microRNAs.

119 tin loss occurs through a contact-dependent, post-transcriptional mechanism that is independent of th

120 to Inosine (A-to-I) RNA editing is a co- or post-transcriptional mechanism that modifies genomically

121 RNA splicing represents a post-transcriptional mechanism to generate multiple func

122 lipoprotein receptor abundance by IDOL as a post-transcriptional mechanism underlying the structural

123 RNA editing, a widespread post-transcriptional mechanism, has emerged as a new pla

124 ferent phases of the day and may depend on a post-transcriptional mechanism.

125 in, increases NPC1 levels in cells through a post-transcriptional mechanism.

126 gly, these altered protein levels are due to post-transcriptional mechanisms as the corresponding mRN

127 (ASD) have been identified, but the role of post-transcriptional mechanisms in ASD is not well under

128 d their receptors are potently regulated via post-transcriptional mechanisms in response to various s

129 In this review, we will focus on post-transcriptional mechanisms including noncoding RNAs

130 In this study, we highlight novel post-transcriptional mechanisms that can modulate NLRP3

131 Altogether, we define unexpected post-transcriptional mechanisms that direct appropriate

132 wal and lineage decisions of human HSCs, the post-transcriptional mechanisms that guide HSC fate have

133 h thousands of maternal mRNAs are cleared by post-transcriptional mechanisms.

134 expression through both transcriptional and post-transcriptional mechanisms.

135 ession of DNMT1 and DNMT3a through different post-transcriptional mechanisms.

136 pendent on germline nuclear RNAi factors and post-transcriptional mechanisms.

137 se data support distinct transcriptional and post-transcriptional models underlying the observed pQTL

138 , guide RNA interactions with target RNA for post-transcriptional modification and small nuclear RNA

139 ator methionine tRNA (tRNAi(Met)), a nuclear post-transcriptional modification associated with the st

140 ll non-coding RNA molecules that function in post-transcriptional modification of gene expression.

141 Post-transcriptional modification of RNA by N(6)-methyla

142 Post-transcriptional modification of RNA nucleosides has

143 These results show that stress-induced post-transcriptional modification of U56 and U93 alters

144 RNA processing and maturation, including RNA post-transcriptional modification, appear to be spatiall

145 everal earlier studies indicate that through post-transcriptional modification, direct protonation, o

146 Both post-transcriptional modifications and the enzymes that

147 Post-transcriptional modifications can control protein a

148 f the spliceosome is targeted for additional post-transcriptional modifications in response to cellul

149 ut knowledge about these transcriptional and post-transcriptional modifications is sparse.

150 Second, we demonstrate that post-transcriptional modifications of residues neighbori

151 Furthermore, we identified two types of post-transcriptional modifications, phosphorylation and

152 imprints or facilitate the dissection of RNA post-transcriptional modifications.

153 ppears to be the progenitor, with subsequent post-transcriptional modulation highlighting the complex

154 tudied, relatively little is known about how post-transcriptional modulations determine hESC function

155 somatid pathogens require a distinct form of post-transcriptional mRNA modification for mitochondrial

156 by a previously unidentified mechanism, i.e. post-transcriptional mRNA regulation.

157 Our findings delineate a post-transcriptional network that governs breast cancer

158 bute to improved modelling and prediction of post-transcriptional networks.

159 We aimed to determine novel genetic and post-transcriptional plasma FXI regulators.We performed

160 RNA editing is an essential post-transcriptional process that creates functional mit

161 RNA editing, a post-transcriptional process, allows the diversification

162 mportance of integrating transcriptional and post-transcriptional processes by RNA-binding proteins f

163 they also highlight the importance of these post-transcriptional processes during normal fetal muscl

164 little is understood about the influence of post-transcriptional processes on transcript evolution.

165 RNA-binding proteins play a key role in post-transcriptional processes.

166 adjusting gene transcription and a number of post-transcriptional processes.

167 eposited onto an mRNA transcript to modulate post-transcriptional processing events ensuring proper m

168 re a class of non-coding RNAs that guide the post-transcriptional processing of other non-coding RNAs

169 Despite intense investigation of post-transcriptional processing, chromatin regulators fo

170 Here we address post-transcriptional regulation and the role of miRNAs i

171 accumulation, demonstrating a high degree of post-transcriptional regulation by combinations of multi

172 tive stress, and this is in part mediated by post-transcriptional regulation by the 3'UTR.

173 We present POSTAR, a resource of POST-trAnscriptional Regulation coordinated by RNA-bindi

174 the roles of RNA binding proteins (RBPs) in post-transcriptional regulation during axon regeneration

175 Post-transcriptional regulation for the rhythmic gating

176 s of ionizing radiation on transcription and post-transcriptional regulation in normal human cells.

177 mic candidiasis model, suggesting a role for post-transcriptional regulation in these processes.

178 ozoa, represents an ideal model for studying post-transcriptional regulation in vivo because it invol

179 atures remains a limitation to understanding post-transcriptional regulation in vivo.

180 ndings suggest that mRNA processing-mediated post-transcriptional regulation is a potential mechanism

181 sue-specific, suggesting that their pre- and post-transcriptional regulation is different from that o

182 scribed SINE RNA impacts transcriptional and post-transcriptional regulation is largely unknown.

183 particular, the effect of auxin on pre-mRNA post-transcriptional regulation is mostly unknown.

184 Taken together, these results suggest that post-transcriptional regulation may potentially have a v

185 expression indicates that transcriptional or post-transcriptional regulation mechanisms operate for t

186 arget mRNAs and therefore is a key player of post-transcriptional regulation network.

187 Post-transcriptional regulation of cellular mRNA is esse

188 ce, suggesting that both transcriptional and post-transcriptional regulation of clock components are

189 Post-transcriptional regulation of COX-2 mRNAs translati

190 ointed to an emerging and prominent role for post-transcriptional regulation of epidermal cell fate d

191 Post-transcriptional regulation of gene expression can b

192 ot faithfully predict protein levels, due to post-transcriptional regulation of gene expression media

193 oteins (RBPs) acting at various steps in the post-transcriptional regulation of gene expression play

194 miRNAs) are small noncoding RNAs involved in post-transcriptional regulation of gene expression that

195 ich element-binding proteins (ARE-BPs) offer post-transcriptional regulation of gene expression via p

196 e small non-coding RNAs that are involved in post-transcriptional regulation of gene expression.

197 ransitions controlled by transcriptional and post-transcriptional regulation of gene expression.

198 ese results identify a new role for DLC-1 in post-transcriptional regulation of gene expression.

199 ing RNAs that plays an important role in the post-transcriptional regulation of gene expression.

200 -coding RNAs that play critical roles in the post-transcriptional regulation of gene expression.

201 mRNAs associated with RISC, thereby altering post-transcriptional regulation of gene expression.

202 Although transcriptional and post-transcriptional regulation of IFN-gamma is well und

203 nuclear function of URI and identify a novel post-transcriptional regulation of KAP1 protein that may

204 for the investigation of transcriptional and post-transcriptional regulation of lincRNA in mouse ESCs

205 al a novel role of mTORC1-SRPK2 signaling in post-transcriptional regulation of lipid metabolism and

206 T), transcriptionally silent embryos rely on post-transcriptional regulation of maternal mRNAs until

207 indings identify a new role for hPMR1 in the post-transcriptional regulation of microRNAs in breast c

208 has attracted interest both for its role in post-transcriptional regulation of mitochondrial gene ex

209 MicroRNAs (miRNAs) play a major role in the post-transcriptional regulation of target genes, especia

210 rentiation has been extensively studied, but post-transcriptional regulation of Th17 cell differentia

211 production or functions, we investigated the post-transcriptional regulation of VEGF by the cytoplasm

212 MicroRNA-mediated post-transcriptional regulation plays key roles in stem

213 nsive studies on mammalian neurogenesis, its post-transcriptional regulation remains under-explored.

214 Transcriptional and post-transcriptional regulation shape tissue-type-specif

215 this is achieved by both transcriptional and post-transcriptional regulation through ciliary transcri

216 ell-types, and highlight the contribution of post-transcriptional regulation to shaping tissue-type-s

217 M. prunae utilizes VapC toxins for post-transcriptional regulation under uranium stress to

218 of offspring, suggesting that in both cases post-transcriptional regulation was involved.

219 NA copy number aberrations and signatures of post-transcriptional regulation were recapitulated in ce

220 Gene expression in Plasmodia integrates post-transcriptional regulation with epigenetic marking

221 y stability rates suggests an attenuation of post-transcriptional regulation within hours of hypoxic

222 ts suggest an underappreciated complexity of post-transcriptional regulation, and the importance of H

223 -tail length has been considered critical in post-transcriptional regulation, differences in steady-s

224 , we were able to obtain novel insights into post-transcriptional regulation, such as the putative as

225 porters, which integrate transcriptional and post-transcriptional regulation, to test whether MET is

226 type I and II interferons depends on 3'-UTR post-transcriptional regulation, whereas the promoter dr

227 anistic dissection of this emerging layer of post-transcriptional regulation.

228 hrough meiosis is licensed by YTHDC2 through post-transcriptional regulation.

229 Ps), which play crucial and diverse roles in post-transcriptional regulation.

230 ted mRNA regions (UTRs) are key mediators of post-transcriptional regulation.

231 ted to SETDB1 up-regulation by relieving its post-transcriptional regulation.

232 the expression of a network of genes through post-transcriptional regulation.

233 oss different datasets, suggesting extensive post-transcriptional regulation.

234 nged by findings that show the importance of post-transcriptional regulation.

235 and G2/M phase via both transcriptional and post-transcriptional regulation.

236 lives longer than 2 h, suggesting a role for post-transcriptional regulation.

237 ovide separation between transcriptional and post-transcriptional regulations.

238 ectively, our data uncover Nudt21 as a novel post-transcriptional regulator of cell fate and establis

239 Lin28A is best known as a post-transcriptional regulator of gene expression.

240 Thus, our results uncover CSDE1 as a central post-transcriptional regulator of hESC identity and neur

241 he ubiquitin-specific protease 2 (USP2) as a post-transcriptional regulator of IDOL-mediated LDLR deg

242 Our results suggest that miR-193a-5p is a post-transcriptional regulator of IL-4 expression and co

243 Overall, our in silico search for post-transcriptional regulators identified miR-495 as a

244 on and that timely translation controlled by post-transcriptional regulators is crucial for normal de

245 MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression and a

246 MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression criti

247 Small noncoding microRNAs act as post-transcriptional regulators of gene expression invol

248 As called microRNAs (miRNAs) have emerged as post-transcriptional regulators of gene expression relat

249 A large class of sRNAs act as post-transcriptional regulators of gene expression that

250 MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression that

251 ion, and some have been classified as global post-transcriptional regulators of inflammation.

252 family proteins have recently emerged as key post-transcriptional regulators of mitochondrial gene ex

253 In total, this global analysis reveals post-transcriptional regulators of plant root epidermal

254 eRNAs) have emerged as an important class of post-transcriptional regulators that alter gene expressi

255 rative networks with FMRP and possibly other post-transcriptional regulators to regulate neurogenesis

256 significant cell type-specific expression of post-transcriptional regulators, including expression of

257 t neural-specific inactivation of two murine post-transcriptional regulators, Pumilio 1 (Pum1) and Pu

258 Small noncoding regulatory RNAs (sRNAs) are post-transcriptional regulators, regulating mRNAs, prote

259 al maturation mechanism for a major class of post-transcriptional regulators.

260 regions, improving the predictive design of post-transcriptional regulatory elements that regulate t

261 s to connect multiple RBP binding sites with post-transcriptional regulatory events, phenotypes, and

262 The first step in the post-transcriptional regulatory function of most bacteri

263 ne (m6A) has been shown to possess important post-transcriptional regulatory functions.

264 s an early effort to systematically annotate post-transcriptional regulatory maps and explore the put

265 Precise characterization of post-transcriptional regulatory maps has accelerated dra

266 Alternative splicing (AS) is a key post-transcriptional regulatory mechanism, yet little in

267 A chaperone Hfq drafts an unexpectedly large post-transcriptional regulatory network in this organism

268 Our observations delineate a novel post-transcriptional regulatory network involving carboh

269 icing events and to improve understanding of post-transcriptional regulatory networks during mouse le

270 gh 3' UTR annotations permit reassessment of post-transcriptional regulatory networks, via conserved

271 ic 3' UTR formation and its consequences for post-transcriptional regulatory networks.

272 Our data delineate a post-transcriptional regulatory pathway with a conserved

273 Post-transcriptional regulatory processes may change tra

274 calization-competent mRNA isoforms through a post-transcriptional regulatory program that is induced

275 CsrA is a post-transcriptional regulatory protein that is widely d

276 These sncRNAs may exert critical post-transcriptional regulatory roles in regulating path

277 teins, thus delineating a previously unknown post-transcriptional regulatory subnetwork within the we

278 RNAs (miRNAs) to identify mRNAs targeted for post-transcriptional repression.

279 transcriptional repressor, HES1, tuned by a post-transcriptional repressor, miR-9.

280 single-cell recording of transcriptional and post-transcriptional rhythms in brain explants and cultu

281 itute the first evidence of the existence of post-transcriptional riboregulatory mechanisms in R. con

282 during their biogenesis and are regulated by post-transcriptional RNA editing, splice variation, post

283 Post-transcriptional RNA modifications make up an epitra

284 proteins (RBPs) are important regulators of post-transcriptional RNA processing events, yet their id

285 involvement of genetic variants in mediating post-transcriptional RNA processing, including alternati

286 How this post-transcriptional RNA-regulatory machine impacts cell

287 This work reveals an incredible post-transcriptional robustness in T3SS assembly and aid

288 We propose a post-transcriptional role for modification of replicatio

289 Despite evidence for post-transcriptional roles, no endogenous WT1 target RNA

290 ion and reveal a novel strategy for complete post-transcriptional silencing of a cytoplasmic mRNA.

291 both necessary and sufficient to relieve the post-transcriptional silencing of HAC1 mRNA, yet the pre

292 Cs development are thought to be mediated by post-transcriptional silencing via microRNAs (miRNAs), a

293 uenza virus uses nuclear speckles to promote post-transcriptional splicing of its M1 mRNA.

294 a virus utilizes nuclear speckles to promote post-transcriptional splicing of its M1 mRNA.

295 s their activity at both transcriptional and post-transcriptional stages of the viral life cycle.

296 ucleo-cytoplasmic RNA export is an essential post-transcriptional step to control gene expression in

297 totoxic treatments with inhibition of select post-transcriptional steps of ribosome biogenesis holds

298 Additionally, post-transcriptional suppression by artificial microRNA

299 We propose that the induction of the post-transcriptional suppressor DND1 synergizes with con

300 Previous studies have shed light on post-transcriptional synaptic NMDAR mediated mechanisms