ライフサイエンスコーパス: post-translational

1 ing cells, which appears to be controlled by post-translational acetylation on PFKL.

2 Post-translational activation of GCL offers a novel targ

3 strate a novel mechanism of GSH elevation by post-translational activation of GCL.

4 ellular GSH levels by a novel approach (i.e. post-translational activation of glutamate cysteine liga

5 evolution, has the unique characteristic of post-translational activation through hypusination.

6 nt analytical method for characterization of post-translational and chemical modifications in therape

7 matter' of proteomics-the vast diversity of post-translational and chemical modifications that are u

8 e cilia proteins rely on palmitoylation, the post-translational attachment of a saturated 16-carbon l

9 y reduces BMPR-II transcription and mediates post-translational BMPR-II cleavage via the sheddases, A

10 ich lack nuclei, suggesting the existence of post-translational cellular clock mechanisms in these ce

11 e analysis of abundance and stoichiometry of post-translational chemical modifications across tempora

12 neutral hydrophobic residues facilitate the post-translational cleavage of the CaValpha2delta1 subun

13 A well-characterized post-translational consequence of pattern recognition re

14 suggest that mitochondrial GCN5L1 modulates post-translational control of FoxO1, regulates gluconeog

15 matically characterize three methods for the post-translational control of the PB transposon in four

16 complex at membrane translocase sites in the post-translational cpSRP pathway.

17 and their molecular complexity (by virtue of post-translational disulfide formation and glycosylation

18 MICAL Redox enzymes are important post-translational effectors of actin that stereo-specif

19 he Oct1p processing of Coq5p as an essential post-translational event for proper CoQ production.

20 ations of transcriptional, translational and post-translational events in the human brain are essenti

21 sed cue, which we posit depends upon variant post-translational forms of Celsr1 protein coupled to Fz

22 membrane proteins, and to achieve effective post-translational functional knockdown of ion channels.

23 nhibition of RGGT, an enzyme responsible for post-translational geranylgeranylation of Rab GTPases re

24 on and the temporal ordering and kinetics of post-translational histone and RNA polymerase II modific

25 Chromatin-remodeling complexes and post-translational histone modifications likely play key

26 tfuA and ycaO genes would be responsible for post-translational installation of thioglycine into McrA

27 ins with two different functional groups for post-translational labeling at the specific amino acid p

28 titutively expressed and is regulated at the post-translational level by FRP and/or oligomerization.

29 d at the transcriptional, translational, and post-translational levels.

30 Post-translational lipid modification of Ras proteins pl

31 S-Palmitoylation is the only reversible post-translational lipid modification.

32 ntify CHMP5 as an essential component of the post-translational machinery required for T cell develop

33 xes contain targeting domains that recognize post-translational marks on histones.

34 ersensitivity, yet little is known as to the post-translational mechanism behind its somatosensitizat

35 he burden of unfolded ER proteins suggests a post-translational mechanism for adjusting BiP's activit

36 arget proteins (NQO1 and HO-1), suggesting a post-translational mechanism.

37 phosphorylation is one of the most prominent post-translational mechanisms for protein regulation, wh

38 s were minimal, indicating the importance of post-translational mechanisms in regulating death or sur

39 ranscriptional program works in concert with post-translational mechanisms to regulate heme metabolis

40 genic RAS-mediated degradation of FOXOs, via post-translational mechanisms, blocks these important tu

41 The mechanism and regulation of this post-translational mode of targeting by cpSRP remain unc

42 , ligand binding sites, and various types of post translational modification (PTM) sites.

43 etylation has recently emerged as a dominant post-translational modification (PTM) in Alzheimer's dis

44 Via this top-down analysis, a post-translational modification (PTM) of tyrosine sulfat

45 trometry for simultaneous quantification and post-translational modification (PTM) profiling of targe

46 Protein phosphorylation is a major form of post-translational modification (PTM) that regulates div

47 Lysine methylation is a prevalent post-translational modification (PTM) used by the cell t

48 presence of ufmylation, a metazoan-specific post-translational modification (PTM), on ribosomes and

49 cules that are synthesized in Nature through post-translational modification (PTM), we have exploited

50 unction, one that is surprisingly tunable by post-translational modification (PTM).

51 ADP-ribosylation, a reversible and covalent post-translational modification (PTM).

52 uning of IDPs and IDPRs are mediated through post-translational modification and alternative splicing

53 Post-translational modification by SUMO (small ubiquitin

54 isobutyrylation (Khib) is a newly identified post-translational modification found in animal and yeas

55 ylation is an essential and highly conserved post-translational modification in eukaryotes.

56 ir pairing in disulfide linkages is a common post-translational modification in proteins entering the

57 O-GlcNAcylation is a ubiquitous and dynamic post-translational modification involving the O-linkage

58 on targets in Arabidopsis and show that this post-translational modification is central to the rewiri

59 Thus, neither Ser68 nor Lys124 post-translational modification is essential for long-te

60 Lysine acetylation is a post-translational modification known to regulate protei

61 autophagy protein, on Tyr-233 and that this post-translational modification limits Beclin1 associati

62 ex degradation, and we hypothesize that this post-translational modification may act as a signal for

63 Hence, post-translational modification may be a mechanism by wh

64 ble tyrosine phosphorylation is a widespread post-translational modification mechanism underlying cel

65 Protein S-palmitoylation is a reversible post-translational modification mediated by palmitoyl ac

66 The dynamic post-translational modification O-linked beta-N-acetylgl

67 The latter function involves reversing the post-translational modification of cellular proteins con

68 Covalent, reversible, post-translational modification of cellular proteins wit

69 While chromatin remodeling mediated by post-translational modification of histone is extensivel

70 of variant histone sequences, in addition to post-translational modification of histones, serves to m

71 ts and molecular mechanisms that control the post-translational modification of Imd remain unclear.

72 h menin or ubiquitin was used to demonstrate post-translational modification of menin.

73 y, but it is unclear how mutations affecting post-translational modification of molecular clock prote

74 domain) of OGT, which catalyzes the O-GlcNAc post-translational modification of nuclear and cytosolic

75 O-GlcNAc is a regulatory post-translational modification of nucleocytoplasmic pro

76 iggered upregulation of p53 gene expression, post-translational modification of p53 via phosphorylati

77 tides, a class of natural products formed by post-translational modification of precursor peptides.

78 Post-translational modification of proteins by phosphory

79 Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification of proteins mediated by

80 SUMO post-translational modification of proteins or SUMOylati

81 sly, we have demonstrated that disruption of post-translational modification of proteins with beta-li

82 Post-translational modification of proteins with carbohy

83 rboxylmethyltransferase (ICMT) catalyzes the post-translational modification of RAB GTPases that cont

84 At the same time, the post-translational modification of ribosomally synthesiz

85 su72, Rtr1, and Fcp1), which act through the post-translational modification of the C-terminal domain

86 egulation of HIF1 is primarily controlled by post-translational modification of the HIF1alpha subunit

87 Post-translational modification of the p53 signaling pat

88 Post-translational modification of the proteome, such as

89 its acetylation-a previously uncharacterized post-translational modification of this protein.

90 light phosphorylation of TMPRSS13 as a novel post-translational modification of this TTSP family memb

91 mes catalyzing protein S-acylation, a common post-translational modification on proteins frequently a

92 modifier (SUMO) conjugation is a reversible post-translational modification process implicated in th

93 The post-translational modification reactions of lanthipepti

94 tKB as a sequence reference and PSI-MOD as a post-translational modification reference.

95 MP is subjected to phosphorylation, and this post-translational modification regulates enzymatic acti

96 Glycation is a post-translational modification resulting from the inter

97 Therefore, post-translational modification shapes SCN neuronal stat

98 Protein SUMOylation is a dynamic post-translational modification shown to be involved in

99 arly beneficial for system-wide profiling of post-translational modification sites.

100 Palmitoylation is a critical post-translational modification that anchors proteins to

101 Ubiquitination is a widespread post-translational modification that controls multiple s

102 Polyubiquitylation is a post-translational modification that functions as a tag

103 Protein prenylation is a post-translational modification that has been most commo

104 utyrylation is a recently identified protein post-translational modification that is known to affect

105 N-Glycosylation is an important co- and/or post-translational modification that occurs on the vast

106 ylation of histone proteins is a fundamental post-translational modification that regulates chromatin

107 phosphorylation of Amot(S176) is a critical post-translational modification that suppresses YAP's ab

108 of this molecular apparatus, are subject to post-translational modification through ubiquitination a

109 chromosomal translocation, overexpression or post-translational modification to induce gene expressio

110 protein S-glutathionylation as a regulatory post-translational modification with functional conseque

111 a newly identified, Sox4-regulated site for post-translational modification with small ubiquitin-rel

112 es (PRMTs) introduce arginine methylation, a post-translational modification with the increasingly em

113 ty of cullin E3-ligases is modulated through post-translational modification with the small ubiquitin

114 , we investigate the activation, inhibition, post-translational modification, and localization of TMP

115 anscriptional RNA editing, splice variation, post-translational modification, and subunit composition

116 in regulating LSD1 protein stability through post-translational modification, and the HDAC5-LSD1 axis

117 cylation is an essential, nutrient-sensitive post-translational modification, but its biochemical and

118 hat glycation, an unavoidable age-associated post-translational modification, enhanced alpha-synuclei

119 ollectively, these data demonstrate that the post-translational modification, O-GlcNAcylation, is a n

120 o discover new aspects of regulation by this post-translational modification, we undertook an analysi

121 ysine succinylation is a recently identified post-translational modification.

122 rases is believed to initiate this important post-translational modification.

123 physiologically and pathologically important post-translational modification.

124 ssembly, phase separation, and regulation by post-translational modification.

125 in O-GlcNAcylation, an essential and dynamic post-translational modification.

126 ved modification site (Lys 32) and abolished post-translational modification.

127 roles in catalysis and serving as sites for post-translational modification.

128 GTPase-activating proteins (GAPs), and also post-translational modification.

129 evels of PIM1 can be regulated by a covalent post-translational modification.

130 cylation, a previously under-studied protein post-translational modification.

131 n NEDD8 onto protein targets is an important post-translational modification.

132 e-modifying enzymes and proteins involved in post-translational modification.

133 membrane, protein-protein interactions, and post-translational modification.

134 amine neuron activity is enhanced and drives post translational modifications at the dopamine transpo

135 Over the last decade, numerous histone acyl post-translational modifications (acyl-PTMs) have been d

136 Histone post-translational modifications (HPTMs) were targeted s

137 We report here that RyR2 undergoes post-translational modifications (phosphorylation, oxida

138 e required to assess structural features and post-translational modifications (PTM) and thereby minim

139 ce Steady-State and Lifetime spectroscopy as post-translational modifications (PTM) of Trp and Arg am

140 ing of dry-cured ham that can be affected by post-translational modifications (PTM).

141 tent detection and quantification of protein post-translational modifications (PTMs) across sample co

142 Post-translational modifications (PTMs) affect protein f

143 Post-translational modifications (PTMs) allot versatilit

144 f LSD1 on the relationship between HIF1alpha post-translational modifications (PTMs) and HIF1alpha-in

145 Post-translational modifications (PTMs) control and regu

146 ino acid composition, sequence variants, and post-translational modifications (PTMs) in antibody-deri

147 lterations in protein expression and histone post-translational modifications (PTMs) in bladder carci

148 Detecting and quantifying post-translational modifications (PTMs) in full-length p

149 single cell imaging flow cytometry to detect post-translational modifications (PTMs) in human MDDCs d

150 xistence and functional significance of many post-translational modifications (PTMs) is not well unde

151 genetic variation, alternative splicing, and post-translational modifications (PTMs) of the proteins

152 efficiently translate upstream signals into post-translational modifications (PTMs) on histones and

153 erous alternative splice variants (ASVs) and post-translational modifications (PTMs) reportedly tied

154 hese sensors is sophisticatedly regulated by post-translational modifications (PTMs) resulting in a r

155 Histone proteins are subject to dynamic post-translational modifications (PTMs) that cooperative

156 erences in epigenetic markers, i.e., histone post-translational modifications (PTMs), in the layers o

157 Using a current database of post-translational modifications (PTMs), ProteomeScout,

158 tubules (MTs) are extensively decorated with post-translational modifications (PTMs), such as glutamy

159 Post-translational modifications (PTMs), such as phospho

160 ng of active genomic regions through histone post-translational modifications (PTMs).

161 as the core technology for identification of post-translational modifications (PTMs).

162 1 protein was regulated by transcription and post-translational modifications (PTMs).

163 eted detection of plasma proteins, including post-translational modifications (PTMs).

164 forms that arise from genetic variations and post-translational modifications (PTMs).

165 Among various post-translational modifications affecting APP accumulat

166 , and their regulation is complex, involving post-translational modifications and allosteric regulati

167 K crosstalk as a critical regulator of MyD88 post-translational modifications and IL-1-driven inflamm

168 revealed structural fluctuations induced by post-translational modifications and mediated by modulat

169 ion and quantification of proteins and their post-translational modifications are crucial to decipher

170 These post-translational modifications are essential for funct

171 oved to be suitable to identify and quantify post-translational modifications at native protein level

172 omising glycoforms for antibody therapeutics.Post-translational modifications can affect antibody fun

173 fraction of the involved proteins and their post-translational modifications can be measured, and li

174 allows site-selective in situ monitoring of post-translational modifications catalyzed by the lysine

175 Post-translational modifications contribute to the splic

176 We found multiple new histone post-translational modifications enriched on chromatin b

177 While multiple post-translational modifications have been reported to r

178 cal and biophysical tools to investigate how post-translational modifications impact the aggregated p

179 Epigenetic mechanisms including post-translational modifications in histones are pivotal

180 This is the first report on Khib post-translational modifications in plants, and the stud

181 provide novel insight into the role of Nt17 post-translational modifications in regulating the struc

182 te method (MAM), which can quantify multiple post-translational modifications including deamidation,

183 e excision, signal peptide removal, and some post-translational modifications including oxidation and

184 protein ligation simplifies incorporation of post-translational modifications into the protein scaffo

185 temporal regulation of protein abundance and post-translational modifications is a key feature of cel

186 These findings show how variation in post-translational modifications may explain the emergen

187 Our results demonstrate how post-translational modifications may influence membrane

188 oB enables a direct quantification of single post-translational modifications occurring on cellular p

189 s can modify specific signaling pathways via post-translational modifications of Cys residues in key

190 lation (R-SO3(-)) are irreversible oxidative post-translational modifications of cysteine residues.

191 ts, interaction with auxiliary subunits, and post-translational modifications of either the receptors

192 iver injury leads to a vasculopathy in which post-translational modifications of endothelial nitric o

193 -MITF signalling pathway in melanoma through post-translational modifications of HINT1 can affect the

194 Post-translational modifications of histone proteins reg

195 ertebrate cells is carried epigenetically by post-translational modifications of histone proteins.

196 Post-translational modifications of histones by protein

197 Post-translational modifications of histones have been s

198 proposed essential centromere functions for post-translational modifications of human CENP-A.

199 Here, we discuss recent insights into the post-translational modifications of junctional proteins

200 causes mitochondrial dysfunction by inducing post-translational modifications of mitochondrial protei

201 Neoepitopes derived from post-translational modifications of native antigens are

202 ified by us further supports the notion that post-translational modifications of Numb uncouple Numb f

203 Thus, post-translational modifications of RyR occur downstream

204 low amino acid complexity and poorly defined post-translational modifications of SG components.

205 and if such modulation can be controlled by post-translational modifications of the transcription fa

206 ites.Both transcription binding kinetics and post-translational modifications of transcription factor

207 resent a review and perspective on important post-translational modifications on non-histone proteins

208 Eukaryotic genes are marked by conserved post-translational modifications on the RNA pol II C-ter

209 NA and RPA at the replication fork, and that post-translational modifications on the UNG2 N-terminus

210 Moreover, post-translational modifications such as nitration, phos

211 acterize various protein variants, including post-translational modifications such as oxidation and d

212 Thus, post-translational modifications such as phosphorylation

213 ctors, and a higher number and more types of post-translational modifications than other KMT and KDMs

214 inks, tailoring enzymes introduce additional post-translational modifications that are unique to each

215 dition, Tat undergoes a series of reversible post-translational modifications that regulate distinct

216 ocyclization in combination with rigidifying post-translational modifications to achieve high-potency

217 We examined important post-translational modifications to the DNA packaging hi

218 of compounds, protein-protein interactions, post-translational modifications, and asymmetric intrace

219 g from gene mutations, alternative splicing, post-translational modifications, and other biological p

220 cific sequences of amino acids and localized post-translational modifications, are identified using p

221 genetic and protein interactions, and 38 559 post-translational modifications, as manually annotated

222 of the HECT domain can be relieved by linker post-translational modifications, but complete removal o

223 ibrinogen from healthy controls displayed no post-translational modifications, fibrinogen from patien

224 are regulated through DNA sequence, histone post-translational modifications, histone variants, chro

225 bunit of MCR (McrA) contains several unusual post-translational modifications, including a rare thioa

226 due to the presence of antagonistic histone post-translational modifications, including acetylation

227 lecular chaperone function and influenced by post-translational modifications, including phosphorylat

228 ntional full proteomics workflow, identified post-translational modifications, including the chromoph

229 PDI can become dysfunctional by post-translational modifications, including those promot

230 ers, such as protein-protein interactions or post-translational modifications, may specifically regul

231 Protein post-translational modifications, oxidation and phosphor

232 gh its many protein interactions and various post-translational modifications, PCNA has far-reaching

233 by concordant changes on enzyme abundances, post-translational modifications, reactant concentration

234 We conclude that post-translational modifications, specifically the degre

235 not clear whether Smo is regulated by other post-translational modifications, such as sumoylation.

236 lved in transcription, chromatin remodeling, post-translational modifications, transport and targetin

237 racellular N-terminus, which is a target for post-translational modifications, typically is ignored.

238 combination of tubulin isotypes and tubulin post-translational modifications-can generate microtubul

239 or and its activity is regulated by numerous post-translational modifications.

240 translocation are functionally decoupled by post-translational modifications.

241 mechanisms of the enzymes that carry out the post-translational modifications.

242 by its decoration with various proteins and post-translational modifications.

243 onal crosstalk with other DNA damage-induced post-translational modifications.

244 tides of HSA, containing Cys34 and prominent post-translational modifications.

245 thickness might be at least partially due to post-translational modifications.

246 ngs, the enhanced analysis of (co-occurring) post-translational modifications.

247 ods for quantifying the abundance of histone post-translational modifications.

248 stones displaying a characteristic subset of post-translational modifications.

249 omeric peptides with variant localization of post-translational modifications.

250 basis for regulation of AQP2 trafficking by post-translational modifications.

251 d study of the behavior of peptides carrying post-translational modifications.

252 r the TFAM tail may enable its regulation by post-translational modifications.

253 ementarity-determining regions and potential post-translational modifications.

254 -GPD multidomain enzymes may be modulated by post-translational modifications/mechanisms, allowing th

255 are based on widely used protein domains and post-translational modifications; therefore, many membra

256 Many enzymes, molecular chaperones, and post-translational modifiers facilitate collagen biosynt

257 t temporal control of the temperature allows post-translational modulation of Cpf1-mediated genome ed

258 Here we describe a protocol for 'post-translational mutagenesis' that enables the program

259 tein, the entire procedure for this chemical post-translational mutation takes 2 d and is readily per

260 ranslationally and specifically facilitating post-translational N-terminal acetylation of many transm

261 Post-translational palmitoylation of mVEGFR1 is a binary

262 Therefore, post-translational phosphorylation of DISLL enhances the

263 This study focuses on understanding how the post-translational phosphorylation of Ser-500 integrates

264 ce of any Plasmodium-specific factor such as post-translational phosphorylation.

265 in the cholesterol biosynthetic pathway, the post-translational prenylation of small GTP-binding prot

266 FPP plays a crucial role in the post-translational prenylation of small GTPases that per

267 mmalian cells and is believed to result from post-translational processes involving hydrogen sulfide-

268 is released as a macrocyclic peptide during post-translational processing.

269 Neddylation is a post-translational protein modification associated with

270 Palmitoylation is a reversible post-translational protein modification in which palmiti

271 mation describing the molecular mechanism of post-translational protein modifications catalysed by TP

272 processes including cell-wall biosynthesis, post-translational protein modifications, and signaling.

273 Post-translational protein translocation in yeast requir

274 xplore the role of Sec71-Sec72 subcomplex in post-translational protein translocation.

275 tantial changes that characterize most other post-translational reactions.

276 Post-translational redox modification of methionine resi

277 lusion, we provide here a novel mechanism of post-translational regulation of dysbindin and hypertrop

278 These data show that post-translational regulation of L1 retrotransposons pla

279 We have found that PDHK4 plays a role in the post-translational regulation of mutant KRAS activity.

280 ssel morphogenesis that highlights exquisite post-translational regulation of mVEGFR1 in its role as

281 Here the authors report that the post-translational regulation of PRC1 components CBX4 an

282 idregional proANP, suggesting effects on the post-translational regulation of proBNP.

283 This unusual poise enables gradual post-translational regulation of the BiP chaperone cycle

284 Together, these findings suggest that post-translational regulation of the Thr(567) in the MT1

285 However, its post-translational regulation remains elusive.

286 they are found in nature, and their role in post-translational regulation.

287 other hand, the ORANGE (OR) protein, a major post-translational regulator of PSY with holdase chapero

288 ggesting that druggable translational and/or post-translational regulatory events may be uniquely dia

289 oteins and establish a hitherto unidentified post-translational regulatory mechanism of carotenogenic

290 ysis to propose putative transcriptional and post-translational regulatory mechanisms of metabolic pr

291 our understanding of the transcriptional and post-translational regulatory mechanisms that govern TIA

292 dditionally, Parkin is identified as a novel post-translational regulatory moderator of CHOP stabilit

293 euronal synapses is considered to be a major post-translational regulatory process in nerve cell and

294 herefore likely to promote translational and post-translational research in tomato and additional spe

295 less attention has been paid to the role of post-translational responses to pathogen-associated mole

296 at BB0238-BB0323 interaction is critical for post-translational stability of BB0323, and that this in

297 merization property, however, it reduces the post-translational stability of the binding partner, BB0

298 involvement of SENP1, the major protease of post-translational SUMOylation, in cardiovascular disord

299 dual action of the co-translational Sec and post-translational Tat pathways for integration.

300 ansferases (TPSTs) are enzymes that catalyze post-translational tyrosine sulfation of proteins.