ライフサイエンスコーパス: post-translational modification

1 physiologically and pathologically important post-translational modification.

2 ssembly, phase separation, and regulation by post-translational modification.

3 in O-GlcNAcylation, an essential and dynamic post-translational modification.

4 ved modification site (Lys 32) and abolished post-translational modification.

5 roles in catalysis and serving as sites for post-translational modification.

6 GTPase-activating proteins (GAPs), and also post-translational modification.

7 evels of PIM1 can be regulated by a covalent post-translational modification.

8 cylation, a previously under-studied protein post-translational modification.

9 Protein O-mannosylation is an essential post-translational modification.

10 ent systems to act as gatekeepers regulating post-translational modification.

11 ylated substrates and therefore reverse this post-translational modification.

12 tely determine the functional outcome of the post-translational modification.

13 n NEDD8 onto protein targets is an important post-translational modification.

14 e-modifying enzymes and proteins involved in post-translational modification.

15 membrane, protein-protein interactions, and post-translational modification.

16 ysine succinylation is a recently identified post-translational modification.

17 rases is believed to initiate this important post-translational modification.

18 mechanisms of the enzymes that carry out the post-translational modifications.

19 by its decoration with various proteins and post-translational modifications.

20 ods for quantifying the abundance of histone post-translational modifications.

21 onal crosstalk with other DNA damage-induced post-translational modifications.

22 tides of HSA, containing Cys34 and prominent post-translational modifications.

23 thickness might be at least partially due to post-translational modifications.

24 ngs, the enhanced analysis of (co-occurring) post-translational modifications.

25 stones displaying a characteristic subset of post-translational modifications.

26 omeric peptides with variant localization of post-translational modifications.

27 by altering transcription, translation, and post-translational modifications.

28 cetylation and its role in crosstalk between post-translational modifications.

29 entially lead to improved analyses of labile post-translational modifications.

30 basis for regulation of AQP2 trafficking by post-translational modifications.

31 d study of the behavior of peptides carrying post-translational modifications.

32 r the TFAM tail may enable its regulation by post-translational modifications.

33 ementarity-determining regions and potential post-translational modifications.

34 or and its activity is regulated by numerous post-translational modifications.

35 translocation are functionally decoupled by post-translational modifications.

36 ysis indicates that oxidative stress-related post-translational modifications accumulate in the aging

37 Over the last decade, numerous histone acyl post-translational modifications (acyl-PTMs) have been d

38 Among various post-translational modifications affecting APP accumulat

39 glycan chain and demonstrate that flagellar post-translational modification affects motility and adh

40 n sensitivity, ceramide accumulation and the post translational modification and activity of protein

41 uning of IDPs and IDPRs are mediated through post-translational modification and alternative splicing

42 ral strategy to study the biology of protein post-translational modification and associated recogniti

43 Such multi-layer regulation includes post-translational modification and processing of Wnt pr

44 , and their regulation is complex, involving post-translational modifications and allosteric regulati

45 target pathogens, molecule-binding partners, post-translational modifications and animal models.

46 otein sequence, and also bear information on post-translational modifications and fragmentation patte

47 K crosstalk as a critical regulator of MyD88 post-translational modifications and IL-1-driven inflamm

48 vides distinct advantages to the analysis of post-translational modifications and is a powerful and c

49 revealed structural fluctuations induced by post-translational modifications and mediated by modulat

50 d genome-wide profiles (ChIP-seq) of histone post-translational modifications and p53 binding in huma

51 so quantify other product attributes such as post-translational modifications and site-specific glyco

52 , we investigate the activation, inhibition, post-translational modification, and localization of TMP

53 anscriptional RNA editing, splice variation, post-translational modification, and subunit composition

54 in regulating LSD1 protein stability through post-translational modification, and the HDAC5-LSD1 axis

55 te the most abundant and diverse form of the post-translational modifications, and animal studies hav

56 of compounds, protein-protein interactions, post-translational modifications, and asymmetric intrace

57 g from gene mutations, alternative splicing, post-translational modifications, and other biological p

58 ntify glycosylation, degradation, unexpected post-translational modifications, and three types of seq

59 ion and quantification of proteins and their post-translational modifications are crucial to decipher

60 These post-translational modifications are essential for funct

61 cific sequences of amino acids and localized post-translational modifications, are identified using p

62 genetic and protein interactions, and 38 559 post-translational modifications, as manually annotated

63 amine neuron activity is enhanced and drives post translational modifications at the dopamine transpo

64 oved to be suitable to identify and quantify post-translational modifications at native protein level

65 Tyrosine sulfation is an important post-translational modification but remains difficult to

66 cylation is an essential, nutrient-sensitive post-translational modification, but its biochemical and

67 of the HECT domain can be relieved by linker post-translational modifications, but complete removal o

68 Post-translational modification by SUMO (small ubiquitin

69 lterations, such as amino acid mutations and post-translational modifications, by searching top-down

70 Among these post-translational modifications, C-methylations have be

71 omising glycoforms for antibody therapeutics.Post-translational modifications can affect antibody fun

72 fraction of the involved proteins and their post-translational modifications can be measured, and li

73 combination of tubulin isotypes and tubulin post-translational modifications-can generate microtubul

74 mammalian proteins was first described as a post-translational modification catalyzed by bacterial t

75 allows site-selective in situ monitoring of post-translational modifications catalyzed by the lysine

76 N-Glycosylation is a post-translational modification common to all three doma

77 Post-translational modifications contribute to the splic

78 hat glycation, an unavoidable age-associated post-translational modification, enhanced alpha-synuclei

79 We found multiple new histone post-translational modifications enriched on chromatin b

80 ibrinogen from healthy controls displayed no post-translational modifications, fibrinogen from patien

81 ion of histone H2B at lysine 120 (H2B-Ub), a post-translational modification first discovered in 1980

82 llagen synthesis, structure, and processing; post-translational modification; folding and cross-linki

83 isobutyrylation (Khib) is a newly identified post-translational modification found in animal and yeas

84 There were higher levels of histone post-translational modification hallmarks of transcripti

85 While multiple post-translational modifications have been reported to r

86 are regulated through DNA sequence, histone post-translational modifications, histone variants, chro

87 Histone post-translational modifications (HPTMs) were targeted s

88 cal and biophysical tools to investigate how post-translational modifications impact the aggregated p

89 N-Lysine acylation is a post-translational modification important for both proka

90 Proline hydroxylation is the most prevalent post-translational modification in collagen.

91 ylation is an essential and highly conserved post-translational modification in eukaryotes.

92 ir pairing in disulfide linkages is a common post-translational modification in proteins entering the

93 Sumoylation is a multistep, multienzymatic post-translational modification in which a small ubiquit

94 ion in histones and its crosstalk with other post-translational modifications in histone and non-hist

95 Epigenetic mechanisms including post-translational modifications in histones are pivotal

96 This is the first report on Khib post-translational modifications in plants, and the stud

97 provide novel insight into the role of Nt17 post-translational modifications in regulating the struc

98 osstalk between epigenetic modifications and post-translational modifications in the regulation of PR

99 te method (MAM), which can quantify multiple post-translational modifications including deamidation,

100 e excision, signal peptide removal, and some post-translational modifications including oxidation and

101 Post-translational modifications including phosphorylati

102 bunit of MCR (McrA) contains several unusual post-translational modifications, including a rare thioa

103 due to the presence of antagonistic histone post-translational modifications, including acetylation

104 lecular chaperone function and influenced by post-translational modifications, including phosphorylat

105 ntional full proteomics workflow, identified post-translational modifications, including the chromoph

106 PDI can become dysfunctional by post-translational modifications, including those promot

107 of Beclin-1 is tightly regulated by multiple post-translational modifications, including ubiquitinati

108 protein ligation simplifies incorporation of post-translational modifications into the protein scaffo

109 PARP catalysed ADP-ribosylation is a post-translational modification involved in several phys

110 ults suggest that protein carbonylation is a post-translational modification involved in tomato fruit

111 O-GlcNAcylation is a ubiquitous and dynamic post-translational modification involving the O-linkage

112 on targets in Arabidopsis and show that this post-translational modification is central to the rewiri

113 Thus, neither Ser68 nor Lys124 post-translational modification is essential for long-te

114 on and cardiac excitability and this form of post-translational modification is likely an important c

115 temporal regulation of protein abundance and post-translational modifications is a key feature of cel

116 Lysine acetylation is a post-translational modification known to regulate protei

117 Protein expression and post-translational modification levels are tightly regul

118 autophagy protein, on Tyr-233 and that this post-translational modification limits Beclin1 associati

119 ex degradation, and we hypothesize that this post-translational modification may act as a signal for

120 Hence, post-translational modification may be a mechanism by wh

121 These findings show how variation in post-translational modifications may explain the emergen

122 Our results demonstrate how post-translational modifications may influence membrane

123 ers, such as protein-protein interactions or post-translational modifications, may specifically regul

124 ble tyrosine phosphorylation is a widespread post-translational modification mechanism underlying cel

125 -GPD multidomain enzymes may be modulated by post-translational modifications/mechanisms, allowing th

126 Arginylation is an emerging post-translational modification mediated by arginyltrans

127 Protein S-palmitoylation is a reversible post-translational modification mediated by palmitoyl ac

128 e detection of other biochemical activities, post-translational modifications, nucleic acids, and ino

129 The dynamic post-translational modification O-linked beta-N-acetylgl

130 ollectively, these data demonstrate that the post-translational modification, O-GlcNAcylation, is a n

131 oB enables a direct quantification of single post-translational modifications occurring on cellular p

132 hthamide, a eukaryotic and archaeal specific post-translational modification of a histidine residue o

133 Proteins containing citrulline, a post-translational modification of arginine, are generat

134 The latter function involves reversing the post-translational modification of cellular proteins con

135 Covalent, reversible, post-translational modification of cellular proteins wit

136 Unexpectedly, a post-translational modification of DNA-binding proteins,

137 While chromatin remodeling mediated by post-translational modification of histone is extensivel

138 of variant histone sequences, in addition to post-translational modification of histones, serves to m

139 ts and molecular mechanisms that control the post-translational modification of Imd remain unclear.

140 h menin or ubiquitin was used to demonstrate post-translational modification of menin.

141 d acetylation of alpha-tubulin, an important post-translational modification of microtubules.

142 y, but it is unclear how mutations affecting post-translational modification of molecular clock prote

143 domain) of OGT, which catalyzes the O-GlcNAc post-translational modification of nuclear and cytosolic

144 O-GlcNAc is a regulatory post-translational modification of nucleocytoplasmic pro

145 iggered upregulation of p53 gene expression, post-translational modification of p53 via phosphorylati

146 tides, a class of natural products formed by post-translational modification of precursor peptides.

147 Post-translational modification of proteins by phosphory

148 Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification of proteins mediated by

149 SUMO post-translational modification of proteins or SUMOylati

150 However, autophagy also causes post-translational modification of proteins that are rec

151 sly, we have demonstrated that disruption of post-translational modification of proteins with beta-li

152 Post-translational modification of proteins with carbohy

153 The post-translational modification of proteins with polyubi

154 rboxylmethyltransferase (ICMT) catalyzes the post-translational modification of RAB GTPases that cont

155 At the same time, the post-translational modification of ribosomally synthesiz

156 1-7), and recent studies have suggested that post-translational modification of Sirt1 by cysteine S-n

157 Post-translational modification of steroid receptors all

158 su72, Rtr1, and Fcp1), which act through the post-translational modification of the C-terminal domain

159 egulation of HIF1 is primarily controlled by post-translational modification of the HIF1alpha subunit

160 Post-translational modification of the p53 signaling pat

161 Post-translational modification of the proteome, such as

162 its acetylation-a previously uncharacterized post-translational modification of this protein.

163 light phosphorylation of TMPRSS13 as a novel post-translational modification of this TTSP family memb

164 To identify specific post-translational modifications of apoB100 near the cat

165 ine residues is one of the most well-studied post-translational modifications of chromatin, selective

166 s can modify specific signaling pathways via post-translational modifications of Cys residues in key

167 lation (R-SO3(-)) are irreversible oxidative post-translational modifications of cysteine residues.

168 ts, interaction with auxiliary subunits, and post-translational modifications of either the receptors

169 iver injury leads to a vasculopathy in which post-translational modifications of endothelial nitric o

170 -MITF signalling pathway in melanoma through post-translational modifications of HINT1 can affect the

171 Post-translational modifications of histone proteins reg

172 ertebrate cells is carried epigenetically by post-translational modifications of histone proteins.

173 Post-translational modifications of histones by protein

174 Post-translational modifications of histones have been s

175 proposed essential centromere functions for post-translational modifications of human CENP-A.

176 Here, we discuss recent insights into the post-translational modifications of junctional proteins

177 causes mitochondrial dysfunction by inducing post-translational modifications of mitochondrial protei

178 Neoepitopes derived from post-translational modifications of native antigens are

179 ified by us further supports the notion that post-translational modifications of Numb uncouple Numb f

180 e-tune visual signal transduction, including post-translational modifications of proteins, such as ad

181 Oxidative stress-mediated post-translational modifications of redox-sensitive prot

182 Thus, post-translational modifications of RyR occur downstream

183 low amino acid complexity and poorly defined post-translational modifications of SG components.

184 and if such modulation can be controlled by post-translational modifications of the transcription fa

185 Post-translational modifications of these factors determ

186 ites.Both transcription binding kinetics and post-translational modifications of transcription factor

187 nificance of NO2-Tyr(166)-apoA-I, a specific post-translational modification on apoA-I that is abunda

188 izing the impact of post-transcriptional and post-translational modification on protein location and

189 mes catalyzing protein S-acylation, a common post-translational modification on proteins frequently a

190 resent a review and perspective on important post-translational modifications on non-histone proteins

191 Eukaryotic genes are marked by conserved post-translational modifications on the RNA pol II C-ter

192 NA and RPA at the replication fork, and that post-translational modifications on the UNG2 N-terminus

193 Protein post-translational modifications, oxidation and phosphor

194 on of Wnt secretion by blocking an essential post-translational modification, palmitoleation, provide

195 gh its many protein interactions and various post-translational modifications, PCNA has far-reaching

196 We report here that RyR2 undergoes post-translational modifications (phosphorylation, oxida

197 modifier (SUMO) conjugation is a reversible post-translational modification process implicated in th

198 , ligand binding sites, and various types of post translational modification (PTM) sites.

199 etylation has recently emerged as a dominant post-translational modification (PTM) in Alzheimer's dis

200 This post-translational modification (PTM) of hnRNP E1 promot

201 The post-translational modification (PTM) of proteins by end

202 Via this top-down analysis, a post-translational modification (PTM) of tyrosine sulfat

203 trometry for simultaneous quantification and post-translational modification (PTM) profiling of targe

204 Protein phosphorylation is a major form of post-translational modification (PTM) that regulates div

205 Lysine methylation is a prevalent post-translational modification (PTM) used by the cell t

206 presence of ufmylation, a metazoan-specific post-translational modification (PTM), on ribosomes and

207 cules that are synthesized in Nature through post-translational modification (PTM), we have exploited

208 unction, one that is surprisingly tunable by post-translational modification (PTM).

209 ADP-ribosylation, a reversible and covalent post-translational modification (PTM).

210 e required to assess structural features and post-translational modifications (PTM) and thereby minim

211 ce Steady-State and Lifetime spectroscopy as post-translational modifications (PTM) of Trp and Arg am

212 ing of dry-cured ham that can be affected by post-translational modifications (PTM).

213 tool for evaluating the impact of individual post translational modifications (PTMs) on the biologica

214 tent detection and quantification of protein post-translational modifications (PTMs) across sample co

215 Post-translational modifications (PTMs) affect protein f

216 Post-translational modifications (PTMs) allot versatilit

217 f LSD1 on the relationship between HIF1alpha post-translational modifications (PTMs) and HIF1alpha-in

218 Post-translational modifications (PTMs) control and regu

219 ino acid composition, sequence variants, and post-translational modifications (PTMs) in antibody-deri

220 lterations in protein expression and histone post-translational modifications (PTMs) in bladder carci

221 Detecting and quantifying post-translational modifications (PTMs) in full-length p

222 single cell imaging flow cytometry to detect post-translational modifications (PTMs) in human MDDCs d

223 As one of the most common protein post-translational modifications (PTMs) in mammals, prot

224 xistence and functional significance of many post-translational modifications (PTMs) is not well unde

225 Post-translational modifications (PTMs) of alpha/beta-tu

226 Post-translational modifications (PTMs) of histones regu

227 genetic variation, alternative splicing, and post-translational modifications (PTMs) of the proteins

228 nal regulation can be established by various post-translational modifications (PTMs) on histone prote

229 efficiently translate upstream signals into post-translational modifications (PTMs) on histones and

230 on and S-sulfination are naturally occurring post-translational modifications (PTMs) on proteins indu

231 n handle standard amino acids and those with post-translational modifications (PTMs) or small molecul

232 Post-translational modifications (PTMs) produce signific

233 erous alternative splice variants (ASVs) and post-translational modifications (PTMs) reportedly tied

234 hese sensors is sophisticatedly regulated by post-translational modifications (PTMs) resulting in a r

235 Histone proteins are subject to dynamic post-translational modifications (PTMs) that cooperative

236 erences in epigenetic markers, i.e., histone post-translational modifications (PTMs), in the layers o

237 Using a current database of post-translational modifications (PTMs), ProteomeScout,

238 ts are often asymmetric: functionalized with post-translational modifications (PTMs), substituted wit

239 tubules (MTs) are extensively decorated with post-translational modifications (PTMs), such as glutamy

240 Post-translational modifications (PTMs), such as phospho

241 as the core technology for identification of post-translational modifications (PTMs).

242 1 protein was regulated by transcription and post-translational modifications (PTMs).

243 eted detection of plasma proteins, including post-translational modifications (PTMs).

244 forms that arise from genetic variations and post-translational modifications (PTMs).

245 ng of active genomic regions through histone post-translational modifications (PTMs).

246 cture, both in terms of primary sequence and post-translational modifications (PTMs); however, large-

247 by concordant changes on enzyme abundances, post-translational modifications, reactant concentration

248 The post-translational modification reactions of lanthipepti

249 tKB as a sequence reference and PSI-MOD as a post-translational modification reference.

250 MP is subjected to phosphorylation, and this post-translational modification regulates enzymatic acti

251 Lysine acetylation is a widespread post-translational modification regulating various biolo

252 Glycation is a post-translational modification resulting from the inter

253 Therefore, post-translational modification shapes SCN neuronal stat

254 Protein SUMOylation is a dynamic post-translational modification shown to be involved in

255 arly beneficial for system-wide profiling of post-translational modification sites.

256 We conclude that post-translational modifications, specifically the degre

257 ggest a tissue-specific stoichiometry and/or post-translational modification status for collagen type

258 rmed cells of the nervous system altered the post-translational modification statuses of histones in

259 in protein labeling, photocrosslinking, and post-translational modification studies in Salmonella.

260 Moreover, post-translational modifications such as nitration, phos

261 acterize various protein variants, including post-translational modifications such as oxidation and d

262 Thus, post-translational modifications such as phosphorylation

263 In contrast to other common post-translational modifications, such as phosphorylatio

264 not clear whether Smo is regulated by other post-translational modifications, such as sumoylation.

265 Regulation of protein function by reversible post-translational modification, SUMOylation, is widely

266 ctors, and a higher number and more types of post-translational modifications than other KMT and KDMs

267 Palmitoylation is a critical post-translational modification that anchors proteins to

268 ADP-ribosylation is a post-translational modification that can alter the physi

269 Ubiquitination is a widespread post-translational modification that controls multiple s

270 Polyubiquitylation is a post-translational modification that functions as a tag

271 Protein prenylation is a post-translational modification that has been most commo

272 sults show that Abeta nitrotyrosination is a post-translational modification that increases Abeta syn

273 e for protein geranylgeranylation, a protein post-translational modification that is catalyzed by pro

274 residues in proteins is an important type of post-translational modification that is implicated in re

275 utyrylation is a recently identified protein post-translational modification that is known to affect

276 Protein glycosylation is a post-translational modification that occurs across the w

277 N-Glycosylation is an important co- and/or post-translational modification that occurs on the vast

278 ylation of histone proteins is a fundamental post-translational modification that regulates chromatin

279 phosphorylation of Amot(S176) is a critical post-translational modification that suppresses YAP's ab

280 Protein phosphorylation is a post-translational modification that underlines various

281 inks, tailoring enzymes introduce additional post-translational modifications that are unique to each

282 dition, Tat undergoes a series of reversible post-translational modifications that regulate distinct

283 are based on widely used protein domains and post-translational modifications; therefore, many membra

284 of this molecular apparatus, are subject to post-translational modification through ubiquitination a

285 17.3) catalyzes peptide amidation, a crucial post-translational modification, through the sequential

286 chromosomal translocation, overexpression or post-translational modification to induce gene expressio

287 ocyclization in combination with rigidifying post-translational modifications to achieve high-potency

288 Our structure reveals multiple post-translational modifications to the archaella, inclu

289 We examined important post-translational modifications to the DNA packaging hi

290 lved in transcription, chromatin remodeling, post-translational modifications, transport and targetin

291 racellular N-terminus, which is a target for post-translational modifications, typically is ignored.

292 Similar to other post-translational modifications, ubiquitylation is reve

293 o discover new aspects of regulation by this post-translational modification, we undertook an analysi

294 ation is a very important process in protein post-translational modification, which has been widely i

295 protein S-glutathionylation as a regulatory post-translational modification with functional conseque

296 a newly identified, Sox4-regulated site for post-translational modification with small ubiquitin-rel

297 es (PRMTs) introduce arginine methylation, a post-translational modification with the increasingly em

298 ty of cullin E3-ligases is modulated through post-translational modification with the small ubiquitin

299 First, we discuss post-translational modifications within disordered regio

300 cations in protein expression and associated post-translational modifications within the cells were f