ライフサイエンスコーパス: postinfection

1 ment of the lymph nodes and peaked on day 10 postinfection.

2 three or more inhibitory receptors on day 14 postinfection.

3 izing activity (bNA) close to the first year postinfection.

4 brain, respectively, was measured at 5 weeks postinfection.

5 cumulate significant amounts of genomic mRNA postinfection.

6 alveolar lavage, and spleens of mice at 24 h postinfection.

7 A was substantially diminished at late times postinfection.

8 d airway responsiveness were assessed 1-12 d postinfection.

9 mory population during the maintenance phase postinfection.

10 nary cytokines were measured at 6 h and 24 h postinfection.

11 ), and fetal lung fibroblasts (HFLs) at 72 h postinfection.

12 gp130, and this was sustained for up to 2 mo postinfection.

13 hen given once at the peak of viremia 3 days postinfection.

14 to almost 50% of the vacuoles within 20 min postinfection.

15 tners were followed for a median of 847 days postinfection.

16 ted AIEC intramacrophage survival up to 24 h postinfection.

17 und in the spleens of Irgm3-/- mice at day 4 postinfection.

18 y continued to increase for at least 3 years postinfection.

19 All animals were asymptomatic postinfection.

20 e PCR detection of the bacteria up to day 15 postinfection.

21 changes that occur at early and later times postinfection.

22 etected in 3 of 6 ferrets within 5 to 7 days postinfection.

23 exponentially in the brain from 2 to 5 days postinfection.

24 as dramatically reduced in Il-17ra(-/-) mice postinfection.

25 f infectious virus on day 2 but not on day 4 postinfection.

26 of infected animals during the first 7 days postinfection.

27 ance antiviral responses postvaccination and postinfection.

28 high viremia and died between 9 and 14 days postinfection.

29 noted between both groups of mice on day 16 postinfection.

30 recovered to preinfection levels by 60 days postinfection.

31 ther than latent genes, silencing after 24 h postinfection.

32 (+) Tregs when measured at early time points postinfection.

33 entially expressed genes increased with time postinfection.

34 exposure to antigen even at protracted times postinfection.

35 H. pylori by oral gavage and sacrificed 6 mo postinfection.

36 hose from wild-type (WT) MEFs at 24 and 48 h postinfection.

37 ic acid, was administered at different times postinfection.

38 currents (Isc) and protein levels at 8 hours postinfection.

39 y molecules did not explain loss of function postinfection.

40 cretion of the same cytokines at later times postinfection.

41 d in the lungs of IL-1R(-/-) mice at 14 days postinfection.

42 h viral RNA remaining detectable until day 9 postinfection.

43 nt to gastric dysplasia as early as 25 weeks postinfection.

44 mic and nuclear fractions at different times postinfection.

45 6-kDa early secreted Ag (ESAT-6) before and postinfection.

46 iters in the spleen and serum at early times postinfection.

47 ession that commenced at between 24 and 48 h postinfection.

48 ephalitis and succumbed between 6 and 8 days postinfection.

49 the role of these cells in viral suppression postinfection.

50 t retained the viral genome for at least 4 h postinfection.

51 aneous neutralization observed up to 3 years postinfection.

52 of mucosal-associated invariant T cells 6 mo postinfection.

53 n of inclusion bodies (IBs) from early times postinfection.

54 ed pigs cleared fecal viral shedding at 8 wk postinfection.

55 increased necrosis in infected cells at 10 h postinfection.

56 1 polypeptides, was observed at days 7 to 10 postinfection.

57 and computed tomography at early time points postinfection.

58 he DP148R gene is transcribed at early times postinfection.

59 ICOS in TFH differentiation only after day 6 postinfection.

60 fection, and virus had not cleared by day 13 postinfection.

61 sing infected mice to succumb at 4 to 6 days postinfection.

62 ormal IFN-alpha levels during the first days postinfection.

63 d bacterial burden in lung and liver at 24 h postinfection.

64 positively with chronic viremia at 3 months postinfection.

65 At 16 weeks postinfection, 11% of mice fed high vitamin D diet had c

66 located near the cell nucleus at early times postinfection (2 h) but were redistributed during infect

67 Three days postinfection, a large increase in ASC numbers and rapid

68 d the virus titer by about 100-fold on day 8 postinfection, according to the findings of a virus yiel

69 We simulated the implementation of a postinfection adult vaccine with 60% efficacy and a mean

70 At 2 d postinfection, aged mice suffered 1000-fold higher pulmo

71 semination to all organs in the first 4 days postinfection, albeit with a lower burden, followed by c

72 At 3 months postinfection, all H. saguini-monoassociated gnotobiotic

73 all of which were readily detectable by 24 h postinfection and accumulated to high levels by 72 h.

74 immune responses against RRV at early times postinfection and also impacts viral loads, but it does

75 antly greater than those in WT mice by day 3 postinfection and at all time points thereafter.

76 lungs of H1N1pdm virus-infected ferrets 6 h postinfection and became concentrated at areas of the H1

77 ce of IL-12, which was profoundly suppressed postinfection and correlated with loss of IFN-gamma rele

78 rather than effector memory T cell phenotype postinfection and expressed high levels of PD-1, Lag-3,

79 system drives the myocardial immune response postinfection and harbors a promising potential as a the

80 ntained high mucosal plasma cell frequencies postinfection and if this translated to reduced viremia.

81 A class I expression on infected cells early postinfection and increased at late stages, overcoming v

82 ficiently in lymphoid tissues at early times postinfection and induced higher levels of IFN productio

83 ficiently in lymphoid tissues at early times postinfection and induced higher levels of interferon pr

84 ucleoprotein) reduced viral load immediately postinfection and partially attenuated interferon respon

85 inflammation is detectable as early as 1 day postinfection and peaks 1 to 2 weeks later, after which

86 H2AX, was induced as early as 30 min (0.5 h) postinfection and persisted during in vitro KSHV latency

87 Brain atrophy was observed at 1 mo postinfection and persisted through the 4-mo observation

88 to profile protective immune responses, both postinfection and postvaccination, although no vaccine-d

89 durability of IL-10-producing CD4(+) T cells postinfection and provide information on how IL-10 may c

90 HIV infiltrates the brain at early times postinfection and remains latent within astrocytes and m

91 on, samples were collected at 4, 8, and 16 h postinfection and RNA-Seq data were acquired using an Io

92 the cytoplasm of infected cells within 12 h postinfection and subsequent accumulation of puncta in t

93 y clearance from the blood and organs 7 days postinfection and survival of all animals.

94 e-1 (HO-1), a pivotal cytoprotective enzyme, postinfection and that overexpression of HO-1 inhibits P

95 ndent protein synthesis at early time points postinfection and that pharmacologic inhibition of mTOR

96 hritis and carditis that peak around 3 weeks postinfection and then spontaneously resolve.

97 RNA was isolated at several times postinfection and treated with various RNA-modifying enz

98 ers remained constant until at least 28 days postinfection, and animals showed no outward signs of di

99 ast, map expression was suppressed at 2 days postinfection, and at 4 days postinfection it was totall

100 matory cell recruitment to the lungs at 48 h postinfection, and fluticasone plus AC less markedly red

101 with ehrlichial morulae on days 1, 2, and 3 postinfection, and increased LC3II levels were detected

102 pecific IgM and IgG were detected at 15 days postinfection, and isotyping of the Ig subclass showed t

103 ing in the ipsilateral ankle at days 3 and 7 postinfection, and this correlated with higher levels of

104 aked at approximately 1 x 10(6) PFU on day 5 postinfection, and virus had not cleared by day 13 posti

105 Mice were euthanized 5 days postinfection, and virus titers, levels of neutralizing

106 At 24 weeks postinfection, animals were classified as having active

107 r differentiation into B cells in the spleen postinfection are not defined.

108 y, apolipoprotein B levels in the lung early postinfection are significantly reduced with lipoprotein

109 ing the innate immune response (prior to 7 d postinfection) as well as decreased survival in response

110 pression of several miRNAs was modulated 3 h postinfection (at a multiplicity of infection of 25).

111 matory response was undetectable until day 5 postinfection, at which time CD8(+) T cells infiltrated

112 From day 14 postinfection, bacterial numbers remained constant until

113 inducible NO synthase in the TME merely 4 d postinfection, before significant virus spread or the ap

114 SGs or eIF2alpha phosphorylation at any time postinfection but is unable to fully inhibit SG formatio

115 sections at time points from day 3 to day 10 postinfection, but nearly all appeared degraded with inf

116 hese cells was still detected beyond 60 days postinfection, but these divided cells did not demonstra

117 and massive RNA degradation as early as 4 h postinfection by the seasonal, but not the pandemic, vir

118 At 4 wk postinfection, CD4-depleted WT and MyD88(-/-) mice harbo

119 The factors and steps controlling postinfection CD8(+) T cell terminal effector versus mem

120 and increased bacterial burden at 8 and 20 h postinfection compared to control MRSA-infected mice (P

121 sed [(18)F]-FDG uptake in bone marrow 4 days postinfection compared to surviving NHPs.

122 duced neutrophils in TLR9(-/-) mice on day 1 postinfection compared to the levels in WT mice.

123 of the hepatic central vein at baseline and postinfection, compared with WT.

124 of infection and starting as early as day 1 postinfection, consistent with a functional role not dep

125 ctor functions of anti-HIV-1 antibodies with postinfection control of viremia and/or blocking viral a

126 ency virus type 1 (HIV-1) acquisition and in postinfection control of viremia.

127 Both untreated control animals died on postinfection day 9.

128 iled miRNA expression at 14, 30, and 60 days postinfection (days p.i.) in the intestine of uninfected

129 ort-term (3-d) local CD4(+) T cell depletion postinfection did not influence chemokine levels in corn

130 g both viral and host transcriptomes on days postinfection (dpi) 3, 7, 10, 14, and 100.

131 al lavage samples increased from 1 to 3 days postinfection (dpi) and then declined by 6 dpi.

132 nsiently activated intestinal STAT1 at 1 day postinfection (dpi) but not subsequently at 2 to 3 dpi.

133 leared the infection had occurred by 10 days postinfection (dpi) in vaccinated cattle and by 21 dpi i

134 in a cytopathic effect (CPE) within 14 days postinfection (dpi), despite production of infectious vi

135 with either ET-1 or saline from 2 to 8 days postinfection (dpi).

136 or recovering infectious FMDV up to 400 days postinfection (dpi).

137 pigs were challenged at either 21 or 28 days postinfection (dpi).

138 n within the virus gene at both 1 and 3 days postinfection (dpi).

139 rus-infected bronchiolar epithelium by 1 day postinfection (dpi).

140 icative index than NI-1 isolates 3 to 7 days postinfection (dpi).

141 type 2 infection at 0, 3, 7, 14, and 28 days postinfection (dpi).

142 expansion measured in the DLNs at 3 and 7 d postinfection (dpi); 3) non-cornea-derived DCs that infi

143 or CHIKV infection: early acute (2 to 3 days postinfection [dpi]) and late acute (6 to 8 dpi).

144 in transcriptional activity occurred 20-56 d postinfection, during which fluctuation of innate and ad

145 sids that assist in expressing their genomes postinfection, e.g., retroviruses.

146 yrin (CoPP, a potent HO-1 inducer), pre- and postinfection, effectively inhibited BVDV replication.

147 At 18 h postinfection, epitope copies per cell varied from a low

148 allenge with P. murina at 2, 7, 14, and 28 d postinfection even after CD4(+) T cell depletion.

149 UL92 severely impacts the late (72-h postinfection) expression of nine genes encoding virion

150 iral isolates tested against strain-specific postinfection ferret antisera.

151 th seasonal influenza A(H3N2) (sH3N2), using postinfection ferret antisera.

152 ses from the 1970s-1990s were observed using postinfection ferret antisera.

153 d cardiac magnetic resonance over a 10-month postinfection follow-up did not detect an overt right ve

154 25 mg/kg of body weight/dose) was given 4 h postinfection, followed by twice-daily treatment for 5 d

155 E, and gI, was significantly reduced at 36 h postinfection for the hyperfusogenic mutants.

156 ntrol and infected birds at 2, 3, and 4 days postinfection from two lines that differ in their resist

157 emales and males, carrying the potential for postinfection genital tract sequelae.

158 nce-daily 10 mg/kg iv treatment on days 3-14 postinfection had a significant effect on viremia and mo

159 remia was generally cleared by 2 to 3 months postinfection, hepatitis and liver fibrosis persisted af

160 erapy; 95% CI, 0.057-0.132 d; p < 0.001) and postinfection hospital length of stay (0.134-d increase

161 acrophages and neutrophils for at least 17 h postinfection; however, MNGC formation is not induced in

162 gnificantly less extracellular HSV-1 by 24 h postinfection (hpi), suggesting a unique neuronal respon

163 At 6 to 9 h postinfection (hpi), UL32 accumulated in viral replicati

164 COX-2 mRNA and protein levels at 24 and 36 h postinfection (hpi), with only a transient increase in C

165 on viral events that take place prior to 5 h postinfection (hpi).

166 an early apoptotic checkpoint at around 48 h postinfection (hpi).

167 sponses at early times after infection (12 h postinfection [hpi]), a pattern opposite that previously

168 However, by day 21 postinfection, Icos(-/-) mice accumulated fewer splenic

169 h sepsis to be an independent determinant of postinfection ICU and hospital lengths of stay.

170 therapy to be an independent determinant of postinfection ICU length of stay (0.095-d increase per h

171 However, after day 21 postinfection, IL-10-expressing T cells were also highly

172 Four weeks postinfection, IL-12, type 1 IFN, and IL-27 were all req

173 assay detected F. tularensis on days 1 to 4 postinfection in 21%, 17%, 60%, and 83% of macaques, res

174 of C3, macrophage death was observed at 24 h postinfection in a quarter of the macrophages that conta

175 rrelated positively with viremia at 3 months postinfection in all three infection models.

176 of MCP-1 correlated with viremia at 3 months postinfection in both nonprogressive infections.

177 regions under selection at 1, 3, and 9 days postinfection in chicks.

178 infection in monocytes, compared with 30 min postinfection in fibroblasts and endothelial cells, sugg

179 ction and sustained cell viability at 4 days postinfection in macrophages.

180 etected in the nucleus beginning only at 3 d postinfection in monocytes, compared with 30 min postinf

181 ximately 2.5-fold fewer macrophages at day 5 postinfection in N1347A-infected brains.

182 LD50 resulted in death between 6 and 8 days postinfection in SCID mice.

183 increasing Foxp3(+) Tregs early but not late postinfection in secondary lymphoid tissues is more effi

184 Less disease was seen postinfection in siHMGB1 compared with control mice and

185 amed corneas was determined on days 7 and 16 postinfection in the immunocomplex-treated group of infe

186 ngal growth within the kidney occurs by 24 h postinfection in the mutant mice.

187 ed memory CD4(+) T population(s) at 20 weeks postinfection in the spleen, liver, or bone marrow of WS

188 roduced IFN-gamma but did not upregulate GFP postinfection in vivo.

189 e cytokines upon TLR stimulation in vitro or postinfection in vivo.

190 d by 39.6% at 3 months and 46.7% at 6 months postinfection in women with preinfection measurements.

191 scent bacteria localized in the cecum by 3 h postinfection, indicating that the cecum is not only a m

192 ly, ototopical administration of vinpocetine postinfection inhibited MUC5AC expression and middle ear

193 women were identified at a median of 42 days postinfection (interquartile range, 34-59), contributing

194 ncreased proliferation between days 8 and 14 postinfection is associated with subsequent decreased CD

195 proximately 2 d, whereas treatment given 2 d postinfection is mostly ineffective in accelerating plas

196 elonging to CD8(+) T cells as early as day 2 postinfection is responsible for protection.

197 essed at 2 days postinfection, and at 4 days postinfection it was totally abolished.

198 infection, and depletion beginning at 3 days postinfection led to more pronounced sensitivity than de

199 a-derived DCs that infiltrate the DLNs >24 h postinfection made a modest contribution to CD4(+) T cel

200 As early as 3 weeks postinfection, more pulmonary granulomas were observed i

201 At later time points postinfection, NF-kappaB signaling is inhibited through

202 t, phagocytosis of C. albicans by PMN 60 min postinfection occurred almost independently of C5a and m

203 ntracellular L. monocytogenes detectable 6 h postinfection of epithelial cells.

204 At 14 and 15 weeks postinfection, one group was given praziquantel to treat

205 ific depletion of dendritic cells from day 2 postinfection or by sterile induction of type I IFN.

206 red serum samples collected preinfection and postinfection or vaccination to assess durability of hum

207 pathways were also activated on days 1 and 3 postinfection, ostensibly due to epithelial cell distres

208 an their uninfected counterparts at 16 weeks postinfection (P < 0.0001).

209 breadth was positively associated with time postinfection (P = 0.0001), but contrary to what has bee

210 ale macaques postvaccination (p = 0.018) and postinfection (p = 0.0048) exhibited higher Breg frequen

211 fold lower virus titer in the lung at 5 days postinfection (p.i.) and had markedly reduced weight los

212 icantly decreased the lesion size at 14 days postinfection (p.i.) compared to results for nontreated,

213 orsal root ganglionic (DRG) neurons at day 4 postinfection (p.i.) for both viruses.

214 STAT3 were increased between 94 and 131 days postinfection (p.i.) in brains of mice infected with str

215 ially detected in neurons as early as 3 days postinfection (p.i.) in the brains of RABV-infected mice

216 dentified 5 macaques (38%) from 1 to 2 years postinfection (p.i.) with broadly neutralizing antibodie

217 nregulated to below baseline levels by day 8 postinfection (p.i.), and remains so at the chronic stag

218 ction, level of viral gB DNA in TG on day 28 postinfection (p.i.), and virus reactivation on day 28 p

219 However, on day 3 postinfection (p.i.), the copy number of HSV-1 glycoprot

220 ium isolates obtained at various time points postinfection (p.i.).

221 as cage mates for contact exposure at 1 day postinfection (p.i.).

222 e GI tracts of infected mice at various days postinfection (p.i.).

223 gous B. burgdorferi at different time points postinfection (p.i.).

224 intrinsic pathway later in infection (>10 h postinfection [p.i.]) after maximal virus titers (150 to

225 By 7 days postinfection (PI), mice infected with FMLV-IL-1beta exh

226 and that total reactivity to influenza virus postinfection represented approximately 0.1% of the circ

227 , 44%, and 55% of women at 1, 2, and 3 years postinfection, respectively, and to <500 cells/microL in

228 ed numbers of Foxp3(+) Tregs on days 2 and 4 postinfection resulted in a marked reduction in the deve

229 very 3 days for 21 days, starting at 6 hours postinfection, resulted in effective inhibition of virus

230 NA mediated increased MIP-2 expression early postinfection, resulting in substantial pulmonary neutro

231 achment; in contrast, addition of galectin-1 postinfection results in reduced production of progeny v

232 At 17 weeks postinfection, right ventricular systolic pressure and l

233 Postinfection, RTE numbers contracted less dramatically

234 of infection was not maintained, and by 8 wk postinfection sanroque mice demonstrated an increased ba

235 Pre- and postinfection sera were assayed by enzyme-linked immunos

236 of infection (two as early as 77 and 96 days postinfection) showed substantial cross-neutralization.

237 ocomplex treatment given on days 5, 6, and 7 postinfection significantly increased Foxp3(+) Tregs in

238 to disease or defense are induced within 6 h postinfection, significantly before pathogen multiplicat

239 ently detected in plasma samples at 3 months postinfection, significantly earlier than in gp120 macaq

240 ion of recombinant IL-22 (rIL-22), given 2 h postinfection, significantly reduced the bacterial burde

241 ce with recombinant IL-17A, as late as day 6 postinfection, significantly reduces the viral burden an

242 timately cleared the bacteria within 3 weeks postinfection, similar to the findings for wild-type mic

243 tion activity correlated inversely with days postinfection (Spearman's R=-0.85, P=0.004) and positive

244 nces in both rates of infection and rates of postinfection survival.

245 We determined the early postinfection TCF7(high) population is marked by low TIM

246 Day 5 postinfection, TCF7(high) cells express higher memory-as

247 ity titers in mosquito cells from 24 to 48 h postinfection than did the GI-a and GIII isolates.

248 triggered less colonic hyperplasia on day 14 postinfection than the wild-type strain.

249 Remarkably, at 2 mo postinfection the proportion of IgG2a/c(+) memory B cell

250 At day 70 postinfection, the animals (10 progressors with high vir

251 pressed transcripts between preinfection and postinfection, the greatest change in transcriptional ac

252 However, by 5 wk postinfection, the overall health of MyD88(-/-) mice beg

253 By 17 weeks postinfection, there was a significant increase in pulmo

254 ranscriptional analysis on 38 macaques at 11 postinfection time points during the first 6 mo of M. tu

255 ly, despite this approach being an effective postinfection treatment option, research on novel approa

256 Furthermore, postinfection treatment with RvD1 and RvD5 led to protec

257 Strikingly, postinfection treatment with RvD1 and RvD5 reduced bacte

258 o LACV-induced neurological disease, whereas postinfection treatment with type I IFN provided protect

259 At 62 days postinfection, trigeminal ganglia were excised and profi

260 ed long term with RhCMV to determine whether postinfection vaccination against vIL-10 could change th

261 ing but unfulfilled goal has been to develop postinfection vaccine strategies that could "reboot" the

262 ed to a 26-fold reduction in lung CFU by 6 d postinfection versus nondepleted mice.

263 with CHV-1 for 48 h, and at that time point postinfection, viral plaques could be visualized in the

264 on of interferon (IFN) subtypes up to 5 days postinfection was analyzed by quantitative reverse trans

265 d polymorphisms in Nef during the first year postinfection was associated with impaired protein funct

266 Phagocytosis of C. albicans 10 min postinfection was mediated by C5a-dependent enhancement

267 treatment with MEDI8852 24, 48, or 72 hours postinfection was superior to oseltamivir for H5N1.

268 f-1") expression is FOXO1 independent, early postinfection we report bimodal, FOXO1-dependent express

269 lite changes were detected as early as 1 day postinfection, well before the onset of disease or the s

270 se (PO) response and bacterial load at 24-hr postinfection were ascertained.

271 and brains of infected mice on days 3 and 5 postinfection were markedly virus and time dependent, as

272 grate into the tissues during the first 24 h postinfection were not required for CD4(+) T cell expans

273 on; 2) DCs that infiltrated the cornea >24 h postinfection were responsible for most of the CD4(+) T

274 ction, are uniquely expressed in the EP 60 d postinfection when animals are no longer suffering from

275 After 2 to 4 days postinfection, when map is suppressed, EPEC colonization

276 b(R)LD-infected MyD88(-/-) mice died by 60 d postinfection, whereas the WT mice continued to survive.

277 the autophagy marker LC3 (42% +/- 7%) at 2 h postinfection, which constituted a 5-fold increase over

278 ped bNAb activity after approximately 1 year postinfection, which ultimately mapped to the membrane-p

279 increased in the lungs at early time points postinfection, which was correlated with increased innat

280 d with [(18)F]-FDG uptake and peaked 10 days postinfection, while minimal lymphadenopathy and higher

281 wer than those of the parent strain at 1 day postinfection, while the complemented strain was recover

282 arly 80% of spores were inside cells at 24 h postinfection with 10(4) spores.

283 he immune responses in the lung draining LNs postinfection with a lethal A/HK/483/97 or nonlethal A/H

284 pulmonary M. tuberculosis for at least 6 wk postinfection with a single immunization.

285 Supernatant from plasmacytoid DCs harvested postinfection with BVDV or recombinant bovine IFN-alpha

286 exhibited lower viremia and pathology at 7 d postinfection with Friend retrovirus (FV) compared with

287 in survival or levels of IL-22 in the lungs postinfection with K. pneumoniae.

288 mal proportion of antiviral effector T cells postinfection with lymphocytic choriomeningitis virus (L

289 showed increased [(18)F]-FDG uptake by day 4 postinfection with minimal lymph node enlargement, indic

290 bacterial clearance, and decreased mortality postinfection with P. aeruginosa.

291 l role in protection against disease in vivo postinfection with RSV.

292 rst monocytes to produce IL-10 in vivo early postinfection with S. mansoni cercariae.

293 hedding of the NKG2D ligand MICA is observed postinfection with several strains of human CMV due to a

294 alysis RTA levels were higher at early times postinfection with the G50DblKo mutant than with wild-ty

295 increased dramatically between days 1 and 4 postinfection with VACV.

296 oduce effector cytokines or degranulate late postinfection, with minimally increased function even in

297 leukocyte composition was altered at 10 days postinfection, with notable gains in the frequency of T

298 A rapid host response was observed 24 h postinfection, with over 2,500 significantly differentia

299 Viral persistence for weeks postinfection (wpi) has also been documented by the demo

300 suppressed in challenged animals by 5 weeks postinfection (wpi).