ライフサイエンスコーパス: postmeiotic

1 estricted expression in testis, and a unique postmeiotic alternative splicing pattern supported the i

2 testes revealed that Taf7l(-/Y) mice develop postmeiotic arrest at the first stage of spermiogenesis,

3 eased apoptosis of meiotic spermatocytes and postmeiotic arrest of spermatid differentiation.

4 ntington disease mutations were found in the postmeiotic cell population, suggesting that expansions

5 rtially condensed chromosomes accumulate and postmeiotic cells are lacking.

6 s developmental stages, including in haploid postmeiotic cells.

7 nd providing immune privilege to meiotic and postmeiotic cells.

8 18% of mouse X-linked genes are expressed in postmeiotic cells.

9 and that this expression is predominantly in postmeiotic cells.

10 like SAM68, predominantly within meiotic and postmeiotic cells.

11 nally regulated are initially transcribed in postmeiotic cells.

12 demonstrate that SSTK is required for proper postmeiotic chromatin remodeling and male fertility.

13 st that, for healthy men, (a) sperm carrying postmeiotic chromosomal breaks appear to be more prevale

14 hase II and consequently leads to defects in postmeiotic cytokinesis and cell wall formation.

15 Consequently, the first postmeiotic cytokinesis was abolished without the format

16 However, in the absence of both kinesins, postmeiotic development of the male gametophyte was seve

17 genesis, specifically disrupting meiotic and postmeiotic development, resulting in male infertility r

18 alternative 3'-processing during meiosis and postmeiotic development.

19 are enriched in multicopy genes required for postmeiotic differentiation of round spermatids into spe

20 on and analysis of five mutations induced by postmeiotic ENU treatment.

21 ase homolog that is required to regulate the postmeiotic events of spore wall assembly.

22 is limited to meiotic spermatocytes and that postmeiotic expression of sex-linked genes is variable.

23 Treatment of postmeiotic gametes with ENU induces specific-locus muta

24 -locus mutations observed after treatment of postmeiotic gametes with ENU.

25 In higher plants this is achieved in part by postmeiotic gene activity controlling the development of

26 Postmeiotic gene expression is essential for development

27 e that TAF7L binds to promoters of activated postmeiotic genes in testis.

28 The paucity of postmeiotic genes on the X chromosome has been interpret

29 rectly with TRF2 at promoters of a subset of postmeiotic genes to regulate spermiogenesis.

30 deed, we find that Taf7l and Trf2 coregulate postmeiotic genes, but none of Taf4b-regulated germ stem

31 c lineage tracing that Foxa3 is expressed in postmeiotic germ and interstitial Leydig cells.

32 uestering the events of meiotic division and postmeiotic germ cell development from the systemic circ

33 Thus, meiosis and postmeiotic germ cell development take place in the semi

34 ling of transcription and translation during postmeiotic germ cell differentiation is critical for su

35 or Pf20 in mouse spermatogenesis, sustaining postmeiotic germ cell viability.

36 pstream start site, is transcribed solely in postmeiotic germ cells and is translationally regulated

37 egeneration of late spermatids, sloughing of postmeiotic germ cells from the seminiferous epithelium,

38 spermatids and irregular head morphology in postmeiotic germ cells in the seminiferous epithelium, w

39 Nkx-1.2 mRNA was shown to be present in postmeiotic germ cells of the testis and in mature sperm

40 threonine kinase (SSTK) that is expressed in postmeiotic germ cells, associates with HSP90, and is in

41 The variant form was specific to meiotic and postmeiotic germ cells.

42 1 transcripts were most abundant in pre- and postmeiotic germ cells.

43 cific CREM-regulated mRNAs in mammalian male postmeiotic germ cells.

44 ation factor (CstF-64), in mouse meiotic and postmeiotic germ cells.

45 ns are significantly elevated in meiotic and postmeiotic haploid germ cells when chromatin modificati

46 t at the stages of meiotic spermatocytes and postmeiotic haploid spermatids.

47 c spermatocytes and during the maturation of postmeiotic haploid spermatids.

48 negative genetic interaction results because postmeiotic haploids that are supposed to be under negat

49 he frequency of minisatellite mutation after postmeiotic irradiation of spermatids was similar to tha

50 les deficient for h1-h3 or h4-h9 displayed a postmeiotic lesion with disrupted individualization comp

51 c spindle, divide asymmetrically in a single postmeiotic lineage.

52 eveal large reductions in the mRNA levels of postmeiotic male germ cell mRNAs and smaller reductions

53 ouse protamines are expressed exclusively in postmeiotic male germ cells and are crucial for the comp

54 A storage/translational delay in meiotic and postmeiotic male germ cells of the mouse.

55 notype that was only detected in meiotic and postmeiotic male germ cells, giving us the opportunity t

56 eas the 35-kDa protein, which accumulates in postmeiotic male germ cells, is abundant in the nucleus.

57 are needed to activate mP2 transcription in postmeiotic male germ cells.

58 nd then extended our analysis to meiotic and postmeiotic male germ cells.

59 ark of active sex chromosome-linked genes in postmeiotic male germ cells.

60 e mouse genome is dedicated to expression in postmeiotic male germ cells.

61 he vegetative cell, and their precursor, the postmeiotic microspore, and found that unlike in mammals

62 ting that this process is different from the postmeiotic mitoses observed in other fungi.

63 The postmeiotic mitoses were normal in the homozygous lines;

64 G1 phase prior to DNA synthesis of the first postmeiotic mitosis.

65 reports, many of the translationally delayed postmeiotic mRNAs shift from the RNPs into the polysomes

66 te than premeiotic regimens, suggesting that postmeiotic mutagenesis protocols could be useful in som

67 Spermatogenesis is disrupted in postmeiotic null germ cells with many misshapen and mult

68 last premeiotic mitosis and before the first postmeiotic one of a parental genome-the "perigametic in

69 separation of centriole pairs in M-phase or postmeiotic organization of gamma Tub23C at centrioles.

70 During spermiogenesis, the postmeiotic phase of mammalian spermatogenesis, transcri

71 Akap4 is transcribed only in the postmeiotic phase of spermatogenesis and encodes the mos

72 the de novo transcription of RNA during the postmeiotic phases.

73 Saccharomyces cerevisiae that regulates the postmeiotic program of spore formation.

74 The extent of postmeiotic reactivation of germ-cell-specific X-linked

75 nked genes we examined showed some degree of postmeiotic reactivation.

76 iotically, and we provide evidence that this postmeiotic repression is a downstream consequence of MS

77 is show that the maintenance of X chromosome postmeiotic repression is incomplete.

78 While this postmeiotic repression occurs after the loss of MSUC-rel

79 The early meiotic role of Cak1p, like the postmeiotic role in the Smk1p pathway, is CDC28 independ

80 gh levels in the testes, particularly in the postmeiotic round spermatid compartment of the seminifer

81 Postmeiotic round spermatids advance at most to step 7 o

82 nner, is present in cytoplasmic fractions of postmeiotic round spermatids where the protamine mRNAs a

83 sion of mouse Rad30b occurs predominantly in postmeiotic round spermatids.

84 nia, and pachytene spermatocytes, but not in postmeiotic round spermatids.

85 Msh2-Msh3 activate the MutL homolog 1 (Mlh1)-postmeiotic segregation 1 (Pms1) endonuclease in the pre

86 mispairs whereas addition of MutL homolog 1-postmeiotic segregation 1 had no affect on MMR.

87 tability during DNA replication within human postmeiotic segregation 2 (hPMS2)-deficient and proficie

88 It is shown that postmeiotic segregation 2 (PMS2), an MMR protein, is req

89 In the absence of mei-9 activity, postmeiotic segregation associated with noncrossovers oc

90 se mutants did not accumulate high levels of postmeiotic segregation at the ARG4 recombination hotspo

91 s during meiosis: in a pms1 mutant, frequent postmeiotic segregation indicates a defect in the correc

92 n a mlh2 mutant, crossing-over is normal and postmeiotic segregation is not observed but non-Mendelia

93 f the arrangement of heteroduplex DNA in the postmeiotic segregation products reveals different patte

94 in an Msh6 mutant, leading to high levels of postmeiotic segregation; however, hDNA and gene conversi

95 Most of these events are postmeiotic segregations that represent unrepaired heter

96 We demonstrate that this postmeiotic sex chromatin (PMSC) persists throughout spe

97 into spermatids with the silent compartment postmeiotic sex chromatin (PMSC).

98 aternal germ line and persists thereafter as postmeiotic sex chromatin (PMSC).

99 is required for the epigenetic regulation of postmeiotic sex chromosome expression.

100 st strikingly, profiles of escape genes from postmeiotic silencing diverge significantly between huma

101 and may allow mammals to cope with conserved postmeiotic silencing during the evolutionary past.

102 males for haploid gene transcription during postmeiotic sperm differentiation.

103 he X and Y occupy a novel compartment in the postmeiotic spermatid and adopt a non-Rabl configuration

104 body, creates an immune-privileged site for postmeiotic spermatid development to avoid the productio

105 During postmeiotic spermatid differentiation, gamma Tub23C was

106 phila spermatogenesis, mitochondria in early postmeiotic spermatids aggregate, fuse, and elongate bes

107 70-2 -/-) did not synthesize HSP70-2, lacked postmeiotic spermatids and mature sperm, and were infert

108 clusively in testis and more specifically in postmeiotic spermatids and sperm cells.

109 Postmeiotic spermatids are the only cells of the seminif

110 -64 was limited to meiotic spermatocytes and postmeiotic spermatids in testis.

111 mammals and teleosts, the differentiation of postmeiotic spermatids to spermatozoa (spermiogenesis) i

112 al body is detached from the nucleus in asun postmeiotic spermatids, resulting in abnormalities later

113 gene promoter to express Cre recombinase in postmeiotic spermatids.

114 ident with the onset of MSCI and persists in postmeiotic spermatids.

115 division, and is present in the cytoplasm of postmeiotic spermatids.

116 lar degeneration with increased apoptosis of postmeiotic spermatids.

117 terochromatin in mammalian meiotic and newly postmeiotic spermatocytes.

118 clear extracts from premeiotic, meiotic, and postmeiotic spermatogenic cell types obtained from young

119 rcc1 mRNAs correlated with meiotic and early postmeiotic spermatogenic cells.

120 af7l ablation impairs the expression of many postmeiotic spermatogenic-specific as well as metabolic

121 essed in testes tissues and is necessary for postmeiotic spermiogenesis, but loss of Blanks is not ac

122 uggesting a role for the gene product in the postmeiotic stages of male germ cell development.

123 The mRNA is expressed during the meiotic or postmeiotic stages of spermatogenesis, and the protein i

124 on with x-rays was studied at premeiotic and postmeiotic stages of spermatogenesis.

125 omal mRNAs during the late meiotic and early postmeiotic stages of spermatogenesis.

126 ly regulated and correlates with the meiotic/postmeiotic stages of spermatogenesis.

127 ayed pleiotropic defects, beginning at early postmeiotic stages.

128 s on the Y short arm induce defects at early postmeiotic stages.

129 rentiation during fetal development and into postmeiotic stages.

130 g meiotic prophase and nucleosome removal at postmeiotic stages.

131 ts strengthen the newly emerging notion that postmeiotic transcription is dynamic and integral to the

132 ytene spermatocytes was required for the two postmeiotic transitions, but not for the two premeiotic

133 ermatocytes produce RA to coordinate the two postmeiotic transitions.

134 es now reveal that RA also regulates the two postmeiotic transitions: initiation of spermatid elongat

135 tic cells, the range of mutations induced in postmeiotic zebrafish germ cells has been less thoroughl