ライフサイエンスコーパス: postmitotic

1 e cues is at least in part controlled by the postmitotic activity of the transcription factor Nkx2-1.

2 ferent ways, thus rendering bulk analyses of postmitotic adult cells difficult to interpret.

3 fy 480 proteins that become insoluble during postmitotic aging in Saccharomyces cerevisiae and show t

4 propose that the view of salivary glands as postmitotic and dependent on stem cells for renewal be r

5 ous system, myelinating oligodendrocytes are postmitotic and derive from proliferative oligodendrocyt

6 tes calbindin expression soon after becoming postmitotic and includes RCs, which express the transcri

7 is patterning begins before the cells become postmitotic and is likely linked to the onset of asymmet

8 potent/multipotent stem/progenitor cell to a postmitotic and more differentiated cell.

9 ve potential, innate immune cells are mostly postmitotic and need to be replenished from bone marrow

10 Neurons are postmitotic and thus irreplaceable cells of the central

11 l compartment cells remain undifferentiated, postmitotic, and unresponsive to Notch-dependent lateral

12 are derived from neural crest and because of postmitotic arrest lack competence to repair cell loss f

13 of adult mice in vivo and ex vivo, including postmitotic astrocytes.

14 nd maintenance of mechanosensory function in postmitotic auditory hair cells and could help identify

15 es have shown that the sensory epithelium is postmitotic, but it harbors cells that can behave as pro

16 As EBs differentiate into ECs, they become postmitotic, but undergo extensive growth and DNA endore

17 xpressing progenitors/neuroblasts, and early postmitotic calretinin-expressing neurons were present c

18 Understanding cell cycle regulation in postmitotic cardiomyocytes may lead to new therapeutic a

19 ltiple cell types, as well as replication of postmitotic cardiomyocytes.

20 sed at intercalated discs in human and mouse postmitotic cardiomyocytes.

21 ater role than PAN1 in directing patterns of postmitotic cell expansion that determine the shapes of

22 or maintaining a balance between mitotic and postmitotic cell fates in development of the mammalian s

23 egeneration, and highlight the importance of postmitotic cell growth in gut epithelial repair.

24 ng that the growth of a key compartment of a postmitotic cell involves an extensive switch in gene ex

25 constitute the differentiation program of a postmitotic cell type.

26 scripts accumulate in both proliferating and postmitotic cell types of Arabidopsis plants.

27 de that LRCs in adult TECs are not senescent postmitotic cells and may represent the elusive progenit

28 nscription factors in neural progenitors and postmitotic cells are key regulators in this process.

29 Nucleoli continued to diminish in postmitotic cells following fate specification.

30 mely susceptible to apoptotic signals, while postmitotic cells have developed several strategies to p

31 Because postmitotic cells in higher eukaryotes often do not star

32 in stem cell formation; however, its role in postmitotic cells is largely unknown.

33 -lived proteins (ELLPs) did not turn over in postmitotic cells of the rat central nervous system.

34 how that Pk1 transcripts are detected in the postmitotic cells of the subplate and cortical plate dur

35 s, but their genomic targets and function in postmitotic cells remain poorly understood.

36 ion of proteins in an SDS-insoluble state in postmitotic cells represents a novel autophagic cargo pr

37 associated with dysfunction and loss of the postmitotic cells residing within this tissue.

38 it nuclear activities of PML and PML/RARA in postmitotic cells through CyPN-dependent cytoplasmic seq

39 ore, TGFbeta and growth pathways interact in postmitotic cells to precisely coordinate cell-specific

40 ate regulator, Notch1, were studied in newly postmitotic cells using a conditional allele of Notch1 (

41 meostasis and function, thus rendering these postmitotic cells vulnerable to premature death in retin

42 ifferentiation to hair cells of the normally postmitotic cells was restricted to the Lgr5-positive po

43 different intervals postinjection to follow postmitotic cells' positional changes.

44 e when neurons exit the cell cycle to become postmitotic cells, and it is generally accepted that, on

45 tand the protein composition of these unique postmitotic cells, in which irreversible protein degrada

46 clusively in a nonquiescent subpopulation of postmitotic cells, indicating an asymmetrical distributi

47 RATIONALE: Postmitotic cells, such as cardiomyocytes, seem to be pa

48 ry persists within one cell generation or in postmitotic cells, while long-term memory can survive mu

49 iched at the centrosome both in dividing and postmitotic cells.

50 proliferating cells but also in nondividing postmitotic cells.

51 been identified in extracellular matrices or postmitotic cells.

52 share protein derangements and attrition of postmitotic cells.

53 n the absence of Notch1 in mitotic and newly postmitotic cells.

54 igase that is active both in dividing and in postmitotic cells.

55 erges at distinct embryonic ages and only in postmitotic cells.

56 ve near the future apical membranes, and the postmitotic centrosomes lose all, or nearly all, of thei

57 xpresses both Atoh1 and NeuroD1, a marker of postmitotic cerebellar granule cells.

58 oximal promoter in CGN progenitors and early postmitotic CGNs, and its departure mirrored the initial

59 nstrated a p53-independent abrogation of the postmitotic checkpoint by HPV E6 that induces polyploidy

60 lower affinity than Cdk2, in abrogating the postmitotic checkpoint in E6-expressing cells.

61 mutant-expressing cells while bypassing the postmitotic checkpoint.

62 degradation but competent in abrogating the postmitotic checkpoint.

63 (2014) show that the ATPases RuvBL1/2 drive postmitotic chromatin decondensation, demonstrating that

64 activates proliferation within the normally postmitotic cochlear epithelium.

65 ver, whether extrinsic signals contribute to postmitotic cortical neuronal development is unclear.

66 used conditional inactivation restricted to postmitotic cortical neurons in mice to investigate the

67 s- and gain-of-function, that high levels of postmitotic COUP-TFI (Nr2f1) expression are necessary an

68 study, we demonstrate that the ISL1 controls postmitotic cranial branchiomotor (BM) neurons including

69 ergic fate survive and integrate better than postmitotic DA neurons.

70 Furthermore, postmitotic depletion of Pav-KLP in Drosophila neurons i

71 ls (ACs), beginning with the early stages of postmitotic development.

72 3, but migrate dorsally and laterally during postmitotic development.

73 Postmitotic differentiated neurons are among the most di

74 tivity is critical for cell cycle reentry of postmitotic, differentiated cells, whereas an increase i

75 center (MTOC) in dividing cells and in many postmitotic, differentiated cells.

76 lopmental programs of in vivo progenitor and postmitotic differentiation and whether they develop int

77 nd the transcription factor Runx1 coordinate postmitotic differentiation of nonpeptidergic nociceptor

78 ides an attractive new system to address how postmitotic diploid cells contribute to repair.

79 Here we show that, in postmitotic Drosophila follicular epithelia, aberrant bu

80 r data demonstrates that Bclaf1expression in postmitotic early-born cells facilitates the differentia

81 The mechanism by which this occurs is via postmitotic endoreduplication checkpoint and mitotic cat

82 trointestinal motility due to a reduction in postmitotic enteric neurons.

83 reveal a remarkable homeostatic mechanism in postmitotic epithelia that ensures not only elimination

84 variety of progenitor cells, is expressed in postmitotic epithelial cells of the mouse airways and ep

85 ped corpus callosum astrocytes are uniformly postmitotic, express glutamate receptors, and form aquap

86 All ACs require the postmitotic expression of the bHLH pancreas transcriptio

87 f fast-spiking (FS) interneurons through the postmitotic expression of the transcriptional regulator

88 These phenotypes are rescued by postmitotic expression of Velo in PNs but not by a catal

89 We report a profound disruption of postmitotic expression trajectories in Pet-1(-/-) neuron

90 ic) factor subsequently globally coordinates postmitotic expression trajectories of genes necessary f

91 ast pluripotency, molecular pathways driving postmitotic fates remain poorly defined.

92 cre recombinase line that becomes active in postmitotic fetal 5-HT neurons.

93 acking the class I HDACs, HDAC1 or HDAC2, in postmitotic forebrain neurons to investigate the specifi

94 We generated progenitor-stage and postmitotic forebrain-specific Cited2 conditional knock-

95 These studies establish a novel postmitotic function for rae-1 in neuronal development.

96 ronal life history, from development through postmitotic function.

97 hter cells but must be reversed to allow for postmitotic functions.

98 ave demonstrated a novel role of Cdk1 at the postmitotic G1-like checkpoint in the presence of Cdk2.

99 ndependent function of E6 in attenuating the postmitotic G1-like checkpoint that can lead to polyploi

100 However, it is still unknown whether postmitotic gene expression gradients can determine area

101 Thus, features of postmitotic gene reactivation can provide insights into

102 Here we reveal a new connection between postmitotic genome surveillance and cytokinetic abscissi

103 at ATR activity in midbody-stage cells links postmitotic genome surveillance to abscission timing and

104 inating enzyme required for p97/p47-mediated postmitotic Golgi membrane fusion, is phosphorylated at

105 est that clathrin may provide a template for postmitotic Golgi reassembly and cisternal remodeling.

106 Here we identified a novel step in postmitotic Golgi reassembly that requires the clathrin

107 in pools are membrane-bound and required for postmitotic Golgi reassembly.

108 usters compared with granule progenitors and postmitotic granule neurons.

109 unknown, whether such mechanisms operate in postmitotic, highly differentiated cell types, such as n

110 This postmitotic Hippo network behavior relies on a tissue-re

111 adin (mllt1), using a conditional allele, in postmitotic hippocampal neurons.

112 ression of mitotic chondrocytes to a mature, postmitotic hypertrophic fate.

113 ng for transplantation and demonstrated that postmitotic iDA neurons stably and functionally integrat

114 n birds injected on E12, and most cells were postmitotic in both sexes on E14-E16.

115 ndlin localization and function at a stable, postmitotic intercellular bridge in the Caenorhabditis e

116 iding role in the migration and placement of postmitotic interneurons in the developing cerebral cort

117 monocytes emerge first from marrow, after a postmitotic interval of 1.6 d, and circulate for a day.

118 p27(Kip1) to maintain the quiescent state of postmitotic IPCs.

119 irectly activates p27(Kip1) transcription in postmitotic IPCs.

120 However, in postmitotic larval cells, none of these factors individu

121 (from data in the literature), the earliest postmitotic lateropallial cells likewise express Nr4a2 a

122 d birds is abnormally thin and has a reduced postmitotic layer, consistent with a delay in neurogenes

123 d increased expression of Meis1, a marker of postmitotic LGE neurons.

124 1-expressing progenitors express mCherry and postmitotic Lhx6-expressing MGE-derived interneurons exp

125 pecified cells that give rise to an abundant postmitotic lineage, including epidermal cells, and are

126 ation of adipocyte stem cells (ASCs) to form postmitotic, lipid-filled mature adipocytes.

127 Disruption of postmitotic maintenance mechanisms may result in neurops

128 Postmitotic mammalian cells and cells of invertebrates s

129 nelle that emanates from the surface of most postmitotic mammalian cells and serves as a sensory orga

130 In postmitotic mammalian cells, protein p53R2 substitutes f

131 We conditionally removed both genes in postmitotic mDA neurons using the dopamine transporter-c

132 is a pro/pre- or pre-B cell rather than the postmitotic Merkel cells.

133 he progenitors and only become detectable in postmitotic MNs.

134 s the transmission of positional identity to postmitotic motor neurons later in development.

135 ges in ultrastructure and gene expression in postmitotic mouse cones, between birth and eye opening,

136 conditional deletion of the subunit NF-YA in postmitotic mouse neurons induces progressive neurodegen

137 otentially due to novel mechanisms governing postmitotic mutation.

138 However, the interaction of CSCs with postmitotic myocytes results in the formation of cells w

139 Almost all newly postmitotic N1-CKO cells became rod photoreceptors, wher

140 Given the postmitotic nature of cardiomyocytes, the efficient remo

141 they are one of the first genetic markers of postmitotic neural cells.

142 Depletion of Fezf2 induces apoptosis in postmitotic neural progenitors, with concomitant reducti

143 t, function-defining signaling features of a postmitotic neuron are hardwired together through coordi

144 framework for how functional asymmetry in a postmitotic neuron pair is specified in C. elegans.

145 ivation, and neurotransmitter signaling in a postmitotic neuron represents one key approach to unders

146 insic cytoplasmic asymmetry inherited by the postmitotic neuron, the exposure of the neuron to extrac

147 ion of neural progenitors and, subsequently, postmitotic neuronal differentiation, a relatively poorl

148 ting effects occur in the context of a fixed postmitotic neuronal genome has been an enduring questio

149 Postmitotic neuronal migration was independently disrupt

150 ial glial progenitor cells and impairment of postmitotic neuronal migration, were also observed.

151 E1 and NDEL1 RNAi have comparable effects on postmitotic neuronal migration.

152 ex formation provides a robust mechanism for postmitotic neuronal subtype specification.

153 etion of lamin B1 in retinal progenitors and postmitotic neurons affects nuclear integrity, leads to

154 oncogenic Kras from its endogenous locus in postmitotic neurons after birth.

155 While it has been commonly thought all postmitotic neurons and glia express DNMTs at comparable

156 neural progenitor pool and the production of postmitotic neurons and glia.

157 ne-threonine kinase that is highly active in postmitotic neurons and in many cancers, allows medullob

158 Its functions in postmitotic neurons are not known.

159 but the consequences of genotoxic stress to postmitotic neurons are poorly understood.

160 Postmitotic neurons are subject to a vast array of envir

161 genome editing via HDR is possible in mature postmitotic neurons as well as mitotic cells in mice bra

162 We find that let-7-C is activated in postmitotic neurons born during the larval-to-pupal tran

163 Disruption of RA signaling in postmitotic neurons by dominant-negative retinoid recept

164 1 determines multipolar neuron morphology in postmitotic neurons by regulating genes involved in nucl

165 We have now tested this system in postmitotic neurons by targeting two well-characterized

166 iple that neuronal identity is maintained in postmitotic neurons by the sustained, and often autoregu

167 Specifically, neighboring postmitotic neurons communicate through Notch signaling

168 st that the persistent expression of CUX2 in postmitotic neurons contributes to the maintenance of ge

169 Depletion of Myt1l in primary postmitotic neurons de-repressed non-neuronal programs a

170 In contrast, specific populations of postmitotic neurons derived from these progenitors, incl

171 us trophic factors signaling pathways during postmitotic neurons differentiation.

172 at it is highly expressed in progenitors and postmitotic neurons during cortical development.

173 utual inhibition among groups of neighboring postmitotic neurons during development regulates the rob

174 ethality, while genetic deletion of Bcl7a in postmitotic neurons elicits motor abnormalities and affe

175 Postmitotic neurons express a neuron-specific assembly,

176 In control mice, postmitotic neurons expressed Mef2a, -c, and -d, whereas

177 n LGE progenitors readily differentiate into postmitotic neurons expressing the striatal projection n

178 During nervous system development, postmitotic neurons face the challenge of generating and

179 nt to rescue, in an isoform-specific manner, postmitotic neurons from defects in differentiation caus

180 CLK-GFP is only detected in postmitotic neurons from L3 larvae, suggesting that thes

181 However, the role of Bif-1 in postmitotic neurons has not been investigated.

182 lls display a developmental phenotype: young postmitotic neurons have smaller cell bodies, more exten

183 Dar1 determines the multipolar morphology of postmitotic neurons in Drosophila.

184 ; its expression persists in a population of postmitotic neurons in the 8-week-old retina.

185 nding, deletion of Bcl-xL selectively in the postmitotic neurons in the brain (Bcl-xL(Nex-Cre)) also

186 Sip1 deletion from all postmitotic neurons in the neocortex results in lack of

187 ble expression of terminal effector genes in postmitotic neurons is controlled by a dynamic relay of

188 tal brain and through adulthood, its role in postmitotic neurons is not clear.

189 that the role of 5-hydroxymethylcytosine in postmitotic neurons is to functionally demethylate expre

190 pic overexpression of miR-26b in rat primary postmitotic neurons led to the DNA replication and aberr

191 In response to neurotoxic signals, postmitotic neurons make attempts to reenter the cell cy

192 Postmitotic neurons migrate tangentially from the RMTW t

193 Loss of Notch in postmitotic neurons modulates an axon's target choice.

194 s able to process sensory information, young postmitotic neurons must maintain occasional bursts of a

195 The survival of postmitotic neurons needs continuous degradation of cycl

196 ubclass of MAPKs and is densely expressed in postmitotic neurons of adult mammalian brains.

197 the cell cycle exit and differentiation into postmitotic neurons of NPCs derived from embryonic stem

198 ly, RNAi-mediated knockdown of En and Inv in postmitotic neurons reduces SEP amplitude but also reduc

199 Thus, deletion of La from postmitotic neurons results in defective pre-tRNA and pr

200 , we report that acute inactivation of Rb in postmitotic neurons results in ectopic cell cycle protei

201 rast, loss of Notch in clones of neighboring postmitotic neurons results in erroneous coinnervation b

202 scale location analysis in stem cell-derived postmitotic neurons reveals Top2beta binding to chromoso

203 Intriguingly, postmitotic neurons still express DNA methyltransferases

204 hotomous pattern of PKM expression, in which postmitotic neurons throughout the brain expressed the c

205 mitotic stem cell lineages, is reutilized in postmitotic neurons to control postdifferentiation event

206 hese repressors are continuously required in postmitotic neurons to prevent UNC-3, which is active in

207 1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melan

208 scratch2 knockdown induces postmitotic neurons to re-enter mitosis.

209 rized the effects of genome modifications in postmitotic neurons using biochemical, genetic, electrop

210 lular functions of mitochondrial division in postmitotic neurons using in vivo and in vitro gene knoc

211 Specific deletion of paxillin in postmitotic neurons using Nex-Cre-mediated recombination

212 thereby explaining its contrasting effect in postmitotic neurons versus proliferating cell lines.

213 , production of intermediate progenitors and postmitotic neurons were markedly suppressed.

214 ors within a lineage, possibly by modulating postmitotic neurons' responses to Notch-independent tran

215 dients arise in intermediate progenitors and postmitotic neurons, and are necessary to implement area

216 ism of gene expression regulation in various postmitotic neurons, both over time and in response to e

217 Postmitotic neurons, such as photoreceptor cells in the

218 that SIRT1 was rapidly recruited to DSBs in postmitotic neurons, where it showed a synergistic relat

219 lcytosine (5hmC) occurs at maximal levels in postmitotic neurons, where its accumulation is cell-spec

220 ion of the p53 tumor suppressor to reprogram postmitotic neurons, which can result in tumorigenesis o

221 efficient differentiation of hPS cells into postmitotic neurons.

222 ysis, we identify genes controlled by p53 in postmitotic neurons.

223 ylation states at multiple sites on MeCP2 in postmitotic neurons.

224 ferase 3A (DNMT3A) for active maintenance in postmitotic neurons.

225 stoma cells to induce differentiation toward postmitotic neurons.

226 ural stem cell genes and cell-cycle genes in postmitotic neurons.

227 uired to promote neuronal differentiation of postmitotic neurons.

228 c metabolites and lifelong survival of these postmitotic neurons.

229 vior with age and produce the same number of postmitotic neurons.

230 ing it challenging to apply the technique in postmitotic neurons.

231 tion, regulation of cell cycle, and death in postmitotic neurons.

232 ifferentiation but causes premature death of postmitotic neurons.

233 and shown previously to promote survival of postmitotic neurons.

234 NMT1 and DNMT3a are most highly expressed in postmitotic neurons.

235 genitor cells of the neurogenic zones and in postmitotic neurons.

236 ti-nucleolar effects were most pronounced in postmitotic neurons.

237 cycle exit, differentiation, and survival of postmitotic neurons.

238 ving the cell cycle and differentiating into postmitotic neurons.

239 nvolved in presynaptic protein expression in postmitotic neurons.

240 volved in expression of synaptic proteins in postmitotic neurons.

241 and promotes differentiation and survival of postmitotic neurons.

242 ronal cells and continues to be expressed in postmitotic neurons.

243 crease of both proliferating progenitors and postmitotic neurons.

244 cascade that enhances the survival of young postmitotic neurons; and (2) a previously unrecognized R

245 rt that TCF7l2 is upregulated transiently in postmitotic, newly differentiated oligodendrocytes.

246 plasmic transport, spindle organization, and postmitotic nuclear assembly.

247 cting on proliferating progenitors and their postmitotic offspring.

248 different transcription factors to diversify postmitotic olfactory cell types.

249 The heart is no longer considered a postmitotic organ, but is viewed as a self-renewing orga

250 e mammalian heart has long been considered a postmitotic organ, implying that the total number of car

251 d by H3S10 phosphorylation in differentiated postmitotic osteoblasts and cycling B cells.

252 Our data indicate a crucial role for postmitotic patterning genes in areal specification and

253 virus (AAV)-mediated CRISPR/Cas9 delivery to postmitotic photoreceptors is used to target the Nrl gen

254 Postmitotic podocytes do not have an infinite life span;

255 ved stereotypical stomata lineages through a postmitotic polarity-switching mechanism.

256 ication but arose through differentiation of postmitotic precursor cells.

257 ugh differentiation of two subpopulations of postmitotic precursor cells.

258 rotonin (5-HT) neurons and initially acts in postmitotic precursors to control acquisition of 5-HT tr

259 tch2 appears to safeguard the homeostasis of postmitotic primary neurons by preventing cell cycle re-

260 Elevating replication stress increases this postmitotic process and delays cytokinetic abscission by

261 C/C controls both cell-cycle progression and postmitotic processes through ubiquitin-dependent proteo

262 tin(+) progenitors that, together with their postmitotic progeny expressing NeuN, comprise tumor bulk

263 ervous system, Oli is primarily expressed in postmitotic progeny, and in particular, in distinct vent

264 reening to uncover markers and regulators of postmitotic progeny.

265 p53 accumulation in single cells: an initial postmitotic pulse, followed by low-amplitude oscillation

266 1-positive recycling endosomes in Drosophila postmitotic pupal eye epithelia.

267 When mouse Drp1 was deleted in postmitotic Purkinje cells in the cerebellum, mitochondr

268 aberrant mitosis, and was associated with a postmitotic reattachment defect, and selective removal o

269 g that GATA1 functions as platform for their postmitotic recruitment.

270 erficial layer CPN birth, with a progressive postmitotic refinement in expression, becoming restricte

271 these results elucidate BARHL2 as a critical postmitotic regulator of dI1 subtype diversification, as

272 -1 orchestrates maturation through secondary postmitotic regulatory factors.

273 s prompted greater characterization of their postmitotic repertoire of fate determinants, which inclu

274 hat cell fate decisions can be made in newly postmitotic retinal cells, and reveal some of the regula

275 n both proliferating retinal progenitors and postmitotic retinal cells.

276 overed that selective loss of Atoh1 from the postmitotic retrotrapezoid nucleus (RTN) neurons results

277 When SoxC genes are deleted in postmitotic RGCs, contralateral RGC axons grow poorly on

278 The results demonstrate innate plasticity in postmitotic rod precursors that allows these cells to fo

279 del, we report that loss of DICER1 in mature postmitotic rods leads to robust retinal degeneration ac

280 sible early, at embryonic (E) 10.5, when few postmitotic SF1 neurons have been born, suggesting that

281 e from p1 progenitors and, after they become postmitotic, specifically express the transcription fact

282 served HMG-box transcription factor SOX-2 in postmitotic specification and alternative differentiatio

283 teristics of neurons following their initial postmitotic specification.

284 recisely modulated, especially suppressed in postmitotic spermatogenic cells, to guarantee robustness

285 ), which is restricted to VTA neurons at the postmitotic stage and selectively controls the neurogene

286 Neurons live for decades in a postmitotic state, their genomes susceptible to DNA dama

287 related to terminal cell differentiation and postmitotic state.

288 ent exit from the cell cycle and arrest in a postmitotic state.

289 lea, like most neuronal populations that are postmitotic, terminally differentiated, and non-regenera

290 Skeletal muscle is a highly specialized, postmitotic tissue that must withstand chronic mechanica

291 Skeletal muscle is a postmitotic tissue that repairs and regenerates through

292 idogenesis also leads to the degeneration of postmitotic tissue.

293 Their high efficiency of transduction of postmitotic tissues in vivo, such as heart, brain, and r

294 n, however, about this homeostasis system in postmitotic tissues, where tissue-intrinsic genetic prog

295 accumulation of mtDNA multiple deletions in postmitotic tissues.

296 of pluripotent stem cells with remodeling of postmitotic tissues.

297 (Sox4, 11, and 12) act on the progenitor-to-postmitotic transition to implement contralateral, but n

298 CEACAM6-expressing cells remain essentially postmitotic under conditions in which the other cells of

299 SG1 likely represents a postmitotic unresponsive "resting" population.

300 or Foxd3, which is more broadly expressed in postmitotic V1 interneurons.