ライフサイエンスコーパス: postreceptor

1 beta-adrenergic receptor downregulation and postreceptor abnormalities.

2 y related, share receptors, and have similar postreceptor actions.

3 and saturated amplitude of photoreceptor and postreceptor activity were derived from ERG a- and b- wa

4 eared, implying leptinergic blockade at both postreceptor and receptor levels.

5 In this study, we elucidated the postreceptor attachment stages of HCV entry using HCV ps

6 ffect of MnCl(2) on photoreceptor a-wave and postreceptor b-wave relative to baseline at either obser

7 clustering, and distinguish these from later postreceptor binding events such as changes in cell shap

8 ARS-S may interfere with other early pre- or postreceptor-binding events necessary for efficient vira

9 In contrast, ion demand of central postreceptor, but not receptor, retina was significantly

10 patterns of expression and activation of the postreceptor components of the TGF-beta signaling pathwa

11 dies implicate increased cGMP synthesis as a postreceptor contributor to reduced cardiac sympathetic

12 lpha, and IL-2 on the beta-adrenoceptor- and postreceptor-coupled transmembrane signaling mechanisms

13 In contrast, humans with a selective postreceptor defect in AKT2 manifest increased lipogenes

14 In conclusion, CRF causes a postreceptor defect in GH signal transduction characteri

15 mice, it has been proposed that a selective postreceptor defect in hepatic insulin action is central

16 we found that (1). HCV infection leads to a postreceptor defect in IRS-1 association with the IR and

17 This postreceptor defect may be a cause of the skeletal muscl

18 These postreceptor defects in insulin signaling may contribute

19 and lusitropic responses, thus demonstrating postreceptor defects.

20 ta suggest that there are multiple levels of postreceptor desensitization to insulin action.

21 by such pathways has been modeled in detail, postreceptor down-regulation is less well understood.

22 hreshold is due to photoreceptor rather than postreceptor dysfunction.

23 hat impaired biological activity is due to a postreceptor effect.

24 Immediate postreceptor events activated by IL-1-IL-1R interaction

25 malignancies; however, less is known of the postreceptor events important to TNF action in endotheli

26 lex are used to propose a model of the early postreceptor events in Drosophila Toll receptor signalin

27 sensitive Ca2+ channels, one of the earliest postreceptor events in ET-1 signaling, mediated inductio

28 L-18R alpha and IL-18R beta chains, although postreceptor events likely contribute to IFN-gamma produ

29 inhibition of DNA synthesis is likely due to postreceptor events.

30 addition suggests that the synergy involves postreceptor events.

31 ce were associated with a virtual absence of postreceptor function.

32 s of insulin resistance suggest that partial postreceptor hepatic insulin resistance is a key element

33 xosamine pathway may directly modulate early postreceptor insulin signal transduction, perhaps via po

34 lic effects were paralleled by inhibition of postreceptor insulin signaling critical for glucose tran

35 These alterations in postreceptor insulin signaling were time-dependent and p

36 Alterations in postreceptor insulin signaling, therefore, may be respon

37 scaffold and possibly affect the balance of postreceptor insulin signaling.

38 e oxygen species (ROS) are key components of postreceptor intracellular signaling pathways; however,

39 spatial and temporal links with receptor and postreceptor ion demand.

40 In 6 days of a HFD, mRNA of the postreceptor leptin inhibitor, suppressor of cytokine si

41 activities of signaling intermediates at the postreceptor level account for smoking-induced immunosup

42 ity stimulated at either the receptor or the postreceptor level and (2) does not affect agonist-induc

43 decreases in NMDA receptor signaling at the postreceptor level and propose Src as a nodal point of c

44 ance in the majority of patients lies at the postreceptor level of insulin signaling.

45 ng achieves an equivalent integration at the postreceptor level through adaptor protein complexes, in

46 Such disruption could occur at the postreceptor level, because chronic DAMGO also reduced G

47 At the postreceptor level, however, we found striking reduction

48 se, GIV serves as a key hub in the immediate postreceptor level, which coordinately enhances the meta

49 ERF1 inhibitory effects on ERK1/2 occur at a postreceptor locus.

50 hotoreceptor (S(rod), R(rod)) and rod-driven postreceptor (log sigma, V(max)) response parameters wer

51 ing that PDGFs increase binding avidity by a postreceptor mechanism.

52 esponses mediated by them due to a defect in postreceptor mechanisms of PLC activation.

53 hronic opiate treatment alters receptor- and postreceptor-mediated adenylyl cyclase activity.

54 kt enhances micro-opioid desensitization via postreceptor modifications that interfere with G-protein

55 s and (ii) an alteration of events following postreceptor occupancy (e.g., cell spreading).

56 LIBS have been suggested to contribute to postreceptor occupancy events such as full-scale platele

57 rized the impact of these mutations on three postreceptor pathways involving inhibition of cAMP synth

58 F both require drug binding to the DHPR, but postreceptor pathways may diverge in transmission to the

59 transcription in B lymphocytes; however, the postreceptor pathways that regulate CREB activity and CR

60 mations in CCR2 that are coupled to separate postreceptor pathways.

61 f 19-norD(2) seems to be due to an acquired, postreceptor resistance of the intestine and bone to chr

62 Rod-driven postreceptor response amplitude (V(MAX)) and sensitivity

63 se receptor level effects were paralleled by postreceptor responses.

64 Manganese ion uptake by receptor and postreceptor retina was subnormal in each untreated diab

65 mfERG responses represent postreceptor retinal activity.

66 rated photoresponse amplitude) and anomalous postreceptor retinal circuitry.

67 This study supports the concept of postreceptor retinal neuronal loss as a contributor to r

68 3-month-old diabetic male SD rats, total and postreceptor retinal thickness increased (P < 0.05) with

69 As part of a broader effort to identify postreceptor signal regulators involved in specific dise

70 by exogenous IL-6, suggesting that the IL-6 postreceptor signal transduction remained intact.

71 r and molecular neurobiology (in particular, postreceptor signal transduction) as well as to a better

72 d not adversely impact receptor or immediate postreceptor signaling as determined by tyrosyl phosphor

73 We studied postreceptor signaling by these HGF isoforms in the huma

74 Postreceptor signaling events that lead to stress respon

75 eptors, as well as IGF-1 receptors and their postreceptor signaling partners, are distributed through

76 However, the precise postreceptor signaling pathways and specific roles playe

77 differentiation, and defined three distinct postreceptor signaling pathways important for this effec

78 ecrosis factor-alpha, modify the endothelial postreceptor signaling pathways of NPs, with downregulat

79 tion of beta-adrenergic receptors, depressed postreceptor signaling pathways, impaired calcium libera

80 tion drives the production of adaptations in postreceptor signaling pathways, including regulation of

81 Postreceptor signaling through the insulin receptor subs

82 A role of RGS3 in postreceptor signaling was demonstrated by decreased cal

83 ite normal insulin receptor phosphorylation, postreceptor signaling was reduced and was correlated wi

84 eins into multiprotein complexes involved in postreceptor signaling.

85 atter is believed to be the sole conduit for postreceptor signaling.

86 receptor activation and the transduction of postreceptor signals.

87 rotean agonism and begin to define the first postreceptor step in actions of protean agonist ligands.

88 gnaling pathway bifurcates at the very first postreceptor step, the G protein level.

89 lular alterations leading to this effect are postreceptor steps in insulin signaling.

90 sphorylation of the insulin receptor and its postreceptor substrates are essential determinants of in

91 After ouabain injection, receptor and postreceptor uptake of manganese were subnormal (P < 0.0

92 on, mean scotopic photoreceptor (R(rod)) and postreceptor (V(max) and SOPA(max)) amplitude parameters

93 D), S(ROD), R(CONE), S(CONE)) and rod-driven postreceptor (V(MAX), log sigma) response parameters wer