ライフサイエンスコーパス: posttranscriptional

1 cient cells and hypothesized that decreasing posttranscriptional 3' oligo-adenylation of TERC would c

2 l RNA-controlled feedforward loop relying on posttranscriptional activation of two independent target

3 an evolutionary gain-of-function to provide posttranscriptional alanine substitutions in eukaryotic

4 Epitranscriptomics refers to posttranscriptional alterations on an mRNA sequence that

5 In patients with cirrhosis, HSA exhibits posttranscriptional alterations that likely affect its f

6 egulation and regulates its proteome through posttranscriptional and posttranslational means.

7 Both posttranscriptional and transcriptional gene silencing (

8 e in targeted gene silencing by facilitating posttranscriptional and translational repression.

9 Epigenetic, transcriptional, posttranscriptional, and metabolic changes underlie this

10 We propose that STAT3 operates at the posttranscriptional as well as the transcriptional level

11 that TRAIL induces up-regulation of CAS in a posttranscriptional, caspase-8-dependent manner through

12 y mechanisms controlling transcriptional and posttranscriptional CD16 expression in NK cells is unkno

13 years has begun to shed light on the various posttranscriptional changes that occur in response to a

14 Posttranscriptional chemical modification of RNA bases i

15 e have addressed the lack of knowledge about posttranscriptional contributions to noise by determinin

16 els and how dysregulation of 3' UTR-mediated posttranscriptional control associates with human diseas

17 e timing of proliferation at beta-selection, posttranscriptional control by Zfp36l1/l2 limits DNA dam

18 Defects in AU-rich elements (ARE)-mediated posttranscriptional control can lead to several abnormal

19 ts that sinR mRNA stability is an additional posttranscriptional control mechanism governing the swit

20 le for PSPC1-dependent RNA maturation in the posttranscriptional control of adipose development and f

21 Posttranscriptional control of gene expression is import

22 Our data suggest that posttranscriptional control of glycolytic gene expressio

23 es associated with macrophage phenotype, but posttranscriptional control of human macrophage differen

24 ontrolling miRNA expression and explains the posttranscriptional control of miR-17 approximately 92 e

25 m6A modification as a critical mechanism of posttranscriptional control of mRNA fate in late meiotic

26 ir advantages in probing transcriptional and posttranscriptional control of Pol II genes.

27 egulation of cytokine production through the posttranscriptional control of sortilin expression by TL

28 dings underscore the importance of miRNAs in posttranscriptional control of the biosynthesis of speci

29 g proteins participate in a complex array of posttranscriptional controls essential to cell type spec

30 MPO messenger RNA (mRNA) levels supporting a posttranscriptional defect in MPO production.

31 bination with GeneChip analyses identified a posttranscriptional defect in the accumulation of plasti

32 miR-424(322)/503-dependent posttranscriptional downregulation of CDC25A cooperates

33 lf1 depletion on cardiac transcriptional and posttranscriptional dynamics in neonates has not been ad

34 Herein, we show that Hsp90 controls posttranscriptional dynamics of key messenger RNA (mRNA)

35 P78 mRNA levels were unchanged, suggesting a posttranscriptional event.

36 ive approach to discover transcriptional and posttranscriptional events that control dynamic changes

37 duction is determined by transcriptional and posttranscriptional events.

38 tors include transcription factors (TFs) and posttranscriptional factors such as microRNAs (miRs).

39 e mature adipocytes, but the contribution of posttranscriptional factors to the adipocyte phenotype i

40 ar ribonucleoproteins (hnRNPs) regulates the posttranscriptional fate of RNA during development.

41 ther p53 target gene or as a still undefined posttranscriptional function of p53.

42 Here, we show that posttranscriptional Gcr1 regulation is nutrient dependen

43 dence on RNA-binding proteins for regulating posttranscriptional gene expression and translational co

44 ) of transcripts serve as important hubs for posttranscriptional gene expression regulation.

45 plet organelles that are thought to regulate posttranscriptional gene expression.

46 h RNA G-quadruplexes have been implicated in posttranscriptional gene regulation and diseases, direct

47 Our study demonstrates the significance of posttranscriptional gene regulation by miR-19 in prevent

48 Our study demonstrates that posttranscriptional gene regulation by TTP schedules the

49 (SGs) and processing bodies (PBs), sites of posttranscriptional gene regulation during stress.

50 RNA-155 (miR-155) plays an important role in posttranscriptional gene regulation of the immune system

51 mRNA degradation are critical mechanisms of posttranscriptional gene regulation that help cells resp

52 We evaluate the effect of EWS-FLI1 on posttranscriptional gene regulation using both exon arra

53 ve splicing (AS) are essential components of posttranscriptional gene regulation, necessary for norma

54 atory potential of these kinases by enabling posttranscriptional gene regulation.

55 Specific protein-RNA interactions guide posttranscriptional gene regulation.

56 ver, no existing approach for studying these posttranscriptional gene regulators combines transcripto

57 cleotide inhibitors of microRNAs, a class of posttranscriptional gene regulators, to identify novel s

58 esistance or chemosensitivity, and are major posttranscriptional gene regulators.

59 The elucidation of novel posttranscriptional gene regulatory mechanisms has expan

60 We describe a posttranscriptional gene replacement (PTGR) approach whe

61 s based on their atypical structure, whereas posttranscriptional gene silencing (PTGS) eliminates bot

62 ore the relationship between the exosome and posttranscriptional gene silencing (PTGS) in regulating

63 Posttranscriptional gene silencing (PTGS) of transgenes

64 ress transcription or by targeting mRNAs via posttranscriptional gene silencing (PTGS).

65 tant, which exhibits reduced sense transgene posttranscriptional gene silencing (S-PTGS).

66 ies revealed that plants avert inappropriate posttranscriptional gene silencing of endogenous coding

67 Posttranscriptional gene silencing of TOR using RNA inte

68 L4 and RDR6 that are known to be involved in posttranscriptional gene silencing were required to gene

69 screen that resulted in the isolation of the posttranscriptional gene-silencing components RNA-DEPEND

70 ative PCR and immunohistochemistry indicated posttranscriptional increases in regulatory factor X 5 m

71 ng relative to RNAPII, suggesting functional posttranscriptional interactions.

72 MicroRNAs regulate gene expression at the posttranscriptional level and have recently been demonst

73 tes that NRT1.1 is strongly regulated at the posttranscriptional level by tissue-specific mechanisms.

74 P1) jointly regulate IGF2R expression at the posttranscriptional level in intestinal epithelial cells

75 ion, which represents a new mechanism at the posttranscriptional level in the control of viral replic

76 ential for regulating gene expression at the posttranscriptional level including mRNA export/localiza

77 wever, how p73 activity is controlled at the posttranscriptional level is not well understood.

78 imal transcript needs to be repressed at the posttranscriptional level to preserve CD4(+) T cell capa

79 rity of the genes regulated by PRMT5, at the posttranscriptional level, express mRNA containing an in

80 nvolved in regulating gene expression at the posttranscriptional level, have been recognized as impor

81 ing genes are targeted for regulation at the posttranscriptional level.

82 on by promoting viral gene expression at the posttranscriptional level.

83 the expression of viral or host genes at the posttranscriptional level.

84 ng RNAs that regulate gene expression at the posttranscriptional level.

85 perty to inhibit host gene expression at the posttranscriptional level.

86 lammatory cytokine production in TAMs at the posttranscriptional level.

87 tein expression levels are controlled at the posttranscriptional level.

88 repressing many photosynthesis genes at the posttranscriptional level.

89 s the expression of viral lytic genes at the posttranscriptional level.

90 on, suggesting that VfrB may function at the posttranscriptional level.

91 l division control protein 42 (Cdc42) at the posttranscriptional level.

92 iminished, indicating that Slr1796 acts at a posttranscriptional level.

93 iles were observed at transcriptional and/or posttranscriptional levels and importantly exhibit miRNA

94 RNA silencing at the transcriptional and posttranscriptional levels regulates endogenous gene exp

95 sms at the chromosomal, transcriptional, and posttranscriptional levels together facilitates SETDB1 u

96 gulate gene expression at transcriptional or posttranscriptional levels(1-3).

97 mechanisms operate at transcriptional and/or posttranscriptional levels.

98 sion at the epigenetic, transcriptional, and posttranscriptional levels.

99 its target genes at both transcriptional and posttranscriptional levels.

100 gulation occurred at the transcriptional and posttranscriptional levels.

101 ecting surprisingly both transcriptional and posttranscriptional levels.

102 r, BosR, at both the transcriptional and the posttranscriptional levels.

103 onizes the type III IFN response at pre- and posttranscriptional levels.

104 sion is regulated at the transcriptional and posttranscriptional levels.

105 nd polysome studies suggest IGF2BP1 mediates posttranscriptional loss of BCL11A.

106 d in the encapsulation of S. pneumoniae in a posttranscriptional manner.

107 specific ribonuclease (PARN) is required for posttranscriptional maturation of TERC.

108 AA1 protein is also down-regulated through a posttranscriptional mechanism and rapidly reaccumulates

109 Here, we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates E

110 key inducer of EMT and we have elucidated a posttranscriptional mechanism by which TGFbeta modulates

111 n mock- and VZV-infected cells, indicating a posttranscriptional mechanism for VZV-mediated downregul

112 1 expression, demonstrating another possible posttranscriptional mechanism influencing nitrate uptake

113 This posttranscriptional mechanism of c-Myc regulation provid

114 ction, indicating a new role of HDAC6 in the posttranscriptional mechanism of CD20 regulation.

115 tent reduction in Glut4 mRNA suggests that a posttranscriptional mechanism regulated insulin-independ

116 Our results highlight a new posttranscriptional mechanism regulating LSD1 activity a

117 ken together, we have uncovered an important posttranscriptional mechanism that modulates the express

118 diated control of protein sequestration as a posttranscriptional mechanism to coordinately regulate g

119 we show that FXR activation triggers a rapid posttranscriptional mechanism to degrade Cyp7a1 mRNA.

120 We describe a posttranscriptional mechanism whereby the Hfq-dependent

121 ession of Myc and the PGC1beta protein via a posttranscriptional mechanism, EPHB4 has a greater effec

122 n of the expression of Kv1.1 and Kv1.2 via a posttranscriptional mechanism, resulting in a reduction

123 oncomitant decrease of adult hemoglobin by a posttranscriptional mechanism.

124 We provide a critical review of key posttranscriptional mechanisms (i.e., microRNA) and tran

125 are well known to modulate spermatogenesis, posttranscriptional mechanisms are less well defined.

126 Our results shed new light on the posttranscriptional mechanisms controlling the expressio

127 ndent mechanisms for TNF-alpha and IL-23 and posttranscriptional mechanisms for caspase-1-dependent r

128 regulation of this process, but the role of posttranscriptional mechanisms has received little atten

129 pathways and implicates transcriptional and posttranscriptional mechanisms in this process.

130 essential lytic cycle protein with multiple posttranscriptional mechanisms of action.

131 level, which argues against a major role for posttranscriptional mechanisms that modulate the STAT6-d

132 rict L1 activity by both transcriptional and posttranscriptional mechanisms, L1 derepression occurs i

133 as inhibited by IL-4 via transcriptional and posttranscriptional mechanisms, respectively.

134 lication of HBV via both transcriptional and posttranscriptional mechanisms.

135 e the Piwi-interacting RNA pathway and other posttranscriptional mechanisms.

136 tal muscles through both transcriptional and posttranscriptional mechanisms.

137 HBV replication via both transcriptional and posttranscriptional mechanisms.

138 rotein turnover and may be involved in these posttranscriptional mechanisms.

139 Posttranscriptional methylation of RNA cytosine residues

140 ndard genetic codes, and convoluted modes of posttranscriptional modification and editing.

141 Collectively, our study identifies posttranscriptional modification by RNA editing as a cri

142 modification, perhaps indicating a role for posttranscriptional modification in the sorting of some

143 osine (A-to-I) editing is a highly prevalent posttranscriptional modification of RNA, mediated by ADA

144 se miRNA-induced mRNA recognition, cleavage, posttranscriptional modification, and degradation.

145 nt work has identified and mapped a range of posttranscriptional modifications in mRNA, including met

146 Posttranscriptional modifications of RNA bases are not o

147 , we used mass spectrometry to catalogue the posttranscriptional modifications of the p53 population

148 Posttranscriptional modifications of transfer RNAs (tRNA

149 efined as the study of functionally relevant posttranscriptional modifications of viral RNA transcrip

150 transcriptional level as well as by numerous posttranscriptional modifications that regulate its enzy

151 nts at either the 5' or the 3' terminus, (b) posttranscriptional modifications, (c) ribosome density

152 nction in translation is subtly modulated by posttranscriptional modifications.

153 transcripts for host genes involved in mRNA posttranscriptional modifications.

154 n of protein synthesis plays a vital role in posttranscriptional modulation of gene expression.

155 (hnRNPs) are families of sequence-specific, posttranscriptional modulators of gene expression.

156 We further identified miR-218 as a posttranscriptional negative regulator of CD16a in NK ce

157 Our findings suggest a mechanism for posttranscriptional noise generation that will contribut

158 Moreover, we observed widespread posttranscriptional oligoadenylation, uridylation, and g

159 ent Ca(2+) signaling in regulating the early posttranscriptional phase of auxin growth responses in A

160 pecific trans-acting small RNAs, such as the posttranscriptional PHOTOSYNTHESIS REGULATORY RNA1 (PsrR

161 Many of them are involved in organelle posttranscriptional processes, in a very specific manner

162 owever, relatively little is known about the posttranscriptional processing of miRNAs and a potential

163 Transcriptional regulation and posttranscriptional processing underlie many cellular an

164 d through a multipronged transcriptional and posttranscriptional program during the out-of-control ac

165 on transcription/translation feedback loops, posttranscriptional regulation also plays an important r

166 nylation (APA) is a process that changes the posttranscriptional regulation and translation potential

167 xonisation can contribute to tissue-specific posttranscriptional regulation by expanding the repertoi

168 Here, we show a novel example of ET-1 posttranscriptional regulation by PlGF via action of mic

169 Subsequent analysis of the posttranscriptional regulation demonstrated that KSR1 pr

170 Our study highlights the broad role of posttranscriptional regulation during the EMT and the im

171 reas miR-218 provides an additional layer of posttranscriptional regulation during the maturation pro

172 Posttranscriptional regulation encompassed darkness- and

173 V. cholerae and highlight the importance of posttranscriptional regulation for collective behaviors

174 genesis, underscoring the complexity of MDM2 posttranscriptional regulation in cancer.

175 ied transcriptional regulation, the roles of posttranscriptional regulation in cardiac cell fate deci

176 These findings expand the knowledge of posttranscriptional regulation in EHEC.

177 Posttranscriptional regulation in eukaryotes requires ci

178 ox proteins control alternative splicing and posttranscriptional regulation in mammalian brain and ar

179 Posttranscriptional regulation is a major mechanism to r

180 ly, we present preliminary data suggesting a posttranscriptional regulation mechanism, involving miR-

181 This connection to sRNA-mediated posttranscriptional regulation might also apply to other

182 d downregulates its activity, modulating HuR posttranscriptional regulation of a network of target mR

183 bles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPalpha, which in t

184 NA-induced silencing complex (RISC)-mediated posttranscriptional regulation of chromatin remodelers a

185 Currently, both posttranscriptional regulation of COL7A1 and the underly

186 O1) is a central functional component of the posttranscriptional regulation of gene expression and th

187 umerous regulatory mechanisms, including the posttranscriptional regulation of gene expression by mic

188 Posttranscriptional regulation of gene expression by mRN

189 protein involved in the transcriptional and posttranscriptional regulation of gene expression in ani

190 an understanding of the transcriptional and posttranscriptional regulation of gene expression in the

191 Synthetic posttranscriptional regulation of gene expression is imp

192 pre-mRNA) splicing is a critical step in the posttranscriptional regulation of gene expression, provi

193 As (miRNAs, miR) hold important roles in the posttranscriptional regulation of gene expression.

194 ximately 22 nucleotides that are involved in posttranscriptional regulation of gene expression.

195 Small RNA pathways are important players in posttranscriptional regulation of gene expression.

196 omplex process involving transcriptional and posttranscriptional regulation of gene expression.

197 Here, we show the posttranscriptional regulation of HAK5 transport activit

198 an overview of our current understanding of posttranscriptional regulation of immune gene expression

199 nsing was largely imparted by changes in the posttranscriptional regulation of inflammatory cytokines

200 analysis revealed transcriptional as well as posttranscriptional regulation of MCMV gene products by

201 mportant physiological effects through their posttranscriptional regulation of messenger RNA targets.

202 fusion assays documented a role of miR858 in posttranscriptional regulation of MYB83 in the Heteroder

203 However, little is known about posttranscriptional regulation of NOD1- and NOD2-depende

204 To investigate the posttranscriptional regulation of NR4A2, we used a 3' un

205 Posttranscriptional regulation of p21 expression by miR-

206 EN-4 to the spindle midzone by mediating the posttranscriptional regulation of PAR-5.

207 ings to be a starting point for studying the posttranscriptional regulation of PHYL1 effectors in sym

208 The MS data also identified posttranscriptional regulation of protein abundance by G

209 Furthermore, we provide evidence for a posttranscriptional regulation of psaL by PsrR1 in the w

210 ch carotenoid biosynthesis is controlled via posttranscriptional regulation of PSY in plants.

211 Posttranscriptional regulation of RNA facilitates the fi

212 In this study, we assessed posttranscriptional regulation of RORgammat and identifi

213 Our study provides a novel mechanism for the posttranscriptional regulation of TF expression, indicat

214 Posttranscriptional regulation of the 3' untranslated re

215 point to IRE1alpha as an important node for posttranscriptional regulation of the early Ras phenotyp

216 o-RNA (miR)-126 expression, resulting in the posttranscriptional regulation of vascular cell adhesion

217 t changes in the composition of mRNPs during posttranscriptional regulation remain largely unexplored

218 Posttranscriptional regulation, especially pre-mRNA proc

219 cytokine, however, is further controlled by posttranscriptional regulation.

220 ximately 22 nt) that play important roles in posttranscriptional regulation.

221 ng in NPCs related to the disruption of EGFR posttranscriptional regulation.

222 translated region in the transgene preserved posttranscriptional regulation.

223 lity, suggesting transcriptional rather than posttranscriptional regulation.

224 known about the mechanisms underlying their posttranscriptional regulation.

225 asmic ribonucleoprotein granules involved in posttranscriptional regulation.

226 ereby opening opportunities for differential posttranscriptional regulation.

227 of this pathogen are under a large amount of posttranscriptional regulation.

228 and proteins, which can be modulated through posttranscriptional regulation.

229 cently been shown to play important roles in posttranscriptional regulation; however, the contributio

230 thesis by modulating the transcriptional and posttranscriptional regulations of its key enzymes, 1-am

231 The posttranscriptional regulator microRNA-155 (miR-155) is

232 as a player in the DNA damage response as a posttranscriptional regulator of MRE11 and identify cIAP

233 RNAIII is a posttranscriptional regulator of numerous metabolic and

234 The results indicate that LARP4 is a posttranscriptional regulator of ribosomal protein produ

235 -T6SS regulatory elements and found that the posttranscriptional regulator RsmA imposes a concerted r

236 These results show that CmKFB functions as a posttranscriptional regulator that diverts flavonoid met

237 by interactions between transcriptional and posttranscriptional regulators at the molecular level.

238 synergistic or antagonistic interactions of posttranscriptional regulators determine gene expression

239 MicroRNAs (miRNAs) are a class of powerful posttranscriptional regulators implicated in the control

240 Micro-RNAs are recognized as important posttranscriptional regulators in plants.

241 MicroRNAs (miRNAs) are major posttranscriptional regulators of a wide variety of biol

242 MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression and mo

243 MicroRNAs (miRNAs) are key posttranscriptional regulators of gene expression in ani

244 MicroRNAs (miRNAs) are tiny posttranscriptional regulators of gene expression in met

245 ls of microRNAs, suggesting a role for these posttranscriptional regulators of gene expression in str

246 NAs) are noncoding RNAs that function as key posttranscriptional regulators of gene expression.

247 g (PTB) protein family of RBPs are important posttranscriptional regulators of gene expression.

248 cate that the OR proteins serve as the major posttranscriptional regulators of PSY.

249 gene expression, microRNAs (miRNAs) are key posttranscriptional regulators of the plant stress respo

250 ribed, but little is known about the role of posttranscriptional regulators such as microRNAs (miRNAs

251 inding proteins (RBPs) are recognized as key posttranscriptional regulators that not only modulate th

252 PUM)1 and PUM2, members of the PUF family of posttranscriptional regulators, are essential for hemato

253 , which lacked the woodchuck hepatitis virus posttranscriptional regulatory element (WPRE) sequence.

254 xport activity regulated by the hepadnaviral posttranscriptional regulatory element.

255 ubject to a multitude of stimulus-dependent, posttranscriptional regulatory events, consistent with i

256 These results indicate that posttranscriptional regulatory factors, such as microRNA

257 gnificantly more complex transcriptional and posttranscriptional regulatory features (40% more transc

258 conclude that GEMIN2 is a key component of a posttranscriptional regulatory mechanism that ensures th

259 Plasmodium parasites employ posttranscriptional regulatory mechanisms as their life

260 Although it has been shown that posttranscriptional regulatory mechanisms control PD-L1

261 sis and respiratory function are well known, posttranscriptional regulatory mechanisms remain unclear

262 nally, we discuss the competition effects in posttranscriptional regulatory networks that may arise o

263 ies reveal that multiple transcriptional and posttranscriptional regulatory pathways are triggered in

264 Our results demonstrate that manipulating posttranscriptional regulatory pathways may be a potenti

265 arly embryos lack appreciable transcription, posttranscriptional regulatory processes control their d

266 Less attention has been paid to posttranscriptional regulatory processes such as alterna

267 oded transcripts and thus presumably reflect posttranscriptional regulatory processes.

268 these transcripts behave unequally due to a posttranscriptional regulatory program governed by their

269 reveal that RNA structure governs a complex posttranscriptional regulatory program of alpha-1-antitr

270 when grown in broth, as well as on RNAIII, a posttranscriptional regulatory RNA important for alpha-h

271 To identify posttranscriptional-regulatory events affected by APA in

272 se RBPs suppress an evolutionarily conserved posttranscriptional regulon consisting of messenger RNAs

273 Posttranscriptional reporter assays confirmed the functi

274 orbate concentrations are determined via the posttranscriptional repression of GDP-l-galactose phosph

275 tarvation at three levels: (1) directly, via posttranscriptional repression of gene expression; (2) i

276 that modulate cellular processes through the posttranscriptional repression of multiple transcripts.

277 trate that GAPDH-TNF mRNA binding results in posttranscriptional repression of TNF and that the TNF m

278 In this study, we detail a mechanism of posttranscriptional repression of TNF mRNA by GAPDH bind

279 rolling diverse biological processes through posttranscriptional repression.

280 We identified miR-218 as a posttranscriptional repressor of DCC and detected coexpr

281 ptomes revealed an early transcriptional and posttranscriptional response signature that was conserve

282 osine methylation (m(6)A) is the most common posttranscriptional RNA modification in mammalian cells.

283 epeat (PPR) proteins are at the core of this posttranscriptional RNA modification.

284 Zfp36l1/l2 therefore act as posttranscriptional safeguards against chromosomal insta

285 How these structures and other posttranscriptional signals affect RNA trafficking and t

286 ARGONAUTE1 (AGO1) mediates posttranscriptional silencing by microRNAs (miRNAs) and

287 for Argonaute (AGO) proteins, which mediate posttranscriptional silencing of target messenger RNAs.

288 RNAs), which regulate mRNA abundance through posttranscriptional silencing, comprises multiple well-o

289 onse element in the GADD34 gene promoter and posttranscriptional stabilization of its mRNA.

290 the induction of gene transcription and the posttranscriptional stabilization of mRNAs.

291 1 despite only weak contributions to HIV-1's posttranscriptional stages.

292 did not interact with FAK, is affected at a posttranscriptional step involving protein synthesis and

293 chloroplast, where they mostly intervene at posttranscriptional steps.

294 g-lived RNAs that are generated via numerous posttranscriptional steps.

295 through numerous proteins that intervene at posttranscriptional steps.

296 We propose that posttranscriptional stochasticity can be linked to cycle

297 f multiple cytokine receptors via selective, posttranscriptional suppression of Stat3 protein levels.

298 Nonsense-mediated decay (NMD) is a posttranscriptional surveillance mechanism in eukaryotes

299 works with KSRP to optimize an AKT-regulated posttranscriptional switch that controls myogenic differ

300 many gene products through transcriptional, posttranscriptional, translational, and posttranslationa