ライフサイエンスコーパス: posttranslational

1 The proteolytic cleavage and posttranslational acetylation modification of CREBH are

2 We report an approach inspired by the posttranslational acetylation/deacetylation of lysine re

3 n response to glucose, and we estimated that posttranslational activation of GCK enhances glucose met

4 Posttranslational activation of the CaMKII pathway is sp

5 hypusine synthase, an enzyme involved in the posttranslational activation of the eukaryotic initiatio

6 Glycylation and glutamylation, the posttranslational addition of glycines and glutamates to

7 that the mechanism of this downregulation is posttranslational and identify a C-terminally truncated

8 ently reported that the regulation is mainly posttranslational and that the C-terminal part of the al

9 ptor (EGFR) signaling network, the immediate posttranslational changes that occur in response to grow

10 In cyanobacteria, timing is generated by a posttranslational clock consisting of KaiA, KaiB, and Ka

11 k between cytosolic Ca(2+) signaling and the posttranslational control of respiratory CO2 refixation

12 PI-1 repression by bile acids is mediated by posttranslational destabilization of HilD.

13 ) defines 24 h of time via a transcriptional/posttranslational feedback loop in which transactivation

14 define circadian time using transcriptional/posttranslational feedback loops (TTFL) in which express

15 Posttranslational GCK activation can be stimulated throu

16 from latency to lytic replication.IMPORTANCE Posttranslational histone modifications regulate the acc

17 osyldiacylglycerol (MGDG) in the plastid via posttranslational inhibition of MGDG synthase enzymatic

18 f Tail (GET)-anchored protein system for the posttranslational insertion of tail-anchored (TA) protei

19 duction of active TGF-beta is regulated at a posttranslational level and implies release of the matur

20 s at the transcriptional, translational, and posttranslational level.

21 s at the transcriptional, translational, and posttranslational levels.

22 tightly regulated at the transcriptional and posttranslational levels.

23 y known as S-palmitoylation), the reversible posttranslational lipid modification of proteins.

24 Posttranslational lipid modifications mediate the membra

25 I C-methylates a Cys-derived thiazole during posttranslational maturation.

26 rganization is expanded in trypanosomes as a posttranslational means of enzyme regulation.

27 its proteome through posttranscriptional and posttranslational means.

28 y, we identify a therapeutically exploitable posttranslational mechanism by which CK2alpha-mediated d

29 studies suggest that a cell cycle-regulated posttranslational mechanism couples resolution of telome

30 Thus, we identified a posttranslational mechanism, regulated by Sonic hedgehog

31 Here, we report that a novel posttranslational mechanism, reversible lysine fatty acy

32 depleted TRAF6 from its host cells through a posttranslational mechanism.

33 research, however, has pointed to additional posttranslational mechanisms that lead to chloroplast re

34 le in cardiac remodeling and injury, but the posttranslational mechanisms that modulate this enzyme a

35 nduction of unregulated cell growth involves posttranslational mechanisms that prevent proteasomal de

36 tivation is regulated by transcriptional and posttranslational mechanisms to prevent aberrant activat

37 s adherens junctions in epithelial cells via posttranslational mechanisms, that is, activation of Src

38 Posttranslational methylation of histones plays a critic

39 revealing a previously unidentified mode of posttranslational microtubule regulation in neurons and

40 Recently, we have determined that posttranslational modification (neddylation) of Cullin-4

41 alidate a quantitative assay for detecting a posttranslational modification (phosphorylation at resid

42 asthma-related phenotypes through oxidative posttranslational modification (PTM) of proteins in asth

43 ADP-ribosylation (ADPr) is a posttranslational modification (PTM) of proteins that co

44 Proteins may undergo a type of posttranslational modification - polyglutamylation, wher

45 Lysine acetylation is a widespread posttranslational modification affecting many biological

46 Histone posttranslational modification analysis showed that the

47 irst case, to our knowledge, of both ex situ posttranslational modification and pharmacological repro

48 es associated with this poorly characterized posttranslational modification and provides a unique ins

49 ctivity by simultaneously repressing Fat via posttranslational modification and recruiting Dachs to t

50 nert C-terminal domain (CTD) of TOP2 and its posttranslational modification are critical to this chec

51 Protein glycation is an age-dependent posttranslational modification associated with several n

52 Protein lysine posttranslational modification by an increasing number o

53 mechanism in which the leader peptide guides posttranslational modification by positioning the cross-

54 I (IFN-I) response has been shown to rely on posttranslational modification by ubiquitin (Ub) and Ub-

55 rsulfide donor for protein persulfidation, a posttranslational modification by which H2S is postulate

56 Poly(ADP-ribosyl)ation (PARylation) is a posttranslational modification catalyzed by poly(ADP-rib

57 Timing of this posttranslational modification coincides with the ATM-me

58 -kappaB protein p65 on Ser-536 and that this posttranslational modification controls its nuclear loca

59 t that global quantitative rate analysis for posttranslational modification enzymes in complex milieu

60 (or O-GlcNAcylation) is a dynamic, inducible posttranslational modification found on proteins associa

61 While posttranslational modification has been demonstrated to

62 demonstrate that acetylation is a widespread posttranslational modification impacting proteins encode

63 Moreover, we identified the same posttranslational modification in eEF1A from Schizosacch

64 Maximal activity of EF-P requires a posttranslational modification in Escherichia coli, Pseu

65 Arginine methylation is a common posttranslational modification in eukaryotes catalyzed b

66 the mechanistic details of the role of this posttranslational modification in the virus life cycle r

67 charomyces cerevisiae eEF1A, we identified a posttranslational modification in which the alpha amino

68 Pupylation is a posttranslational modification in which the prokaryotic

69 t in increased myocardial S-nitrosylation, a posttranslational modification increasingly implicated i

70 is a novel glutamylation substrate, and this posttranslational modification is critical for its funct

71 egulation, the molecular basis governing its posttranslational modification is enigmatic.

72 nts the most prolific and well-characterized posttranslational modification known.

73 On a genome-wide scale, some of the histone posttranslational modification landscapes show significa

74 will be useful for projects aimed at histone posttranslational modification mapping in chromatin extr

75 ecific sites and quantitative levels of this posttranslational modification modulate cellular pathway

76 dified by this glutaminylation and that this posttranslational modification occurs at all stages of y

77 ponsive transcriptional cascades through the posttranslational modification of CES and redundantly ac

78 Our results point to posttranslational modification of chromatin-bridging pro

79 ermediate filaments and proteins involved in posttranslational modification of collagen.

80 S is proposed to occur via persulfidation, a posttranslational modification of cysteine residues (RSH

81 ion (SNO-protein), the nitric oxide-mediated posttranslational modification of cysteine thiols, is an

82 in B. subtilis, a previously uncharacterized posttranslational modification of EF-P can modulate the

83 sm that controls the activation of ER by the posttranslational modification of epigenetic regulators,

84 his proteostatic mechanism, dependent on the posttranslational modification of GRP78, allows cells to

85 Taken together, our findings reveal a novel posttranslational modification of HBx by HDM2 which regu

86 asses of viral proteases observed to reverse posttranslational modification of host proteins by ubiqu

87 hese results expand our understanding of the posttranslational modification of KLF4 and of its role i

88 Even though the ubiquitin-like posttranslational modification of neddylation, that conj

89 methylation is an important and much-studied posttranslational modification of nuclear and cytosolic

90 O-GlcNAcylation is a common posttranslational modification of nucleocytoplasmic prot

91 Posttranslational modification of proteins by ubiquitin

92 Posttranslational modification of proteins expands their

93 ms involving nitric oxide (NO) synthesis and posttranslational modification of proteins.

94 esis, LanB-like dehydratases involved in the posttranslational modification of ribosomal peptides, an

95 Posttranslational modification of ribosomally synthesize

96 Our findings indicate that posttranslational modification of SR proteins underlies

97 k of processes that generate ssDNA, and that posttranslational modification of ssNucs may generate no

98 s essential for surface exposure of PorU and posttranslational modification of T9SS cargo proteins.

99 We propose that posttranslational modification of TCP14/15 by SPY inhibi

100 h was associated with transcriptional and/or posttranslational modification of the central cell-cycle

101 In all cells, IL-6 treatment results in posttranslational modification of the proapoptotic prote

102 is insufficient to stabilize opening; thus, posttranslational modification of the protein may be req

103 ins, resulting in a widespread, irreversible posttranslational modification of the protein's structur

104 ription of the POR and CHLP genes but to the posttranslational modification of their protein products

105 O-fucosylation is a common posttranslational modification of thrombospondin type 1

106 al therapies to target it, is to examine the posttranslational modification of viral proteins and its

107 mall-molecule inhibitors targeting essential posttranslational modification of Wnt reduced tumour gro

108 is-unsaturated fatty acyl group, a necessary posttranslational modification of Wnts, by multiple FZD

109 eir cell surface, and MS analysis revealed a posttranslational modification on cysteine 328 (C328) by

110 functionally identified a novel Her4-induced posttranslational modification on MDMX at Ser-314, a put

111 teogenic amino acids, which may then require posttranslational modification or the recruitment of coe

112 SUMOylation is a ubiquitin-related transient posttranslational modification pathway catalyzing the co

113 The posttranslational modification pathway leading to lipopr

114 Dysfunction of protein posttranslational modification plays critical roles in t

115 ncrease in their catalytic production of the posttranslational modification poly(ADP-ribose) (PAR) to

116 Poly(ADP-ribose) (PAR) is a posttranslational modification predominantly synthesized

117 Protein ADP-ribosylation is a covalent posttranslational modification regulating cellular prote

118 t MC159 inhibited NEMO polyubiquitination, a posttranslational modification required for IKK and down

119 at eEF1A glutaminylation is a yeast-specific posttranslational modification that appears to influence

120 Disulfide bonds are a common posttranslational modification that contributes to the f

121 ADP-ribosylation is a posttranslational modification that exists in monomeric

122 Arginine methylation is a common posttranslational modification that has been shown to re

123 Palmitoylation is a reversible, posttranslational modification that helps target protein

124 ein tyrosine sulfation (PTS) is a widespread posttranslational modification that induces intercellula

125 AMPylation is an emerging posttranslational modification that involves the additio

126 S-palmitoylation is a dynamic posttranslational modification that is important for tra

127 independently of its gamma-carboxylation, a posttranslational modification that is known to hamper O

128 s, referred to as polysialylation, is a rare posttranslational modification that is mainly known to c

129 Protein acetylation is a prevalent posttranslational modification that is regulated by dive

130 Lysine acetylation is a key posttranslational modification that regulates diverse pr

131 Linear ubiquitination is a key posttranslational modification that regulates immune sig

132 Ubiquitination is a posttranslational modification that regulates many cellu

133 Ubiquitination, the crucial posttranslational modification that regulates the eukary

134 UT decreased PP2A activity through posttranslational modification that was accompanied by a

135 Protein AMPylation is a conserved posttranslational modification with emerging roles in en

136 Posttranslational modification with ubiquitin chains con

137 ubstrates is an important disease-associated posttranslational modification, although few inhibitors

138 S-acylation is a major posttranslational modification, catalyzed by the zinc fi

139 oproteins formed by the most complex form of posttranslational modification, glycosylation.

140 and, as is compatible with a crucial role in posttranslational modification, its N-terminal glycine i

141 While investigating the function of this posttranslational modification, we serendipitously disco

142 Ubiquitination is a key posttranslational modification, which affects numerous b

143 the individual nuclei using histone type- or posttranslational modification- (PTM-) specific antibodi

144 residues of the C-terminal tail generates a posttranslational modification-dependent PDZ/14-3-3 inte

145 line, the product of the most abundant human posttranslational modification.

146 er biological investigations of this central posttranslational modification.

147 be modified by SUMOylation, a ubiquitin-like posttranslational modification.

148 with increased binding to HLA-DQ8trans upon posttranslational modification.

149 ITM3 is activated by palmitoylation, a lipid posttranslational modification.

150 inity changes that occur upon stress-related posttranslational modification.

151 bout how DAG kinase activity is regulated by posttranslational modification.

152 , promoting allostery, or allowing efficient posttranslational modification.

153 alter Runx1 transcriptional function through posttranslational modification.

154 ion, the most widespread and complex form of posttranslational modification.

155 secondary metabolites that undergo extensive posttranslational modification.

156 Ubiquitin can be subjected to further posttranslational modifications (e.g., phosphorylation a

157 ntain repeated sequence motifs and extensive posttranslational modifications (glycosylation), and the

158 emical reactions referred to as nonenzymatic posttranslational modifications (NEPTMs), such as glycox

159 Posttranslational modifications (PTMs) affecting E2 func

160 dependent conformational cycle influenced by posttranslational modifications (PTMs) and assisted by a

161 ampal neurons, Abeta acutely induces tubulin posttranslational modifications (PTMs) and stabilizes dy

162 Posttranslational modifications (PTMs) are key contribut

163 genetic marks, including DNA methylation and posttranslational modifications (PTMs) in histones, are

164 aging method to measure histones and histone posttranslational modifications (PTMs) in single cells.

165 Posttranslational modifications (PTMs) of tubulin specif

166 Posttranslational modifications (PTMs) regulate protein

167 Proteins can be modified by multiple posttranslational modifications (PTMs), creating a PTM c

168 Protein posttranslational modifications (PTMs), including acetyl

169 genesis revealed specific and well-conserved posttranslational modifications (PTMs), including O-myco

170 Mapping posttranslational modifications (PTMs), which diversely

171 CoA, can modify proteins, leading to protein posttranslational modifications (PTMs).

172 placed in recent years on roles for histone posttranslational modifications and chromatin-remodeling

173 n mechanics, including congenital mutations, posttranslational modifications and ligand binding, and

174 environmental cues, acquiring distinguishing posttranslational modifications and performing discrete

175 acellular domains, providing clues as to how posttranslational modifications and receptor function in

176 Posttranslational modifications are covalent changes mad

177 Furthermore, we show that posttranslational modifications are enriched at key loca

178 because tools and techniques to detect these posttranslational modifications are scarce.

179 itope in T1D and suggest there may be common posttranslational modifications at the C terminus of the

180 he process of gastric carcinogenesis and its posttranslational modifications by N-glycosylation have

181 Posttranslational modifications by small ubiquitin-like

182 torial tubulin code written in two different posttranslational modifications can arise through the ac

183 Posttranslational modifications can have profound effect

184 ated with an abnormal composition of histone posttranslational modifications compared with mIC1.

185 Changes in protein by posttranslational modifications comprise an important me

186 Posttranslational modifications control microtubule beha

187 Posttranslational modifications control the functional a

188 These posttranslational modifications create functionally dist

189 Known posttranslational modifications function at the outer su

190 Histone posttranslational modifications have been associated wit

191 ed primarily in bacteria and is regulated by posttranslational modifications in eukaryotes, and both

192 our findings suggest a stimulatory role for posttranslational modifications in PB accumulation and r

193 disease through the ability of Be to induce posttranslational modifications in preexisting HLA-DP2-p

194 three-step approach for installing authentic posttranslational modifications in recombinant proteins.

195 of the Golgi, which is required for accurate posttranslational modifications in the Golgi.

196 ion between alternative splicing and histone posttranslational modifications in the nucleus accumbens

197 data therefore support an important role of posttranslational modifications in the structural polymo

198 d is vital to understand how these important posttranslational modifications modulate biological func

199 cular the cerebellum, nor the effects of any posttranslational modifications of FOXP2 in the brain an

200 elevance of these findings and the potential posttranslational modifications of HDAC1 remained elusiv

201 m may include more than 100 residue-specific posttranslational modifications of histones forming the

202 Posttranslational modifications of LARP6 and how they af

203 ns of the core histones constitute sites for posttranslational modifications of major epigenetic impa

204 Phosphorylation and other posttranslational modifications of MeCP2 have been descr

205 but have since diverged to control distinct posttranslational modifications of NCAM1.

206 FKBP23 (FKBP7), and FKBP65 (FKBP10), due to posttranslational modifications of proline residues in t

207 roteomic approaches to understand changes in posttranslational modifications of proteins that may exp

208 n ubiquitination is one of the most powerful posttranslational modifications of proteins, as it regul

209 These posttranslational modifications of RyR1 were mediated by

210 note "stressorins." We highlight the role of posttranslational modifications of stressorins as key re

211 main enzymes catalyze adenylylation or other posttranslational modifications of target proteins to co

212 unctional constraints, we dissected here the posttranslational modifications of the nuclear basket pr

213 if the positive charge and susceptibility to posttranslational modifications of these lysines contrib

214 f neurodegenerative diseases, the effects of posttranslational modifications on the molecular propert

215 This study highlights the influence of posttranslational modifications on viral protein functio

216 phylquinone (CTQ) cofactor that is formed by posttranslational modifications that are catalyzed by a

217 N-terminal histone tails are subject to many posttranslational modifications that are recognized by a

218 ns (IDRs) of proteins are often the sites of posttranslational modifications that control cell-signal

219 muli relies on the generation of cascades of posttranslational modifications that promote protein-pro

220 activity of multiple proteins via oxidative posttranslational modifications to fine-tune guard cell

221 s, histones are subject to a large number of posttranslational modifications whose sequential or comb

222 Posttranslational modifications with small ubiquitin-lik

223 Therefore, MCa is potentially subjected to posttranslational modifications within recipient cells.

224 distinct nucleotide states or with different posttranslational modifications).

225 Like other, more well-studied posttranslational modifications, AMPylation is predicted

226 htly controlled through cyclin interactions, posttranslational modifications, and binding of inhibito

227 activity of sirtuins toward additional lysyl posttranslational modifications, and show that sirtuins

228 he reprogramming of DNA methylation, histone posttranslational modifications, and small noncoding RNA

229 ear to change due to H2O2 treatment, nor did posttranslational modifications, as measured by two-dime

230 teins (IDPs) are known to undergo a range of posttranslational modifications, but by what mechanism d

231 most studied and best characterized histone posttranslational modifications, but it is not known if

232 mental details of how peptidases accommodate posttranslational modifications, including glycosylation

233 Tau is subject to various posttranslational modifications, including phosphorylati

234 damage response components is fine-tuned by posttranslational modifications, including ubiquitinatio

235 etter characterization of Drd3 signaling and posttranslational modifications, like palmitoylation, ma

236 brane organization of CD82, through specific posttranslational modifications, regulates N-cadherin cl

237 Collagens are subjected to extensive posttranslational modifications, such as lysine hydroxyl

238 conserved waters also correspond to sites of posttranslational modifications, suggesting that the con

239 otential regulation of ZBP1 function through posttranslational modifications.

240 ecursor peptide, TbtA, by a complex array of posttranslational modifications.

241 tion of type I collagen and causes excessive posttranslational modifications.

242 es oscillates by regulated expression and/or posttranslational modifications.

243 actions by transcriptional reprogramming and posttranslational modifications.

244 ly nucleation factors, tubulin isoforms, and posttranslational modifications.

245 network of protein-protein interactions and posttranslational modifications.

246 mporally and spatially controlled by tubulin posttranslational modifications.

247 Its functions are regulated tightly by posttranslational modifications.

248 otein can undergo a diverse array of co- and posttranslational modifications.

249 keleton and mediate phenotypic responses via posttranslational modifications.

250 sponse to Ag is largely regulated by protein posttranslational modifications.

251 rchestrated process involving a multitude of posttranslational modifications.

252 protein-protein interactions, as well as by posttranslational modifications.

253 SF1 at S303/307, previously known repressive posttranslational modifications.

254 hat the BMV CP contains a complex pattern of posttranslational modifications.

255 microtubule-associated proteins, and tubulin posttranslational modifications.

256 in interactions, proteolytic activities, and posttranslational modifications.

257 mining the kinetic isotope effects (KIEs) of posttranslational modifying enzymes.

258 -myristoyltransferases (NMT) catalyze co- or posttranslational myristoylation of Src family kinases a

259 regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.

260 The posttranslational oscillator of the Kai system can be en

261 impact of changes in microRNA expression on posttranslational processes involved in TNF-alpha signal

262 mate brain leads to changes in the levels or posttranslational processing of proteins central to AD p

263 These differences suggest that the posttranslational processing of the spikes and nucleocap

264 Posttranslational processing requires a signal peptidase

265 During posttranslational processing, the fusion peptide of F is

266 fferential splicing and poorly characterized posttranslational processing.

267 Glycosylation is an important posttranslational protein modification in all eukaryotes

268 ADP-ribosylation is a posttranslational protein modification in which ADP-ribo

269 tein, is an important and frequently studied posttranslational protein modification.

270 two enzymes PADI3 and TGM3, responsible for posttranslational protein modifications, and their targe

271 NO regulates posttranslational protein modifications, S-nitrosation,

272 ntial biological processes are controlled by posttranslational protein modifications.

273 n addition, we investigated the role of MKP1 posttranslational regulation in plant defense by testing

274 tress responses as well as translational and posttranslational regulation in plants.

275 itro data argue for the existence of a tight posttranslational regulation in the associated biochemic

276 roteomic analysis revealed the importance of posttranslational regulation mechanisms during sugarcane

277 Therefore, posttranslational regulation of caspase-8 confers resist

278 vely, our findings provide insights into the posttranslational regulation of cytokine production thro

279 his review focuses on the molecular basis of posttranslational regulation of eukaryotic myosins from

280 It was suggested recently that posttranslational regulation of Family I soluble inorgan

281 in liver regeneration and the importance of posttranslational regulation of growth factor signaling

282 ween Suc, organic acids, and amino acids via posttranslational regulation of phosphoenolpyruvate carb

283 Previously, we have reported that posttranslational regulation of sigma(S) in the aquatic

284 eptide-scale physical interpretation for the posttranslational regulation of the highly abundant prot

285 lation, mitochondrial protein synthesis, and posttranslational regulation of the translation represso

286 nvolved in sugar/energy homeostasis, and the posttranslational regulation of WRI1.

287 mployed proteomics to identify mechanisms of posttranslational regulation on cell survival signaling

288 ith the aim to identify differences in their posttranslational regulation.

289 ient for attaining harmonic system function, posttranslational regulatory mechanisms are often used.

290 Here, we uncover posttranslational regulatory mechanisms in the prokaryot

291 These data reinforce sumoylation as a key posttranslational regulatory modification of STAT1 and i

292 The overrepresented coincidence of this posttranslational regulatory signal and local conformati

293 Sumoylation is a posttranslational reversible modification of cellular pr

294 ls, these results demonstrate that intrinsic posttranslational S-palmitoylation of BACE1 has a signif

295 Escherichia coli provides one example where posttranslational signaling noise has been deduced from

296 itical to pancreatic beta-cell function, the posttranslational signals governing beta-cell mitochondr

297 presence of low-activity CLPX increases the posttranslational stability of ALAS, causing increased A

298 ntaneous decline of the currents, suggesting posttranslational stabilization by VX-809.

299 ing by signal recognition particle (SRP) and posttranslational targeting by SecA and SecB.

300 Moreover, posttranslational up-regulation of p21 achieved in both