ライフサイエンスコーパス: potency of

1 everal showed partial agonist activity, with potency of 0.8-76 nM, mimicking E2 in inhibiting growth

2 SUMO conjugation in biochemical assays with potencies of 1.9-5.8 mm.

3 electivity score of 0.006 and an outstanding potency of 1.0 nM.

4 However, the potency of 17nt sgRNAs relative to the full-length 20nt

5 This seems to account for the enhanced potency of (1S,3R,4S,5R)5-O-Caffeoylquinic acid to reduc

6 Broad cellular antiproliferative potency of 24 is supported by demonstration of JAK-STAT

7 Verinurad specifically inhibits URAT1 with a potency of 25 nM.

8 es of the chemical reactivity and biological potency of 3.

9 tures appeared to contribute to the anti-HIV potency of [5P7]CCL5, including the distinct chemokine o

10 ibition animal model, confirmed the observed potency of 6a and 7 in biochemical and cellular assays.

11 as a result of GnRH receptor activation with potencies of 9.3 +/- 0.1 (pEC50 value, buserelin) and 7.

12 enic potency based on the concentrations and potencies of a small number of targeted PAHs results in

13 randomized study is designed to evaluate the potency of a combination of 1.2 mg RSV in situ gel with

14 in a mouse model Alum-TLR7 greatly improved potency of a CRM197-MenC vaccine increasing anti-MenC an

15 tribution profile and enhance the anticancer potency of a drug payload (doxorubicin hydrochloride).

16 Here we show that the potency of a drug to reverse cancer-associated gene expr

17 ctivity is often critical in such cases: the potency of a macrocyclic compound can depend on the ster

18 mor and its associated stroma, and prove the potency of a novel combined approach suitable for immedi

19 These results highlight the potency of a PTM-binding protein to regulate DNA accessi

20 The breast cancer stem cell (CSC) potency of a series of copper(II)-phenanthroline complex

21 stem cell (CSC) and bulk breast cancer cell potency of a series of metallopeptides containing dichlo

22 site-directed mutagenesis, and measuring the potency of a series of Tg analogues.

23 -cell RNA-Seq profiles, that differentiation potency of a single cell can be approximated by computin

24 , respectively, based on a difference in the potency of acetylcholine to activate them.

25 The risk increased with increasing potency of acid inhibition and decreased after medicatio

26 re found to be important determinants of the potency of activation and entry inhibition.

27 Thus, the objectives were to evaluate the potency of ADHLSCs to control bleeding in a hemophilia A

28 tigen receptors (CARs) determine the overall potency of adoptively transferred T cells.

29 Herein, we discuss the increased potency of (-)-agelastatin E as compared to (-)-agelasta

30 of AHR in any given cell, the abundance and potency of AHR ligands within certain tissues, and the t

31 the present study, we examined the relative potencies of all the currently used in the clinic AT(1)R

32 MC and that activation of CXCR4 enhances the potency of alpha1-AR agonists.

33 des preclinical evidence for the therapeutic potency of AMI in treating HD, but it also represents an

34 The D52A(2.50) mutation also decreased the potency of amiloride with respect to ligand displacement

35 21CFR680.3(e) states that when measured, the potency of an allergenic extract is assessed according t

36 The trapping potency of anchors is dictated by association rates and

37 These effects could hinder the potency of animal weapons, such as the mantis shrimp's r

38 The in vitro potency of antibody-drug conjugates (ADCs) increases wit

39 new technique to determine the frequency and potency of antigen-specific CD8 T cells.

40 The in vivo potency of antisense oligonucleotides (ASO) has been sig

41 2 titers and that the in vivo neutralization potency of Apobec3/Rfv3-resistant antisera was dependent

42 These results illustrate the feasibility and potency of approaches incorporating advanced gene-editin

43 ay offer a unique opportunity to enhance the potency of AR-targeted therapies for the treatment of an

44 generates potent cytotoxins which exceed the potency of asmarine A (1.2 muM IC50) and supersede the m

45 lycoprotein receptor (ASGR) has improved the potency of ASO drugs approximately 30-fold in the clinic

46 us represent a viable approach for enhancing potency of ASO drugs in the clinic without adding signif

47 The Gln-1291 mutations did not alter the potency of ATP at stimulating current or ATP-dependent g

48 y, and significantly enhanced the inhibitory potency of ATRA on HCC cell growth, improving IC50 by ov

49 olism in HepG2 cells, resulting in increased potency of atRA toward RAR activation.

50 ound that quinacrine (QN) had 60-fold higher potency of autophagy inhibition than chloroquine (CQ), a

51 The potency of AZD0914 for inhibition of supercoiling and th

52 We have compared the dynamics and the potency of beta-catenin mutations in vivo.

53 The potency of blood and intestinal gammadelta T-APCs was co

54 can partially account for differences in the potency of BMP inhibition within the DAN family.

55 c state-dependent modulators, the inhibitory potency of both compounds is highly dependent on the amb

56 r results show that HER ligands enhanced the potency of BP to stimulate oncogene expression and breas

57 Further, we compared the hormonal potency of BPS and BPF to that of BPA.

58 nant protein account for the greater seeding potency of brain aggregates.

59 The relative potency of C47 to the reference compound flutamide was o

60 continuity of use after onset of psychosis, potency of cannabis consumed, and frequency of use after

61 Reports indicate that the potency of cannabis preparation has been increasing.

62 e rise globally alongside an increase in the potency of cannabis sold on both black and legal markets

63 y be an effective strategy for improving the potency of CAR T cell therapies.

64 The risk factor potency of cardiovascular drugs on the severity of anaph

65 ons to reduce or even abolish the allergenic potency of cashew and pistachio.

66 Here, the potency of CC-115, a novel inhibitor of mammalian target

67 ock of VACCs accounts for the apparent lower potency of Cd(2+) on spontaneous release of GABA than on

68 lymerization-based assay for determining the potency of cellulolytic enzyme formulations on pretreate

69 The potency of cGAMP for cutaneous vaccination was ascribed

70 in the fluoroquinolone-resistant mutant, the potency of ciprofloxacin for inhibition of supercoiling

71 Regarding inhibitory potency of ciproxifan on rat brain MAO, these findings s

72 The potency of cisapride was not altered for tetramers conta

73 thesis by L-buthionine sulfoxamine increases potency of citral.

74 The potency of complement activation by IgG Abs can be incre

75 s cost-effective tools for determining toxic potencies of complex mixtures in the environment.

76 Interestingly, the increased potency of compound 27 was facilitated by the formation

77 otheses for factors affecting the biological potency of compounds in mammals.

78 lls from reactive metabolites, increased the potency of curcumin and decreased the amount of curcumin

79 n this study the molecular basis for reduced potency of current inhibitors against GT-3 NS3/4A protea

80 s and the NOD mouse model to investigate the potency of CXCR1/2 inhibition to prevent inflammation- a

81 osteric modulator of CXCR4 that enhances the potency of CXCR4 ligands.

82 e selectivity of EGFR x c-MET bsAbs with the potency of cytotoxic agents via bispecific antibody-toxi

83 tor subtypes, with the general rank order of potency of D3R > D4R >/= D2SR >/= D2L.

84 Understanding the exceptional potency of DCV was a key objective of this study.

85 Antiradical potency of DHCA and DHFA was compared with that exerted

86 epared and shown to retain the low nanomolar potency of dictyostatin.

87 and molecular conformation in antioxidative potency of dihydrocaffeic acid (DHCA) and dihydroferulic

88 is known that MscL expression increases the potency of dihydrostreptomycin, it has remained unclear

89 of native TRAIL and poor apoptosis-inducing potency of dimeric agonist mAbs despite their long serum

90 of Earth's biosphere; for understanding the potency of disease-causing microorganisms; and in biotec

91 ontaining 0 to 3 S631A subunits, whereas the potency of dofetilide was a graded function of the numbe

92 overall secondary structure and IgE-binding potency of DRPs was comparable to that of intact conglut

93 ful preclinical method to evaluate inhibitor potencies of drugs that target pathogen-derived toxins.

94 The incorporation of halogens to improve the potency of drugs is now fairly standard in medicinal che

95 these residues appears to correspond to the potency of dTTP inhibition.

96 Moreover, the high potency of E6 allowed us to administer this peptide usin

97 estrogens after correcting for the in vitro potency of each compound.

98 vity from FcDDS and determine the prognostic potency of each variable for in vivo prediction of formu

99 the human blood-brain barrier and the lower potency of elacridar to inhibit ABCG2 may be an explanat

100 t to be the primary drivers of reinforcement potency of energy sources.

101 otypes in EV-producing cells can enhance the potency of EVs for vascularization.

102 We need to find ways of enhancing the potency of existing antibiotics, and, with this in mind,

103 and binding assay to investigate the binding potency of flame retardants and dust extracts to human P

104 and T47C substitutions reduced the apparent potency of GABA at alpha1beta2gamma2 receptors by 50-fol

105 owed that D43C and T47C reduced the apparent potency of GABA.

106 residue (D43C or T47R) reduced the apparent potency of GABA.

107 cal composition and, consequently, bioactive potency of garlic are also discussed.

108 zing enzyme expression levels, enhancing the potency of Gemcitabine within tumor cells in vivo and in

109 In conclusion, modulating potency of GLP-1 by physiologically regulated endocannab

110 9.2 muM OEA enhances the potency of GLP-1 in stimulating cAMP production by 10-fo

111 In this study, we found that the potency of GLP-1, not exendin 4, is specifically enhance

112 ceptors, expressed in HEK cells, reduced the potencies of glycine, beta-alanine and taurine by 9-, 6-

113 alanine at position 168 (D168A) reduced the potency of grazoprevir, its combination with R155K unexp

114 evealed dose-dependent profiles with greater potency of HDACis over CyA (IC50 values of 82.0 nM and 1

115 inhibition is at the base of the exceptional potency of herbicides and potentially a target for the d

116 -based drug design effort to improve the ITK potency of high-throughput screening hits, ultimately de

117 t be necessary to evaluate the developmental potency of hPSCs.

118 n GARP expression significantly impaired the potency of HSCs to suppress the proliferation of and IFN

119 RanBP9 significantly diminishes the anti-tau potency of Hsp90/Hsc70 inhibitors as well as Hsc70 varia

120 M, quantitatively ranked the selectivity and potency of hundreds of compounds and identified previous

121 ety, pharmacokinetics, pharmacodynamics, and potency of i.v. administrations in healthy subjects.

122 The specificity and potency of ICP47 inhibition result from contacts between

123 ardiac-lineage cells; and test the embryonic potency of iCPCs via injection into the cardiac crescent

124 igen-processing DCs may explain the enhanced potency of IL-15:IL-15Ralpha-coated nanoparticles for an

125 Overall, the potency of illicit cannabis plant material has consisten

126 ogen bonding network contribute to the great potency of imidazoleisoindole derivatives.

127 Moreover, the increasing potency of improved inhibitors correlates with the forma

128 t a mechanism for diminishing the functional potency of individual cMyBP-C molecules.

129 onding single MAbs, while the neutralization potency of individual MAbs was maintained.

130 T) NMDARs to assess the mutation's effect on potency of inhibition by Mg(2+) and other channel blocke

131 cted mutagenesis of GluN1-Glu781 reduced the potency of inhibition by NVP-AAM077, thus confirming the

132 Protein kinase A-dependent increase in the potency of inositol 1,4,5-triphosphate-induced Ca(2+) si

133 The potency of integrase inhibitors against 3'-processing an

134 In this study, we examined the stem cell potency of IP-DPSCs.

135 The potency of islets implanted onto the omentum, using an i

136 MET, which resulted in the enhanced in vitro potency of JNJ-61186372 against the less highly expresse

137 362 is responsible for the generally greater potency of KCa activators on KCa3.1.

138 Current safety guidelines require that potency of KV11.1 block is assessed in the preclinical p

139 potency of L-SOP inhibition relative to the potency of L-glutamate activation in mGluR1 mutants and

140 pped between mGluR1 and mGluR4 increased the potency of L-SOP inhibition relative to the potency of L

141 indings give a mechanistic rationale for the potency of LD activity regulation and provide a molecula

142 rsuing a protein target or to drive improved potency of lead compounds.

143 to simultaneously evaluate the dynamics and potency of ligands that bind to ERalpha.

144 SCs as well as our inability to maintain the potency of lineage-committed progenitors.

145 Overall, these results highlight the potency of localized TRM deposition as a means of pathog

146 ator of the ToxT regulon and demonstrate the potency of loss-of-function TIS sequencing screens for d

147 continues, the effects of increased use and potency of marijuana on water and wastewater treatment p

148 es the generation, survival, and suppressive potency of MDSC, and that a feedback homeostatic mechani

149 of cellular compartments could modulate the potency of membrane curvature to recruit lipidated prote

150 Using RAW 264.7 macrophages, we showed the potency of microcystin-LR (MC-LR) to stimulate productio

151 t contributes to improved RXFP4 affinity and potency of mINSL5 compared with hINSL5.

152 with declines in the survival and angiogenic potency of miPSC-ECs, and capillary and arterial density

153 nd to the HA head domain, the neutralization potency of monoclonal stalk-binding antibodies was vastl

154 , prospective clinical trials evaluating the potency of MSCs have however not been published.

155 vironmental changes from pFUS also increased potency of MSCs in situ to further enhance their efficac

156 matrix, leading to markedly greater trapping potency of multiple invading species without saturating

157 e genetic attenuation of which inhibited the potency of multiple noncleavable antibody-maytansine ADC

158 stinal organoids to quantitatively study the potency of multivalent cholera toxin inhibitors.

159 test the correlation between the anesthetic potency of n-alcohols and effects on Tc.

160 We evaluated the prevalence, breadth, and potency of NAb responses in 98 CRF07_BC-infected individ

161 ll mutations and substantially increases the potency of negative selection.

162 This study examines the potency of neoadjuvant TSL HT combination therapy in two

163 The unprecedented breadth and potency of neutralization by MEDI8852 support its develo

164 be expanded to acquire increased breadth and potency of neutralization merits further investigation.I

165 Here, we evaluate the differential potency of NGF, glial cell line-derived neurotrophic fac

166 and long-lasting (>30 weeks) decrease in the potency of nicotine but not (+)-EPI or varenicline.

167 tic analysis revealed that both location and potency of NLSs in terminase subunits evolved more rapid

168 However, the speed and potency of NO's metabolic effects at physiological conce

169 Potencies of NOD2 and NLRP3 stimulation are found compar

170 In contrast, the potencies of noncleavable ADCs carrying the structurally

171 The potency of norepinephrine for adrenergic alpha2A recepto

172 Given the hedonic potency of odor stimuli and the amygdala's anatomical pr

173 de mechanistic insights into the renewal and potency of olfactory stem cells.

174 the two antibodies and explain the very high potency of one of the antibodies.

175 -specific antibiotics, and for improving the potency of orthosomycins.

176 l activity against EHEC and complemented the potency of other colicins.

177 the cyanopyridones, enabled us to drive the potency of our 1,6-naphthyridin-2-one fragment hit from

178 ecent studies have highlighted the increased potency of oxygen analogs of organophosphorus pesticides

179 bleeding with a less effect with increasing potency of P2Y12 inhibition.

180 100) significantly decreased with increasing potency of P2Y12 RI (83.9+/-11%, 73+/-14%, 66.3+/-15%, 4

181 nzo[a]pyrene, phenanthrene, and carcinogenic potency of PAH mixtures were highest when samplers were

182 se in vitro methods to rank the AHR-mediated potency of PAHs in birds.

183 We investigated the hypothesis that the potency of parabens can be increased with HER ligands, s

184 We studied the antiviral potency of pegylated interferon-alpha (pegIFNalpha) agai

185 l approach can be widely used to improve the potency of peptidic fusion inhibitors against other enve

186 ntially reflecting the nearly 10-fold-higher potency of PGT121 against this SHIV.

187 The potency of phenyl esters largely exceeded that of beta-l

188 phenyl group to improve the selectivity and potency of PI3Kalpha.

189 disrupting bacterial membranes, the greater potency of pleurocidin is linked to its ability to penet

190 that human precursors can increase mutagenic potencies of pools and spas and that this increase is as

191 A simple route for improving the potency of progesterone as a modulator of P-gp-mediated

192 The specificity and potency of proteins would enable them to be effective in

193 In this study, we investigate the potency of Ptf1a to cell autonomously confer a specific

194 n dromedary camels, further illustrating the potency of replication-deficient chimpanzee adenovirus v

195 Cs, whose manipulation may lead to increased potency of reprogrammed HSCs for transplantation.

196 in polymerization by lowering the regulatory potency of RhoA and DAD on mDiaN.

197 This method relies on the potency of ROS generation by His-mSOG, the mini singlet

198 confirm the previously noted specificity and potency of rosette-modulating molecules, expand our unde

199 The mutagenic potencies of samples from a brominated site correlated b

200 Mutagenic potencies of samples from a chlorinated site correlated

201 al evaluation with respect to efficiency and potency of selected bioreceptors and biotransducers.

202 as to determine the PPARgamma ligand binding potency of several major flame retardants, including pol

203 Furthermore, APS-2-79 increased the potency of several MEK inhibitors specifically within Ra

204 ng variation in target copy number, inherent potency of sgRNA guides, and expression level of Cas9 an

205 Prior efforts to improve the in vitro potency of site II-specific antibodies did not translate

206 corresponding residue in KCa2.3 reduces the potency of SKA-121 by 7-fold, suggesting that R362 is re

207 ), we observed a significant increase in the potency of SNC80 to inhibit mechanical hyperalgesia and

208 Here, we investigated the potency of specific Wnt proteins, when expressed in the

209 g ligand (sTRAIL) would markedly enhance the potency of sTRAIL and specifically induce BPL cell apopt

210 the role of the A subunits in the increased potency of Stx2 has not been fully investigated.

211 However, the potency of such antibodies is generally low.

212 ding landscape together with relatively high potency of such interactions translates into a considera

213 nic vanadate complexes are reviewed, and the potency of such vanadium coordination complexes as antid

214 The potency of sulfide was enhanced when oxygen concentratio

215 The potency of synergistic combinations of B2088 and antibio

216 ts at the T-B cell interface to modulate the potency of T cell help needed to promote autoantibody pr

217 hese findings demonstrate a greater in vitro potency of tedizolid than linezolid against NTM and sugg

218 , although this can influence the estrogenic potency of test compounds.

219 The potency of tetrachlorodibenzo-p-dioxin (TCDD) and 18 pol

220 The remarkable diversity and potency of TFs as drivers of cell transformation justifi

221 The observed potencies of the effector lines in aminergic and choline

222 P. aeruginosa, which may explain the low RCL potency of the abundantly secreted PAE during host infec

223 e conditions, dependent on the structure and potency of the Ag, were required to induce hyporesponsiv

224 0-nm-sized degradable polymeric nanogels the potency of the agonist to activate TLR7/8 in in vitro cu

225 The potency of the amiloride derivatives was assessed by the

226 mechanism, which enabled us to optimize the potency of the analogs.

227 and to follow precise rules determining the potency of the antigen in the context of T cell activati

228 ost on burying beetles, which rises with the potency of the antimicrobial defence.

229 INK128 enhanced the antiviral potency of the CCR5 antagonist maraviroc, and had favora

230 Likely mechanisms for the superior potency of the CD4-10-17b CAR over the CD4-35-17b CAR in

231 ctivity, suggesting a role in modulating the potency of the cellular polarizing activity of the LIT-1

232 ses for future studies intended to prove the potency of the combined modification approach to produce

233 Resynthesis confirmed the potency of the compound, which suppressed viral RNA synt

234 significantly improved the ligand efficiency/potency of the cyclized compound relative to its acyclic

235 enerally depends on the frequency of use and potency of the drug used.

236 level of viremia, and the immunosuppressive potency of the drug(s) used.

237 ity and those promoting exchange reduced the potency of the drug.

238 The rank order potency of the EROD-active congeners in all three specie

239 However, the selectivity and potency of the existing atRA metabolism inhibitors towar

240 l and simple strategy to greatly enhance the potency of the existing peptide-based HIV fusion inhibit

241 ey had activity against A. suum, most of the potency of the extract derived from CA.

242 4501 inhibitors may also determine the toxic potency of the extracts.

243 ays, ML380 caused robust enhancements in the potency of the full agonists, acetylcholine (ACh), carba

244 Based on the potency of the haloacetonitriles and halonitromethanes,

245 Because of variations in potency of the human-derived product, limited availabili

246 rofiles is likely to enhance the breadth and potency of the humoral immune response against HCV.

247 T cells provide essential information about potency of the immune response.

248 hibitory concentrations (MIC) quantified the potency of the in situ click products and demonstrated t

249 e importance of several methyl groups to the potency of the inhibitors is highlighted as well as the

250 Evaluating the potency of the many known inhibitory compounds is a tedi

251 The potency of the new molecules, compounds 2-75 [4-(3-(4-cy

252 best compounds of our series maintained the potency of the original pharmacophores at both receptors

253 peptide (15M S.A.) retained the activity and potency of the parent peptide and demonstrated improved

254 esults further reveal that the difference in potency of the positive modulators in potentiating SK2 c

255 The cytotoxic potency of the released paclitaxel was also confirmed in

256 muli further enhances both the diversity and potency of the response.

257 may be due, at least in part, to inadequate potency of the selected cord blood unit (CBU).

258 onal novelties speaks to the persistence and potency of the selective forces in marine environments t

259 copy number, but is highly dependent on the potency of the sgRNA guide sequence.

260 elicit target mutation, particularly if the potency of the sgRNA is also low.

261 The potency of the sHsps to suppress aggregation of model su

262 ugmented SSFs reduced the overall estrogenic potency of the supplied water by 25% on average and remo

263 The potency of the synthesized inhibitors was increased with

264 The potency of the synthetic cannabinoid identified in these

265 Thus, the potency of the T cell response to histoincompatible tiss

266 In this work, we investigated the potency of the time-resolved fluorescence parameters of

267 M. haemolytica Lkt but that it enhances the potency of the toxin.

268 d hyperekplexia following a reduction in the potency of the transmitter glycine; this resulted from a

269 represent a valuable tool for improving the potency of therapeutic cancer vaccines through the effic

270 tus of the immune system, disease morbidity, potency of therapeutic intervention and vaccine efficacy

271 h the aim to improve nuclease resistance and potency of therapeutic siRNAs by introducing 4'-C-methox

272 161, providing a molecular mechanism for the potencies of these drugs, including the activity of VT-1

273 using the A3R5 neutralization assay, and the potencies of these neutralizing agents differed among En

274 cells and a correlation existed between the potencies of these two activities.

275 ffer evidence of the combinatorial antitumor potency of these agents in several preclinical models of

276 culated from the crystal structures, and the potency of these compounds in potentiating the SK2 chann

277 in vivo assays indicated only weak calcemic potency of these compounds in the intestinal calcium tra

278 Resistance mutations in CA decreased the potency of these compounds, demonstrating that CA is the

279 2, explaining the remarkable selectivity and potency of these inhibitors.

280 ry, with the aim to estimate the antiradical potency of these molecules.

281 oil motif and NHR fragments on the antiviral potency of these NHR-trimers.

282 al, ZCZ011 is brain penetrant, increased the potency of these orthosteric agonists in mouse behaviora

283 vated by the ten-fold increase in antibiotic potency of thiotetroamide C ascribed to the acetamide gr

284 Such enhanced retention may increase the potency of this chemotherapy agent and allow for reduced

285 uction of tachycardia and the arrhythmogenic potency of this drug.

286 These results highlight the potency of this model and raise the question of how usef

287 voriconazole provides an explanation for the potency of this relatively small molecule, whereas the c

288 In addition, the high potency of Toc-HDO results in a reduction of liver dysfu

289 Antiviral potency of TOE1 and its cell-penetrating capability have

290 y of proteins can be applied to increase the potency of topical microbicides and vaccine-elicited ant

291 drug delivery approaches to maximize in vivo potency of TRAIL in TRAIL-resistant tumor xenografts by

292 ng pathway and contributes to the angiogenic potency of transplanted miPSC-derived ECs.

293 ivotal role in determining the cannabinergic potency of tricyclic classical cannabinoids, and we have

294 in renal cancer cells correlates with their potency of tumor development and progression.

295 Here we compare the potency of two previously described inhibitors of wild t

296 These concepts can be applied to enhance the potency of vaccine-elicited antibodies and microbicides

297 r each receptor, we showed that the relative potency of various agonist chemokines was not identical

298 Mechanistically, the enhanced in vitro potency of VEGF dual dAb, in comparison to other anti-VE

299 cating both self-renewal and differentiation potency of virus-specific T cells sharing their TCR repe

300 n with Env trimers accounts for the increase potency of VRC01 and CD4i antibody mixtures.