ライフサイエンスコーパス: potently

1 d to a similar extent by kappa-ORs, but more potently (60%) via mu- and delta-ORs.

2 s, enhanced their radiosensitivity, and more potently abrogated PDAC growth in preclinical mouse mode

3 echanism could be bypassed by seeding, which potently accelerated aggregation and was a prerequisite

4 brane-associated polyphosphate nanoparticles potently activate factor XII.

5 Stressful experiences potently activate kappa opioid receptors (kappaORs).

6 ctivity of these Tat-friendly SECs, we could potently activate latent HIV-1 without using any drugs.

7 iger mosquito (Ae. albopictus) HP-I peptides potently activated Ae. aegypti NPYLR1.

8 AR1) is a G-protein-coupled receptors (GPCR) potently activated by a variety of molecules besides tra

9 is one of three human PARP enzymes that are potently activated during the cellular DNA damage respon

10 eral, 2d was 20-fold more potent than 2c and potently activated mGlu4,6,8 in the low-mid nanomolar ra

11 Although Mn(2+) potently activates other integrins and increases affinit

12 properties with plasmacytoid DCs (pDCs) but potently activates T cells, thus redefining pDCs; a new

13 dopamine (NADA) is an endogenous lipid that potently activates the transient receptor potential vani

14 creatitis, and regulates disease severity by potently activating CTSB.

15 to 100 muM, whereas the macrocyclic AS-48 is potently active against pathogenic and drug-resistant ba

16 Thus, AgRP neurons can potently affect POMC neuron function without contributin

17 Cell models of AML, CML, and T-ALL were potently affected by KDM1A inhibition, and cells bearing

18 We found that GML potently altered order and disorder dynamics in the plas

19 We conclude that EE potently alters the form and function of microglia in a

20 Moreover, slow-releasing ATRA potently and dose-dependently inhibited HCC growth in mi

21 ent with our prior work, knockdown of LRRC8A potently and equally suppressed the release of radiolabe

22 Exosomal microRNAs in particular can potently and fundamentally alter the transcriptome of re

23 in mice and found the following: (1) the IGC potently and monosynaptically inhibits the OB output neu

24 Enzyme activity is potently and reversibly inhibited by the drug disulfiram

25 Taken together, the described compounds both potently and selectively inhibit COT kinase in primary h

26 -aroyl-N-aryl-phenylalaninamides (AAPs)-that potently and selectively inhibit Mtb RNAP and Mtb growth

27 droxypyrimidine-2,4-dione (HPD) subtype that potently and selectively inhibited RNase H without inhib

28 PUM potently and selectively inhibits bacterial RNAP in vitr

29 Compound 18 potently and selectively inhibits cell growth in human l

30 lectively, our data demonstrate that RCB-185 potently and selectively inhibits Dxr in P. falciparum,

31 ty of breast CSCs to mitochondrial damage to potently and selectively kill breast CSCs.

32 reported that abacavir, an anti-HIV-1 drug, potently and selectively kills ATL cells.

33 Small molecules that bind to RNA potently and specifically are relatively rare.

34 we present direct evidence that manassantin potently and specifically inhibits the mitochondrial com

35 that the best molecule bound the M1 protein potently and weakened M1-M1 self-association.

36 While bNAbs potently antagonize infection with cell-free virus, inhi

37 5'-Methyl 25 and ethyl 26 esters potently antagonized 5HT2Rs with moderate selectivity in

38 onse to Exserohilum and that corticosteroids potently attenuate the immune response to this pathogen.

39 verse events.Twice daily RCE intake over 1 y potently attenuated BMD loss caused by estrogen deficien

40 MYST3 inhibition with inducible MYST3 shRNAs potently attenuated breast tumor growth in mice.

41 with the GLP-1R antagonist exendin-9 (Ex-9) potently attenuated the LiCl-induced suppression of dopa

42 Food and Drug Administration-approved drug, potently binds Hck with high selectivity.

43 Compound 5 potently binds to RIP1 with exquisite kinase specificity

44 ve been isolated from HIV-1 patients and can potently block infection of a wide spectrum of HIV-1 sub

45 hird, ectopic expression of IFITMs, known to potently block influenza virus fusion with late compartm

46 Furthermore, these compounds potently blocked infectivity of viruses harboring mutant

47 Inhibiting this pathway potently blocked lung and lymph node metastasis; however

48 CHMFL-BTK-11 potently blocked the anti-IgM stimulated BCR signaling i

49 kis-(2'-pyridylmethyl)ethylenediamine (TPEN) potently blocked Vpx-mediated SAMHD1 degradation and inh

50 wed better efficacy than rapamycin or TORKi, potently blocking cancer-derived, activating mutants of

51 ynthetic version of the mature 68-aa peptide potently blocks biofilm development on solid substrates

52 able clinical stage CDK-selective inhibitor, potently blocks CDK9, the transcriptional regulator of M

53 SAMHD1 potently blocks HIV-1 replication in DCs, although the u

54 mutation of Ser-1916 or Ser-1943 to alanine potently blocks recruitment of GFP-NM-IIA filaments to l

55 tivates STAT3 and show that inhibiting STAT3 potently blocks TGFbeta signaling, matrix remodeling, an

56 methylation inhibitor 5-azacytidine (5-AzaC) potently blocks the increased cell motility and invasive

57 Our results indicate that Civacir potently, broadly, and dose-dependently neutralizes all

58 0-enriched extracellular vesicles, which are potently chemotactic for cells of the innate immune syst

59 rprisingly also generated two compounds that potently co-inhibit TRPA1, known to function as chemical

60 ent murine tumor models and human cell lines potently cooperated with MEK inhibitors to kill these ca

61 uman monoclonal antibody (mAb), ZKA190, that potently cross-neutralizes multi-lineage ZIKV strains.

62 tion to a synthesis of chlorolissoclimide, a potently cytotoxic labdane diterpenoid.

63 2 is nontoxic to cells, but potently cytotoxic to cancer cells upon brief irradiatio

64 PC2-directed antibody-drug conjugate that is potently cytotoxic to GPC2-expressing neuroblastoma cell

65 Overall, PI3K/mTOR inhibition potently decreased ALL burden in vivo; antileukemia acti

66 In this article, we show that NADA potently decreases in vivo systemic inflammatory respons

67 been found to affect metabolism with MOTS-c potently decreasing weight gain in mice on a high-fat di

68 ZIKV potently depleted patient-derived GSCs grown in culture

69 and optogenetics to demonstrate that ethanol potently depresses both MSN- and fast-spiking interneuro

70 In 6-day animals, oral and inhaled R507 more potently diminished mononuclear graft infiltration than

71 However, although PMA potently down-regulated PKCalpha, prolonged activation b

72 well characterized "detonator" synapses that potently drive postsynaptic cell firing through their pr

73 Environmental rhythms potently drive predictive resource allocation in time, t

74 Activation of SuM(Nos1/Vglut2) neurons potently drives wakefulness, whereas inhibition reduces

75 fforded compounds targeting specifically and potently engineered BET bromodomains designed as part of

76 so its coligand B7-2 directly, superantigens potently enhance the avidity between B7-2 and CD28, indu

77 c1 and Cstb deletion genetically interact to potently enhance the degenerative phenotype of the NPC c

78 CRF-receptive (CRFR1) neurons in the CeA is potently enhanced by CRF and that CRFR1 signaling in the

79 However, short-term exposure to JWH-133 potently enhanced chemoattractant-induced eosinophil sha

80 -reactive and, although poorly neutralizing, potently enhanced ZIKV and DENV infection in vitro and l

81 We currently lack a therapy that potently enhances axon regeneration in patients with tra

82 llenge via lipopolysaccharide administration potently enhances seizure frequency and upregulates the

83 ound that TGF-beta interacts with IL-37, and potently enhances the binding affinity of IL-37 to the A

84 ed NZB/W F1 mice with agonist anti-Ox40 mAbs potently exacerbated renal disease, which was accompanie

85 In vitro, ILC2 were increased and potently expressed IL-13 in the presence of BCG or tumor

86 uring accrual of distant point mutations can potently facilitate poxvirus adaptation to host defenses

87 ing cellular gene expression, certain miRNAs potently facilitate replication of specific positive-str

88 that acyl-coenzyme A-binding protein (ACBP) potently facilitates very-long acyl chain ceramide synth

89 dividually, is sufficient to protect neurons potently from degeneration.

90 gamma from CD4 cells and CD8 cells, but most potently from MAIT cells (median IFN-gamma-positive freq

91 r, these results demonstrate that inhibition potently gates transitions between cortical activity sta

92 gliogenesis induced by misexpression of the potently gliogenic Notch pathway transcriptional effecto

93 ibited hENT1-mediated uridine transport most potently (IC50 value, 0.7 mum) followed by ponatinib > b

94 hese results demonstrate that Ag density can potently impact immune outcomes following RBC transfusio

95 -tolerated RSV/HPIV3 vaccine candidate, with potently improved immunogenicity, which can be returned

96 sine kinase-dependent activation of RAS more potently in colorectal cancer than in melanoma and cause

97 Treatment with b-AP15 potently increased DR5 levels including cell surface DR5

98 Finally, we identify that IL-27 potently increases expression of the antiviral oligoaden

99 a bacterial metabolite with the capacity to potently induce a prion.

100 ssibly stabilize the immunologic synapse and potently induce antibody-dependent cell-mediated antivir

101 ain-of-function experiments show that it can potently induce endothelial gene expression.

102 ase activity in vitro and in cells, and they potently induced cell death in chronic myelogenous leuke

103 Among them, Phen consistently and potently induced differentiation and mineralization in v

104 s, showed that luminal but not abluminal LPC potently induced permeability, and that this required si

105 This compound potently induced Th1-biasing IFN-gamma and IL-12 in huma

106 In vitro, harmine potently induced the expression of thermogenic genes in

107 CCR1 activation potently induces multiple myeloma PC migration toward CC

108 particular, 10-nitro oleic acid (10-NO2-OA) potently induces Nrf2-dependent antioxidant gene express

109 However, LPS more potently induces pro-inflammatory cytokine and inflammas

110 with Wnt7b production in vivo and that dsRNA potently induces Wnt7b in a manner that requires Ptgs2.

111 GE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta transcription, as well as boo

112 l root ganglion (DRG) produce PD-L1 that can potently inhibit acute and chronic pain.

113 ly with VEGFR2 binding of KIF13B and thereby potently inhibit angiogenesis.

114 cal analyses revealing that cyclic boronates potently inhibit both nucleophilic serine and zinc-depen

115 ectrum serine beta-lactamase inhibitors that potently inhibit clinically relevant class A, C and D be

116 (POMC) neurons release peptide products that potently inhibit food intake and reduce body weight.

117 (POMC) neurons release peptide products that potently inhibit food intake and reduce body weight.

118 IX, and XII inhibitors, whereas they did not potently inhibit hCA I.

119 We demonstrated that BBI could potently inhibit HIV replication in macrophages without

120 tinct from that of type I interferon and can potently inhibit HIV-1 in primary CD4(+) T cells and a n

121 MINIs potently inhibit HIV-1 replication during virion maturat

122 healthy donors who do not use illicit drugs potently inhibit HIV-1.

123 e antibiotics, including roxithromycin, that potently inhibit KCNJ5MUT, but not KCNJ5WT.

124 ngly, we have developed novel compounds that potently inhibit LTB4 generation whilst leaving PGP degr

125 as produced in Escherichia coli and found to potently inhibit lysis of rabbit erythrocytes in assays

126 es from poorly metastatic melanoma cells can potently inhibit metastasis to the lung.

127 ntioxidant pathway mimicked Nrf2 ablation to potently inhibit pancreatic cancer ex vivo and in vivo,

128 HDACIs potently inhibit survival of MYC-driven MB cells in vitr

129 ted that enforced expression of TRIM14 could potently inhibit the infection and replication of HCV in

130 drugs, nalidixic acid and dorzolamide, that potently inhibit the NA activity of oseltamivir-resistan

131 Cyclic boronates also potently inhibit the non-essential penicillin-binding pr

132 Herein, we demonstrate that EGCG can potently inhibit the proinflammatory enzyme myeloperoxid

133 They potently inhibit VEGF-driven angiogenesis in a chamber m

134 stamine receptor antagonist chlorpheniramine potently inhibited adipocyte UCP1 mRNA induction by mast

135 neous administration; D538G tumors were more potently inhibited by AE than Y537S tumors.

136 Neisseria encodes a functional FabI that was potently inhibited by AFN-1252.

137 Abeta into non-aggregating fragments but is potently inhibited by cystatin C (CysC).

138 (p)ppGpp synthesis is potently inhibited by the binding of single-stranded RNA

139 All APDS mutations were potently inhibited by the Food and Drug Administration-a

140 -S4, forms functional sodium channels and is potently inhibited by the NaV1.7 VSD2 targeted peptide t

141 the mechano-enzymatic pathway is indeed more potently inhibited by tolcapone than by tafamidis but ne

142 MC38-derived PD-L1 potently inhibited CD8(+) T cell cytotoxicity.

143 Treatment with TNT009 was safe and potently inhibited CP activity.

144 Pin1 knockdown potently inhibited HCC cell proliferation and tumor grow

145 macological block of mast cell degranulation potently inhibited histamine release by mast cells and i

146 ow that dynamin-mediated membrane fission is potently inhibited in vitro when an excess of endophilin

147 LSEVh-LS-F potently inhibited in vivo HIV-1 and SHIV infection in h

148 LSEVh-LS-F potently inhibited in vivo HIV-1 and simian-human immuno

149 Indeed, heme potently inhibited Leishmania replication in bone marrow

150 BTKB66 potently inhibited lipopolysaccharide-mediated activatio

151 Notably, in PDAC cells, Mito-Met10 potently inhibited mitochondrial complex I, stimulating

152 yme inhibition and selectivity for CDPK1 and potently inhibited parasite growth in vitro.

153 ibodies elicited by natural Pf exposure that potently inhibited parasite transmission and development

154 GSK690693 potently inhibited PrkA kinase activity biochemically an

155 rt, we show that an anti-CD46 ADC (CD46-ADC) potently inhibited proliferation in myeloma cell lines w

156 BBD also potently inhibited replication of clinically-isolated MT

157 of action, selected antiviral analogues also potently inhibited reverse transcriptase (RT) associated

158 site was saturated by 50 muM Ca(2+), Ln(3+) potently inhibited RyR's open probability (Kd Eu(3+) = 1

159 IB also potently inhibited survival of primary human FLT3/ITD(+)

160 nalogs that undergo oxidative transformation potently inhibited the pro-inflammatory transcription fa

161 , ganetespib, SNX2112, AT13387, and CUDC305) potently inhibited the proliferation of bladder cancer 5

162 P extract potently inhibited the release of nitric oxide (NO) and

163 t stem cell-derived sensory neurons in vitro potently inhibited their response to both electrical and

164 Fifteen compounds potently inhibited tubulin polymerization.

165 Moreover, KDM3A knockdown also potently inhibited tumorigenic potentials of breast canc

166 nerated broad-spectrum T-cell responses that potently inhibited tumour growth.

167 In vivo, DHTS potently inhibited xenograft tumor growth in a HuR-depen

168 body responses generated to one variant were potently inhibiting IL-1beta, antibody responses induced

169 f paclitaxel and promoted apoptosis, thereby potently inhibiting the growth of ABCB1 overexpressing t

170 An Escherichia protein, CsgC potently inhibits amyloid formation of curli amyloid pro

171 or, gigastasin, from the giant Amazon leech, potently inhibits C1s and MASP-2, whereas it is also a g

172 -microglobulin -binding nanobody, Nb24, more potently inhibits D76N beta2-microglobulin fibrillogenes

173 hown that adenosine generated by tumor cells potently inhibits endogenous antitumor T cell responses

174 ion of ZIKV envelope protein, designated Z2, potently inhibits infection of ZIKV and other flavivirus

175 om of the tarantula Pamphobeteus nigricolor, potently inhibits NaV1.7 (IC50 0.9 nM) with at least 40-

176 rate that a tamoxifen analog, 6c, which more potently inhibits PKC than tamoxifen but lacks affinity

177 as the MC-supportive mediator par excellence potently inhibits pseudo-allergic degranulation, while i

178 Together, these results suggest that SAB potently inhibits pulmonary fibrosis.

179 rs DAPK1 kinase activation, and active DAPK1 potently inhibits RIG-I stimulated IRF3 activity and int

180 Concurrent helminth infection potently inhibits T cell immunity; however, whether helm

181 78 to be a new antiviral small molecule that potently inhibits the cellular entry of the Junin virus

182 Recombinant proSAAS potently inhibits the fibrillation of alpha-synuclein in

183 argeting of proliferating PDGFRbeta(+) cells potently inhibits the formation of the pericyte-like sca

184 accinia virus harbors antiapoptotic F1L that potently inhibits the mitochondrial apoptotic checkpoint

185 n, a plant-derived rotenoid, selectively and potently inhibits the motility and development of nemato

186 e naphthalenethiobarbiturate derivative that potently inhibits the NF-kappaB subunit c-Rel.

187 humans, that the mitochondrial protein LACTB potently inhibits the proliferation of breast cancer cel

188 physiological experiments revealed that Ae1a potently inhibits the voltage-gated sodium channel BgNaV

189 ndin-4, inhibits the shuttling of MondoA and potently inhibits TXNIP and ARRDC4 expression.

190 tiviral kinase protein kinase R (PKR), which potently inhibits virus replication.

191 In vitro, duvelisib potently killed 3 of 4 TCL lines with constitutive phosp

192 S17 potently killed gastric cancer cells with causing modula

193 ide I displaces low affinity substrates more potently leading to substrate selective inhibition of ki

194 ular shape among BACE inhibitors reported to potently lower central Abeta in nonrodent preclinical sp

195 Syndecans potently modulate agouti-related peptide (AgRP) signalin

196 Epileptic seizures potently modulate hippocampal adult neurogenesis, and ad

197 The auxiliary gamma1-3 subunits potently modulate the BK channel by shifting its voltage

198 Helminth parasites secrete molecules that potently modulate the immune responses of their hosts an

199 urons by determining that the CT neurons are potently modulated by acetylcholine acting on both nicot

200 Conversely, metabolic state potently modulates sleep and circadian behavior; yet, th

201 These findings provide a potently more immunogenic version of this well-tolerated

202 a growing list of DprE1 inhibitors that are potently mycobactericidal.

203 ultiple antibodies have been identified that potently neutralize a broad range of circulating HIV str

204 characterization of MAbs with the ability to potently neutralize diverse HIV-1 isolates have reinvigo

205 Although all 3 mAbs potently neutralized cytotoxicity, only SA-15 and SA-17

206 antibody (E1) binds antibody HM14c10, which potently neutralizes DENV serotype 1.

207 us of the ebolavirus glycoproteins (GPs) and potently neutralizes Ebola, Sudan, Bundibugyo, and Resto

208 2, on the surface of transduced TZM.bl cells potently neutralizes multiple subtypes of HIV-1 isolates

209 ion would likely have the dual capacities of potently neutralizing a broad range of HIV-1 isolates an

210 ise in HIV prevention as they are capable of potently neutralizing a considerable breadth of genetica

211 codes epitopes recognized by virus-specific, potently neutralizing antibodies, and EIII is believed t

212 f HIV-1 vaccine research on the induction of potently neutralizing antibodies.

213 ntibodies that are both broadly reactive and potently neutralizing.

214 o cytoplasmic actin, whereas Drosophila Fhod potently nucleates both cytoplasmic and sarcomeric actin

215 CdGAP expression potently perturbs junctions and Ajuba binding inhibits C

216 ceptor antagonist has recently been shown to potently prevent liver injury in murine models of ALD.

217 Here we show that Bri2 BRICHOS monomers potently prevent neuronal network toxicity of Abeta, whi

218 soluble product, shed LRP1 (sLRP1), which is potently proinflammatory.

219 show that DCs activated by dectin-1 agonists potently promote naive CD4(+) T cells to differentiate i

220 L-37 is a novel pro-angiogenic cytokine that potently promotes endothelial cell activation and pathol

221 mitochondrial function in alpha-cells exerts potently protective effects on beta-cells, preserving be

222 xpression of the MHC-II Ealpha:Ebeta complex potently protects nonobese diabetic (NOD) mice, which no

223 first synthesized in 1938 and identified as (potently) psychoactive in 1943.

224 In particular, compound 3b potently reduced in vitro chemotherapeutic resistance of

225 Intriguingly, moDCs potently reduced the ability of cDCs to stimulate T cell

226 sly absent for the related Na channels, also potently regulated by calmodulin.

227 ereas many cytokines and their receptors are potently regulated via post-transcriptional mechanisms i

228 acid adenine dinucleotide phosphate (NAADP) potently releases Ca(2+) from acidic intracellular endol

229 e growth-promoting properties of BRD4 and is potently repressed by BRD4-NUT, a driver of NUT midline

230 rast, selective activation of NRF2 signaling potently repressed the release of the proinflammatory cy

231 ed the pan-kinase inhibitor foretinib, which potently rescued sympathetic, sensory, and motor wt and

232 en innate and adaptive immunity, rapidly and potently respond to pathogen infection in mucosal tissue

233 Here we show that GBP5 potently restricts HIV-1 and other retroviruses.

234 gether, we conclude that combination therapy potently reverses immunosuppression and eradicates tumou

235 Importantly, antagonism of miR-128-3p potently reverses metastasis and chemoresistance of high

236 lass beads and polyanionic heparin molecules potently seeds the amyloid conversion process.

237 ptides not only induce cell killing but also potently sensitize PEL to the proapoptotic agents tumor

238 med that inhibition of CREB1 phosphorylation potently sensitized resistant cells to platinum therapy

239 t TNFalpha in a receptor-specific fashion to potently silence gene expression and protein secretion.

240 he use of small bioactive compounds that can potently stimulate and expedite reparative dentin format

241 alamic agouti-related peptide (AgRP) neurons potently stimulate food intake, whereas proopiomelanocor

242 ileum, but not the colon, 300 mmol/L glucose potently stimulated GLP-1 release.

243 s that enhance the levels of SEC-P-TEFb also potently stimulated HSV reactivation from latency both i

244 9a (hG9a) unlike its mouse orthologue (mG9a) potently stimulated p53 transcriptional activity.

245 We find that IFN-? potently stimulates activation of the primary autophagy

246 inc finger transcription factor 281 (ZNF281) potently stimulates cardiac reprogramming by genome-wide

247 nhibited by WASP's CA region, even though CA potently stimulates cross-linking, suggesting that slow

248 er multiple tumor antigens in a fashion that potently stimulates endogenous immune responses against

249 inase C/nuclear factor-kappaB signaling, and potently stimulates expression of CD69, degranulation, m

250 YAP overexpression potently stimulates fetal cardiomyocyte (CM) proliferati

251 recent years it has emerged that foreign DNA potently stimulates the innate immune response, particul

252 fibrosis-inducing E3 ligase 1 (FIEL1), which potently stimulates the TGFbeta signaling pathway throug

253 rein, we have demonstrated that Foxp3+ Tregs potently suppress autoimmune responses in vivo through i

254 an array of IFN-stimulated genes (ISGs) and potently suppress Human immunodeficiency virus type 1 (H

255 acid, a transaminase inhibitor, was able to potently suppress PGC-1alpha acetylation stimulated by m

256 Mycolactone-mediated Sec61 blockade also potently suppressed both antigen cross-presentation and

257 e that TDP-43 acetylation-mimic pathology is potently suppressed by an HSF1-dependent mechanism that

258 Sensory-evoked activity is potently suppressed by anaesthesia.

259 lls is mediated by wild-type human Dicer and potently suppressed by both NS1 of IAV as well as virion

260 In contrast, conventional NK cells were potently suppressed by MDSCs, an effect abrogated comple

261 In addition, ZNF750 potently suppressed cell migration by directly inhibitin

262 , 3-d IL-33 treatment before Con A challenge potently suppressed development of immune-mediated hepat

263 vation of either ILPFC or LHb in normal rats potently suppressed dopamine neuron population activity,

264 signalling by shRNA or anti-PTPRZ1 antibody potently suppressed GBM tumour growth and prolonged anim

265 BTSA1 potently suppressed human acute myeloid leukemia (AML) x

266 found that interference with CCL2 signaling potently suppressed LPS-induced seizures.

267 PD-L1 also potently suppressed nociceptive neuron excitability in h

268 ediated translational repression using ISRIB potently suppressed PERK-dependent inflammatory gene exp

269 The results demonstrate that N6-LS potently suppressed plasma viral loads in the majority o

270 Furthermore, dinaciclib potently suppressed the clonogenic potential of relapsed

271 -carboxamide-1-beta-D-ribofuranoside (AICAR) potently suppressed upregulation of ER stress marker mRN

272 As miR-135a potently suppresses AR expression, this results in a neg

273 diol, eliminating a proresolving signal that potently suppresses IL-8-driven neutrophil transepitheli

274 and show that PRMT5 knockdown or inhibition potently suppresses in vivo GBM tumors, including patien

275 Finally, we show that Zfp106 potently suppresses neurotoxicity in a Drosophila model

276 of its anti-tetherin activity, RBF206 O-Vpu potently suppresses NF-kappaB activation and reduces CD4

277 stimulation of primary somatosensory cortex potently suppresses SpVc responses to noxious stimuli an

278 In vitro, the latter interaction potently suppresses the aggregation of various non-glyco

279 The host-cell restriction factor SERINC5 potently suppresses the infectivity of HIV, type 1 (HIV-

280 therapeutic administration of PEG-IFNlambda potently suppresses these effects.

281 ulosis, with a lead compound from this study potently suppressing carbenicillin resistance in multipl

282 Tumor-resident Treg cells were potently suppressive and their gene-expression pattern r

283 However, the SAA fragments potently synergized with CCL3 to induce monocyte migrati

284 ctonase, a key component of NADPH synthesis, potently synergizes MB activity.

285 nd HSP90, similar to (compound 1005) or more potently than (compound 2-75) SAHA.

286 Abs from two patients neutralized DENV1 more potently than DENV2.

287 lisib, decreased xenograft tumor growth more potently than each drug alone.

288 l nutrients stimulate insulin secretion more potently than intravenous (IV) glucose administration un

289 6OTD inhibited the growth of GSCs more potently than it did the growth of differentiated non-st

290 mbranes could catalyze aggregation even more potently than seeds, in a process that caused significan

291 d inhibited phospho-ERK and phospho-AKT more potently than the combination of single receptor-binding

292 -resistant T. ni insects up to 335-fold more potently than wild-type Cry1Ac.

293 icular, this shorter aptamer blocked equally potently the activity of both the GluK1 and GluK2 kainat

294 The designed peptides potently trigger disruption of the mitochondrial outer m

295 Moreover, Mito-Met10 potently triggered G1 cell-cycle phase arrest in PDAC ce

296 ate immune activation in human monocytes but potently triggers IL-1beta release upon pro-inflammatory

297 ic dinucleotides (cdNs) by the STING pathway potently triggers the antiviral response.

298 miR-708 was also potently upregulated by triggering endoplasmic reticulum

299 ctor and survival signalling, and cooperates potently with c-MYC during tumorigenesis.

300 ntly, we showed HMAs and HSPC-NK cells could potently work together to target AML cell lines and pati