ライフサイエンスコーパス: potently

1 hich does not block ethanol teratogenesis as potently.

2 , with IFN-lambda driving these effects most potently.

3 entraps an early neural lineage network, is potently abrogated by bromodomain inhibitor JQ1, leading

4 Local application of MaR1 potently accelerated extraction socket healing.

5 type S. aureus and a DeltahemB SCV prototype potently activate glycolysis in host cells.

6 eic acid and nitro-conjugated linoleic acid) potently activate SIRT6.

7 to generate high-affinity TCR variants that potently activate T cells, and they also create soluble

8 YAP-expressing hepatocytes rapidly and potently activate the expression of proteins that promot

9 Viruses potently activate the immune system and can damage beta

10 irst-in-class profile: it preferentially and potently activated beta-arrestin recruitment in vitro an

11 Strikingly, TadNaC6 was potently activated by the general DEG/ENaC channel block

12 without causing receptor desensitization and potently activated protection pathways in human endothel

13 imulation in the subcutaneous adipose tissue potently activates Ca(2+) cycling fat thermogenesis and

14 TLR-induced signaling potently activates cells of the innate immune system and

15 Transforming growth factor beta (TGFbeta) potently activates hepatic stellate cells (HSCs), which

16 esponse to Nutlin-3A, an MDM2 inhibitor that potently activates p53.

17 This nanobody potently activates the Hedgehog pathway in vitro and in

18 a hydrophobic moiety known as lipid A, which potently activates the host innate immune response.

19 m the Gram-negative bacterial outer membrane potently activates the human innate immune system.

20 F7L6 potently activates WNT/beta-catenin signaling in a manne

21 ishes that combined epigenetic modifiers are potently active in PTCL patients.

22 Thus, an orally available SCD inhibitor potently ameliorates PD phenotypes, positioning this app

23 It potently amplifies inflammation via Toll-like receptor f

24 f binding surface, binds to SNX9 and AP2 and potently and acutely inhibits CME.

25 Many neuroactive steroids potently and allosterically modulate pentameric ligand-g

26 Human monoclonal antibodies that potently and broadly neutralise HIV-1 are under developm

27 Finally, the GNP-glycans can potently and completely inhibit DC-SIGN-mediated augment

28 rm treatment of subgenomic replicons with 13 potently and durably decreased HCV RNA levels for gt1a,

29 mechanoreceptors, but not other cell types, potently and durably inhibit hunger-promoting AgRP neuro

30 perine is a KCNQ-dependent vasorelaxant that potently and isoform-selectively activates KCNQ5 by bind

31 lex with the FK506-binding protein (FKBP12), potently and selectively binds the human centrosomal pro

32 These compounds potently and selectively degraded MEK1/2 by hijacking th

33 Insulin potently and selectively increased I(Na) in Akita mice w

34 development of two PROTACs (C3 and C5) that potently and selectively induce the degradation of Mcl-1

35 and SLCO2A1 have been previously shown to be potently and selectively inhibited by compounds such as

36 Here, we show that RU.521 is capable of potently and selectively inhibiting mouse and human cGAS

37 or tyrosine kinase inhibitor (EGFR-TKI) that potently and selectively inhibits both EGFR-TKI-sensitiz

38 n T-cells and B-cell lymphoma lines, MLT-231 potently and selectively inhibits the proteolytic activi

39 Antibodies are capable of potently and specifically binding individual antigens an

40 that TRIM69 is an antiviral defense that can potently and specifically block VSIV infection.

41 We also show that IPA more potently and specifically inhibits NSF/Sec18 activity th

42 Tralokinumab is a fully human mAb that potently and specifically neutralizes IL-13.

43 ifficult to design a glycoconjugate that can potently and specifically target a particular multimeric

44 We designed TGP-377 to potently and specifically upregulate VEGFA in human umbi

45 NAP potently antagonizes ethanol inhibition of L1 adhesion b

46 use as there are no examples of complex and potently anticancer (nM) ETPs being directly used as con

47 We then developed potently anticoronavirus ACE2-Ig proteins that are broad

48 IGNIFICANCE STATEMENT Within the BLA, NPY is potently anxiolytic.

49 the TORC1 inhibitor everolimus and neratinib potently arrested the growth of neratinib-resistant xeno

50 TRuC-T cells kill tumor cells as potently as second-generation CAR-T cells, but at signif

51 d drive premature transcription termination, potently attenuating the activity of target genes.

52 e found Tubastatin A, an HDAC6 inhibitor, to potently bind HDAC10.

53 t structures of neutralizing antibodies that potently block gB-induced membrane fusion.

54 nuclear pore complex blockade in cells that potently block infection by wild-type capsid, demonstrat

55 encoded reagents in cells, these monobodies potently block necroptotic cell death.

56 enzymatically inactivated ACE2 variants that potently block SARS-CoV-2 infection of cells.

57 in, heparin lyases, and lung heparan sulfate potently block spike protein binding and/or infection by

58 ecombinant ACE2-Ig proteins that are able to potently block these viral infections, providing a promi

59 , but BMP6 and related activin proteins also potently blocked HCV replication independently of IFN.

60 nd MHCII, and LRRK2-phosphorylation of Rab10 potently blocks EHBP1L1-mediated recycling tubules and c

61 as well as systemic administration of BK1.3 potently blocks inflammation in vivo Identification and

62 Treatment after disease onset potently blocks progression of disease and further alpha

63 ein associated with an atypical liver cancer potently blocks RIalpha LLPS and induces aberrant cAMP s

64 wentoxin-IV, a component of tarantula venom, potently blocks sodium channels and is an attractive sca

65 This anti-tryptase antibody potently blocks tryptase enzymatic activity in a humaniz

66 Potently bound off-targets of clinical inhibitors sugges

67 es have also shown that ubiquitin E3 ligases potently control TGF-beta signaling through targeted deg

68 Several antibodies potently cross-neutralize SARS-CoV, SARS-CoV-2, and the

69 tudies identify an extra-embryonic origin of potently cytotoxic NK cells, suggesting that ontogenic o

70 omoting resolution of eosinophils, and MCTR3 potently decreased airway hyperreactivity to methacholin

71 ly, our data showed that although kisspeptin potently decreases the intracellular proinsulin and insu

72 erm treatment with concentrations of SP that potently degrade XPB does not lead to global dysregulati

73 alpha4- and alpha2-containing receptors were potently desensitized by the epibatidine analogs.

74 For example, we describe Fc mutants that potently disrupted influenza B-mediated agglutination of

75 glyoxal modification is easily installed and potently disrupts nucleic acid structure and function.

76 Aquaporin (Aqp) 11 was also potently down-regulated, whereas Aqp5/AQP5 expression pe

77 omic analysis revealed that exposure to BETi potently downregulated a network of genes involved in re

78 A potently downregulated gene in both datasets was spleen

79 Ras genes potently drive human cancers, with mutated proto-oncogen

80 vated beta-arrestin recruitment in vitro and potently elicited lower lip retraction in vivo, a compon

81 However, PAG-projecting neurons most potently encoded choice in cued tasks, whereas contralat

82 as contralateral PFC-projecting neurons most potently encoded reward context in an uncued task.

83 d to test which knockin gene constructs most potently enhance primary cell functions in vivo.

84 me, that triphenylphosphonium-conjugated ATO potently enhanced the antiproliferative effect of ATO in

85 Pharmacological mTOR inhibition potently enhanced the suppressive effects of alpelisib o

86 ly demonstrated that chronic nicotine (cNIC) potently enhances nAChR function in dendrites of MHb neu

87 Shisa7 also potently enhances the action of diazepam, a classic benz

88 aining cobalt-porphyrin-phospholipid (CoPoP) potently enhances the functional antibody response.

89 all molecule (TGP-377) that specifically and potently enhances VEGFA expression by the targeting of a

90 Furthermore, this interaction potently exploits a DNA-repair defect found in many canc

91 Necroptotic cell death is potently immunogenic and limits IAV spread by directly e

92 f caudal, but not rostral, dmPFC CRF neurons potently impaired working memory, whereas inhibition of

93 IACS-13909 potently impeded proliferation of tumors harboring a bro

94 s the nanovesicles to capture virulence more potently in vitro.

95 We further demonstrate that select analogs potently increase cell surface expression of CD22, a pro

96 e showed that blockade of A(2B) AR signaling potently increased GB cell death induced by the chemothe

97 NDRG1 overexpression potently increased the levels of mitogen-inducible gene

98 a demonstrate that dopaminergic transmission potently increases D1-SPN excitability with a time cours

99 In neoantigen-fixed models, dMLH1 tumors potently induce T cell priming and lose resistance to ch

100 both the hepatocytes and the mouse liver is potently induced by the chemical ER stress inducer tunic

101 e or together with a low dose of doxorubicin potently induced p53 expression and suppressed colony an

102 These compounds potently induced the degradation of mutant but not wild-

103 Ultra-high dose rate irradiation more potently induces clonogenic cell death than conventional

104 pressed on T(H)2 cells (CRTH2) receptor axis potently induces cytokine production and ILC2 migration.

105 These results indicate that Delta9-THC potently induces IL-10, while reducing proinflammatory c

106 This glucorhamnan potently induces inflammatory cytokine (TNFalpha) secret

107 We found that at sub-lethal doses, UMI-77 potently induces mitophagy, independent of apoptosis.

108 gulators of T cell activation, but CD28 less potently induces TCR-proximal signaling.

109 n vivo, we identified a specific strain that potently induces Th17 cells.

110 Restriction of dietary serine and glycine potently induces the accumulation of deoxysphingolipids

111 SD-36 potently induces the degradation of STAT3 protein in vit

112 causes an arrest of protein synthesis, which potently induces tumor cell apoptosis.

113 ytic leukaemia, achieving deep remissions by potently inducing apoptosis and increasing the risk for

114 adly neutralizing HIV antibodies (bNAbs) can potently inhibit a wide range of HIV-1 strains by bindin

115 Excitingly, key compounds of the series potently inhibit all four molecular targets and show ant

116 A subset of the antibodies was able to potently inhibit authentic SARS-CoV-2 infection at a con

117 (FGF15; human ortholog FGF19) in the gut to potently inhibit bile acid (BA) synthesis in the liver.

118 t RAF inhibitors are monomer selective, they potently inhibit BRAF V600 monomers but their inhibition

119 monoclonal antibodies, CHK-124 and CHK-263, potently inhibit CHIKV infection in vitro and in vivo.

120 s and other mobile genetic elements that can potently inhibit CRISPR-Cas systems.

121 ns revealed that gallinamide and its analogs potently inhibit cruzain and are exquisitely toxic towar

122 Finally, pharmacological inhibitors of Lsd1 potently inhibit growth of Gfi1-driven tumors.

123 Although antiretroviral therapies (ARTs) potently inhibit HIV replication, they do not eradicate

124 Because EVAs potently inhibit inflammation in many preclinical models

125 this study, that losartan and its metabolite potently inhibit monocyte recruitment through the noncom

126 We identified several compounds that potently inhibit motility representing either novel drug

127 hat symmetrically substituted dichlorophenes potently inhibit NAPE-PLD in cultured cells and have sig

128 tudy discovered that Pralatrexate is able to potently inhibit SARS-CoV-2 replication with a stronger

129 The analogues from series I potently inhibit the generation of Abeta(42) in vitro wh

130 taphylococcus aureus immune evasion proteins potently inhibit the neutrophil serine proteases (NSPs)

131 ed to a dimeric compound with the ability to potently inhibit the p47phox(SH3A-B)-p22phox interaction

132 acids, as well as Glc analogs, were found to potently inhibit the R(N) stimulation by Pro and Ala but

133 t of pyruvate kinase side reaction, and both potently inhibit two key glycolytic enzymes, triosephosp

134 eavage at the MA-CA junction was observed to potently inhibit virus infection: incorporation of small

135 markably, systemically administered morphine potently inhibited acute thermal and mechanical nocicept

136 AR) derived from Streptococcus gordonii (Sg) potently inhibited adherence of Pg to streptococci and r

137 CGRP potently inhibited alarmin-driven type 2 cytokine produc

138 ct BMP9-induced Smad1/5 phosphorylation, but potently inhibited ALK3-dependent BMP4-induced Smad1/5 p

139 mes with the Nogo-66 domain on their surface potently inhibited axonal regeneration of mechanically i

140 Compound 3 potently inhibited binding of trimethyllysine-containing

141 ediated gene silencing and one lead compound potently inhibited breast tumor growth in murine xenogra

142 Ca(V) 1/Ca(V) 2 channels are potently inhibited by a four-member sub-family of Ras-li

143 rats reduced respiration, a reflex that was potently inhibited by activation of SubM.

144 ants had higher affinities for and were more potently inhibited by aggregates versus more stable vari

145 rential regulation by the alarmones as it is potently inhibited by both ppGpp and pGpp, but only mode

146 ) helix, RGS19 is the most flexible and most potently inhibited by CCG-50014, followed by RGS4 and RG

147 also observed that TWIK-1 Rb(+) currents are potently inhibited by intracellular K(+) (IC(50) = 2.8 m

148 GRK5 is potently inhibited by the calcium-sensing protein calmod

149 model with the highest (18)F-TRX uptake, was potently inhibited by TRX-CBI.

150 Compound 4a potently inhibited cell proliferation and colony formati

151 5a and 5e potently inhibited different influenza genera in vitro.

152 Recombinant ApoA-IV potently inhibited eosinophil responsiveness in vitro as

153 In contrast, ATRA binding to CRABP2 potently inhibited HCV via suppression of LD accumulatio

154 At a low micromolar concentration, PF74 potently inhibited HIV-1 infection without affecting rev

155 ectively inhibited hOCT1, whereas crizotinib potently inhibited hOCT3-mediated mIBG uptake.

156 Importantly, GBP2 potently inhibited MNV in these human epithelial cells.

157 the peptide-binding cleft, HLA-B*57:01 more potently inhibited NK cell activation.

158 These kinases represent the most potently inhibited off-targets of PARP inhibitors identi

159 valently modify other closely related PRMTs, potently inhibited PRMT6 in cells, and was selective for

160 Serum isolated from glioma-bearing mice potently inhibited proliferation and functions of T cell

161 that SARS-CoV S murine polyclonal antibodies potently inhibited SARS-CoV-2 S mediated entry into cell

162 romidepsin, an FDA-approved anticancer drug, potently inhibited tail regeneration when embryos were t

163 Functional studies revealed that AdA potently inhibited the formation of the chemoattractant

164 ng mutant B-Raf, MKK6 activation rapidly and potently inhibited the pro-proliferative extracellular s

165 In this study, we demonstrated that miR-200c potently inhibited TNBC cell growth and tumor developmen

166 Furthermore, AF8 potently inhibited tumor growth in a HCT116 xenograft mu

167 finity for ULK1/2 compared with SBI-0206965, potently inhibited ULK1/2 enzymatic activity in vitro an

168 nd a pharmacologic AdipoR agonist, AdipoRon, potently inhibited uterine myometrial strip contractions

169 TRIM69 potently inhibited VSV(IND) replication through a previo

170 Even under these conditions, BT200 potently inhibited VWF activity and VWF-dependent platel

171 lation, whereas Ca(2+) mobilization was less potently inhibited.

172 TFEB potently inhibits apoptosis in VSMCs, and transcriptome

173 y selective, irreversible BTK inhibitor that potently inhibits BCR- and Fc receptor-mediated signalin

174 In contrast, ECD-scFvhFc potently inhibits beta-arrestin-2 recruitment after PTH

175 nd mouse complement component C3/C3b/C3c and potently inhibits C3 cleavage by the alternative pathway

176 ely characterize a lead compound (4a), which potently inhibits clinically derived vancomycin-resistan

177 s with the host translation factor eEF1A and potently inhibits eukaryotic protein translation by an u

178 nce, reduces tumor-supportive TAMs (M2), and potently inhibits GBM growth.

179 og, which we named burkfloxacin (BFX), which potently inhibits growth of intracellular Burkholderia,

180 An optimized degrader, DGY-08-097, potently inhibits HCV in a cellular infection model, and

181 etherin is a host transmembrane protein that potently inhibits human immunodeficiency virus type 1 (H

182 In the absence of secondary signal, IL-10 potently inhibits IL-1beta processing, providing a previ

183 nds with picomolar affinity to human C4b and potently inhibits in vitro complement C3 deposition thro

184 nomolar affinity and that nucleosome binding potently inhibits its catalytic activity.

185 The binding of telaprevir potently inhibits its enzymatic activity, and using drug

186 nctions of alphaSNAP, showing that alphaSNAP potently inhibits liposome fusion by: binding to syntaxi

187 macological activation of lipolysis by ABHD5 potently inhibits mTORC1 signaling, leading to a signifi

188 tinib, a novel KIT and PDGFRA inhibitor that potently inhibits PDGFRA D842V, in patients with advance

189 MF) induce a cellular antiviral program that potently inhibits replication of SARS-CoV2 across cell l

190 candidate interferon-lambda1a (IFN-lambda1a) potently inhibits SARS-CoV-2 replication in primary huma

191 BI-4020 potently inhibits the above-described EGFR variants and

192 membrane delivery of a split-toxin construct potently inhibits the growth of xenograft tumors express

193 TIM-1 more potently inhibits the release of Nef-deficient relative

194 evelopment, appears to be parasiticidal, and potently inhibits the two Cryptosporidium species most r

195 reening, we identified TRIM69 as an ISG that potently inhibits VSIV.

196 es as well as surfaced other kinases that it potently inhibits.

197 nd largely believed to be benign bystanders, potently kills P. falciparum at low exogenous concentrat

198 IL-33 potently liberates AA and elicits LTC(4), PGD(2), and th

199 is study, we show that TLR2 and TLR7 ligands potently lower the Ag threshold for cytokine production

200 oltage-activated potassium (BK) channels are potently modified by their functional coupling with regu

201 especially by endogenous neuropeptides that potently modulate ASICs.

202 hich social interactions can immediately and potently modulate behavior.

203 nzymatic degradation, and to selectively and potently modulate RNA function in vivo.

204 sue injury, we demonstrated that miR-135a-3p potently modulated p38 signaling and angiogenesis in res

205 These projections are potently modulated through opposite actions of D1R signa

206 Since physical activity potently modulates glycogen metabolism, this provides a

207 Nicotinamide also potently modulates thermosensory responses in L3s, sugge

208 st four antibodies to the spike protein that potently neutralize SARS-CoV-2, individually as well as

209 isrupt the SARS-CoV-2 S-ACE2 interaction can potently neutralize the virus without undergoing extensi

210 odies target this epitope and three of these potently neutralize the virus.

211 MBP134 potently neutralized all ebolaviruses and demonstrated g

212 Among these are nineteen antibodies that potently neutralized authentic SARS-CoV-2 in vitro, nine

213 Of these, 28 potently neutralized authentic SARS-CoV-2 with IC(100) a

214 It potently neutralized mouse-adapted SARS-CoV-2 in wild-ty

215 It potently neutralized replication-competent SARS-CoV-2 bu

216 CTC-445.2d potently neutralized SARS-CoV-2 infection of cells in vi

217 Moreover, CD4-VLPs potently neutralized viral swarms that were completely r

218 ent with an active Zika virus infection that potently neutralized virus infection in Vero cells at th

219 RB1, is equipotent on RSV A and B subtypes, potently neutralizes a diverse panel of clinical isolate

220 ased assays confirmed that ACE-083 binds and potently neutralizes myostatin, activin A, activin B and

221 NiV receptor-binding glycoprotein (GP), and potently neutralizes NiV, indicating its potential as a

222 One antibody (named S309) potently neutralizes SARS-CoV-2 and SARS-CoV pseudovirus

223 nd the maturation process that gives rise to potently neutralizing Abs is needed.

224 g the minimal somatic mutation is needed for potently neutralizing antibodies against SARS-CoV-2.

225 virus-specific and flavivirus cross-reactive potently neutralizing antibodies that have been mapped t

226 scape variants of the ZIKV MR766 strain to a potently neutralizing antibody, AC10, exhibited an amino

227 oncentration of 2 ng ml(-1), one of the most potently neutralizing flavivirus-specific antibodies eve

228 virion in complex with Fab fragments of the potently neutralizing human monoclonal antibody ZIKV-195

229 in human survivors and identified a pair of potently neutralizing mAbs that cooperatively bound to t

230 Two potently neutralizing monoclonal antibodies, COV2-2196 a

231 Potently neutralizing TS mAbs recognized sites principal

232 ion in animal models (but not in humans), is potently obesogenic and plays putative roles governing c

233 tumor maintenance, whereas mutant-PDGFRA is potently oncogenic.

234 ate carbon dioxide, VE/VCO2) during exercise potently predicts outcomes in advanced heart failure wit

235 as neurotherapeutics due to their ability to potently promote neuronal growth.

236 SP potently promoted VEC activation in vitro and blockade o

237 The optimized compound, ML417 (20), potently promotes D3R-mediated beta-arrestin translocati

238 CM-272 potently reduced HCC and LX2 cells proliferation and que

239 loss attenuated myogenic differentiation and potently reduced the levels of the myogenic transcriptio

240 atment with hypoxia-activated prodrug TH-302 potently reduces NEPC tumor growth.

241 eir grafted counterparts, free mucin glycans potently regulate bacterial phenotypes even at relativel

242 Long noncoding (lnc)RNAs potently regulate gene expression programs in physiology

243 Glucagon-containing alpha-cells potently regulate glucose homeostasis, but the developme

244 We conclude that POA Tac1 neurons can potently reinforce arousal both against endogenous and d

245 nd a CD19(hi)CD11c(+) memory population that potently responds to immune activation.

246 These data reveal that hA3G can potently restrict active ERV in vivo and suggest that ex

247 s antiviral innate immune responses, thereby potently restricting viral replication.

248 In this study, we discovered that LASV potently restricts dsRNA accumulation during infection a

249 D2), a constitutively expressed protein that potently restricts HIV replication at or during reverse

250 The human integral membrane protein SERINC5 potently restricts HIV-1 infectivity and sensitizes the

251 lymphocyte antigen 6 complex, locus E (LY6E) potently restricts infection by multiple CoVs, including

252 TRIM5alpha, is an innate immune sensor that potently restricts retrovirus infection by binding to hu

253 However, it failed to potently reverse already established fibrosis.

254 Upon fertilization, this process is potently reversed, which is essential for parental genom

255 ease neuropeptides from their terminals that potently shape the function of innate and adaptive immun

256 iRNA sponging, we found that miR-671-5p more potently silenced an axis of CDR1as and its antisense tr

257 The unintegrated retroviral DNAs are potently silenced, and we provide evidence that the supp

258 lective estrogen receptor modulators (SERMs) potently stabilize intracellular calcium and thereby cou

259 (OEG(2))(2)-IP4 potently stabilizes calciprotein particle (CPP) growth,

260 vation of beta-adrenergic receptor (beta-AR) potently stimulate adipose tissue thermogenesis and incr

261 We find that recombinant human GCN2 is potently stimulated by ribosomes and, to a lesser extent

262 More specifically, we observed that LPS potently stimulated GFAT2 isoform mRNA and protein expre

263 f the peptide forms stable DQ8 complexes and potently stimulates autoreactive CD4 T cells from T1D pa

264 Local delivery of Bifidobacterium potently stimulates STING signaling and increases cross-

265 -deficient (DeltaM2) CPXV-infected cells can potently suppress B7 ligand-mediated T cell proliferatio

266 DK) inhibitors targeting CDK7/12/13 and CDK9 potently suppress chordoma cell proliferation.

267 or the regulation of energy intake, and both potently suppress energy intake.

268 D. melanogaster potently suppress sleep in response to starvation, and p

269 It is a worldwide pest on tomato and can potently suppress the host's natural resistance.

270 Rab10 knockdown and LRRK2 kinase inhibition potently suppress the maturation of macropinosome-derive

271 Optogenetic activation of CeA(GA) potently suppressed both pain-elicited reflexive and sel

272 report that metformin + 2-DG treatment more potently suppressed IFN-gamma production and cell prolif

273 s; consequently, SULT1A3 turnover can now be potently suppressed in an isoform-specific manner in hum

274 c downregulation of the receptor using shRNA potently suppressed invasion, growth, survival, and redu

275 e to fatty acids in the lymphoma environment potently suppressed NK cell effector response and cellul

276 le agent or in combination with osimertinib, potently suppressed tumor cell proliferation in vitro an

277 treous injection of sunitinib microparticles potently suppresses choroidal neovascularization in mice

278 ibitor of Janus kinase 1 and Janus kinase 2, potently suppresses cytokine signaling involved in AD pa

279 id protein in complex with an inhibitor that potently suppresses DENV-2 but not other DENV serotypes.

280 an endogenous anti-inflammatory protein that potently suppresses effector cell functions in eosinophi

281 mbination anti-retroviral drug therapy (ART) potently suppresses HIV-1 replication but does not resul

282 S2, which generates acetyl-CoA from acetate, potently suppresses the conversion of bolus fructose int

283 subsequent activation of the NOTCH pathway, potently suppressing the growth of SCLC.

284 ein (mSncg) promoter, which specifically and potently sustained transgene expression in mouse RGCs an

285 Furthermore, CBD-IL-12 potently synergized with CPI to eradicate large establis

286 rmeable MARCKS effector domain (ED) peptides potently target all GBM molecular classes while sparing

287 ChR PAMs increase neuronal excitability more potently than agonists, while the remarkable occurrence

288 nhibitor) resistance in FGbeta(3) cells more potently than bortezomib.

289 liver microenvironmental cells fivefold more potently than hepatocytes.

290 developed that blocks Kv1.3 > 100 times more potently than Kv1.1, and has completed Phase 1b clinical

291 en relapsed AML cells into killer cells more potently than newly diagnosed AML cells.

292 derived xenograft model systems in vivo more potently than single treatments in the absence of toxici

293 uM) and inhibited STAT3 activation even more potently than the ATP-competitive drug candidate CX-4945

294 MAPK, inhibited p300 activation 20-fold more potently than the p38alpha/beta MAPK inhibitor, SB202190

295 choactive effects to act faster and far more potently than those of Amphetamine alone.

296 y of small molecules, ascarosides, which act potently to communicate increased population density and

297 to chronic infection and cancer and respond potently to immune checkpoint blockade.

298 Our study reveals that targeting NQO1 potently triggers innate sensing within TME that synergi

299 rostate cells and expression is directly and potently upregulated by all-trans retinoic acid (atRA).

300 inhibitors to identify an enzyme that reacts potently with a covalent monoacylglycerol lipase inhibit