ライフサイエンスコーパス: pre-B cell receptor

1 critical tumor suppressor downstream of the pre-B cell receptor.

2 s that are activated by cross-linking of the pre-B cell receptor.

3 subunits, Ig alpha and Ig beta, comprise the pre-B cell receptor.

4 very early stage, prior to formation of the pre-B cell receptor.

5 des a protein necessary for signaling by the pre-B-cell receptor.

6 large pre-B cells in both species expressed pre-B cell receptors.

7 In contrast, expression of the pre-B cell receptor and activation of 'downstream' signa

8 eagues surveyed the activation status of the pre-B cell receptor and comprehensively investigated dow

9 Mutations in genes encoding subunits of the pre-B cell receptor and molecules involved in pre-B cell

10 -kinase delta (PI3Kdelta), a linchpin in the pre-B-cell receptor and interleukin 7 receptor signaling

11 nals from the interleukin-7 receptor and the pre-B-cell receptor and is dependent on cyclin D3 and c-

12 Thus, the pre-B cell receptor appears to censor the development of

13 At the pre-B cell receptor (BCR) checkpoint, developing pre-B c

14 h surrogate light chains and assemble into a pre-B cell receptor (BCR) complex in pre-B cells, and ex

15 During B lymphoid ontogeny, assembly of the pre-B cell receptor (BCR) is a principal developmental c

16 n these B-ALLs encode proteins implicated in pre-B-cell receptor (BCR) signaling and migration/adhesi

17 With expression of a functional pre-B-cell receptor (BCR), cytokine signaling is attenua

18 vy chain and VpreB on the cell surfaces (ie, pre-B-cell receptor [BCR](+)).

19 rucial mediator of negative selection at the pre-B cell receptor checkpoint and a safeguard against l

20 dly, that Bach2 also plays a key role in the pre-B cell receptor checkpoint and functions as a tumor

21 We show that FOXM1 levels peak at the pre-B-cell receptor checkpoint but are dispensable for n

22 at their expression transiently peaks at the pre-B-cell receptor checkpoint.

23 B cell precursors transiently express a pre-B cell receptor complex consisting of a rearranged m

24 bly with a surrogate light chain to form the pre-B cell receptor complex is critical for development

25 mu heavy chain, and other components of the pre-B cell receptor complex, including lambda 5/14.1, ca

26 cell surface, is a critical component of the pre-B cell receptor complex.

27 Defects in pre-B-cell receptor components or in downstream signalin

28 We report here a role for the pre-B cell receptor, composed of Ig heavy and surrogate

29 o apoptosis in response to metabolic stress (pre-B cell receptor crosslinking, oncogene activation).

30 cell development by integrating cytokine and pre-B cell receptor-dependent signals to expand the pool

31 from B cell precursors that are arrested at pre-B cell receptor-dependent stages.

32 We suggest that this is due to poor 8/G0 pre-B cell receptor expression and to an inability to fo

33 5 surrogate light chain results in decreased pre-B cell receptor formation and contributes to reduced

34 ll subpopulations indicated that loss of the pre-B cell receptors from surrogate light chain gene sil

35 Here, we demonstrate that the pre-B cell receptor functions as a tumor suppressor upst

36 ice excludes an essential role for pro-B and pre-B cell receptors in VpreB regulation.

37 Early events that are controlled by the pre-B cell receptor include positive selection for cells

38 Initial cell surface expression of the pre-B cell receptor induces proliferation.

39 The pre-B cell receptor is a key checkpoint regulator in dev

40 signaling pathway, even if expression of the pre-B cell receptor itself is compromised.

41 Hence, pre-B cell receptor-mediated activation of BCL6 limits p

42 Pre-B cell receptor-mediated cell cycle arrest in Ph(+)

43 it as the endpoint of an emerging pathway of pre-B cell receptor-mediated tumor suppression.

44 ration and clonal maturation dictated by the pre-B cell receptor (mu/lambda5/VpreB).

45 rrently known genes encode components of the pre-B cell receptor or proteins that are activated by cr

46 Checkpoints at the stage of pre-B cell receptor (pre-BCR) and BCR expression can eli

47 ted by the requirement for expression of the pre-B cell receptor (pre-BCR) and the BCR at the pre-B a

48 ALL therapy.To investigate the effect of the pre-B cell receptor (pre-BCR) complex on the response of

49 marrow, the expression and activation of the pre-B cell receptor (pre-BCR) constitute crucial checkpo

50 Pre-B cell receptor (pre-BCR) expression is critical for

51 Besides binding glycans, GAL1 is also a pre-B cell receptor (pre-BCR) ligand that induces recept

52 The pre-B cell receptor (pre-BCR) serves as a checkpoint in

53 Pre-B cell receptor (pre-BCR) signaling and migration fr

54 u depend on the ability of each HC to form a pre-B cell receptor (pre-BCR) signaling complex with the

55 bitor dasatinib due to its inhibition of the pre-B cell receptor (pre-BCR) signaling complex.

56 In developing B cells, pre-B cell receptor (pre-BCR) signals initiate immunoglo

57 B cell precursor ALLs that differed by their pre-B cell receptor (pre-BCR) status were induced and di

58 e pre-B stage depends on the expression of a pre-B cell receptor (pre-BCR), consisting of an Ig mu H

59 e show an essential role of these kinases in pre-B cell receptor (pre-BCR)- mediated NF-kappaB activa

60 ific epigenetic landscape at Igk dictated by pre-B cell receptor (pre-BCR)-dependent Erk activation.

61 These libraries are based on the pre-B cell receptor (pre-BCR).

62 t of H chain genes and the expression of the pre-B cell receptor (pre-BCR).

63 ein (mu) in a signaling complex known as the pre-B cell receptor (pre-BCR).

64 holipase Cgamma2 (PLCgamma2) is critical for pre-B-cell receptor (pre-BCR) and BCR signaling.

65 Expression of the pre-B-cell receptor (pre-BCR) by pre-BII cells constitut

66 utations in genes encoding components of the pre-B-cell receptor (pre-BCR) complex.

67 The pre-B-cell receptor (pre-BCR) is an important checkpoint

68 The pre-B-cell receptor (pre-BCR) is composed of two immunog

69 are newly generated pre-B cells that express pre-B-cell receptor (pre-BCR) on the surface and are hig

70 on in B-cell progenitors, and is involved in pre-B-cell receptor (pre-BCR) signaling.

71 The pre-B-cell receptor (pre-BCR), composed of Ig heavy and

72 unique type of binding protein based on the pre-B-cell receptor (pre-BCR).

73 is present in 5%-7% of pediatric and 50% of pre-B-cell receptor (preBCR(+)) acute lymphocytic leukem

74 These studies on the mouse and human pre-B cell receptor provide a model system to investigat

75 Mutations that affect the pre-B-cell receptor result in early B-cell differentiati

76 ducible activation of BCL6 downstream of the pre-B cell receptor results in transcriptional repressio

77 ion of the earliest stages of commitment, on pre-B cell receptor selection, and B cell tolerance duri

78 tein encoded by this gene interacts with the pre-B cell receptor signal transduction pathway or is in

79 Pre-B cell receptor signaling also led to rapid repositi

80 re-B cell receptor and molecules involved in pre-B cell receptor signaling culminate in X-linked and

81 After productive VH-DJH gene rearrangement, pre-B cell receptor signaling ends BACH2-mediated negati

82 we demonstrate that inducible activation of pre-B cell receptor signaling induces cell-cycle exit th

83 cooperation with downstream molecules of the pre-B cell receptor signaling pathway, even if expressio

84 of a mu heavy chain, however, activation of pre-B cell receptor signaling strongly induces BCL6 expr

85 uivalent to acute activation of autoreactive pre-B cell receptor signaling, which engaged a deletiona

86 reversal of locus contraction in response to pre-B cell receptor signaling, which physically separate

87 ctor IRF-4, whose expression was elevated by pre-B cell receptor signaling.

88 BLNK adaptor protein has a key role in the pre-B-cell receptor signaling cascade, as illustrated by

89 Collectively, our studies identify a pre-B-cell receptor signaling induced inhibitory network

90 multiple targets in key pathways, including pre-B-cell receptor signaling, cell cycle progression, a

91 ain complex is an essential component of the pre-B cell receptor, the expression of which serves as a

92 inking of either mu m- or D mu m- containing pre-B cell receptors triggered signal transduction react