ライフサイエンスコーパス: pre-mRNA

1 he removal of introns from premessenger RNA (pre-mRNA).

2 processed from the precursor messenger RNA (pre-mRNA).

3 ice site, and the branchsite (BS) of nascent pre-mRNA.

4 n and alternative splicing of the single MVC pre-mRNA.

5 as significantly upregulated relative to its pre-mRNA.

6 hat is mediated by structural changes in the pre-mRNA.

7 otic mRNAs requires splicing of introns from pre-mRNA.

8 NA levels to levels of transiently expressed pre-mRNA.

9 components of the splicing machinery and the pre-mRNA.

10 cruiting the endonuclease CPSF-73 to histone pre-mRNA.

11 e results from alternative splicing of BEST1 pre-mRNA.

12 ain also exhibited aberrant splicing of Numb pre-mRNA.

13 ossess the machinery to alternatively splice pre-mRNA.

14 r nuclear processing and retention of ATP5G1 pre-mRNA.

15 as a single promoter that generates a single pre-mRNA.

16 7 expression of the early E6E7 polycistronic pre-mRNA.

17 to the regulation of alternative splicing of pre-mRNA.

18 nRNPs and the U2 snRNA is base-paired to the pre-mRNA.

19 ecreased transcription and processing of Asc pre-mRNA.

20 n intronic and exonic sequences of regulated pre-mRNA.

21 ing the association of splicing factors with pre-mRNA.

22 by the direct binding of ADAR3 to the GRIA2 pre-mRNA.

23 st that affected U2AF1 residues also contact pre-mRNA.

24 defective transcription or processing of the pre-mRNA.

25 eath and a significant increase in unspliced pre-mRNAs.

26 xcision of selected introns from a subset of pre-mRNAs.

27 art site, whereas Set2 was distributed along pre-mRNAs.

28 targeting a conserved GCAUG sequence within pre-mRNAs.

29 I-containing complexes to process snRNAs and pre-mRNAs.

30 gulates the alternative splicing of neuronal pre-mRNAs.

31 nad1 i4 and several other intron-containing pre-mRNAs.

32 equired for the proper processing of histone pre-mRNAs.

33 re derived from mRNAs or from the introns of pre-mRNAs.

34 accessory proteins that excises introns from pre-mRNAs.

35 suppressing internal polyadenylation of MVC pre-mRNAs.

36 which are key components in the splicing of pre-mRNAs.

37 ol II termination of lincRNAs as compared to pre-mRNAs.

38 2- and U12 spliceosomes occur within nuclear pre-mRNAs.

39 ng to U1-70K to induce splicing of lipogenic pre-mRNAs.

40 roteins, leading to mis-splicing of numerous pre-mRNAs.

41 However, the DSP1 complex does not affect pre-mRNA 3' end cleavage, suggesting that plants may use

42 or 6 (CPSF6), a cellular protein involved in pre-mRNA 3' end processing that binds HIV-1 capsid and c

43 ce the decision between alternative modes of pre-mRNA 3' end processing.

44 SPF73-I), which is the nuclease cleaving the pre-mRNA 3' end.

45 s well established that canonical eukaryotic pre-mRNA 3' processing is carried out within a macromole

46 s a paralog of CPSF-73, the endonuclease for pre-mRNA 3'-end processing.

47 function was linked to regulation of Aldh1a3 pre-mRNA 3'-end processing.

48 snRNP may reside before its release from the pre-mRNA 5' splice site.

49 me during alternative splicing of amelogenin pre-mRNA, a novel mature miRNA is generated from exon4.

50 ently regulating the alternative splicing of pre-mRNAs, a plausible link between SMN function and the

51 CPF cleaves pre-mRNAs, adds a polyadenylate tail, and triggers trans

52 AF3), and demonstrate its role in protecting pre-mRNA against degradation by the processome.

53 L1 variations, some of which induce aberrant pre-mRNA AIPL1 splicing leading to the production of alt

54 Pre-mRNA alternative splicing (AS) generates protein var

55 Pre-mRNA alternative splicing and alternative polyadenyl

56 erminal domain and stabilize U6 ACAGAGA stem-pre-mRNA and Brr2-U4 small nuclear RNA interactions.

57 modified nucleic acids that base-pair with a pre-mRNA and disrupt the normal splicing repertoire of t

58 nger protein required for mRNP-gRNP docking, pre-mRNA and RECC loading, and RNP formation with a shor

59 R) occurs when an intron is transcribed into pre-mRNA and remains in the final mRNA.

60 tein, participates in the processing of this pre-mRNA and so controls capsid gene access via its role

61 established between the 5' splice site of a pre-mRNA and the 5' end of the U1 snRNA.

62 ated by a productive interaction between the pre-mRNA and the U1 snRNP, in which a short RNA duplex i

63 cifically designed to alter splicing of SMN2 pre-mRNA and thus increase the amount of functional surv

64 SS), causing frequent exon7 skipping in SMN2 pre-mRNA and yielding a truncated protein.

65 B2, diminished binding affinity between DRD2 pre-mRNA and ZRANB2 and abolished the ability of ZRANB2

66 9^3434 splicing of both viral early and late pre-mRNAs and E1^E4 production through interaction with

67 spliceosome removes non-coding introns from pre-mRNAs and joins exons.

68 Many RNAs, including pre-mRNAs and long non-coding RNAs, can be thousands of

69 ence for exon 2 regions of intron-containing pre-mRNAs and poly(A) proximal sites.

70 confirmed the capture of pre-messenger RNA (pre-mRNA) and exposed distinctions in diversity and abun

71 sembly of the spliceosome on precursor mRNA (pre-mRNA) and extensive remodelling to form the spliceos

72 ore or soon after exon definition in nascent pre-mRNA, and while m(6)A is not required for most splic

73 riptionally because NAD-RNA is also found on pre-mRNAs, and only on mitochondrial transcripts that ar

74 Histone pre-mRNAs are cleaved at the 3' end by a complex that co

75 scribed eukaryotic precursor messenger RNAs (pre-mRNAs) are processed at their 3' ends by the 1-mega

76 , which leave these sites to splice cellular pre-mRNAs at transcribing genes, we reveal a functional

77 , which leave these sites to splice cellular pre-mRNAs at transcribing genes, we reveal a functional

78 is analysis discovers novel modes of U2snRNA:pre-mRNA base-pairing conserved in yeast and provides in

79 reby raw lariat reads are refined by U2snRNP/pre-mRNA base-pairing models to return the largest curre

80 t SLM2 and Sam68 similarly bind to Neurexin2 pre-mRNA, both within the mouse cortex and in vitro.

81 ion region (BSRR), which base pairs with the pre-mRNA branch site during splicing.

82 ase II (Pol II) and introns are removed from pre-mRNA by the spliceosome.

83 4F) mutant and identify aberrantly processed pre-mRNAs by deep sequencing.

84 and splicing regulation of apoptosis-linked pre-mRNAs by SPF45 was shown to depend on interactions b

85 are able to be removed from their respective pre-mRNAs by the spliceosome.

86 that HeLa cell chromatin-associated nascent pre-mRNA (CA-RNA) contains many unspliced introns and m(

87 787 is an inhibitor of the influenza A virus pre-mRNA cap-binding protein PB2.

88 a small fraction exhibited differential mRNA/pre-mRNA changes suggestive of increased mRNA stability.

89 -associated huge protein (FLASH) and histone pre-mRNA cleavage complex (HCC) consisting of several po

90 spanning NUDT21, which encodes a subunit of pre-mRNA cleavage factor Im.

91 FLASH involved in U7 snRNP binding, histone pre-mRNA cleavage, and HLB localization are all required

92 Multiprotein editosomes catalyze pre-mRNA cleavage, uridine (U) insertion or deletion, an

93 We identified several m(6)A sites in RTA pre-mRNA crucial for splicing through interactions with

94 ween high delay and late intron retention in pre-mRNA data, indicating significant splicing-associate

95 re, PABPN1 aggregates are able to trap TNNT3 pre-mRNA, driving it outside nuclear speckles, leading t

96 cytes also leads to aberrant splicing of the pre-mRNA encoding the excitation-contraction coupling co

97 blockage of m(6)A inhibited splicing of the pre-mRNA encoding the replication transcription activato

98 sses ASTR, with consequential effects on rga pre-mRNA expression.

99 ing and alternative polyadenylation (APA) of pre-mRNAs greatly contribute to transcriptome diversity,

100 a prevalent role for secondary structure in pre-mRNAs has proven more elusive.

101 We indeed found pre-mRNA in the C-NHEJ complex.

102 is depleted and that ZC3H14 binds to ATP5G1 pre-mRNA in the nucleus.

103 b2 mutant cells accumulate intron-containing pre-mRNA in vivo We extend this analysis to identify gen

104 regulator that supports splicing of selected pre-mRNAs in an intron-specific manner in Schizosaccharo

105 p of ubiquitous proteins that associate with pre-mRNAs in eukaryotic cells to produce a multitude of

106 ckpoint to ensure proper splicing of certain pre-mRNAs in fission yeast.

107 eferentially to proximal intronic regions on pre-mRNAs in human transcriptome, and this binding requi

108 We show that FTO binds preferentially to pre-mRNAs in intronic regions, in the proximity of alter

109 The spliceosome excises introns from pre-mRNAs in two sequential transesterifications-branchi

110 ation regarding the regulatory properties of pre-mRNA, including the RNA secondary structure context.

111 the spliceosome contacts U2 proteins and the pre-mRNA, indicating that the U2 snRNP-intron interactio

112 s similar to the formation and resolution of pre-mRNA intron lariats and therefore suggests that simi

113 ractions, thereby inhibiting excision of the pre-mRNA intronic region.

114 p in the assembly of human spliceosomes onto pre-mRNA involves the recognition of regulatory RNA cis

115 cells the autophagy-related factor 7 (Atg7) pre-mRNA is abnormally processed, which unexpectedly is

116 The excision of introns from pre-mRNA is an essential step in mRNA processing.

117 The coding sequence of each human pre-mRNA is interrupted, on average, by 11 introns that

118 U1 snRNP, and show how the 5' splice site of pre-mRNA is recognised by U1 snRNP.

119 cap-snatching," where the 5'-cap of cellular pre-mRNA is recognized by the PB2 subunit and cleaved 10

120 Splicing of pre-mRNA is required for the proper expression of the va

121 ons on how alternative RNA splicing of HPV18 pre-mRNAs is subject to regulation by viral RNA cis elem

122 e that the alternative RNA splicing of HPV18 pre-mRNAs is subject to regulation by viral RNA cis elem

123 splicing in vivo, including that of the SR45 pre-mRNA itself.

124 egulated alternative splicing of many target pre-mRNAs, leading to the multisystemic symptoms in DM1.

125 Pre-mRNA maturation frequently occurs at the same time a

126 echanism; instead, SIC likely contributes to pre-mRNA metabolism, and the splice variants that accumu

127 Pre-mRNA molecules with two alternative 3ss can be bound

128 to a dynamic and heterogeneous population of pre-mRNA molecules, each responding to a particular coll

129 The pre-mRNA of two genes related to macrophage maturation (

130 on of the hexanucleotide AAUAAA motif in the pre-mRNA polyadenylation signal by the cleavage and poly

131 In particular, the effect of auxin on pre-mRNA post-transcriptional regulation is mostly unkno

132 In addition, ICP27 induced expression of pre-mRNAs prematurely cleaved and polyadenylated from cr

133 BP) with established roles in transcription, pre-mRNA processing and DNA damage response.

134 n; however, the molecular mechanisms linking pre-mRNA processing and light signaling are not well und

135 ranscription/export) complex is critical for pre-mRNA processing and mRNA nuclear export.

136 rate that inhibition or slowing of canonical pre-mRNA processing events shifts the steady-state outpu

137 ant (v)U1 snRNAs (vU1s), also participate in pre-mRNA processing events.

138 onucleoprotein-associated protein 1 (Snu13), pre-mRNA processing factor 31 (Prp31), and Prp3 to U4/U6

139 Our results identify the pre-mRNA processing factor PfCPSF3 as a promising antima

140 These data suggest that ZC3H14 modulates pre-mRNA processing of select mRNA transcripts and plays

141 he FgSrp1 SR protein is likely important for pre-mRNA processing or splicing of various genes in diff

142 Pre-mRNA processing protein 40 (Prp40) is a nuclear prot

143 ue to the creation of a binding site for the pre-mRNA processing protein hnRNP A1.

144 s a genetically and epigenetically regulated pre-mRNA processing to increase transcriptome and proteo

145 otential to act as NXF1 adaptors that couple pre-mRNA processing to mRNA export.

146 reduction promotes widespread alterations in pre-mRNA processing, including intron retention and chan

147 Posttranscriptional regulation, especially pre-mRNA processing, is a key modulator of gene expressi

148 SR proteins function in nuclear pre-mRNA processing, mRNA export, and translation.

149 tes cap-related biological functions such as pre-mRNA processing, nuclear export and cap-dependent pr

150 ing chromatin structure, gene transcription, pre-mRNA processing, or aspects of mRNA metabolism.

151 some SNORDs likely function in both rRNA and pre-mRNA processing, which increases the repertoire of s

152 H and/or U7 snRNP in the HLB impairs histone pre-mRNA processing.

153 tor 30 (CPSF30) is a key protein involved in pre-mRNA processing.

154 tor (CPSF30), a cellular protein involved in pre-mRNA processing.

155 ionarily conserved Schizosaccharomyces pombe pre-mRNA-processing factor, SpPrp18.

156 RBM20, by excluding specific exons from the pre-mRNA, provides the substrate to form this class of R

157 AU-rich hexamer (AAUAAA) sequence present in pre-mRNA, providing the first molecular-based evidence t

158 Altered pre-mRNA recognition emerges as a molecular theme among

159 r repress alternative exons depending on the pre-mRNA recruitment position.

160 een the galectin-3-U1 snRNP particle and the pre-mRNA results in a productive spliceosomal complex, l

161 However, considering roles for SF1 in pre-mRNA retention and transcriptional repression, as we

162 In silico pre-mRNA secondary and tertiary structure analysis revea

163 teins and SRSF3 are associated with unpaired pre-mRNA segments upstream of U2AF-repressed 3'ss.

164 Alternative splicing of pre-mRNAs significantly contributes to the complexity of

165 ribed prematurely cleaved and polyadenylated pre-mRNAs, some of which contain novel ORFs, were typica

166 requently mutated SF3B1 residues contact the pre-mRNA splice site.

167 Aberrant alternative pre-mRNA splicing (AS) events have been associated with

168 Alternative pre-mRNA splicing (AS) is a critical regulatory mechanis

169 is study demonstrates two instances in which pre-mRNA splicing actually enhances the synthesis of pro

170 ish AKAP95 as a mostly positive regulator of pre-mRNA splicing and a possible integrator of transcrip

171 nstrate that H2A.Z is required for efficient pre-mRNA splicing and indicate a role for H2A.Z in coord

172 actions during the regulation of alternative pre-mRNA splicing and other processes.

173 , RRP6, with in vivo consequences of altered pre-mRNA splicing and poly(A) tail length control.

174 ons of SR (serine/arginine-rich) proteins in pre-mRNA splicing and processing are modulated by revers

175 ctional ncRNA, known for its pivotal role in pre-mRNA splicing and regulation of RNA 3' end processin

176 (eU1s) have the unique ability to reprogram pre-mRNA splicing and restore exon 7 inclusion in SMN1 c

177 DDX41 lesions caused altered pre-mRNA splicing and RNA processing.

178 Small molecule inhibitors of pre-mRNA splicing are important tools for identifying ne

179 e DEAH-box helicase Prp43 is a key player in pre-mRNA splicing as well as the maturation of rRNAs.

180 urther supported by genetic interactions and pre-mRNA splicing assays.

181 ntified a small molecule that inhibits human pre-mRNA splicing at an intermediate stage during conver

182 an essential role of m(6)A in regulating RTA pre-mRNA splicing but also suggest that KSHV has evolved

183 ce of the coordinated control of alternative pre-mRNA splicing by chromatin structure and transcripti

184 cate that the Psis in U2 snRNA contribute to pre-mRNA splicing by directly altering the binding/ATPas

185 a new potential mechanism for regulation of pre-mRNA splicing by lysine methylation of a splicing fa

186 depletion caused a significant reduction in pre-mRNA splicing efficiency, as demonstrated through RN

187 low temperature effects on a large subset of pre-mRNA splicing events.

188 ript half-life but are not required for most pre-mRNA splicing events.

189 Alternative pre-mRNA splicing expands the complexity of the transcri

190 The pre-mRNA splicing factor PRPF8 is a crucial component of

191 One of these, the pre-mRNA splicing factor SF3B1, is also frequently mutat

192 How the essential pre-mRNA splicing factor U2AF(65) recognizes the polypyr

193 Pre-mRNA splicing factors play a fundamental role in reg

194 Somatic mutations of pre-mRNA splicing factors recur among patients with myel

195 dramatic translocation of Hnrnpa1 and other pre-mRNA splicing factors to the nucleus in a transcript

196 ediated by 'hotspots' of the SF3B1 and U2AF1 pre-mRNA splicing factors.

197 ecular theme among MDS-relevant mutations of pre-mRNA splicing factors.

198 Here we demonstrate that pre-mRNA splicing homeostasis is a biomarker and predict

199 tron recognition in the majority of cases of pre-mRNA splicing in eukaryotes.

200 display altered hematopoiesis and changes in pre-mRNA splicing in hematopoietic progenitor cells by w

201 n ABA signalling, shows a dramatic defect in pre-mRNA splicing in rbm25 mutants.

202 ases to institute phosphorylation control of pre-mRNA splicing in the nucleus.

203 CPAMD8 splice-site mutations caused aberrant pre-mRNA splicing in vivo or in vitro.

204 hibitor resistance mechanism and we identify pre-mRNA splicing interference as a potential therapeuti

205 Pre-mRNA splicing is an essential step of eukaryotic gen

206 witching oligonucleotides (SSOs) to modulate pre-mRNA splicing is increasingly evident in a number of

207 Our data demonstrate that pre-mRNA splicing may be regulated by chromatin structur

208 ical cancers harbouring U2AF1 mutations with pre-mRNA splicing modulators like sudemycins.

209 SFPS regulates pre-mRNA splicing of a large number of genes, of which m

210 lated developmental processes by controlling pre-mRNA splicing of light signaling and circadian clock

211 pathway that operationally links alternative pre-mRNA splicing of the hypoxia-inducible death protein

212 The CTD mutations did not affect pre-mRNA splicing or snRNA levels.

213 ides a surprising link between a pleiotropic pre-mRNA splicing pathway and the precise control of suc

214 the evolutionarily conserved Nrl1 protein in pre-mRNA splicing regulation, R-loop suppression and in

215 RBFox2 is a well-characterized pre-mRNA splicing regulator, but we now encounter an une

216 nts, suggesting that specific changes in the pre-mRNA splicing sites may be a mechanism by which MAP

217 ar-reaching effect of an exonic variation on pre-mRNA splicing that is mediated by structural changes

218 SF3B1 mutations are associated with aberrant pre-mRNA splicing using cryptic 3' splice sites (3'SSs),

219 he highly conserved histone variant H2A.Z in pre-mRNA splicing using the intron-rich model yeast Schi

220 In particular, pre-mRNA splicing was reported to be associated with slo

221 etary restriction, we find defects in global pre-mRNA splicing with age that are reduced by dietary r

222 ckout (KO) results in substantial changes in pre-mRNA splicing with prevalence of exon skipping event

223 ifferent approaches used to target and alter pre-mRNA splicing with SSOs.

224 During pre-mRNA splicing, a central step in the expression and

225 beyond transcription initiation and regulate pre-mRNA splicing, and thereby mRNA isoform production,

226 rtant roles in the regulation of alternative pre-mRNA splicing, but their role in other gene regulato

227 ic transcription initiation, nor alternative pre-mRNA splicing, contributed to the observed changes i

228 at these positions reduce the efficiency of pre-mRNA splicing, leading to growth-deficient phenotype

229 o SR proteins-SRSF3 and SRSF7, regulators of pre-mRNA splicing, nuclear export and translation-intera

230 th cases, AON delivery fully restored CEP290 pre-mRNA splicing, significantly increased CEP290 protei

231 leocytoplasmic transport, DNA damage repair, pre-mRNA splicing, stress granule dynamics, and others.

232 y protein ICP27 causes partial inhibition of pre-mRNA splicing, with the resultant accumulation of bo

233 differentiation is regulated by alternative pre-mRNA splicing.

234 nd utilize sudemycin compounds that modulate pre-mRNA splicing.

235 ngly, RTA induced m(6)A and enhanced its own pre-mRNA splicing.

236 vation of RBM39 by indisulam causes aberrant pre-mRNA splicing.

237 ceosome, the molecular machine that executes pre-mRNA splicing.

238 ed NS proteins via its role in governing MVC pre-mRNA splicing.

239 on by regulating tissue-specific alternative pre-mRNA splicing.

240 ts N-terminal region, and directly regulates pre-mRNA splicing.

241 ated in processes such as gene silencing and pre-mRNA splicing.

242 cular, branched RNAs (bRNAs) produced during pre-mRNA splicing.

243 and splice-site RNAs are likely to influence pre-mRNA splicing.

244 dipocyte gene expression include alternative pre-mRNA splicing.

245 stood, but may act in both transcription and pre-mRNA splicing.

246 Glut4 mRNA and decreased efficiency of Glut4 pre-mRNA splicing.

247 suggesting that it could play a key role in pre-mRNA splicing.

248 oupled functional role for these proteins in pre-mRNA splicing.

249 in muscle, likely independent of its role in pre-mRNA splicing.

250 1 (MBNL1) and hamper its normal function in pre-mRNA splicing.

251 nd have been implicated in the regulation of pre-mRNA splicing.

252 p40) is a nuclear protein that has a role in pre-mRNA splicing.

253 ed NS proteins via its role in governing MVC pre-mRNA splicing.IMPORTANCE The Parvovirinae are small

254 ytosine and CTCF mediate opposing effects on pre-mRNA splicing: CTCF promotes inclusion of weak upstr

255 nificantly expand our current concept of the pre-mRNA "splicing code" to include dynamic intragenic D

256 M39 associates with precursor messenger RNA (pre-mRNA) splicing factors, and inactivation of RBM39 by

257 Precursor mRNA (pre-mRNA) splicing is a fundamental link between gene ex

258 Precursor mRNA (pre-mRNA) splicing is catalyzed by a large ribonucleopro

259 Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of g

260 Precursor mRNA (pre-mRNA) splicing proceeds by two consecutive transeste

261 In eukaryotes, precursor mRNA (pre-mRNA) splicing removes non-coding intron sequences t

262 matin in the regulation of premessenger RNA (pre-mRNA) splicing.

263 f glioblastoma stem-like cells by modulating pre-mRNA stability and expression of the FOXM1 gene.

264 lymerase to the 3' terminus, thus leading to pre-mRNA stabilization, or decay depending on the occurr

265 5 bp downstream), induces cis alterations in pre-mRNA structure that result in the formation of a sta

266 d to accommodate the spatial requirements of pre-mRNA substrate recognition and catalysis.

267 ient to load the galectin polypeptide onto a pre-mRNA substrate.

268 pecifically change splicing of suboptimal BS pre-mRNA substrates.

269 Upon inhibition of pre-mRNA synthesis, ZFP106 translocates with other splic

270 he binding of the resulting compound for Tau pre-mRNA target as well as on the stabilization upon com

271 esults indicate that the galectin-3-U1 snRNP-pre-mRNA ternary complex is a functional E complex and t

272 reveals an increase in the amount of ATP5G1 pre-mRNA that reaches the cytoplasm when ZC3H14 is deple

273 major (one early and one late) polycistronic pre-mRNAs that are regulated by alternative RNA splicing

274 ribed as part of a polygenic precursor mRNA (pre-mRNA) that is initiated within a several-kilobase-lo

275 against a structured RNA, derived from XBP1 pre-mRNA, that folds as two contiguous hairpins.

276 ectly bind to two distinct sites of the SMN2 pre-mRNA, thereby stabilizing a yet unidentified ribonuc

277 Once transcribed into pre-mRNA, these introns must be removed within the splic

278 down of Aurora A reconfigures splicing of AR pre-mRNA to discriminately down-regulate synthesis of AR

279 interact in the variable exon region of CD44 pre-mRNA to inhibit spliceosome assembly in favor of exp

280 g key functional 3' end elements involved in pre-mRNA to mRNA maturation with antisense drugs can lea

281 ion, such as RNA splicing, which can cause a pre-mRNA to produce one or more mature messenger RNAs co

282 lymerase binds the cap structure of cellular pre-mRNA to promote its cleavage by the PA subunit.

283 nscription elongation rates, (ii) binding to pre-mRNA to recruit splicing factors, and/or (iii) block

284 ernative RNA splicing of viral polycistronic pre-mRNAs to produce a repertoire of viral early and lat

285 It processes host pre-mRNAs to serve as primers for viral mRNA and is an a

286 ings indicate that KPAF3 selectively directs pre-mRNA toward adenylation rather than uridylation, whi

287 1 to form an Ire1 focus, (ii) targeting HAC1 pre-mRNA toward the Ire1 focus that cleaves out an inhib

288 rstanding of when and where in the life of a pre-mRNA transcript the modifications are made.

289 and the predicted effects on splicing of the pre-mRNA transcript.

290 ernative splicing of its single gene-encoded pre-mRNA transcript.

291 ear RNA surveillance system is active on all pre-mRNA transcripts and modulated by nutrient availabil

292 Most pre-mRNA transcripts in eukaryotic cells must undergo sp

293 However, they tended to have much longer pre-mRNA transcripts.

294 Here, we report that PACE4 pre-mRNA undergoes DNA methylation-sensitive alternative

295 bitory to the 233^416 splicing of HPV18 E6E7 pre-mRNAs via binding to hnRNP A1, a well-characterized,

296 hether the alternative RNA splicing of Bcl-x pre-mRNA was modulated by MDA-7/IL-24, which would sugge

297 zation predicted against intronic regions of pre-mRNAs was tested and confirmed.

298 ting nuclear long non-coding RNA Malat 1 and pre-mRNA were degraded by nuclear XRN2.

299 1-containing minitranscript show accumulated pre-mRNA, whereas the lariat intron-exon 2 splicing inte

300 S-MaPseq to compare the in vivo structure of pre-mRNAs with their mature isoforms.