ライフサイエンスコーパス: pre-mRNA splicing

1 differentiation is regulated by alternative pre-mRNA splicing.

2 he expression of a subset of human genes via pre-mRNA splicing.

3 o 45% of synonymous SNPs are likely to alter pre-mRNA splicing.

4 hat recently discovered snRNPs functioned in pre-mRNA splicing.

5 e binding of RNA polymerase to promoters and pre-mRNA splicing.

6 at greatly influences mRNA levels as well as pre-mRNA splicing.

7 us plays a crucial role at an early stage of pre-mRNA splicing.

8 Overexpression of CHK2 promoted pre-mRNA splicing.

9 stood, but may act in both transcription and pre-mRNA splicing.

10 ties of eight RNA helicases are required for pre-mRNA splicing.

11 Prp16-mediated spliceosome remodeling during pre-mRNA splicing.

12 n results in multiple competing pathways for pre-mRNA splicing.

13 ion is required for normal cotranscriptional pre-mRNA splicing.

14 ht highly conserved proteins is critical for pre-mRNA splicing.

15 uitin mark from ubH2B and co-transcriptional pre-mRNA splicing.

16 suggesting that it could play a key role in pre-mRNA splicing.

17 ing of pri-miRNAs in addition to its role in pre-mRNA splicing.

18 hether TRAMP may have any potential roles in pre-mRNA splicing.

19 oupled functional role for these proteins in pre-mRNA splicing.

20 mplex macromolecular machine responsible for pre-mRNA splicing.

21 viral regulator, at the level of alternative pre-mRNA splicing.

22 in muscle, likely independent of its role in pre-mRNA splicing.

23 ions as a spliceosome assembly factor during pre-mRNA splicing.

24 xport of newly synthesized RNA and disrupted pre-mRNA splicing.

25 nserved heterotrimeric complex essential for pre-mRNA splicing.

26 A/RNA-binding protein with a nuclear role in pre-mRNA splicing.

27 el system for understanding the chemistry of pre-mRNA splicing.

28 2p is one of eight RNA helicases involved in pre-mRNA splicing.

29 n though haploinsufficiency of SmD3 supports pre-mRNA splicing.

30 ibonucleoproteins (snRNPs) which function in pre-mRNA splicing.

31 ated to involve dysregulation of alternative pre-mRNA splicing.

32 f stochastic promoter choice and alternative pre-mRNA splicing.

33 es neuron degeneration through distortion of pre-mRNA splicing.

34 olymerase II transcripts undergo alternative pre-mRNA splicing.

35 to predict the effects of point mutations on pre-mRNA splicing.

36 osphorylation/dephosphorylation cycle during pre-mRNA splicing.

37 zing exonic splicing enhancers (ESEs) during pre-mRNA splicing.

38 1 (MBNL1) and hamper its normal function in pre-mRNA splicing.

39 third of all disease-causing mutations alter pre-mRNA splicing.

40 eins in the nuclear speckles and mediate the pre-mRNA splicing.

41 3' splice site during the initial stages of pre-mRNA splicing.

42 ls, we further show that Psi93 has a role in pre-mRNA splicing.

43 act near the 3' splice site is important for pre-mRNA splicing.

44 RNA element UGCAUG and regulate alternative pre-mRNA splicing.

45 mpair both CARM1-activated transcription and pre-mRNA splicing.

46 ry few such reagents have been described for pre-mRNA splicing.

47 i-tumor activity of SSOs that modulate Bcl-x pre-mRNA splicing.

48 roles in both transcriptional activation and pre-mRNA splicing.

49 nd have been implicated in the regulation of pre-mRNA splicing.

50 p40) is a nuclear protein that has a role in pre-mRNA splicing.

51 ngly, RTA induced m(6)A and enhanced its own pre-mRNA splicing.

52 vation of RBM39 by indisulam causes aberrant pre-mRNA splicing.

53 ceosome, the molecular machine that executes pre-mRNA splicing.

54 on by regulating tissue-specific alternative pre-mRNA splicing.

55 nd utilize sudemycin compounds that modulate pre-mRNA splicing.

56 ts N-terminal region, and directly regulates pre-mRNA splicing.

57 ated in processes such as gene silencing and pre-mRNA splicing.

58 cular, branched RNAs (bRNAs) produced during pre-mRNA splicing.

59 and splice-site RNAs are likely to influence pre-mRNA splicing.

60 dipocyte gene expression include alternative pre-mRNA splicing.

61 ed NS proteins via its role in governing MVC pre-mRNA splicing.

62 Glut4 mRNA and decreased efficiency of Glut4 pre-mRNA splicing.

63 rge ribonucleoprotein complex that catalyzes pre-mRNA splicing.

64 athy and display numerous defects in cardiac pre-mRNA splicing.

65 matin in the regulation of premessenger RNA (pre-mRNA) splicing.

66 During pre-mRNA splicing, a central step in the expression and

67 mediated gene silencing independently of its pre-mRNA splicing activity and indicate that the dual ro

68 is study demonstrates two instances in which pre-mRNA splicing actually enhances the synthesis of pro

69 Alternative pre-mRNA splicing allows dramatic expansion of the eukar

70 ish AKAP95 as a mostly positive regulator of pre-mRNA splicing and a possible integrator of transcrip

71 factors play widespread roles in alternative pre-mRNA splicing and are known to promote splice site r

72 kinase is known for its roles in regulating pre-mRNA splicing and beyond.

73 linos were designed to both genes to prevent pre-mRNA splicing and block translation.

74 ) is a nuclear protein that is implicated in pre-mRNA splicing and cell cycle progression, but the po

75 glutelin mRNA metabolism, perhaps in nuclear pre-mRNA splicing and cytosolic localization to the cist

76 This mutation was found to disrupt Gon4l pre-mRNA splicing and dramatically reduce expression of

77 mouse liver resulted in profound changes in pre-mRNA splicing and gene expression, leading to impair

78 site, and reinforces the notion that nuclear pre-mRNA splicing and group II intron splicing have a co

79 nstrate that H2A.Z is required for efficient pre-mRNA splicing and indicate a role for H2A.Z in coord

80 inducible RNA helicase RCF1 is essential for pre-mRNA splicing and is important for cold-responsive g

81 other set of interactions was focused on the pre-mRNA splicing and maturation machinery, potentially

82 Pre-mRNA splicing and mRNA stability are fundamentally a

83 tion in essential cellular processes such as pre-mRNA splicing and mRNA translation and also regulate

84 ents in cell physiology by the regulation of pre-mRNA splicing and mRNA translation.

85 inct activities at the levels of alternative pre-mRNA splicing and mRNA translation.

86 gest two new nuclear roles for Ago-2: one in pre-mRNA splicing and one in transcriptional repression.

87 tiple mRNA isoforms, produced by alternative pre-mRNA splicing and other mechanisms, and that most al

88 actions during the regulation of alternative pre-mRNA splicing and other processes.

89 , RRP6, with in vivo consequences of altered pre-mRNA splicing and poly(A) tail length control.

90 ons of SR (serine/arginine-rich) proteins in pre-mRNA splicing and processing are modulated by revers

91 ounds also potently improve FXTAS-associated pre-mRNA splicing and RAN translational defects, while n

92 ctional ncRNA, known for its pivotal role in pre-mRNA splicing and regulation of RNA 3' end processin

93 (eU1s) have the unique ability to reprogram pre-mRNA splicing and restore exon 7 inclusion in SMN1 c

94 DDX41 lesions caused altered pre-mRNA splicing and RNA processing.

95 among them are nuclear proteins involved in pre-mRNA splicing and RNA stability and transport.

96 mall nuclear and nucleolar RNAs that program pre-mRNA splicing and rRNA processing have a signature 5

97 However, a direct link between alternative pre-mRNA splicing and small RNA pathways has remained el

98 PRP19 is a ubiquitin ligase involved in pre-mRNA splicing and the DNA damage response (DDR).

99 inase 11 (CDK11)(p110) kinase, implicated in pre-mRNA splicing and transcription, was identified as a

100 gets; strongly suggesting that SRSF1 couples pre-mRNA splicing and translation.

101 n of HIV-1 gene and host gene transcription, pre-mRNA splicing, and cancer immunology.

102 1 silencing can be uncoupled from defects in pre-mRNA splicing, and the RNAi and splicing machineries

103 beyond transcription initiation and regulate pre-mRNA splicing, and thereby mRNA isoform production,

104 ed the first evidence that TRAMP facilitates pre-mRNA splicing, and we interpreted this as a fail-saf

105 Small molecule inhibitors of pre-mRNA splicing are important tools for identifying ne

106 whose functions and molecular mechanisms in pre-mRNA splicing are presently poorly understood.

107 ms that regulate alternative precursor mRNA (pre-mRNA) splicing are largely unknown.

108 chronic lymphocytic leukemia and highlights pre-mRNA splicing as a critical cellular process contrib

109 Here we identify interference with pre-mRNA splicing as a mechanism to combat vemurafenib r

110 current mutation in U2AF1 implicates altered pre-mRNA splicing as a potential mechanism for MDS patho

111 e DEAH-box helicase Prp43 is a key player in pre-mRNA splicing as well as the maturation of rRNAs.

112 Aberrant alternative pre-mRNA splicing (AS) events have been associated with

113 Alternative pre-mRNA splicing (AS) is a critical regulatory mechanis

114 le of chromatin in regulation of alternative pre-mRNA splicing (AS).

115 gene, OPRM1, undergoes extensive alternative pre-mRNA splicing, as illustrated by the identification

116 urther supported by genetic interactions and pre-mRNA splicing assays.

117 ntified a small molecule that inhibits human pre-mRNA splicing at an intermediate stage during conver

118 cl-x are produced as a result of alternative pre-mRNA splicing: Bcl-x(L) (the long form) is anti-apop

119 an essential role of m(6)A in regulating RTA pre-mRNA splicing but also suggest that KSHV has evolved

120 os, demonstrating the involvement of Hoip in pre-mRNA splicing, but not in transcription, of muscle s

121 rtant roles in the regulation of alternative pre-mRNA splicing, but their role in other gene regulato

122 ze mainly in the nucleus where they regulate pre-mRNA splicing, but they are also involved in mRNA tr

123 ce of the coordinated control of alternative pre-mRNA splicing by chromatin structure and transcripti

124 holino oligonucleotides (AMOs) can reprogram pre-mRNA splicing by complementary binding to a target s

125 cate that the Psis in U2 snRNA contribute to pre-mRNA splicing by directly altering the binding/ATPas

126 ncing data identified a global regulation of pre-mRNA splicing by GnRH.

127 Here, we report that SSA inhibits pre-mRNA splicing by interfering with the spliceosome su

128 a new potential mechanism for regulation of pre-mRNA splicing by lysine methylation of a splicing fa

129 gh-throughput cell-based assay that measures pre-mRNA splicing by utilizing a quantitative reporter s

130 Precursor mRNA (pre-mRNA) splicing can join exons contained on either a

131 nificantly expand our current concept of the pre-mRNA "splicing code" to include dynamic intragenic D

132 et al. reported single-molecule analyses of pre-mRNA splicing, confirming transcription-coupled spli

133 ic transcription initiation, nor alternative pre-mRNA splicing, contributed to the observed changes i

134 ytosine and CTCF mediate opposing effects on pre-mRNA splicing: CTCF promotes inclusion of weak upstr

135 t a number of different levels by regulating pre-mRNA splicing, deadenylation and mRNA stability.

136 om the Hoechst query improves DM1-associated pre-mRNA splicing defects in cell and mouse models of DM

137 Alternative pre-mRNA splicing determines the protein output of most

138 s caused by the dysregulation of alternative pre-mRNA splicing due to sequestration of muscleblind-li

139 iates muscle cell function via regulation of pre-mRNA splicing during early vertebrate embryogenesis.

140 We hypothesized that the requirements for pre-mRNA splicing efficiency were likely to vary during

141 depletion caused a significant reduction in pre-mRNA splicing efficiency, as demonstrated through RN

142 wn about how these splicing factors regulate pre-mRNA splicing events, comparatively little is known

143 ript half-life but are not required for most pre-mRNA splicing events.

144 low temperature effects on a large subset of pre-mRNA splicing events.

145 Alternative pre-mRNA splicing expands the complexity of the transcri

146 Yeast Prp28 is a DEAD-box pre-mRNA splicing factor implicated in displacing U1 snR

147 The pre-mRNA splicing factor PRPF8 is a crucial component of

148 One of these, the pre-mRNA splicing factor SF3B1, is also frequently mutat

149 rgoes isoform switching mediated by ESRP1, a pre-mRNA splicing factor that regulates EMT.

150 mic associations between SR-like protein and pre-mRNA splicing factor to promote target specificity i

151 The essential pre-mRNA splicing factor U2AF(65) is faced with the para

152 How the essential pre-mRNA splicing factor U2AF(65) recognizes the polypyr

153 l for appropriate subnuclear organization of pre-mRNA splicing factors and for promoting normal cell

154 Select pre-mRNA splicing factors have been implicated in RNAi i

155 Although Son precisely colocalizes with pre-mRNA splicing factors in nuclear speckles, its deple

156 ed by proteomics as Ser/Arg-rich alternative pre-mRNA splicing factors or Sfrs1, Sfrs2, Sfrs5, and Sf

157 Pre-mRNA splicing factors play a fundamental role in reg

158 Somatic mutations of pre-mRNA splicing factors recur among patients with myel

159 l genomic screening, we identify a set of 26 pre-mRNA splicing factors that are required for sister c

160 dramatic translocation of Hnrnpa1 and other pre-mRNA splicing factors to the nucleus in a transcript

161 Cotranscriptional recruitment of pre-mRNA splicing factors to their genomic targets facil

162 ecular theme among MDS-relevant mutations of pre-mRNA splicing factors.

163 teractions with U2AF ligand motifs (ULMs) of pre-mRNA splicing factors.

164 R) proteins constitute a conserved family of pre-mRNA splicing factors.

165 ediated by 'hotspots' of the SF3B1 and U2AF1 pre-mRNA splicing factors.

166 M39 associates with precursor messenger RNA (pre-mRNA) splicing factors, and inactivation of RBM39 by

167 karyotic Sm proteins play essential roles in pre-mRNA splicing, forming the cores of spliceosomal sma

168 previously showed that redirection of Bcl-x pre-mRNA splicing from Bcl-x(L) to -x(S) induced apoptos

169 eukaryotic transcripts by removing introns, pre-mRNA splicing greatly impacts protein composition of

170 Evidence of altered pre-mRNA splicing has been detected in CLL cases with SF

171 he proteome expanding effects of alternative pre-mRNA splicing have had a profound impact on eukaryot

172 Here we demonstrate that pre-mRNA splicing homeostasis is a biomarker and predict

173 ed NS proteins via its role in governing MVC pre-mRNA splicing.IMPORTANCE The Parvovirinae are small

174 es a direct link to couple transcription and pre-mRNA splicing in a manner differing from the other s

175 sequestration of splicing factors and alters pre-mRNA splicing in a range of downstream effector gene

176 ne-rich RNA-binding protein AtGRP7 regulates pre-mRNA splicing in Arabidopsis.

177 tron recognition in the majority of cases of pre-mRNA splicing in eukaryotes.

178 large ribonucleoprotein complex that guides pre-mRNA splicing in eukaryotic cells.

179 uss the roles of RNA editing and alternative pre-mRNA splicing in generating CaV channel isoforms wit

180 Despite the critical role of pre-mRNA splicing in generating proteomic diversity and

181 display altered hematopoiesis and changes in pre-mRNA splicing in hematopoietic progenitor cells by w

182 Bcl-x SSO resulted in modification of Bcl-x pre-mRNA splicing in lung metastases and reduced tumor l

183 rticipate in both constitutive and regulated pre-mRNA splicing in mammalian cells.

184 U2AF(65) is essential for pre-mRNA splicing in most eukaryotes.

185 n ABA signalling, shows a dramatic defect in pre-mRNA splicing in rbm25 mutants.

186 regulatory protein 1 (ESRP1) on alternative pre-mRNA splicing in the corneal epithelial context.

187 ases to institute phosphorylation control of pre-mRNA splicing in the nucleus.

188 dentified 10 new compounds that both inhibit pre-mRNA splicing in vitro and modify splicing of endoge

189 CPAMD8 splice-site mutations caused aberrant pre-mRNA splicing in vivo or in vitro.

190 Our quantitative analysis of the kinetics of pre-mRNA splicing in yeast reveals that ribosomal protei

191 Yeast pre-mRNA splicing initiates via formation of a complex c

192 hibitor resistance mechanism and we identify pre-mRNA splicing interference as a potential therapeuti

193 Pre-mRNA splicing involves two transesterification steps

194 Alternative pre-mRNA splicing is a central element of eukaryotic gen

195 Pre-mRNA splicing is a complex regulatory nexus modulate

196 Alternative pre-mRNA splicing is a major gene expression regulatory

197 Eukaryotic pre-mRNA splicing is an essential step in gene expressio

198 Pre-mRNA splicing is an essential step of eukaryotic gen

199 Pre-mRNA splicing is carried out by the spliceosome, whi

200 Pre-mRNA splicing is catalyzed by the large ribonucleopr

201 Pre-mRNA splicing is catalyzed through the activity of t

202 Pre-mRNA splicing is coupled to transcription by RNA pol

203 ongation rate increases, and the kinetics of pre-mRNA splicing is delayed with respect to RNAPII elon

204 Pre-mRNA splicing is frequently coupled to transcription

205 A role for Bud31 in pre-mRNA splicing is implicated by virtue of its associa

206 witching oligonucleotides (SSOs) to modulate pre-mRNA splicing is increasingly evident in a number of

207 Pre-mRNA splicing is regulated by developmental and envi

208 Pre-mRNA splicing is required for the accurate expressio

209 An established paradigm in pre-mRNA splicing is the recognition of the 5' splice si

210 A) site usage and how this interrelates with pre-mRNA splicing is then reviewed.

211 Cell-specific alternative pre-mRNA splicing is thought to optimize protein functio

212 Precursor messenger RNA (pre-mRNA) splicing is a critical step in the posttranscr

213 Precursor mRNA (pre-mRNA) splicing is a fundamental link between gene ex

214 Precursor mRNA (pre-mRNA) splicing is catalyzed by a large ribonucleopro

215 While U2AF is considered essential for pre-mRNA splicing, its requirement for splicing on a gen

216 at these positions reduce the efficiency of pre-mRNA splicing, leading to growth-deficient phenotype

217 ll nuclear RNAs (U-snRNAs) are essential for pre-mRNA splicing, little is known regarding their funct

218 stem for the reading of histone marks by the pre-mRNA splicing machinery.

219 e produced when the precursor messenger RNA (pre-mRNA) splicing machinery "backsplices" and covalentl

220 These results suggest that alternative pre-mRNA splicing may be an important regulatory mechani

221 Our data demonstrate that pre-mRNA splicing may be regulated by chromatin structur

222 ical cancers harbouring U2AF1 mutations with pre-mRNA splicing modulators like sudemycins.

223 We find that small-molecule pre-mRNA splicing modulators reduce BRAF3-9 production a

224 o SR proteins-SRSF3 and SRSF7, regulators of pre-mRNA splicing, nuclear export and translation-intera

225 As pre-mRNA splicing occurs co-transcriptionally, changes i

226 Alternative pre-mRNA splicing occurs extensively in the nervous syst

227 Pre-mRNA splicing occurs in spliceosomes whose assembly

228 Pre-mRNA splicing occurs mainly co-transcriptionally, an

229 SFPS regulates pre-mRNA splicing of a large number of genes, of which m

230 sponse to DNA damage, this complex regulates pre-mRNA splicing of a number of genes involved in DNA d

231 -acceptor mutation, c.101-1G>C, which alters pre-mRNA splicing of ARLBP2 in blood RNA, was identified

232 Prp19 complexes, which specifically impaired pre-mRNA splicing of early zygotic but not maternally en

233 lated developmental processes by controlling pre-mRNA splicing of light signaling and circadian clock

234 Prevention of skipping of exon 7 during pre-mRNA splicing of Survival Motor Neuron 2 (SMN2) hold

235 pathway that operationally links alternative pre-mRNA splicing of the hypoxia-inducible death protein

236 cleotide (ASO) was used to correct defective pre-mRNA splicing of transcripts from the USH1C gene wit

237 Pre-mRNA splicing, once thought to be a strictly posttra

238 not sufficient to enhance co-transcriptional pre-mRNA splicing or capping in vivo.

239 The CTD mutations did not affect pre-mRNA splicing or snRNA levels.

240 al domains responsible for regulating either pre-mRNA splicing or transcriptional activation.

241 ides a surprising link between a pleiotropic pre-mRNA splicing pathway and the precise control of suc

242 ndition-sensitive changes in precursor mRNA (pre-mRNA) splicing pattern, we mapped the transcriptome

243 in Argonaute-2 (Ago-2) regulates alternative pre-mRNA splicing patterns of specific transcripts in th

244 in myotonic discharges, a shift toward adult pre-mRNA splicing patterns, reduced myofiber hypertrophy

245 gene expression through altering alternative pre-mRNA splicing patterns.

246 These mutations alter pre-mRNA splicing patterns.

247 Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of g

248 These results demonstrate that coding and pre-mRNA splicing pressures co-evolve and that a modifie

249 In xenograft models, interference with pre-mRNA splicing prevents tumour formation and slows gr

250 Precursor mRNA (pre-mRNA) splicing proceeds by two consecutive transeste

251 fect of spliceosomal mutations, we evaluated pre-mRNA splicing profiles by RNA deep sequencing.

252 ssential for regulation of transcription and pre-mRNA splicing prompted us to investigate how automet

253 Consequently, alternative pre-mRNA splicing provides an important RNA-based layer

254 ructed, characterized, and used in a nuclear pre-mRNA splicing reaction.

255 nce specificity of lariat formation with the pre-mRNA splicing reaction.

256 to alterations in RNA polymerase elongation, pre-mRNA splicing regulation and chromatin accessibility

257 the evolutionarily conserved Nrl1 protein in pre-mRNA splicing regulation, R-loop suppression and in

258 Here, we identified SLU7, which encodes a pre-mRNA splicing regulator that is inhibited in hepatoc

259 RBFox2 is a well-characterized pre-mRNA splicing regulator, but we now encounter an une

260 In eukaryotes, precursor mRNA (pre-mRNA) splicing removes non-coding intron sequences t

261 n and nutrient deficiency-induced changes in pre-mRNA splicing represent parallel, but potentially in

262 tabolic processes, such as mRNA translation, pre-mRNA splicing, ribosome biogenesis, and double-stran

263 iptional regulators of RNA and can influence pre-mRNA splicing, RNA localization, and stability.

264 on of spliceosome assembly requires ATP, key pre-mRNA splicing sequences and intact U1 and U2 snRNAs.

265 th cases, AON delivery fully restored CEP290 pre-mRNA splicing, significantly increased CEP290 protei

266 hypoxia-ischemia reciprocally altered Bcl-x pre-mRNA splicing, similar to the in vitro studies.

267 nts, suggesting that specific changes in the pre-mRNA splicing sites may be a mechanism by which MAP

268 leocytoplasmic transport, DNA damage repair, pre-mRNA splicing, stress granule dynamics, and others.

269 calized with SR33-YFP, a protein involved in pre-mRNA splicing, suggesting a possible role for GmHSP4

270 hibited GzmA-mediated cell death and rescued pre-mRNA splicing, suggesting that hnRNP A1 is an import

271 son as an approach to evaluate the impact on pre-mRNA splicing suggests that up to 45% of synonymous

272 ar-reaching effect of an exonic variation on pre-mRNA splicing that is mediated by structural changes

273 sembly, as well as the downstream effects on pre-mRNA splicing that result from a decrease in SMN.

274 During pre-mRNA splicing, the spliceosome is activated for cata

275 To promote fidelity in nuclear pre-mRNA splicing, the spliceosome rejects and discards

276 The Bcl-x pre-mRNA undergoes alternative pre-mRNA splicing to generate Bcl-x(L) or Bcl-x(S) matur

277 Becker muscular dystrophy (BMD) by altering pre-mRNA splicing to restore an open reading frame, allo

278 NA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic re

279 SF3B1 mutations are associated with aberrant pre-mRNA splicing using cryptic 3' splice sites (3'SSs),

280 he highly conserved histone variant H2A.Z in pre-mRNA splicing using the intron-rich model yeast Schi

281 In mammalian cells, NMD is also linked to pre-mRNA splicing, usually PTCs trigger strong NMD only

282 the first evidence that CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11(p110).

283 Dysregulation of IR pre-mRNA splicing was confirmed in a chemically induced

284 In particular, pre-mRNA splicing was reported to be associated with slo

285 e effect of the Glrb(spa) LINE1 insertion on pre-mRNA splicing was studied using a minigene approach.

286 vestigate the mechanisms underlying accurate pre-mRNA splicing, we developed an in vitro assay sensit

287 is inhibits not only transcription, but also pre-mRNA splicing, we reasoned that constraints on splic

288 e of the cardiac phenotype, strongly affects pre-mRNA splicing, whereas other mutations with incomple

289 The spliceosome regulates pre-mRNA splicing, which is a critical process in normal

290 pathway for mRNAs during the second step of pre-mRNA splicing, which is a potential step to regulate

291 etary restriction, we find defects in global pre-mRNA splicing with age that are reduced by dietary r

292 ckout (KO) results in substantial changes in pre-mRNA splicing with prevalence of exon skipping event

293 The ability to control pre-mRNA splicing with small molecules could facilitate

294 ifferent approaches used to target and alter pre-mRNA splicing with SSOs.

295 nine domain-containing proteins and mediates pre-mRNA splicing with unclear function in neurons.

296 SF2/ASF is an oncoprotein that functions in pre-mRNA splicing, with additional roles in other posttr

297 tiple mRNA isoforms derived from alternative pre-mRNA splicing, with each alternative exon controlled

298 y protein ICP27 causes partial inhibition of pre-mRNA splicing, with the resultant accumulation of bo

299 lly, we demonstrated that inhibition of B19V pre-mRNA splicing within the second intron by targeting

300 mall molecules that either inhibit or modify pre-mRNA splicing would be valuable for research and pot